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Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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Neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： Krisztián Pajer Tamás Bellák Antal Nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(Khyeam et al.,2021).

关键词： injured capacity modified

Phase Transition for Dielectric Breakdown Model

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communications in Nonlinear science and Numerical simulation 1997年第4期2卷 201-206页

作者： Fuxuan cHANG &Houqiang LI &De L IU &L ibin L IN (Department of Physics. Open laboratory of Radiation Physics and Technology,sichuan University,chengdu,6 1 0 0 6 4,china) 1The paper was received on Nov. 2 0 ,1997 Department of Physics Open laboratory of Radiation Physics and Technology Sichuan University Chengdu 610064 China

In this paper,the phase transition for DBM whenηvaries is investigated by using real- space renormalization-group method. The resultdemonstrates that there are phase transitions for almost all the value ofη,and we f... 详细信息

关键词： DBM phase transition renormalization-group

TLR2 and TLR4 in Parkinson’s disease pathogenesis:the environment takes a toll on the gut

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Translational Neurodegeneration 2021年第4期10卷 611-629页

作者： Anastazja M.Gorecki chidozie c.Anyaegbu Ryan s.Anderton school of Biological science University of Western AustraliaCrawleyWAAustralia Neurodegenerative Disorders Research Group Perron Institute for Neurological and Translational ScienceNedlandsWAAustralia curtin Health Innovation Research Institute Ralph and Patricia Sarich Neuroscience Research InstituteCurtin UniversityNedlandsWAAustralia Faculty of Medicine Nursing and Midwifery and Faculty of Health SciencesUniversity of Notre Dame AustraliaFremantleWAAustralia school of Nursing MidwiferyHealth Sciences and PhysiotherapyUniversity of Notre Dame AustraliaFremantleWAAustralia

Parkinson's disease(PD)is an incurable,devastating disorder that is characterized by pathological protein aggregation and neurodegeneration in the substantia *** recent years,growing evidence has implicated the gut environment and the gut-brain axis in the pathogenesis and progression of PD,especially in a subset of people who exhibit prodromal gastrointestinal ***,perturbations of gut homeostasis are hypothesized to contribute toα-synuclein aggregation in enteric neurons,which may spread to the brain over decades and eventually result in the characteristic central nervous system manifestations of PD,including neurodegeneration and motor ***,the mechanisms linking gut disturbances andα-synuclein aggregation are still unclear.A plethora of research indicates that toll-like receptors(TLRs),especially TLR2 and TLR4;are critical mediators of gut *** their established role in innate immunity throughout the body,studies are increasingly demonstrating that TLR2 and TLR4 signalling shapes the development and function of the gut and the enteric nervous ***,TLR2 and TLR4 are dysregulated in patients with PD,and may thus be central to early gut dysfunction in *** better understand the putative contribution of intestinal TLR2 and TLR4 dysfunction to earlyα-synuclein aggregation and PD,we critically discuss the role of TLR2 and TLR4 in normal gut function as well as evidence for altered TLR2 and TLR4 signalling in PD;by reviewing clinical,animal model and in vitro *** evidence on the immunological aetiology ofα-synuclein aggregation is also discussed,with a focus on the interactions ofα-synuclein with TLR2 and *** propose a conceptual model of PD pathogenesis in which microbial dysbiosis alters the permeability of the intestinal barrier as well as TLR2 and TLR4 signalling,ultimately leading to a positive feedback loop of chronic gut dysfunction promotingα-synuclein aggregation in enteric an

关键词： Parkinson’s disease TLR2 TLR4 α-synuclein Gut-brain axis Gut barrier Gut homeostasis

Effect of Excited and Fourth Generation Leptons in Lepton Flavor Violating μ− → e- 2γ Decay

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chinese Physics Letters 2011年第8期28卷 51-53页

作者： s.c.İnan Department of Physics Cumhuriyet UniversitySivas 58140Turkey

We study the lepton flavor violatingμ−→e-2γdecay induced by the mediation of heavy leptons,such as the excited and fourth generation *** of these leptons inμ−→e-2γdecay are *** is found that the branching ratio of this decay is very sensitive to excited and fourth generation ***,we obtain the bounds on model parameters by using the current experimental limit of this decay.

关键词： decay excited branching

Direct Graviton Production via Photon-Photon Fusion at the cERN-LHc

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chinese Physics Letters 2012年第3期29卷 63-66页

作者： s.c.İnan Department of Physics Cumhuriyet University58140SivasTurkey

The potential of pp→pγγp/→pGp process in scenarios of the Arkani-Hamed,Dimopoulos,Dvali(ADD)and Randall-sundrum(Rs)model at the LHc is examined,and 95%*** on the model parameters are *** is found that the sensitiv... 详细信息

关键词： reaction bounds LHc

Pregnant women's knowledge of perinatal HIV infection in a resource limited setting

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Asian Pacific Journal of Tropical Medicine 2008年第3期1卷 69-71页

