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作者： s.masunaga Research Reactor Institute Kyoto University

BACKGROUNDs AND PURPOsEs:Human solid tumors are thought to contain moderately large fractions of quiescent(Q) tumor cells that are out of the cell cycle and stop cell division,but are viable compared with established experimental animal tumor lines that have been employed for various oncology *** presence of Q cells is probably due,in part,to hypoxia and the depletion of nutrition in the tumor core,which is another consequence of poor vascular *** a result,Q cells are viable and clonogenic,but stop cell *** general,radiation and many DNA-damaging chemothe-

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Development of New Tumor Targeting 10B-carrier:Boron Cluster-Cyclic RGD Pentapeptide Conjugates for Boron Neutron Capture Therapy

Development of New Tumor Targeting 10B-carrier:Boron Cluster...

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作者： s.Kimura s.Ueda K.Okuda s.masunaga H.Nagasawa Laboratory of Medicinal & Pharmaceutical Chemistry Gifu Pharmaceutical University

INTRODUCTION:A neutron capture reaction in boron[B(n,α) Li]is,in principle,very effective in destroying tumors selectively,providing that sufficient amount of B can be accumulated in the target tumor. However one of the major limitations in boron neutron capture therapy(BNCT) is insufficient and heterogeneous delivery of B from currently clinical-used B carriers, such as sodium mercaptoundecahydrododecaborate-B (BsH) and L-4-boronophenylalanine-B(BPA),into the target *** augment the efficiency of BNCT,we developed new B carriers containing the Arg-Gly-Asp

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Optical imaging of Intratumor HIF-1 Activity to Optimize Treatment Regimen for the Combination of a HIF-1 Inhibitor with Radiation Therapy

Optical imaging of Intratumor HIF-1 Activity to Optimize Tre...

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作者： H.Harada s.Itasaka K.shibuya s.masunaga M.Hiraoka Department of Radiation Oncology and Image-applied Therapy Kyoto University Graduate School of Medicine

BACKGROUND & PURPOsE:Tumor cells in which the transcriptional activity of hypoxia-inducible factor 1 (HIF-1) is extremely high are recognized as potential targets in cancer therapy because HIF-1 has been strongly associated with not only tumor angiogenesis,invasion, metastasis but also poor prognosis after radiation therapy. Here,we performed a series of optical imaging experiments to clarify the postirradiation changes in intratumor HIF-1 *** on the information,we intended to optimize the protocol for the combination of a HIF-1 inhibitor, YC-1,with radiation therapy.

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Influence of Manipulating Hypoxia in solid Tumors on Radiation Dose-Rate Effect in Vivo,with Reference to That in Quiescent Tumor Cell Population

Influence of Manipulating Hypoxia in Solid Tumors on Radiati...

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作者： s.masunaga R.Hirayama A.Uzawa G.Kashino Y.sakurai H.Tanaka M.suzuki Y.Kinashi Y.Liu s.Koike K.Ando K.Ono National Institute of Radiological sciences Heavy Ion Medical Center Gunma University

BACKGROUNDs AND PURPOsEs:Intensity modulated radiotherapy(IMRT) and stereotactic irradiation have become common as a new radiotherapy technique for treatment of *** modalities generally use multiple arc or fixed-portal radiation beams,and radiation beams are exposed *** techniques often require 30 rain or a longer time in one treatment session for precise positioning of *** of irradiation time may reduce a radiation effect,and evokes a major concern for the dose rate ***,it is needed to clarify the

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Manipulating Hypoxia in solid Tumors Has the Potential to Influence Lung Metastases in vivo

Manipulating Hypoxia in Solid Tumors Has the Potential to In...

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作者： s.masunaga Y.Matsumoto R.Hirayama G.Kashino Y.sakurai H.Tanaka M.suzuki Y.Kinashi Y.Liu K.Ando K.Ono National Institute of Radiological sciences Heavy Ion Medical Center Gunma University

BACKGROUNDs AND PURPOsEs:Many cells in solid tumors are quiescent in situ but are still clonogenic .Quiescent(Q) tumor cells are more resistant to low-LET radiation because of their larger hypoxic fraction and greater capacity to recover from radiation -induced DNA damage than proliferating(P) tumor *** original method for selectively detecting the response of intratumor Q cells has made it possible to evaluate the usefulness of various modalities for cancer therapy in terms of effectiveness against intratumor Q

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Usefulness of Hexamethylenetetramine as an Adjuvant to Radiotherapy and Cisplatin Treatment for solid Tumors:its independency of p53 status

Usefulness of Hexamethylenetetramine as an Adjuvant to Radio...

