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Endoscopic excision of a prolapsing malignant polyp which caused intermittent gastric outlet obstruction

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World journal of Gastroenterology 2005年第33期11卷 5245-5247页

作者： Hugh j freeman Department of Medicine (Gastroenterology) University of British Columbia Vancouver BC V6T 1W5 Canada Correspondence to:Dr.Hugh J FreemanGastroenterologyUBC Hospital2211 Wesbrook MallVancouverBCV6T 1W5

A 69-year-old male with chronic lymphocytic leukemia presented with iron deficiency anemia and post-prandial abdominal fullness. Endoscopy showed a large polyp on a stalk, protruding through the pylorus into the duodenum causing intermittent gastric outlet obstruction. While prolapsing gastric antral polyps are usually benign and hyperplastic, inflammatory or regenerative in type, excisional snare polypectomy here led to complete resolution of his symptoms, but showed a malignant polyp.

关键词： Gastric adenoma Gastric carcinoma Endoscopic polypectomy Neoplastic gastric polyps

Field-resolved high-order sub-cycle nonlinearities in a terahertz semiconductor laser

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Light(science & Applications) 2021年第12期10卷 2531-2540页

作者： j.Riepl j.Raab P.Abajyan H.Nong j.R.freeman L.H.Li E.H.Linfield A.G.Davies A.Wacker T.Albes C.jirauschek C.Lange s.s.Dhillon R.Huber Department of Physics University of RegensburgRegensburgGermany Laboratoire de Physique de l’Ecole Normale supérieure ENSUniversitéPSLCNRSSorbonne UniversitéUniversitéde ParisParisFrance school of Electronic and Electrical Engineering University of LeedsWoodhouse LaneLeedsUK Mathematical Physics and NanoLund Lund UniversityLundSweden Department of Electrical and Computer Engineering Technical University of MunichMunichGermany Department of Physics TU Dortmund UniversityDortmundGermany

The exploitation of ultrafast electron dynamics in quantum cascade lasers(QCLs)holds enormous potential for intense,compact mode-locked terahertz(THz)sources,squeezed THz light,frequency mixers,and comb-based metrology *** the important sub-cycle dynamics have been notoriously difficult to access in operational THz ***,we employ high-field THz pulses to perform the first ultrafast two-dimensional spectroscopy of a free-running THz *** incoherent and coherent nonlinearities up to eight-wave mixing are detected below and above the laser *** data not only reveal extremely short gain recovery times of 2 ps at the laser threshold,they also reflect the nonlinear polarization dynamics of the QCL laser transition for the first time,where we quantify the corresponding dephasing times between 0.9 and 1.5 ps with increasing bias currents.A density-matrix approach reproducing the emergence of all nonlinearities and their ultrafast evolution,simultaneously,allows us to map the coherently induced trajectory of the Bloch *** observed high-order multi-wave mixing nonlinearities benefit from resonant enhancement in the absence of absorption losses and bear potential for a number of future applications,ranging from efficient intracavity frequency conversion,mode proliferation to passive mode locking.

关键词： polarization mixer cycle

sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi sun shiqian shen Robert j.Thomas M.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

The spirit of Henry Norman Bethune and gastroenterology

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World journal of Gastroenterology 2008年第2期14卷 174-179页

作者： Hugh j freeman Department of Medicine University of British Columbia Vancouver BC Canada

Henry Norman Bethune was a physician and surgeon from Canada. He had a highly impressive medical career in Montreal but did his most important work in China where he cared for soldiers on the battlefield. He died in 1939 and was recognized as a hero, but only much later received recognition in Canada. He was a skilled doctor, both as a physician and as a surgeon. However, he was much more and will serve as an inspiration for this series. He was an innovator, an idealist and a perfectionist. It is hoped that this series will gather expert commentaries on a range of issues critical to the subspecialty from fundamental science to clinical care so that future directions can be defined.

