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Neural Regeneration Research 2025年第5期20卷 1407-1408页

作者： Daniel Adam Felix Langerscheidt hans Zempel Institute of Human Genetics University Hospital CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany

TAU is a neuronal microtubule-associated protein preferentially located in *** a battery of neurodegenerative diseases termed"tauopathies,"including Alzheimer's disease (AD),TAU is missorted and abnormally phosphorylated,leading to filamentous accumulations of hyperphosphorylated TAU,a pathological hallmark and potential disease driver of AD and related tauopathies (Zempel,2024).

关键词： Alzheimer tau diseases

Effects of P301L-TAU on post-translational modifications of microtubules in human iPsC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad Al Kabbani Christoph Köhler hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-KO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

signatures of non-Euclidean metrics in the optical features of microcavities

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science China(Physics,Mechanics & Astronomy) 2025年

作者： hans-Jürgen st?ckmann Fachbereich Physik der Universit?t Marburg

starting with the nineties of the last century disc-shaped dielectric cavities have received a lot of attention because of their interest in the design of micro-lasers and integrated optics applications [1-5]. The light can be trapped inside the dielectric cavity by total internal reflection, or can partly escape by refraction, depending on the angle of incidence with respect to the boundary.

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Plant-substrate biochar properties critical for mediating reductive debromination of 1,2-dibromoethane

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Journal of Environmental sciences 2025年第1期147卷 1-10页

作者： Jonathan H.Lindhardt Peter E.Holm Yong-Guan Zhu Changyong Lu hans Christian B.hansen Department of Plant and Environmental sciences Faculty of ScienceUniversity of CopenhagenThorvaldsensvej 401871 Frederiksberg CDenmark Key lab of Urban Environment and Health Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China sino-Danish Center for education and research China and DenmarkDalgas Avenue 4DK-8000 Aarhus C.Denmark

Dibromoethane is a widespread,persistent organic *** are known mediators of reductive dehalogenation by layered Fe^(Ⅱ)-Fe^(Ⅲ)hydroxides(green rust),which can reduce 1,2-dibromoethane to innocuous bromide and ***,the critical characteristics that determine mediator functionality are lesser *** biochar substrates were pyrolyzed at 600℃and 800℃,characterized by elemental analysis,X-ray photo spectrometry C and N surface speciation,X-ray powder diffraction,specific surface area analysis,and tested for mediation of reductive debromination of 1,2-dibromoethane by a green rust reductant under anoxic conditions.A statistical analysis was performed to determine the biochar properties,critical for debromination kinetics and total debromination *** was shown that selected plant based biochars can mediate debromination of 1,2-dibromoethane,that the highest first order rate constant was 0.082/hr,and the highest debromination extent was 27%in reactivity experiments with 0.1μmol(20μmol/L)1,2-dibromoethane,≈22 mmol/L Fe^(Ⅱ)GR,and 0.12 g/L soybean meal biochar(7 days).Contents of Ni,Zn,N,and P,and the relative contribution of quinone surface functional groups were significantly(psitively correlated with 1,2-dibromoethane debromination,while adsorption,specific surface area,and the relative contribution of pyridinic N oxide surface groups were significantly negatively correlated with debromination.

关键词： Environmental remediation Biochar Persistent organic pollutants(POPs) Environmental catalysis Green rust

site index determination using a time series of airborne laser scanning data

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Forest Ecosystems 2025年第01期 93-103页

作者： Maria ?snes Moan Ole Martin Bollands?s svetlana saarela Terje Gobakken Erik N?sset hans Ole ?rka Lennart Noordermeer Faculty of Environmental sciences and Natural Resource Management Norwegian University of Life Sciences

site index (sI) is determined from the top height development and is a proxy for forest productivity,defined as the expected top height for a given species at a certain index *** Norway,an index age of 40 years is *** using bi-temporal airborne laser scanning (ALs) data,sI can be determined using models estimated from sI observed on field plots (the direct approach) or from predicted top heights at two points in time (the height differential approach).Time series of ALs data may enhance sI determination compared to conventional methods used in operational forest inventory by providing more detailed information about the top height *** used longitudinal data comprising spatially consistent field and ALs data collected from training plots in 1999,2010,and 2022 to determine sI using the direct and height differential approaches using all combinations of years and performed an external *** also evaluated the use of data *** of root mean square error obtained from external validation were in the ranges of 16.3%–21.4%and 12.8%–20.6%of the mean fieldregistered sI for the direct approach and the height differential approach,*** were no statistically significant effects of time series length or the number of points in time on the obtained *** assimilation did not result in any substantial improvement in the obtained *** a time series of ALs data did not yield greater accuracies compared to using only two points in time,a larger proportion of the study area could be used in ALs-based determination of sI when a time series was *** was because areas that were unsuitable for sI determination between two points in time could be subject to sI determination based on data from another part of the time series.

