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Incorporation of a nanotechnology-based additive in cementitious products for clay stabilisation

Journal of Rock Mechanics and Geotechnical Engineering 2020年第5期12卷 1056-1069页

作者： E.U.Eyo s.ng’ambi s.J.Abbey school of Energy Construction and EnvironmentFaculty of EngineeringEnvironment and ComputingCoventry UniversityCoventryUK Faculty of Environment and Technology Department of Geography and Environmental ManagementCivil Engineering ClusterUniversity of the West of EnglandBristolUK

The mechanical performances and water retention characteristics of clays,stabilised by partial substitution of cement with by-products and inclusion of a nanotechnology-based additive called RoadCem(RC),are studied in this *** unconfined compression tests and one-dimensional oedometer swelling were performed after 7 d of curing to understand the influence of addition of 1%of RC material in the stabilised soils with the cement partially replaced by 49%,59%and 69%of ground granulated blast furnace slag(GBBs)or pulverised fuel ash(PFA).The moisture retention capacity of the stabilised clays was also explored us.ng the soil-water retention curve(sWRC)from the measured *** confirmed an obvious effect of the use of RC with the obtained strength and swell properties of the stabilised clays suitable for road application at 50%replacement of *** outcome is associated with the in-depth and penetrating hydration of the cementitious materials by the RC and water which results in the production of needle-like matrix with interlocking filaments e a phenomenon referred to as the‘wrapping’*** the other hand,the sWRC used to describe the water holding capacity and corresponding swell mechanism of clays stabilised by a proportion of RC showed a satisfactory *** moisture retention of the RC-modified clays was initially higher but reduced subsequently as the saturation level increased with decreas.ng *** phenomenon confirmed that clays stabilised by including the RC are water-proof in nature,thus ensuring reduced porosity and suction even at reduced water ***,the stabilised clays with the combination of cement,GGBs and RC showed a better performance compared to those with the PFA included.

关键词： Cement Ground granulated blast furnace slag(GBBs) Fly ash RoadCem(RC) swell stabilisation Unconfined compressive strength soil-water retention curve(sWRC)

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Mitochondrial therapeutics and mitochondrial transfer for neurodegenerative diseases and aging

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Neural Regeneration Research 2025年第3期20卷 794-796页

作者： Neville ng Michelle Newbery Nicole Miles Lezanne Ooi Molecular Horizons and school of Chemistry and Molecular Bioscience University of WollongongWollongongNSWAustralia

Mitochondrial dysfunction and neurodegeneration:Progressive neurodegenerative diseases affect a significant proportion of the population;in a s.ngle year,there are as many as 276 million disabilities and 9 million dea... 详细信息

关键词： degenerative diseases Mitochondrial

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Robust interface and excellent as-built mechanical properties of Ti–6Al–4V fabricated through laser-aided additive manufacturing with powder and wire

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 154-168页

作者： Fei Weng Guijun Bi Youxiang Chew shang sui Chaolin Tan Zhenglin Du Jinlong su Fern Lan ng Key Laboratory for Liquid-solid structural Evolution and Process.ng of Materials Ministry of EducationShandong Engineering&Technology Research Center for Superhard MaterialSchool of Materials Science and EngineeringShandong UniversityJinan 250061China Institute of Intelligent Manufacturing Guangdong Academy of SciencesGuangzhou 510095China s.ngapore Institute of Manufacturing Technology 5 Cleantech Loop636732Singapore

The feasibility of manufacturing Ti-6Al-4V samples through a combination of laser-aided additive manufacturing with powder(LAAM_(p))and wire(LAAM_(w))was explored.A process study was first conducted to successfully circumvent defects in Ti-6Al-4V deposits for LAAM_(p) and LAAM_(w),*** the optimized process parameters,robust interfaces were achieved between powder/wire deposits and the forged substrate,as well as between powder and wire *** characterization results revealed the epitaxial prior β grains in the deposited Ti-6Al-4V,wherein the powder deposit was dominated by a finerα′microstructure and the wire deposit was characterized by lamellar α *** mechanisms of microstructure formation and correlation with mechanical behavior were analyzed and *** mechanical properties of the interfacial samples can meet the requirements of the relevant Aerospace Material specifications(AMs 6932)even without post heat *** fracture occurred within the interfacial area,further suggesting the robust *** findings of this study highlighted the feasibility of combining LAAM_(p) and LAAM_(w) in the direct manufacturing of Ti-6Al-4V parts in accordance with the required dimensional resolution and deposition rate,together with sound strength and ductility balance in the as-built condition.

