Genetics of macrovascular complications in type 2 diabetes
作者机构：Department of Genomic MedicineD.O.Ott Research Institute of ObstetricsGynecology and ReproductologySaint-Petersburg 199034Russia Laboratory of Biobanking and Genomic Medicine of Institute of Translation BiomedicineSt.Petersburg State UniversitySaint-Petersburg 199034Russia
出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)
年 卷 期：2021年第12卷第8期
页 面：1200-1219页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：Supported by Ministry of Science and Higher Education of the Russian Federation within the Applied Science Research Program,No.AAAA-A20-120041390028-0 Estonia-Russia Cross Border Cooperation Programme 2014-2020,No.ER24
主 题：Type 2 diabetes Epigenetics Genetics Macrovascular complications
摘 要：Type 2 diabetes mellitus(T2DM)is a metabolic disorder that currently affects more than 400 million worldwide and is projected to cause 552 million cases by the year ***-term vascular complications,such as coronary artery disease,myocardial infarction,stroke,are the leading causes of morbidity and mortality among diabetic *** recent advances in genome-wide technologies have given a powerful impetus to the study of risk markers for multifactorial *** date,the role of genetic and epigenetic factors in modulating susceptibility to T2DM and its vascular complications is being successfully studied that provides the accumulation of genomic *** the future,this will provide an opportunity to reveal the pathogenetic pathways in the development of the disease and allow to predict the macrovascular complications in T2DM *** review is focused on the evidence of the role of genetic variants and epigenetic changes in the development of macrovascular pathology in diabetic patients.
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