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In search of a pan-coronavirus vaccine:next-generation vaccine design and immune mechanisms

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Cellular & molecular Immunology 2024年第2期21卷 103-118页

作者： s.Cankat m.U.Demael L.swadling Division of Infection and Immunity Institute of Immunity and TransplantationUniversity College LondonPears BuildingLondon NW32PPUK

members of the coronaviridae family are endemic to human populations and have caused several epidemics and pandemics in recent *** this review,we will discuss the feasibility of and progress toward the ultimate goal of creating a pan-coronavirus vaccine that can protect against infection and disease by all members of the coronavirus *** will detail the unmet clinical need associated with the continued transmission of sARs-CoV-2,mERs-CoV and the four seasonal coronaviruses(HCoV-OC43,NL63,HKU1 and 229E)in humans and the potential for future zoonotic *** will highlight how first-generation sARs-CoV-2 vaccines and natural history studies have greatly increased our understanding of effective antiviral immunity to coronaviruses and have informed next-generation vaccine *** will then consider the ideal properties of a pan-coronavirus vaccine and propose a blueprint for the type of immunity that may offer ***,we will describe a subset of the diverse technologies and novel approaches being pursued with the goal of developing broadly or universally protective vaccines for coronaviruses.

关键词： Vaccine Coronavirus Cross-reactive immunity Cross-protection Universal

Factors influencing farmers’adoption of solar water-pumping systems in Gujarat

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Clean Energy 2024年第3期8卷 157-165页

作者： m sathish Kumar Y.A.Lad R.s.Pundir International Agribusiness management Institute Anand Agricultural UniversityAnand388110GujaratIndia Department of HRD&Pm International Agribusiness Management InstituteAnand Agricultural UniversityAnand388110GujaratIndia Department of Agribusiness Economics and Policies International Agribusiness Management InstituteAnand Agricultural UniversityAnand388110GujaratIndia

Agriculture has played an important role in the growth of the Indian *** and electricity are essential inputs for agriculture *** produces the third-largest amount of electricity in the world,behind China and the *** an incentive to increase production,most states provide free electricity to *** electricity has decreased groundwater levels and increased electricity *** objective of this study was to find out the factors that influenced farmers to adopt a solar water-pumping system in *** samples were randomly *** study examined the entire state of *** hundred and fifty farmers who adopted solar water-pumping systems were interviewed,including 50 banana farmers,50 cotton farmers and 50 groundnut *** data were collected through an *** adoption of solar water-pumping systems by farmers was identified using factor *** software was used to analyse the data *** this study,only two factors contributed to the variance of 59.469%.The adoption of solar water pumps by farmers was influenced by government policy and economic *** economic benefit variance of 33.20%was found,while a government policy variance was 26.27%.A solar water-pumping system has low initial costs,flexible credit policies motivate adoption,solar water-pumping systems can save electricity,and maintenance and repair costs are *** policy that includes solar water-pumping systems is motivated by awareness,subsidies for adoption and a fair price to sell energy *** are recommended to adopt a solar water-pumping system in conjunction with a drip irrigation system to receive additional *** successful scheme will be recommended to other states in India for implementation.

关键词： solar water-pumping system factor analysis banana cotton groundnut famers

Acceleration of solar wind particles due to inertial Alfvén waves

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Communications in Theoretical Physics 2024年第6期76卷 137-141页

作者： Kiran Batool Imran A Khan m shamir Abdul Kabir s Ayaz Theoretical Physics Department National Centre for PhysicsIslamabad 44000Pakistan Department of space sciences Institute of Space TechnologyIslamabad 44000Pakistan space and Astrophysics Research Lab(sARL) National Center of GIS and Space Applications(NCGSA)Islamabad 44000Pakistan salam Chair Department of PhysicsGC University LahoreKatchery RoadLahorePunjab 54000Pakistan Department of space science and CsPAR University of Alabama in HuntsvilleHuntsvilleAL 35899United States of America

Gaining an understanding of the effects and dynamics of the solar wind is crucial for the study of space weather,Earth's magnetosphere,spacecraft protection,the dynamics of the solar system,and various other *** show that Alfvén waves effectively transfer energy to resonant *** study demonstrates how inertial Alfvén waves deliver their energy to resonant plasma particles in different solar environments under certain *** analysis shows that inertial Alfvén waves experience more rapid damping with increasing parallel wavenumber,ambient magnetic field strength,and particle number density,coupled with a decrease in *** rate of energy transfer to resonant particles intensifies with higher temperatures and reduced parallel wavenumber and particle number *** with higher initial velocities actively participate in Landau damping,especially in regions with a stronger ambient magnetic field.