关键词： laser-aided additive manufacturing powder deposition wire deposition interfacial characteristic mechanical behavior

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A pan-cancer fingerprint:common molecular denominators of the human tumor microenvironment

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signal Transduction and Targeted Therapy 2021年第12期6卷 3371-3372页

作者： susanna s.ng sonia Leonardelli Michael Hölzel Institute of Experimental Oncology University Hospital BonnUniversity of Bonn53127 BonnGermany

In a recent study published in Cancer Cell,Bagaev et *** a pan-cancer tumor microenvironment(TME)classification that can be predictive of response to immune checkpoint inhibitor(ICI)therapy.1 The authors presented a detailed visualization that can be generated for each tumor,which combines the 29 functional gene expression signatures(Fges)used to subtype the TME with targetable genomic *** the compartments and pathways within the TME could aid decision-making in patient-specific treatment of cancer,especially in the context of immunotherapies.2 The increas.ng use of ICIs have shown promis.ng clinical outcomes in several cancer ***,response to treatment is heterogenous and often results in immune-related adverse events.3 Therefore,efforts are focused on the development of prognostic tools to predict response to *** analysis of 468 melanoma patients resulted in grouping of the TME into four major subsets based on manually curated Fges.

关键词： cancer alterations

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A Causality-guided statistical Approach for Modeling Extreme Mei-yu Rainfall Based on Known Large-scale Modes——A Pilot study

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Advances in Atmospheric sciences 2022年第11期39卷 1925-1940页

作者： Kelvin s.ng Gregor C.LECKEBUsCH Kevin I.HODGEs school of Geography Earth and Environmental SciencesUniversity of BirminghamBirmingham B152TTUnited Kingdom Department of Meteorology and NCAs University of ReadingReading RG66BBUnited Kingdom

Extreme Mei-yu rainfall(MYR)can cause catastrophic impacts to the economic development and societal welfare in *** significant improvements have been made in climate models,they often struggle to simulate local-to-regional extreme rainfall(e.g.,MYR).Yet,large-scale climate modes(LsCMs)are relatively well represented in climate *** there exists a close relationship between MYR and various LsCMs,it might be possible to develop causality-guided statistical models for MYR prediction based on *** statistical models could then be applied to climate model simulations to improve the representation of MYR in climate *** this pilot study,it is demonstrated that skillful causality-guided statistical models for MYR can be constructed based on known *** relevancy of the selected predictors for statistical models are found to be consistent with the *** importance of temporal resolution in constructing statistical models for MYR is also shown and is in good agreement with the *** results demonstrate the reliability of the causality-guided approach in studying complex circulation systems such as the East Asian summer monsoon(EAsM).some limitations and possible improvements of the current approach are *** application of the causality-guided approach opens up a new possibility to uncover the complex interactions in the EAsM in future studies.

关键词： extreme rainfall Mei-yu front causality-guided approach large-scale climate modes

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Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

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Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently caus.ng a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

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Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed us.ng the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the process.ng mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

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Clinically relevant factors associated with quantitative optical coherence tomography angiography metrics in deep capillary plexus in patients with diabetes

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Eye and Vision 2020年第1期7卷 64-74页

作者： Fang Yao Tang Erica O.Chan Zihan sun Raymond Wong Jerry Lok simon szeto Jason C.Chan Alexander Lam Clement C.Tham Danny s.ng Carol Y.Cheung Department of Ophthalmology and Visual sciences The Chinese University of Hong KongHong Kong Special Administrative RegionKowloonChina Hong Kong Eye Hospital Hong Kong Special Administrative RegionKowloonChina CUHK Eye Centre Hong Kong Eye Hospital147K Argyle StreetKlnKowloonHong KongChina