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Mapping Properties of Fourier Transforms,Revisited

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Acta Mathematica sinica,English series 2025年第1期41卷 231-254页

作者： Dorothee D.Haroske Leszek skrzypczak hans Triebel Institute of Mathematics Friedrich Schiller University Jena07737 JenaGermany Faculty of Mathematics&Computer science Adam Mickiewicz Universityul.Uniwersytetu Pozna´nskiego 461-614 Pozna´nPoland

The paper deals with continuous and compact mappings generated by the Fourier transform between distinguished Besov spaces B_(p)^(s)(R^(n))=B_(p,p)^(s)(R^(n)),1≤p≤∞,and between sobolev spaces Hs p(R^(n)),1st to the paper ***,Mapping properties of Fourier ***.41(2022),133–152,based mainly on embeddings between related weighted spaces,we rely on wavelet expansions,duality and interpolation of corresponding(unweighted)spaces,and(appropriately extended)Hausdorff-Young *** degree of compactness will be measured in terms of entropy numbers and approximation numbers,now using the symbiotic relationship to weighted spaces.

关键词： Fourier transform Besov spaces sobolev spaces entropy numbers approximation numbers

Rainfall impacts on nonpoint nitrogen and phosphorus dynamics in an agricultural river in subtropical montane reservoir region of southeast China

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Journal of Environmental sciences 2025年第3期149卷 551-563页

作者： Yuanyi Wang Hai Xu Xingchen Zhao Lijuan Kang Yu Qiu hans Paerl Guangwei Zhu Huiyun Li Mengyuan Zhu Boqiang Qin Yunlin Zhang Mingliang Liu Key Laboratory of Lake and Watershed science for Water security Nanjing Institute of Geography&LimnologyChinese Academy of SciencesNanjing 210008China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China school of Geography and Ocean science Nanjing UniversityNanjing 210023China Institute of Marine sciences University of North Carolina at Chapel HillNC 28557USA Hangzhou Institute of Ecological and Environmental sciences Hangzhou 310005China

The increased frequency and intensity of heavy rainfall events due to climate change could potentially influence the movement of nutrients from land-based regions into recipient ***,little information is available on how the rainfall affect nutrient dynamics in subtropicalmontane rivers with complex land *** study conducted high-frequency monitoring to study the effects of rainfall on nutrients dynamics in an agricultural river draining to Lake Qiandaohu,a montane reservoir of southeast *** results showed that riverine total nitrogen(TN)and total phosphorus(TP)concentrations increased continuously with increasing rainfall intensity,while TN:TP *** heavy rainfall and rainstorm drove more than 30%of the annual N and P loading in only 5.20%of the total rainfall period,indicating that increased storm runoff is likely to exacerbate eutrophication in montane ***_(3)^(−)-N is the primary nitrogen form lost,while particulate phosphorus(PP)dominated phosphorus *** source of N is cropland,and themain source of P is residential ***,forestedwatersheds have better drainage quality,while it is still a potential source of nonpoint pollution during rainfall *** and TP concentrations were significantly higher at sites dominated by cropland and residential area,indicating their substantial contributions to deteriorating river water ***,TN and TP concentrations reached high values in May-August when rainfall was most intense,while they were lower in autumn and winter than that in spring and summer under the same rainfall *** results emphasize the influence of rainfall-runoff and land use on dynamics of riverine N and P loads,providing guidance for nutrient load reduction planning for Lake Qiandaohu.

