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Neural Regeneration Research 2025年第5期20卷 1407-1408页

作者： Daniel adam Felix Langerscheidt Hans Zempel Institute of Human Genetics University Hospital CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany

TAU is a neuronal microtubule-associated protein preferentially located in *** a battery of neurodegenerative diseases termed"tauopathies,"including Alzheimer's disease (AD),TAU is missorted and abnormally phosphorylated,leading to filamentous accumulations of hyperphosphorylated TAU,a pathological hallmark and potential disease driver of AD and related tauopathies (Zempel,2024).

关键词： Alzheimer tau diseases

Nanohybrid TiO_2/carbon black sensor for NO_2 gas

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China Particuology 2007年第3期5卷 225-229页

作者： Wei-Jen liou Department of Materials Engineering Tatung University Taipei 104 Taiwan China

A nanohybrid sensor of nanosized TiO2-coated carbon black particles, prepared by sol-gel technology for the detection of NO2 gas, has been developed. The response of the electric resistance of the hybrid sensor to NO2 concentration is investigated, showing that the sensitivity of the hybrid sensor is raised as certain ratio of the TiO2 content in the sensor. Easy and cheap to fabricate, the hybrid TiO2/carbon black promises to be a practical sensor for detecting NO2 gas. 2007 Chinese society of Particuology and Institute of Process Engineering, Chinese Academy of sciences. Published by Elsevier B.V.

关键词： Carbon black TiO2 Gas sensing Hybrid

Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural Regeneration Research 2025年第5期20卷 1336-1349页

作者： Chao Weng adam M.R.Groh Moein Yaqubi Qiao-Ling Cui Jo Anne stratton G.R.Wayne Moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

Characterization of gold/PMMA hybrid nanomaterials synthesized by hard X-ray synchrotron radiation

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Particuology 2010年第3期8卷 234-239页

作者： Hueywen liou Weijen liou Hongming Lin Yeukuang Hwu Wenchang Chen Department of Materials Engineering Tatung University No. 7-1 DeHui St. Institute of Physics Academia Sinica Nankang Department of Chemical and Materials Engineering National Yunlin University of Science and Technology

In this study, new types of hybrid gold poly（methyl methacrylate）（PMMA） nanomaterials are synthesized. Both PMMA spheres coated with gold nanoparticles and gold nanoparticles coated with PMMA can be synthesized using different ratios of HAuCl4 and MMA precursors, by exposing the mixtures to hard X-ray synchrotron radiation without the use of a reducing agent. According to the photochemical mechanism, gold nanoparticles will precipitate from a solution of HAuCl4 on exposure to synchrotron radiation, followed by the synthesis of PMMA by the polymerization of MMA monomers. These reactions can result in the formation of two different types of new hybrid nanomaterials. When a 1：1 volume ratio of HAuCI4 to MMA is used, we obtain PMMA spheres coated with gold nanoparticles. When a 10：1 ratio of HAuCl4 and MMA is used, we obtain gold nanoparticles coated with PMMA. The hybrid gold/PMMA nanostructures are characterized by transmission electron microscopy, elemental analysis, dynamic-light scattering analysis, gel permeation chromatography and Raman spectroscopy. The hybrid nanomaterials have potential application in the fields of biosensors and drug delivery.

关键词： Nanoparticle Gold Poly(methyl methacrylate) Hard X-ray

Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

A systematic review of progenitor survival and maturation in Parkinsonian models

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

High Temperature Phase Transitions of Graphene Oxide Paper from Graphite Oxide solution

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Journal of Materials science & Technology 2014年第11期30卷 1088-1091页

作者： Yan-Jia liou Wu-Jang Huang Department of Environmental Engineering and science National Ping-Tung University of Science and Technology

Graphene oxide paper （GOP） can be prepared through simplified filtration of a graphite oxide solution. It possesses similar properties to graphene. In this study, the graphite oxide solution was synthesized from commercial graphite by means of Hummer＇s method. It corresponds to the dried GOP that was prepared by deposition on a cellulose filter. It is found that the mesophase of the dried graphene oxide papers obtained from the graphite was thermotropic hexagonal columnar liquid crystal. Its higher temperature transitions were found at 80 ℃, 150 ℃ and 170 ℃-180 ℃. Therefore, it could be used for thermal storage and conductive materials in the future.

