检索结果-南通市图书馆

A systematic review of progenitor survival and maturation in Parkinsonian models

Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promis.ng emergent therapy for Parkinson's disease based on years of foundational research us.ng human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Physiological significance of nitrergic transmission in human penile erection

引用

Asian Journal of Andrology 2000年第1期2卷 51-56页

作者： P.G.Adaikan s.C.ng Department of Obstetrics & Gynaecology National University Hospital National University of Singapore Lower Kent Ridge Road Singapore 119 074Department of Obstetrics & Gynaecology National University Hospital National University of Singapore Lower Kent Ridge Road Singapore 119 074

Aim: Epididymal proteins are known to play an important role in the maturation of spermatozoa, we ought to deter-mine if there are regional differences in androgen-dependent epididymal proteins. Methods: A group of adult rats wascastrated and epididymides were removed three days following castration. The epididymides were dissected into caput,corpus and cauda segments, homogenized, and proteins were fractionated by anion exchange HPLC. Proteins in select-ed fractions were resolved by sDs-PAGE and visualized by silver staining. Results: It was observed that the levels ofmultiple proteins drastically reduced in the various regions of epididymis of the orchiectomized rats. Conclusion: Theepididymal proteins appear to be useful markers to study androgenic action in the epididymis.

关键词： erection neurotransmission corpus cavernosum nitric oxide cyclic GMP

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Composition Dependence of surface Phonon Polariton Mode in Wurtzite InxGa1-xN （0 ≤ x ≤ 1） Ternary Alloy

引用

Chinese Physics Letters 2008年第12期25卷 4378-4380页

作者： s. s. ng Z. Hassan H. Abu Hassan Nano-Optoelectronics Research and Technology Laboratory School of Physics Universiti Sains Malaysia 11800 Minden Pulau Pinang Malaysia

We present a theoretical study on the composition dependence of the surface phonon polariton （sPP） mode in wurtzite structure α-InxGa1-xN ternary alloy over the whole composition range. The sPP modes are obtained by the theoretical simulations by means of an anisotropy model. The results reveal that the sPP mode of α-InxGa1-xN semiconductors exhibits one-mode behaviour. From these data, composition dependence of the sPP mode with bowing parameter of-28.9 cm^-1 is theoretically obtained.

关键词： field emission molybdenum dioxide enhancement factor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neutrophils in cancer—unresolved questions

引用

science China(Life sciences) 2021年第11期64卷 1829-1841页

作者： Melissa s.F.ng Leonard Tan Quanbo Wang Charles R.Mackay Lai Guan ng s.ngapore Immunology Network(sIgN) A*STAR(Agency for ScienceTechnology and Research)Biopolis 138648Singapore school of Pharmaceutical sciences Shandong Analysis and Test CenterQilu University of Technology(Shandong Academy of Sciences)Jinan 250014China state Key Laboratory of Experimental Hematology Institute of HematologyChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020China

There is growing recognition that neutrophils play an important role in cancer initiation, progression and metastasis. Although they are typically characterized as short-lived effector cells, neutrophils have been shown to acquire immunosuppressive and pro-tumorigenic functions that promote tumor progression and escape. As such, inhibition of their function or depletion of neutrophils are being explored as potential cancer therapies. However, growing evidence of neutrophil diversification in cancer and their potential anti-tumor roles raise many unresolved questions. Here, we review recent advances that address the definition,origin and function of neutrophils in cancer, and elaborate on obstacles that make the study of neutrophils challenging. We envision that this review will provide the groundwork for focused design of therapeutics that will specifically target "tumorreprogrammed" neutrophils while sparing normal neutrophils to improve patient outcomes.

关键词： neutrophils cancer myeloid-derived suppressor cells(MDsCs) immunotherapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

引用

Neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： Krisztián Pajer Tamás Bellák Antal Nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(Khyeam et al.,2021).

关键词： injured capacity modified

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

COUPLED VIBRATION OF sTRUCTURAL THIN-WALLED COREs

引用

Acta Mechanica solida sinica 2000年第1期13卷 81-88页

作者： shiu Cho ng J.s.Kuang Department of Civil Engineering Hong Kong University of Science and Technology

This paper presents an analysis of the coupled vibration of asymmetric core structures in tall buildings. The governing equation of free vibration and its corresponding eigenvalue problem, which is a set of equations for laterally flexural vibrations in two different directions coupled by a warping-st. Venant torsional vibration, are derived. Based on the Calerkin method, a generalized approximate method is developed for the analysis of coupled vibration and thus proposed for determining the natural frequencies and mode shapes of the structure in triply-coupled vibration. The results of the proposed method for the example structure show good agreement with those of the FEM analysis. The proposed method has been shown to provide a simple and rapid, yet accurate, means for coupled vibration analysis of core structures.

