检索结果-南通市图书馆

Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang sonata s Y yau Kwok-Fai so Li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNs Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina state Key Laboratory of Brain and Cognitive science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Canonical metrics on complex manifold

引用

science China Mathematics 2008年第4期51卷 503-508页

作者： yau s.ing-tung(yau s.-T.) Department of Mathematics Harvard University

Complex manifolds are topological spaces that are covered by coordinate charts where the coordinate changes are given by holomorphic *** example,Riemann surfaces are one dimensional complex *** order to understand complex manifolds,it is useful to introduce metrics that are compatible with the complex *** general,we should have a pair(M,ds^2_M)where ds^2_M is the *** metric is said to be canonical if any biholomorphisms of the complex manifolds are automatically *** metrics can naturally be used to describe invariants of the complex structures of the manifold.

关键词：云门

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Metrics on complex manifolds

引用

science China Mathematics 2010年第3期53卷 565-572页

作者： yau s.ing-tung Department of Mathematics Harvard University Cambridge

In this note we discuss various canonical metrics on complex manifolds. A generalization of the Bergman metric is proposed and the relations of metrics on moduli spaces are commented. At last, we review some existence... 详细信息

关键词： intrinsic metrics generalized Bergman metrics Weil-Petersson metric strominger system

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

New results on the geometry of the moduli space of Riemann surfaces

引用

science China Mathematics 2008年第4期51卷 632-651页

作者： yau s.ing-tung Center of Mathematical sciences Zhejiang University

We briefly survey our recent results about the Mumford goodness of several canonical metrics on the moduli spaces of Riemann surfaces, including the Weil-Petersson metric, the Ricci metric, the Perturbed Ricci metric and the Kahler-Einstein metric. We prove the dual Nakano negativity of the Weil-Petersson metric. As applications of these results we deduce certain important results about the L 2-cohomology groups of the logarithmic tangent bundle over the compactified moduli spaces.

关键词： moduli spaces canonical metrics good metrics L 2-cohomology 14D20 14H20 32G13 53C55

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Exploring geometry of genome space via Grassmann manifolds

引用

The Innovation 2024年第5期5卷 92-99,91页

作者： Xiaoguang Li Tao Zhou Xingdong Feng s.ing-tung yau stephen s.-T.yau school of statistics and Management Shanghai University of Finance and EconomicsShanghai 200433China Department of Mathematical sciences Tsinghua UniversityBeijing 100084China Yanqi Lake Beijing Institute of Mathematical sciences and Applications Beijing 101408China

It is important to understand the geometry of genome space in *** transforming genome sequences into frequency matrices of the chaos game representation(FCGR),we regard a genome sequence as a point in a suitable Grassmann manifold by analyzing the column space of the corresponding *** assess the sequence similarity,we employ the generalized Grassmannian distance,an intrinsic geometric distance that differs from the traditional Euclidean distance used in the classical k-mer frequency-based *** this method,we constructed phylogenetic trees for various genome datasets,including influenza A virus hemagglutinin gene,Orthocoronavirinae genome,and sARs-CoV-2 complete genome *** comparative analysis with multiple sequence alignment and alignment-free methods for large-scale sequences revealed that our method,which employs the subspace distance between the column spaces of different FCGRs(FCGR-sD),outperformed its competitors in terms of both speed and *** addition,we used low-dimensional visualization of the sARs-CoV-2 genome sequences and spike protein nucleotide sequences with our methods,resulting in some intriguing *** not only propose a novel and efficient algorithm for comparing genome sequences but also demonstrate that genome data have some intrinsic manifold structures,providing a new geometric perspective for molecular biology studies.

关键词： methods. manifold geometry

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Revisiting cerebral endothelial cells in Alzheimer’s disease

引用

Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

引用

Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the proces.ing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

引用

Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Characterization of isolated homogeneous hypersurface singularities in C^4

引用

science China Mathematics 2006年第11期49卷 1576-1592页

作者： yau stephen s T Department of Mathematics statistics and Computer science University of Illinois at ChicagoChicagoIL 60607-7045USA

Let V be a hypersurface with an isolated singularity at the origin in Cn+1. It is a natural question to ask when V is defined by weighted homogeneous polynomial or homogeneous polynomial up to biholomorphic change of coordinates. In 1971, a beautiful theorem of saito gives a necessary and sufficient condition for V to be defined by a weighted homogeneous polynomial. For a two-dimensional isolated hypersurface singularity V, Xu and yau found a coordinate free characterization for V to be defined by a homogeneous polynomial. Recently Lin and yau gave necessary and sufficient conditions for a 3-dimensional isolated hypersurface singularity with geometric genus bigger than zero to be defined by a homogeneous polynomial. The purpose of this paper is to prove that Lin-yau's theorem remains true for singularities with geometric genus equal to zero.

关键词： homogeneous polynomials, hypersurface singularity, weighted homogeneous polynomial, geometric genus.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The diffeomorphic types of the complements of arrangements in CP^3Ⅱ

引用

science China Mathematics 2008年第4期51卷 785-802页

作者： yau stephen s-T Department of Mathematics Statistics and Computer ScienceUniversity of Illinois at Chicago

For any arrangement of hyperplanes in CP^3,we introduce the soul of this arrangement. The soul,which is a pseudo-complex,is determined by the combinatorics of the arrangement of hyper- *** this paper,we give a sufficient combinatoric condition for two arrangements of hyperplanes to be diffeomorphic to each *** particular we have found sufficient conditions on combinatorics for the arrangement of hyperplanes whose moduli space is *** generalizes our previous result on hyperplane point arrangements in CP^3.

关键词： arrangement of hyperplanes soul of arrangement combinational geometry of arrangement differential and topological structure of complement of arrangement

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：