作者： Onwere s Okoro O chigbu B Kamanu c Aluka c Feyi-Waboso P Department of Obstetrics and Gynaecology Abia State University Teaching HospitalP.M.B.7004AbaAbia StateNigeria

The purpose of the study was to assess pregnant women s knowledge of perinatal human immunodeficiency virus (HIV) infection.A descriptive study involving 100 consecutive and consenting patients at the antenatal clinic of Abia state University Teaching Hospital(ABsUTH),Aba,south Eastern Nigeria,over the period 1st November, 2007 to 15th January,2008 was *** a structured questionnaire,the respondents’sociodemographic data were recorded as well as their knowledge of perinatal HTV *** 85%of the pregnant women were aware of perinatal HTV transmission,only 69%knew that if a baby tested positive to HIV at delivery,it meant that the mother is infected with *** one percent of the pregnant women wrongly thought that all babies bom to mothers with HIV also get infected whilst 83%knew that HTV can be transmitted through breast *** pregnant women demonstrated an incomplete knowledge of perinatal HTV transmission. The findings of this study underscore the continued need for intensified health education about prevention of perinatal HTV infection in our community in order to reduce the impact of HIV,especially in

关键词： pregnant women knowledge perinatal HIV transmission

Immediate, Fast, and Overcome Response of the Organism in Response to Energy Osteopathy on the Model of Primary Gonarthrosis (Polyparametric and statistical studies)

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chinese Medicine and culture 2019年第4期2卷 196-202页

作者： Yu 0.Novikov 0.G.Kantor JeanPierre Guiliani Federal state Budget Funded Educational Institution of Higher Education“Bashkortostan state Medical University ”Ministry of Healthcare of the Russian Federation Ufa state Petroleum Technological University UfaRepublic of BashkortostanRussian Federation sFERE college of Traditional chinese Energetics La Tour-d’AiguesFrance

In 26 patients with confirmed primary verified gonarthrosis(PGA),a clinical and instrumental examination was conducted to evaluate the response energy osteopathy followed by statistical processing of the *** types of the body’s response to treatment were identified:immediate,fast,and delayed,which,despite the different informative value of the data of the polyparametric study,allowed judging the effectiveness of the method used.

关键词： Energy osteopathy fast and delayed response of the organism instantaneous polyparametric study primary gonarthrosis

Vascular endothelial growth factor:a double-edged sword in the development of white matter lesions

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Neural Regeneration Research 2025年第1期20卷 191-192页

作者： Narek Manukjan Daniel Fulton Zubair Ahmed WMatthijs Blankesteijn sébastien Foulquier Department of Pharmacology and Toxicology Maastricht UniversityMaastrichtThe Netherlands cARIM-school for cardiovascular Diseases Maastricht UniversityMaastrichtThe Netherlands Neuroscience and Ophthalmology Institute of Inflammation and AgeingUniversity of BirminghamEdgbastonBirminghamUK centre for Trauma sciences Research University of BirminghamEdgbastonBirminghamUK MHeNs-school for Mental Health and Neuroscience Maastricht UniversityMaastrichtThe Netherlands Department of Neurology Maastricht University Medical CenterMaastrichtThe Netherlands

As the population ages,the burden of age-related diseases becomes ***,over 55 million people suffer from dementia worldwide,with Alzheimer’s disease being the most common ***,it is becoming clearer that underlying vascular pathology such as cerebral small vessel disease(csVD)may be a more detrimental cause for dementia(cuadrado-Godia et al.,2018).It is estimated that 10%-30%of the elderly population and 35%-90%of all dementia patients exhibit signs of *** term csVD refers to pathology affecting the small vessels of the brain,which can lead to lacunar cerebral infarcts,enlarged perivascular spaces,and cortical hemorrhages(cuadrado-Godia et al.,2018).csVD is often associated with cognitive decline,gait problems,and dementia(cuadrado-Godia et al.,2018).

关键词： pathology becoming white

The Transport Properties of concrete under the simultaneous coupling of Fatigue Load and Environment Factors

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Journal of Wuhan University of Technology(Materials science) 2012年第1期27卷 181-186页

作者： WANG caihui sUN Wei JING Jinyang HAN Jiande R0NG Hui school of Materials science and Engineering Southeast University Jiangsu Key Laboratory of construction Materials

A set of coupling experimental instrument was designed to study the transport properties of chloride ion in concrete under simultaneous coupling action of fatigue load and environmental factors. Firstly the water-saturated performance of modem concrete was investigated, then diffusion performance of chloride ion under different stress levels and different temperature were studied respectively; meanwhile, the time- dependent behavior of the chloride ion diffusion in concrete was also researched. The results showed that the saturation degree of concrete can reach as high as 99%. Besides, diffusion coefficient of chloride ion increased with increasing of the stress level and temperature, and when the stress level and temperature are at 0.6 and 60 ℃ respectively, the diffusion coefficient is 6.3 ×10 -14 m2/s, moreover the diffusion coefficient of chloride ion in concrete decreased with time under the simultaneous coupling action of fatigue load and environment factors.

关键词： chloride diffusion fatigue load concrete stress level temperature time dependent