Background:To test clinically relevant factors associated with quantitative artifact-free deep capillary plexus(DCP)metrics in patients with diabetes mellitus(DM).Methods:563 eligible eyes(221 with no diabetic retinopathy[DR],135 with mild DR,130 with moderate DR,and 77 with severe DR)from 334 subjects underwent optical coherence tomography-angiography(OCT-A)with a swept-source OCT(Triton DRI-OCT,Topcon,Inc.,Tokyo,Japan).strict criteria were applied to exclude from analysis those DCP images with artifacts and of poor quality,including projection artifacts,motion artifacts,blurriness,signal loss,B-scan segmentation error,or low-quality score.A customized MATLAB program was then used to quantify DCP morphology from the artifact-free DCP images by calculating three metrics:foveal avascular zone(FAZ),vessel density(VD),and fractal dimension(FD).Results:166(29.5%)eyes were excluded after quality control,leaving in the analysis 397 eyes(170 with no DR,101 with mild DR,90 with moderate DR,36 with severe DR)from 250 *** the multiple regression models,larger FAZ area was associated with more severe DR(β=0.687;p=0.037),shorter axial length(AL)(β=−0.171;p=0.003),thinner subfoveal choroid thickness(β=−0.122;p=0.031),and lower body mass index(BMI)(β=−0.090;p=0.047).Lower VD was associated with more severe DR(β=−0.842;p=0.001),shorter AL(β=0.107;p=0.039),and poorer visual acuity(VA)(β=−0.133;p=0.021).Lower FD was associated with more severe DR(β=−0.891;psions:Quantitative artifact-free DCP metrics are associated with VA,DR severity,AL,subfoveal choroidal thickness,age,and BMI in diabetic *** effects of ocular and systemic factors should be considered for meaningful interpretations of DCP changes in DM patients.

关键词： Optical coherence tomography angiography Diabetic retinopathy Deep capillary plexus Visual acuity

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文化外交在促进双边关系中的角色：马拉维孔子学院案例研究

文化外交在促进双边关系中的角色：马拉维孔子学院案例研究

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作者： Tilipo ng'ambi 吉林大学

学位级别：硕士

笔者对马拉维孔子学院对马中文化外交和双边关系的影响进行了深入的分析。本文旨在全面了解孔子学院在马拉维的建立过程以及在马拉维学校里推广汉语学习和传播中华文化对马中双边关系的影响。在本文中,笔者主要采用了定性研究方法,具体... 详细信息