关键词： solar wind inertial Alfven waves resonant particles

multiple scales method for analyzing a forced damped rotational pendulum oscillatorwithgallows

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Communications in Theoretical Physics 2024年第5期76卷 58-67页

作者： Haifa A Alyousef Alvaro H salas B m Alotaibi s A El-Tantawy Department of Physics College of SciencePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia Department of mathematics and statistics Universidad Nacional de ColombiaFIZMAKO Research GroupColombia Department of Physics Faculty of SciencePort Said UniversityPort Said 42521Egypt Research Center for Physics(RCP) Department of PhysicsFaculty of Science and ArtsAl-MikhwahAl-Baha UniversityAl-Baha 1988Saudi Arabia

This study reports the analytical solution for a generalized rotational pendulum system with gallows and periodic excited *** multiple scales method(msm)is applied to solve the proposed *** types of rotational pendulum oscillators are studied and talked about in *** include the forced damped rotating pendulum oscillator with gallows,the damped standard simple pendulum oscillator,and the damped rotating pendulum oscillator without *** msm first-order approximations for all the cases mentioned are derived in *** obtained results are illustrated with concrete numerical *** first-order msm approximations are compared to the fourth-order Runge-Kutta(RK4)numerical ***,the maximum error is estimated for the first-order approximations obtained through the msm,compared to the numerical approximations obtained by the RK4 ***,we conducted a comparative analysis of the outcomes obtained by the used method(msm)and He-msm to ascertain their respective levels of *** proposed method can be applied to analyze many strong nonlinear oscillatory equations.

关键词： rotational pendulum system multiple scales method approximate solution damped oscillations forced pendulum with gallows he-multiple scales method

Higgs-like(pseudo)scalars in Ads_(4),marginal and irrelevant deformations in CFT_(3),and instantons on s^(3)

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Chinese Physics C 2024年第4期48卷 68-81页

作者： m.Naghdi Department of Physics Faculty of Basic SciencesUniversity of IlamIlamIran

Employing a 4-form ansatz of 11-dimensional supergravity over a non-dynamical Ads_(4)×s^(7)/Z_(k)background and setting the internal space as an s1 Hopf fibration on CP3,we obtain a consistent ***(pseudo)scalars,in the resulting scalar equations in Euclidean Ads_(4)space,may be considered to arise from(anti)m-branes wrapping around the internal directions in the(Wick-rotated)skew-whiffed m2-brane background(as the resulting theory is for anti-m2-branes),thus realizing the modes after swapping the three fundamental representations 8_(s),8_(c),and 8_(v) of sO(8).Taking the backreaction on the external and internal spaces,we obtain the massless and massive modes,corresponding to exactly marginal and marginally irrelevant deformations on the boundary CFT3,***,we obtain a closed solution for the bulk equation and compute its correction with respect to the background ***,considering the Higgs-like(breathing)mode m^(2)=18,having all supersymmetries as well as parity and scale-invariance broken,solving the associated bulk equation with mathematical methods,specifically the Adomian decomposition method,and analyzing the behavior near the boundary of the solutions,we realize the boundary duals in the sU(4)×U(1)-singlet sectors of the ABJm ***,introducing the new dual deformationΔ_(+)=3,6 operators made of bi-fundamental scalars,fermions,and U(1)gauge fields,we obtain the sO(4)-invariant solutions as small instantons on a three-sphere with the radius at infinity,which correspond to collapsing bulk bubbles leading to big-crunch singularities.