关键词： Graphite oxide Graphite Graphene Phase transition

Perspectives on the role of mTORC2 in B lymphocyte development,immunity and tumorigenesis

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Protein & Cell 2011年第7期2卷 523-530页

作者： adam s.Lazorchak Bing su Department of Immunobiology and the Vascular Biology and Therapeutic Program Yale School of MedicineNew HavenCT 06519USA

Mammalian target of rapamycin complex 2(mTORC2)is a key downstream mediator of phosphoinositol-3-kinase(PI3K)dependent growth factor *** lymphocytes,mTORC2 has emerged as an important regulator of cell development,homeostasis and immune ***,our current understanding of mTORC2 functions and the molecular mechanisms regulating mTORC2 signaling in B and T cells are still largely *** studies have begun to shed light on this important *** have previously reported that mTORC2 mediates growth factor dependent phosphorylation of Akt and facilitates Akt dependent phosphorylation and inactivation of transcription factors FoxO1 and *** have recently explored the functions of mTORC2 in B cells and show that mTORC2 plays a key role in regulating survival and immunoglobulin(Ig)gene recombination of bone marrow B cells through an Akt2-FoxO1 dependent *** recombination is suppressed in proliferating B cells to ensure that DNA double strand breaks are not generated in actively dividing *** results raise the possibility that genetic or pharmacologic inhibition of mTORC2 may promote B cell tumor development as a result of inefficient suppression of Ig recombination in dividing B *** also propose a novel strategy to treat cancers based on our recent discovery that mTORC2 regulates Akt protein stability.

关键词： mTOR lymphocyte B cell cancer mTORC2 FoxO Akt sin1

Quantitative Analysis of Graphene sheet Content in Wood Char Powders during Catalytic Pyrolysis

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Journal of Materials science & Technology 2013年第5期29卷 406-410页

作者： Yan-Jia liou Wu-Jang Huang Department of Environmental Engineering and science National Ping-Tung University of Science and TechnologyPing-Tung CountyTaiwanChina

The quantitative characterization of the graphene sheet content in carbon-containing materials is arguable and has not yet been developed. The authors report on a feasible method to characterize graphene sheet content quantitatively in pyrolized carbon materials using an X-ray diffraction （XRD） spectrometer. A direct carbonation at 300℃ followed by catalytic pyrolysis （heat-treatment temperature was set at 700-1400 ℃） under a vacuum condition was used for turning wood waste into pyrolized wood char powders. The graphene content in the samples was calculated through an analysis of full width at half maximum （FWHM） of the carbon （100） crystal plane at around 42°-43° in XRD. Results showed that the FWHM and the calculated graphene sheet content of pyrolized wood char powders depended on the heat-treatment temperature, and the FWHM of wood char powder with well-developed graphene sheets （100%） was determined to be 5.0. In addition, the trend to 100% graphene sheet-contained pyrolized carbon powder was obtained at a heattreatment temperature of 2700 ℃. The resistivity of the wood char powder with 100% graphene sheets was predicted to be 0.01 Ω cm, close to our experimental data of 0.012 and 0.006 Ω cm for commercial graphite and graphene products, respectively.

关键词： Wood char Full width at half maximum Graphene Pyrolysis

Long Wave Reflection and Transmission over A sloping step

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海洋工程：英文版 2004年第3期18卷 371-380页

作者： Hsien-Kuo CHANG Jin-Cheng liou Department of Civil Engineering National Chiao Tung University 1001 Ta Hsuech Road Hsinchu 300 ChinaDepartment of Civil Engineering National Chiao Tung University 1001 Ta Hsuech Road Hsinchu 300 China

This investigation examines long wave reflection and transmission induced by a sloping step. Bellman and Kalaba's (1959) invariant imbedding is introduced to find wave reflection. An alternative method matching both the surface elevation and its surface slope of each region at the junction is applied to the determination of wave reflection and transmission. The proposed methods are compared with the accurate numerical results of Porter and Porter (2000) and those of Mei (1983) for a vertical step. The wave reflection obtained for a mildly sloping step differs significantly from the result of Mei. The wave reflection is found to fluctuate owing to wave trapping for the mild sloping step. The height and the face slope of the step are important for determining wave reflection and transmission coefficients.

关键词： long wave reflection coefficient wave transmission wave trapping