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作者： s.masunaga K.Tano J.Nakamura M.Watanabe G.Kashino A.Takahashi H.Tanaka Y.sakurai M.suzuki K.Ohnishi Y.Kinashi Y.Liu T.Ohnishi K.Ono University of North Carolina at Chapel Hill USA Nara Medical University

BACKGROUNDs AND PURPOsEs:Formaldehyde preserves or fixes tissue or cells by irreversibly cross-linking primary amine groups in proteins with other nearby nitrogen atoms in protein or DNA through a -CH2- *** acid-dependent formaldehyde donor, hexamethylenetetramine(HMTA),has been used as an antiseptic for urinary tract infections and it has been supposed to be characterized as a non-carcinogen in animals. In the hypoxic condition in a solid tumor,pyruvate

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soil Development and Fertility Characteristics of Inland Valleys in the Rain Forest Zone of Nigeria: Mineralogical Composition and Particle-size Distribution

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Pedosphere 2009年第4期19卷 505-514页

作者： s. s. ABE G. O. OYEDIRAN T. masunaga s. YAMAMOTO T. HONNA T. WAKATsUKI Africa Rice Center (WARDA) Faculty of Agriculture Tottori University Department of Agronomy Ladoke Akintola University of Technology Ogbamoso (Nigeria) Faculty of Life and Environmental science Shimane University Faculty of Agriculture Kinki University

The particle-size distribution and mineralogical composition of the clay （〈 2 μm） and fine-sand （0.25-0.10 mm） fractions in soils of two inland valleys in Abakaliki and Bende, southeast Nigeria, were investigated to provide basic information on soil-forming processes and agricultural potentials. These soils were silty or clayey, deriving from Cretaceous or Tertiary shale materials. The particle-size distribution and its computation on a clay-free basis revealed relatively remarkable lithologic breaks in a couple of pedons. The effect of lithologic discontinuities on soil mineralogical composition was not, however, conspicuous. Petrographic investigation revealed that quartz predominantly comprised the fine-sand fraction in the soils at both study sites. Nevertheless, the clay mineralogical composition of the soils was a mixture of kaolinite, irregularly interstratified smectite-illite intergrades （s/I）, hydroxyl-A1 interlayered 2：1 type clays （HICs）, vermiculite, smectite, halloysite and illite along with fine-sized quartz in Abakaliki. The soils of Bende predominantly contained smectite, which was partially interlayered with hydroxyl-A1 and kaolinite. It is suggested that seasonal floodwater has slowed the disintegration of weatherable clay minerals inherited from the shale, while quartz originating from the sandstone is predominant in the fine-sand fraction. Additionally, a possible soil-forming process observed at the both study sites was ferrolysis, which was indicated by a clear decreasing pattern of HICs downward in the soil profiles, The entry of s/I and vertical distribution patterns for a couple of clay minerals in the pedon suggested that the soils in Abakaliki have developed under the significant influence of aeolian dust delivered by the Harmattan. The findings might describe a site-specific deposition pattern of Harmattan dusts as well as hydromorphic soil-forming processes in the wetlands of the inland valleys.

关键词： aeolian dust ferrolysis hydromorphic soil hydroxyl-A1 interlayered 2:1 type clays southeast Nigeria

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starbase:A Potential Modern Company Town

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空中英语教室（高级版．彭蒙惠英语） 2021年第9期 32-34,47,48页

作者： samantha masunaga 不详

The secluded Texas beachside community of Boca Chica Village was once a haven for retirees,snowbirds and outdoorsy ***,traffic backs up the lone highway out of the unincorporated area that’s now home to only about half a dozen residents-and spaceX’s starship *** test launches,residents receive a notice suggesting they temporarily evacuate for safety.

关键词： base beach haven

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