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ccdc141 is required for left-right axis development by regulating cilia formation in the Kupffer's vesicle of zebrafish

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Journal of Genetics and Genomics 2024年第9期51卷 934-946页

作者： Pengcheng Wang Wenxiang shi sijie Liu Yunjing shi Xuechao Jiang fen Li sun Chen Kun sun Rang Xu Department of Pediatric Cardiology Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghai 200092China Department of Cardiovascular Medicine Heart Failure CenterRuijin HospitalRuijin Hospital Lu Wan BranchShanghai Jiao Tong University School of MedicineShanghai 200025China scientific Research Center Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghai 200092China Department of Pediatric Cardiology Shanghai Children's Medical CenterShanghai Jiao Tong University School of MedicineShanghai 200127China

Laterality is a crucial physiological process intricately linked to the cilium-centrosome complex during embryo *** in the process can result in severe organ ***-coil domain containing 141(CCDC141)has been previously known as a centrosome-related gene,but its role in left-right(LR)asymmetry has not been *** this study,we utilize the zebrafish model and human exome analysis to elucidate the function of ccdc141 in laterality *** knockdown of ccdc141 in zebrafish disrupts early LR signaling pathways,cilia function,and Kupffer's vesicle *** ccdc141-knockdown embryos exhibiting aberrant LR patterns,ccdc141-null mutants show no apparent abnormality,suggesting a genetic compensation response *** parallel,we observe a marked reduction inα-tubulin acetylation levels in the ccdc141 *** treatment with histone deacetylase(hDAC)inhibitors,particularly the hDAC6 inhibitor,rescues the ccdc141 crispant ***,exome analysis of 70 patients with laterality defects reveals an increased burden of CCDC141 mutations,with in-vivo studies verifying the pathogenicity of the patient mutation *** findings highlight the critical role of ccdc141 in ciliogenesis and demonstrate that CCDC141 mutations lead to abnormal LR patterns,identifying it as a candidate gene for laterality defects.

关键词： Left-right axis Cilia WEs Laterality defects Zebrafish CCDC141

Vitamin D,selenium,and antidiabetic drugs in the treatment of type 2 diabetes mellitus with hashimoto's thyroiditis

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World Journal of Diabetes 2024年第2期15卷 209-219页

作者： fen feng Bin Zhou Ci-La Zhou Ping huang Gang Wang Kuang Yao school of Pharmacy Shaoyang UniversityShaoyang 422099Hunan ProvinceChina Department of Endocrinology The Central Hospital of ShaoyangShaoyang 422099Hunan ProvinceChina

BACKGROUND Diabetes and thyroiditis are closely *** occur in combination and cause significant damage to the *** is no clear treatment for type-2 diabetes mellitus(T2DM)with hashimoto's thyroiditis(hT).While single symptomatic drug treatment of the two diseases is less effective,combined drug treatment may improve *** To investigate the effect of a combination of vitamin D,selenium,and hypoglycemic agents in T2DM with *** This retrospective study included 150 patients with T2DM and hT treated at The Central hospital of shaoyang from March 2020 to February *** patients were assigned to the control group,test group A,and test group B according to different treatment *** control group received low-iodine diet guidance and hypoglycemic drug *** group A received the control treatment plus vitamin D *** group B received the group A treatment plus *** levels of markers of thyroid function[free T3(FT3),thyroid stimulating hormone(Tsh),free T4(FT4)],autoantibodies[thyroid peroxidase antibody(TPOAB)and thyroid globulin antibody(TGAB)],blood lipid index[low-density lipoprotein cholesterol(LDL-C),total cholesterol(TC),triacylglycerol(TG)],blood glucose index[fasting blood glucose(FBG),and hemoglobin A1c(hbA1c)]were measured pre-treatment and 3 and 6 months after *** relationships between serum 25-hydroxyvitamin D3[25(Oh)D3]level and each of these indices were *** The levels of 25(Oh)D3,FT3,FT4,and LDL-C increased in the order of the control group,test group A,and test group B(all Phe TPOAB,TGAB,TC,TG,FBG,hbA1c,and Tsh levels increased in the order of test groups B,A,and the control group(all Phe above indices were compared after 3 and 6 months of ***-treatment,there was no divergence in serum 25(Oh)D3 level,thyroid function-related indexes,autoantibodies level,blood glucose,and blood lipid index between the control group,test groups A and B(all P>

关键词： Type-2 diabetes mellitus hashimoto's thyroiditis Vitamin D selenium agent hypoglycemic drugs Curative effect

Weakly supervised Network with scribble-supervised and Edge-Mask for Road Extraction from high-Resolution Remote sensing Images