关键词： Ads_(4)/CFT_(3)correspondence scalar equations in Ads_(4) instantons marginal and irrelevant operators (anti)m-branes

Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity

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Bone Research 2024年第1期12卷 180-198页

作者： morten s.Hansen Kaja madsen maria Price Kent søe Yasunori Omata mario m.Zaiss Caroline m.Gorvin morten Frost Alexander Rauch molecular Endocrinology Laboratory(KmEB) Department of EndocrinologyOdense University HospitalDK-5000 Odense CDenmark Department of Clinical Research Faculty of Health SciencesUniversity of Southern DenmarkDK-5000 Odense CDenmark Clinical Cell Biology Pathology Research UnitDepartment of Clinical ResearchUniversity of Southern DenmarkDK-5000 Odense CDenmark Institute of metabolism and systems Research(ImsR)and Centre for Diabetes Endocrinology and Metabolism(CEDAM)University of BirminghamBirmingham B152TTUK Centre for membrane Proteins and Receptors(COmPARE) Universities of Birmingham and NottinghamBirmingham B152TTUK Department of molecular medicine University of Southern DenmarkDK-5000 Odense CDenmark Department of Orthopedic surgery Faculty of MedicineThe University of TokyoTokyo 113-8655Japan Department of Internal medicine 3 Rheumatology and ImmunologyFriedrich-Alexander-University Erlangen-Nürnberg(FAU)and Universitätsklinikum ErlangenD-91054 ErlangenGermany Deutsches Zentrum Immuntherapie(DZI) Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum ErlangenD-91054 ErlangenGermany steno Diabetes Center Odense Odense University HospitalDK-5000 Odense CDenmark

Enhanced osteoclastogenesis and osteoclast activity contribute to the development of osteoporosis,which is characterized by increased bone resorption and inadequate bone *** novel antiosteoporotic therapeutics are needed,understanding the genetic regulation of human osteoclastogenesis could help identify potential treatment *** study aimed to provide an overview of transcriptional reprogramming during human osteoclast *** were differentiated from CD14+monocytes from eight female *** sequencing during differentiation revealed 8980 differentially expressed genes grouped into eight temporal patterns conserved across *** patterns revealed distinct molecular functions associated with postmenopausal osteoporosis susceptibility genes based on RNA from iliac crest biopsies and bone mineral density *** analyses revealed mutual dependencies between temporal expression patterns and provided insight into subtype-specific transcriptional *** donor-specific expression patterns revealed genes at the monocyte stage,such as filamin B(FLNB)and oxidized low-density lipoprotein receptor 1(OLR1,encoding LOX-1),that are predictive of the resorptive activity of mature *** expression of differentially expressed G-protein coupled receptors was strong during osteoclast differentiation,and these receptors are associated with bone mineral density sNPs,suggesting that they play a pivotal role in osteoclast differentiation and *** regulatory effects of three differentially expressed G-protein coupled receptors were exemplified by in vitro pharmacological modulation of complement 5 A receptor 1(C5AR1),somatostatin receptor 2(ssTR2),and free fatty acid receptor 4(FFAR4/GPR120).Activating C5AR1 enhanced osteoclast formation,while activating ssTR2 decreased the resorptive activity of mature osteoclasts,and activating FFAR4 decreased both the number and resorptive activity of mature *** conclus

关键词： osteoclast programming identif

Comparison of QT Correction methods in the Pediatric Population of a Community Hospital: A Retrospective study

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Congenital Heart Disease 2024年第1期19卷 107-121页

作者： Koren Hyogene Kwag ibrahim Kak Ying Li Walid Khass Alec mcKechnie Oksana Nulman Brande Brown manoj Chhabra Department of Pediatrics New York Presbyterian Brooklyn Methodist HospitalBrooklyn11215USA Department of Population Health sciences Division of BiostatisticsWeill Cornell MedicineNew York10065USA