关键词： Non-point source pollution Rainfall events Land use type Mountain area Deepwater reservoir

Dietary supplementation of valine,isoleucine,and tryptophan may overcome the negative effects of excess leucine in diets for weanling pigs containing corn fermented protein

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Journal of Animal science and Biotechnology 2025年第1期16卷 267-281页

作者： Andrea P.Mallea Charmaine D.Espinosa su A Lee Minoy A.Cristobal Leidy J.Torrez‑Mendoza hans H.stein Division of Nutritional sciences University of IllinoisUrbanaIL 61801USA Department of Animal sciences University of IllinoisUrbanaIL 61801USA Present Address:EnviroFlight RaleighNCUSA.

Background Diets with high inclusion of corn co-products such as corn fermented protein(CFP)may contain excess Leu,which has a negative impact on feed intake and growth performance of pigs due to increased catabolism of Val and Ile and reduced availability of Trp in the brain for serotonin ***,we hypothesized that the negative effect of using CFP in diets for weanling pigs may be overcome if diets are fortified with crystalline sources of Val,Trp,and(or)*** Three hundred and twenty weanling pigs were randomly allotted to one of 10 dietary treatments in a com-pletely randomized design,with 4 pigs per pen and 8 replicate pens per treatment.A corn-soybean meal diet and 2 basal diets based on corn and 10%CFP or corn and 20%CFP were *** additional diets were formu-lated by fortifying the basal diet with 20%CFP with Ile,Trp,Val,Ile and Val,Ile and Trp,Trp and Val,or Ile,Trp and Val.A two-phase feeding program was used,with d 1 to 14 being phase 1 and d 15 to 28 being phase *** scores were recorded every other *** samples were collected on d 14 and 28 from one pig per *** d 14,fecal samples were collected from one pig per pen in 3 of the 10 treatments to determine volatile fatty acids,ammonium concen-tration,and microbial *** pigs were also euthanized and ileal tissue was *** There were no effects of dietary treatments on any of the parameters evaluated in phase *** of 10%or 20%CFP in diets reduced(Pse 2 and for the entire experimental ***,pigs fed the CFP diet supplemented with Val,Ile,and Trp had final body weight,ADFI,ADG and gain to feed ratio in phase 2 and for the entire experiment that was not different from pigs fed the control *** scores in phase 2 were reduced(Ps *** Corn fermented protein may be included by up to 20%in diets for weanling pi

关键词： Branched-chain amino acids Corn fermented protein Leucine Tryptophan Valine Weanling pigs

Independent and interactive effects of N and P additions on foliar P fractions in evergreen forests of southern China

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Forest Ecosystems 2025年第01期 66-73页

作者： Qingquan Meng Zhijuan shi Zhengbing Yan hans Lambers Yan Luo Wenxuan Han Key Laboratory of Plantsoil Interactions Ministry of EducationCollege of Resources and Environmental SciencesChina Agricultural University Institute of Botany Chin–ese Academy of Sciences school of Biological sciences The University of Western Australia Key Laboratory of Oasis Ecology of Education Ministry College of Ecology and EnvironmentXinjiang University

Fertilization or atmospheric deposition of nitrogen(N) and phosphorus(P) to terrestrial ecosystems can alter soil N(P) availability and the nature of nutrient limitation for plant growth. Changing the allocation of leaf P fractions is potentially an adaptive strategy for plants to cope with soil N(P) availability and nutrient-limiting ***, the impact of the interactions between imbalanced anthropogenic N and P inputs on the concentrations and allocation proportions of leaf P fractions in forest woody plants remains elusive. We conducted a metaanalysis of data about the concentrations and allocation proportions of leaf P fractions, specifically associated with individual and combined additions of N and P in evergreen forests, the dominant vegetation type in southern China where the primary productivity is usually considered limited by P. This assessment allowed us to quantitatively evaluate the effects of N and P additions alone and interactively on leaf P allocation and use *** addition(exacerbating P limitation) reduced the concentrations of leaf total P and different leaf P fractions. Nitrogen addition reduced the allocation to leaf metabolic P but increased the allocation to other fractions, while P addition showed opposite trends. The simultaneous additions of N and P showed an antagonistic(mutual suppression) effect on the concentrations of leaf P fractions, but an additive(summary) effect on the allocation proportions of leaf P fractions. These results highlight the importance of strategies of leaf P fraction allocation in forest plants under changes in environmental nutrient availability. Importantly, our study identified critical interactions associated with combined N and P inputs that affect leaf P fractions, thus aiding in predicting plant acclimation strategies in the context of intensifying and imbalanced anthropogenic nutrient inputs.

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