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Computers, Materials & Continua 2024年第4期79卷 549-562页

作者： supeng Yu fen huang Chengcheng Fan College of Artificial Intelligence Nanjing Agricultural UniversityNanjing210095China Innovation Academy for Microsatellites of CAs Shanghai201210China shanghai Engineering Center for Microsatellites Shanghai201210China Key Laboratory of satellite Digital Technology Shanghai201210China

significant advancements have been achieved in road surface extraction based on high-resolution remote sensingimage processing. Most current methods rely on fully supervised learning, which necessitates enormous humaneffort to label the image. Within this field, other research endeavors utilize weakly supervised methods. Theseapproaches aim to reduce the expenses associated with annotation by leveraging sparsely annotated data, such asscribbles. This paper presents a novel technique called a weakly supervised network using scribble-supervised andedge-mask (WssE-net). This network is a three-branch network architecture, whereby each branch is equippedwith a distinct decoder module dedicated to road extraction tasks. One of the branches is dedicated to generatingedge masks using edge detection algorithms and optimizing road edge details. The other two branches supervise themodel’s training by employing scribble labels and spreading scribble information throughout the image. To addressthe historical flaw that created pseudo-labels that are not updated with network training, we use mixup to blendprediction results dynamically and continually update new pseudo-labels to steer network training. Our solutiondemonstrates efficient operation by simultaneously considering both edge-mask aid and dynamic pseudo-labelsupport. The studies are conducted on three separate road datasets, which consist primarily of high-resolutionremote-sensing satellite photos and drone images. The experimental findings suggest that our methodologyperforms better than advanced scribble-supervised approaches and specific traditional fully supervised methods.

关键词： semantic segmentation road extraction weakly supervised learning scribble supervision remote sensing image

Paravertebral block's effect on analgesia and inflammation in advanced gastric cancer patients undergoing transarterial chemoembolization and microwave ablation

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World Journal of Gastrointestinal surgery 2024年第1期16卷 196-204页

作者： Ying-fen Xiong Ben-Zhong Wei Yu-feng Wang Xiao-feng Li Cong Liu Department of Anesthesiology The First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Anesthesiology Nanjing Gulou Hospital Group Yizheng HospitalYangzhou 211400Jiangsu ProvinceChina Nuclear Medicine Department Xuzhou Cancer HospitalXuzhou 221000Jiangsu ProvinceChina Department of Radiology Xuzhou Cancer HospitalXuzhou 221000Jiangsu ProvinceChina Department of Minimally Invasive Oncology Xuzhou New Health Hospital(Xuzhou Hospital Affiliated to Jiangsu University)Xuzhou 221000Jiangsu ProvinceChina

BACKGROUND Transarterial chemoembolization(TACE)combined with microwave ablation(MWA)is an effective treatment strategy for patients with advanced gastric cancer and liver ***,it may cause severe postoperative pain and inflammatory *** paravertebral block(PVB)is a regional anesthetic technique that provides analgesia to the thoracic and abdominal *** To evaluate the effect of PVB on postoperative analgesia and inflammatory response in patients undergoing TACE combined with MWA for advanced gastric cancer and liver *** sixty patients were randomly divided into PVB and control *** PVB group received ultrasound-guided PVB with 0.375%ropivacaine preoperatively,whereas the control group received intravenous analgesia with *** primary outcome was the visual analog scale(VAs)score for pain at 6 h,12 h,24 h,and 48 h after the *** outcomes were the dose of sufentanil used,incidence of adverse events,and levels of inflammatory markers(white blood cell count,neutrophil percentage,C-reactive protein,and procalcitonin)before and after the *** The PVB group had significantly lower VAs scores at 6 h,12 h,24 h,and 48 h after the procedure compared with the control group(Phe PVB group also had a significantly lower consumption of sufentanil and a lower incidence of nausea,vomiting,and respiratory depression than did the control group(Ph the control group,the PVB group had significantly lower levels of inflammatory markers 24 h and 48 h after the procedure(PsION PVB can effectively reduce postoperative pain and inflammatory responses and improve postoperative comfort and recovery in patients with advanced gastric cancer and liver metastasis treated with TACE combined with MWA.