关键词： Bethune Gastroenterology China Canada Battlefield surgery

Computational study on influence of RF shielding box on inductance of coil

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Plasma science and Technology 2019年第6期21卷 23-28页

作者： s j KIM j j LEE Y s LEE j H KIM s j YOU Applied Physics lab for PLasma Engineering(APPLE) Department of Physics Chungnam National University Daejeon 34134 Republic of Korea Korea Research Institute of standards and science(KRIss) Daejeon 34113 Republic of Korea

Despite the fact that a radio frequency (RF) shielding box affects a coil inductance used in matching network,RF engineers have used a coil inductance measured in open space on designing matching networks since it is difficult to precisely measure the coil inductance within the RF shielding *** this work,we investigate the influences of the RF shielding box on the coil inductance via a 3D full electromagnetic wave *** results shows that the coil inductance decreases from-6.0% to-11.9% compared with its ideal inductance depending on coil positions within the RF shielding *** inductive and capacitive coupling between the coil and surfaces of the RF shielding box contribute to the reduction of the coil *** expect that these results would be useful for those who design RF matching networks.

关键词： 3D full EM wave simulation RF matching component RF shield inductive and capacitive coupling

Duplicated appendix complicated by appendiceal cancer

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World journal of Gastroenterology 2011年第1期17卷 135-136页

作者： Hugh j freeman Department of Medicine(Gastroenterology) University of British Columbia HospitalVancouverBCV6T 1W5Canada

A 37-year old male presented with an acute abdomen suggestive of an appendiceal *** laparotomy showed a duplicated appendix with one of the lumens involved with appendicitis and a focal periappendicular abscess while the other lumen had a localized appendiceal *** of congenital intestinal duplications in adults is important to avoid serious clinical consequences.

关键词： Duplicated appendix Bifid appendix Appendiceal cancer Congenital duplication.

Treating amyotrophic lateral sclerosis with allogeneic schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal j.Goldschmidt-Clermont Aisha Khan George jimsheleishvili Patricia Graham Adriana Brooks Risset silvera Alexander j.P.Goldschmidt Damien D.Pearse W.Dalton Dietrich Allan D.Levi james D.Guest Miller school of Medicine University of MiamiMiamiFLUSA stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,schwann cell function may also be ***,important signaling and potential trophic activities of schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic schwann cell-derived exosomal vesicles to potentially restore impaired schwann cell and motor neuron *** confirmed that cultured schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s schwann cells to allogeneic schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction schwann cell

Lethal neuroendocrine carcinoma in ulcerative colitis

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World journal of Gastroenterology 2009年第46期15卷 5882-5883页

作者： Hugh j freeman Ken Berean Department of Medicine(Gastroenterology) University of British ColumbiaVancouver Department of Pathology University of British ColumbiaVancouver

A 48-year old male with longstanding and extensive pancolitis developed a high grade and rapidly lethal malignant lesion in the ascending colon characterized by a neuroendocrine *** biopsies obtained from multiple sites in the colon during endoscopic surveillance were reported to show only inflammatory changes without *** operator-dependent,repeated endoscopic studies may have limitations during surveillance programs because the biological behavior of some colonic neoplastic lesions may have a rapid and very aggressive clinical course.

关键词： Colorectal cancer, Neuroendocrine carcinoma Ulcerative colitis surveillance colonoscopy Dysplasia

strip Casting of High Performance structural Alloys

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journal of Rare Earths 2004年第z2期22卷 78-84页

作者： s s Park j G Lee Nack j Kim Center for Advanced Aerospace Materials Pohang University of Science and TechnologyPohang 790-784Korea Center for Advanced Aerospace MaterialsPohang University of Science and TechnologyPohang 790-784Korea Center for Advanced Aerospace MaterialsPohang University of Science and TechnologyPohang 790-784Korea

There exists a great need for the development of high performance alloys due to increasing demands for energy conservation and environmental protection. Application of strip casting shows a strong potential for the improvement of properties of existing alloys and also for the development of novel alloy systems with superior properties. The present paper reviews our Center's activities in the development of high performance alloys by strip casting. Examples include (1) Al alloys, (2) wrought Mg alloys, and (3) bulk metallic glass (BMG) alloys.

关键词： strip casting 6061 Al alloy AZ Mg alloy bulk metallic glass (BMG) alloy dispersion hardening