Objective:Accurate measurement of QT interval,the ventricular action potential from depolarization to repolarization,is important for the early detection of Long QT *** most effective QT correction(QTc)formula has yet to be determined in the pediatric population,although it has intrinsically greater extremes in heart rate(HR)and is more susceptible to errors in *** authors of this study compare six dif-ferent QTc methods(Bazett,Fridericia,Framingham,Hodges,Rautaharju,and a computer algorithm utilizing the Bazett formula)for consistency against variations in HR and RR ***:Descriptive Retrospective *** included participants from a pediatric cardiology practice of a community hospital who had an ECG performed in *** participants were healthy patients with no past medical history and no regular ***:ECGs from 95 participants from one month to 21 years of age(mean 9.7 years)were included with a mean HR of 91 beats per minute(bpm).The two-sample paired t-test or Wilcoxon signed-rank test assessed for any difference between QTc methods.A statistically signiﬁcant difference was observed between every combination of two QTc *** spearman’s rank correlation analysis explored the QTc/HR and QTc/RR relationships for each *** method was most independent of HR and RR with the lowest absolute value of correlation coefﬁ*** and Computer had moderate correlations,while Framingham and Rautaharju exhibited strong *** were positive for Bazett and Computer,reﬂecting results from prior studies demonstrating an over-correction of Bazett at higher *** the linear QTc/HR regression analysis,Bazett had the slope closest to zero,although Computer,Hodges,and Fridericia had comparable ***,Fridericia had the linear QTc/RR regression coefﬁcient closest to *** Bland-Altman method assessed for bias and the limits of agreement between correction *** an

关键词： Corrected QT interval QT prolongation long QT syndrome electrocardiogram retrospective study bazett fridericia framingham hodges rautaharju computer algorithm

Cr-induced fusion reactions to synthesize superheavy elements

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Nuclear science and Techniques 2024年第5期35卷 122-130页

作者： s.madhu H.C.manjunatha N.sowmya B.m.Rajesh L.seenappa R.s.susheela Department of Physics R V College of EngineeringBangalore 560074India Visvesvaraya Technological University BelagaviKarnataka 590018India Department of Physics Government First Grade CollegeSrinivasapurKarnataka 563135India Department of Physics Government First Grade CollegeDevanahallyKarnataka 562110India Department of Physics Government First Grade CollegeMulbagalKarnataka 563131India Department of Physics Government First Grade collegeNanjangudOoty RoadMysore 571301India

We investigated ^(50,52-54)Cr-induced fusion reactions for the synthesis of the superheavy element in the 104≤Z≤122 *** cross sections produced in this investigation using ^(54)Cr projectiles were compared with those obtained in prior *** estimated cross sections from this analysis are consistent with the findings of prior *** the current study,the predicted cross section was found to be 42fb at 236 meV for ^(53)Cr+^(243)Am,23.2 fb at 236 meV for ^(54)Cr+^(247)Cm,95.6 fb at 240 meV for ^(53)Cr+248Bk,and 1.33 fb at 242 meV for ^(53)Cr+***,these projected cross sections with excitation energy and beam energy will be useful in future Cr-induced fusion reaction investigations.

关键词： Fusion cross sections Compound nucleus formation probability survival probability Evaporation residue cross sections

The asymptotic behavior for a binary alloy in energy and material science:The unified method and its applications

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Journal of Ocean Engineering and science 2024年第4期9卷 373-378页

作者： m.Adel K.Aldwoah F.Alahmadi m.s.Osman Department of mathematics Faculty of ScienceIslamic University of MadinahMedinaSaudi Arabia Department of mathematics Faculty of ScienceCairo UniversityGiza 12613Egypt

The Cahn-Hilliard system was proposed to the first time by Chan and Hilliard in *** model(or system of equations)has intrinsic participation energy and materials sciences and depicts significant characteristics of two phase systems relating to the procedures of phase separation when the temperature is *** instance,it can be noticed when a binary alloy(“Aluminum+Zinc”or“Iron+Chromium”)is cooled down *** this case,partially or totally nucleation(nucleation means the appearance of nuclides in the material)is observed:the homogeneous material in the initial state gradually turns into inhomogeneous,giving rise to a very accurate dispersive ***,when the time scale is slower the microstructure becomes *** this work,to the first time,the unified method is presented to investigate some physical interpretations for the solutions of the Cahn-Hilliard system when its coefficients varying with time,and to show how phase separation of one or two components and their concentrations occurs dynamically in the ***,2D and 3D plots are introduced to add more comprehensive study which help to understand the physical phenomena of this *** technique applied in this analysis is powerful and efficient,as evidenced by the computational work and *** technique can also solve a large number of higher-order evolution equations.

关键词： Cahn-Hilliard system Traveling wave solutions The unified method Variable coefficients