关键词： coupled vibration analysis asymmetric core structure Galerkin method natural frequency mode shape

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

species delimitation in the White-faced Cuckoo-dove(Turacoena manadensis) based on bioacoustic data

引用

Chinese Birds 2016年第1期7卷 40-47页

作者： Nathaniel s.R.ng Frank E.Rheindt Department of Biological sciences National University of Singapore

Background: The White-faced Cuckoo-dove(Turacoena manadensis) is a poorly-known Wallacean endemic with a limited distribution on sulawesi and its satellites, including the Togian, Banggai and sula archipelagoes. In 1900, populations from the sula archipelago were awarded subspecies status T. manadensis sulaensis based on smaller size and minor differences in plumage; however, this distinction has not been corroborated subsequently, and T. manadensis is considered by most modern sources to be monotypic across its ***: We conducted vocal analysis of the cuckoo-doves' main s.ng us.ng recordings collected from across the taxon's natural range. Descriptive information on the s.ngs was obtained from the recordings us.ng bioacoustic analysis software, after which several statistical methods were used to investigate differences in vocalizations among ***: We report deep bioacoustic divergences in vocal trait pattern from across the cuckoo-doves' range, with birds from Peleng and Taliabu in the east having a different vocal trait pattern from birds from sulawesi, Buton, and Togian in the west. These patterns agree with changes in landmass that accompanied the sea level fluctuations caused by Pleistocene glacial cycles, and indicate that eastern and western cuckoo-dove populations are at the level of different biological ***: We propose that the eastern taxon be elevated to species level as T. sulaensis. Given the rampant degree of habitat destruction in its limited range, this taxonomic change will have important implications on the conservation status of T. sulaensis.

关键词： Wallacea sulawesi Peleng Taliabu Buton Pleistocene Island biogeography

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Vascular endothelial growth factor:a double-edged sword in the development of white matter lesions

引用

Neural Regeneration Research 2025年第1期20卷 191-192页

作者： Narek Manukjan Daniel Fulton Zubair Ahmed WMatthijs Blankesteijn sébastien Foulquier Department of Pharmacology and Toxicology Maastricht UniversityMaastrichtThe Netherlands CARIM-school for Cardiovascular Diseases Maastricht UniversityMaastrichtThe Netherlands Neuroscience and Ophthalmology Institute of Inflammation and AgeingUniversity of BirminghamEdgbastonBirminghamUK Centre for Trauma sciences Research University of BirminghamEdgbastonBirminghamUK MHeNs-school for Mental Health and Neuroscience Maastricht UniversityMaastrichtThe Netherlands Department of Neurology Maastricht University Medical CenterMaastrichtThe Netherlands

As the population ages,the burden of age-related diseases becomes ***,over 55 million people suffer from dementia worldwide,with Alzheimer’s disease being the most common ***,it is becoming clearer that underlying vascular pathology such as cerebral small vessel disease(csVD)may be a more detrimental cause for dementia(Cuadrado-Godia et al.,2018).It is estimated that 10%-30%of the elderly population and 35%-90%of all dementia patients exhibit signs of *** term csVD refers to pathology affecting the small vessels of the brain,which can lead to lacunar cerebral infarcts,enlarged perivascular spaces,and cortical hemorrhages(Cuadrado-Godia et al.,2018).CsVD is often associated with cognitive decline,gait problems,and dementia(Cuadrado-Godia et al.,2018).

关键词： pathology becoming white

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Interaction of oblique waves with an array of long horizontal circular cylinders

引用

science China(Technological sciences) 2007年第4期50卷 490-509页

作者： ng Chiu-On Department of Mechanical Engineering the University of Hong Kong Pokfulam Road Hong Kong China

The scattering and radiations of linear oblique waves by multiple long horizontal circular cylinders submerged in water of finite depth are investigated us.ng the multipole expansion method. Analytical expressions for the diffracted and radiated potentials are given as a linear combination of infinite multipoles. The unknown coefficients in the expressions are determined by us.ng the addition theorem of the Bessel function and the cylinder boundary conditions. Also analytical expressions for wave forces, hydrodynamic coefficients and reflection and transmission coeffi-cients are derived. The present analytical solution is verified through the boundary element method and applied to investigate three different cases of the interaction of oblique waves with multiple submerged horizontal circular cylinders. The results show that the number of cylinders, the arrangement and spacing between cylinders play an important role in wave forces, hydrodynamic coefficients and reflection and transmission coefficients. some interesting and important phenomena are ob-served in numerical experiments.

关键词： scattering and radiation water waves analytical technique hydrodynamic characteristics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

An Efficient stacked-LsTM Based User Clustering for 5G NOMA systems

引用

Computers, Materials & Continua 2022年第9期72卷 6119-6140页

作者： s.Prabha Kumaresan Chee Keong Tan Yin Hoe ng Faculty of Engineering Multimedia UniversityCyberjaya63100Malaysia school of Information Technology Monash UniversitySubang Jaya47500Malaysia

Non-orthogonal multiple access(NOMA)has been a key enabling technology for the fifth generation(5G)cellular *** on the NOMA principle,a traditional neural network has been implemented for user clustering(UC)to maximize the NOMA system’s throughput performance by considering that each sample is independent of the prior and the subsequent ***,the prediction of UC for the future ones is based on the current clustering information,which is never used again due to the lack of memory of the ***,to relate the input features of NOMA users and capture the dependency in the clustering information,time-series methods can assist us in gaining a helpful insight into the *** its mathematical complexity,the essence of time series comes down to examining past behavior and extending that information into the ***,in this paper,we propose a novel and effective stacked long short term memory(s-LsTM)to predict the UC formation of NOMA users to enhance the throughput performance of the 5G-based NOMA *** the proposed strategy,the s-LsTM is modelled to handle the time-series input data to improve the predicting accuracy of UC of the NOMA users by implementing multiple LsTM layers with hidden *** implemented LsTM layers have feedback connections that help to capture the dependency in the clustering information as it propagates between the ***,we develop,train,validate and test the proposed model to predict the UC formation for the futures ones by capturing the dependency in the clustering information based on the time-series *** results demonstrate that the proposed scheme effectively predicts UC and thereby attaining near-optimal throughput performance of 98.94%compared to the exhaustive search method.

关键词： Non-orthogonal multiple access(NOMA) deep neural network(DNN) long short term memory(LsTM) temporal channel user clustering

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：