笔者对马拉维孔子学院对马中文化外交和双边关系的影响进行了深入的分析。本文旨在全面了解孔子学院在马拉维的建立过程以及在马拉维学校里推广汉语学习和传播中华文化对马中双边关系的影响。在本文中,笔者主要采用了定性研究方法,具体通过案例分析、文献综述以及与包括马拉维孔子学院的学生和决策者等在内的利益相关者进行访谈对话等方式来收集数据,这使我能够全面评估孔子学院在文化交流、语言能力培养、沟通理解和知识共享上所发挥的作用。研究结果显示,马拉维孔子学院的建立对学生和马拉维社区的文化和教育都产生了积极影响。在马拉维的大中小学中推广汉语学习在使学生在提高语言能力的同时也有助于他们更多地了解中国文化,这不仅增进了马中两国的文化理解,还促进了双边关系的发展。此外,研究发现,孔子学院在增进马中相互理解方面发挥着重要作用。通过开展一系列丰富多彩的文化活动,如中马语言文化交流活动、文化讲习班、奖学金和人道主义援助,孔子学院促进了马中人民之间的友好互动。此外,本文还强调孔子学院积极推动着马中两国的知识交流与沟通。孔子学院通过提供奖学金和开放汉语资源中心使马拉维学生能够获取中国的教育资源,这极大地帮助了他们。这样的信息交流不仅有助于提高马拉维学生的汉语流利性,而且还促进了经验和能力在其他领域的转移。但是,本文研究也发现,马中文化交流互鉴过程存着一定程度上的不足,也面临一些挑战,其中包括员工短缺、孔子学院工作人员的工作许可证延迟、影响不均衡、行政管理缺乏透明度、互联网设备有限和电力资源不足以及难以实现汉语和文化课程的本土化教授。以上,这些研究结果将在更广泛范围内讨论文化机构在改善双边关系的作用时具有重要的启发意义,也能为那些寻求最大限度地发挥孔子学院在促进双边合作与沟通理解方面的作用的政策制定者和从业者提供有益的见解。第二个子部分本文共分五章,各章具体研究内容如下:第一章为“引言”,总体上介绍了文化外交在促进双边关系中的作用,并具体以马拉维孔子学院为案例展开研究,具体包括本文的研究问题即本文主题、主要论点、研究意义、文献综述、研究方法和论文结构。研究主题部分,简要介绍了两国关系、文化外交和孔子学院在世界范围内的历史背景;谈及研究意义,笔者认为本文对于如何填补文献空白以及在实践中如何应用等问题上都做出了贡献;在进行文献综述时,笔者概述了与本文研究主题相关的其他作者的作品和研究成果,包括约瑟夫·奈的“软实力”概念、文化外交、孔子学院的背景情况和外交意义以及当前面临的质疑和挑战;研究方法方面,笔者在此重点探讨了开展研究时所采用的数据收集方法;最后是论文结构部分,通过对后续章节进行简要的概述,而这将成为读者进一步了解论文谋篇布局和具体研究过程的路线图;值得注意的是,本文的主要论文也将在本章中有所体现。第二章考察了马拉维与中国之间的关系,尤为强调马中之间文化外交的作用。为更加透彻地理解这种关系,笔者调查了为马中双边互动关系奠定基础的历史环境。本章以马中建交为开篇,具体着眼于促使马拉维于2007年正式承认中华人民共和国的历史背景,值得一提的是,马拉维对中华人民共和国的正式承认也标志着马中关系的开始。笔者同时也关注到了那些影响马中关系的重大趋势,其中包括双边协议的签署、两国互访和经济发展。本章深入探讨了马中两国的文化外交活动和双边协议,比如马中两国协力达成的《马中文化协定》的第2(a)条就强调:缔约双方同意推动双方的文化交流与。作为中马文化外交另一重要方面,《孔子学院协议》在促进孔子学院在马拉维建立时发挥着重要作用,这些学院后来成为汉语教学和中华文化传播的活动中心。本章的最后则集中介绍了中国向马拉维提供的奖学金项目和培训课程,这些项目也是文化外交在国家间互动中发挥作用的见证。实践证明,这些项目的确对马拉维年轻人、政府工作人员、私营企业人员和社会个体有益。第三章集中探讨了孔子学院在马拉维的建立过程与具体运作。本章主要分析了孔子学院和汉语资源中心在马拉维的背景情况、解释了它们成立的原因、具体的运作程序,此外,本章还介绍了孔子学院和资源中心在马拉维开展的各种活动,包括文化工作坊、中马语言文化交流活动、学业奖学金和人道主义援助项目。同样在第三章中,笔者进一步分析了孔子学院的使命任务、目标宗旨及其项目范围。孔子学院旨在推广汉语学习和促进中国文化传播,同时促进中马人民之间的互通互鉴和同心协作。同时,笔者也分析了孔子学院开展了的各类项目,如开设汉语课程、设置HsK考试、共庆中国节日和兴建图书馆等,这些措施有助于加深当地人民和学生对中国历史和文化的了解。此外,笔者还考察了孔子学院与其他利益相关者之间的合作努力,同时发现孔子学院与当地教育机构的存在重要合作。值得注意的是,许多中小学已经将汉语学习纳入了课程学习中,这些学校里的学生踊跃参加“汉语桥”普通话比赛。笔者也进一步

关键词：孔子学院

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