关键词： Transarterial chemoembolization Microwave ablation Paravertebral block Visual analog scale sufentanil Inflammatory markers

Recent Progress in Improving Rate Performance of Cellulose-Derived Carbon Materials for sodium-Ion Batteries

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Nano-Micro Letters 2024年第8期16卷 102-147页

作者： Fujuan Wang Tianyun Zhang Tian Zhang Tianqi he fen Ran state Key Laboratory of Advanced Processing and Recycling of Non‑Ferrous Metals Lanzhou University of TechnologyLanzhou 730050People’s Republic of China school of Materials science and Engineering Lanzhou University of TechnologyLanzhou 730050People’s Republic of China school of Mechanical and Electronical Engineering Lanzhou University of TechnologyLanzhou 730050People’s Republic of China

Cellulose-derived carbon is regarded as one of the most promising candidates for high-performance anode materials in sodium-ion batteries;however,its poor rate performance at higher current density remains a challenge to achieve high power density sodium-ion *** present review comprehensively elucidates the structural characteristics of cellulose-based materials and cellulose-derived carbon materials,explores the limitations in enhancing rate performance arising from ion diffusion and electronic transfer at the level of cellulose-derived carbon materials,and proposes corresponding strategies to improve rate performance targeted at various precursors of cellulose-based *** review also presents an update on recent progress in cellulose-based materials and cellulose-derived carbon materials,with particular focuses on their molecular,crystalline,and aggregation ***,the relationship between storage sodium and rate performance the carbon materials is elucidated through theoretical calculations and characterization ***,future perspectives regarding challenges and opportunities in the research field of cellulose-derived carbon anodes are briefly highlighted.

关键词： Cellulose hard carbon Anode materials Rate performance sodium-ion batteries

Area Operators on Bergman spaces

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Acta Mathematica sinica,English series 2024年第5期40卷 1161-1176页

作者： Xiao fen LV Jordi PAU Mao Fa WANG Department of Mathematics Huzhou UniversityHuzhou 313000P.R.China Departament de Matemàtiques i Informàtica Universitat de Barcelona08007 BarcelonaCataloniaSpain school of Mathematics and statistics Wuhan UniversityWuhan 430072P.R.China

We completely characterize the boundedness of area operators from the Bergman spaces A_(α)^(p)(Bn)to the Lebesgue spaces L^(q)(s_(n))for all 0he case n=1,some partial results were previously obtained by Wu in[Wu,Z.:Volterra operator,area integral and Carleson measures,*** Math.,54,2487–2500(2011)].Especially,in the case qs,we obtain some characterizations for the area operators to be *** solve the cases left open there and extend the results to n-complex dimension.

关键词： Area operator Bergman space tent space area formula

search for production of dark fermion candidates in association with heavy neutral gauge boson decaying to dimuon in proton-proton collisions at√s=8 TeV using CMs open data

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Chinese Physics C 2024年第4期48卷 6-13页

作者： Y.Mahmoud h.Abdallah M.T.hussein s.Elgammal Centre for theoretical physics The British University in EgyptEgypt Physics Department Faculty of ScienceCairo UniversityEgypt

In this study,we conducted a search for dark matter using a part of the data recorded by the CMs experiment during run-I of the LhC in 2012 with a center of mass energy of 8 TeV and an integrated luminosity of 11.6 fb−*** data were gathered from the CMs open *** matter,in the framework of the simplified model(mono-Z′),can be produced from proton-proton collisions in association with a new hypothetical gauge boson,Z′.Thus,the search was conducted in the dimuon plus large missing transverse momentum *** benchmark scenario of mono-Z′,which is known as light vector,was used for interpreting the CMs open *** evidence of dark matter was observed,and exclusion limits were set on the masses of dark matter and Z′at 95%confidence level.

关键词： dark matter large hadron collider CMs open data search for new physics dark fermion

Model dependent analysis of D^(+)_(s)→η^(′)l+v_(l) decays in beyond standard model

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Chinese Physics C 2024年第9期48卷 82-95页

作者： s.Mahata M.Mandal h.Mahapatra s.Biswas s.sahoo Department of Physics National Institute of Technology Durgapur Durgapur 713209West BengalIndia

Motivated by the recent experimental results of branching fractions for D^(+)_(s)→η^(′)l+v_(l) decays,which deviate from their sM predictions,we hve investigated these decays in W' model and scalar leptoquark model to determine potential signatures of new physics(NP) in semileptonic charm decays induced by c→(s,d)l+v_(l) *** recent experimental results of branching fractions for semileptonic D meson decays,new coupling parameters are predicted for the aforementioned NP *** fraction,forward-backward asymmetry,and lepton polarization asymmetry are examined by considering the predicted NP coupling *** results of branching fractions in scalar leptoquark model are found very close to the experimental results and exist around the range of 1σ *** presented a comparative study of the NP models to check their sensitivity on these *** anticipate that further research on these decays will significantly support our findings.

关键词： charm decay new physics W′boson scalar leptoquark flavour changing charged current

Genetic diversity of the s-type small subunit ribosomal RNA gene of Plasmodium knowlesi isolates from sabah,Malaysian Borneo and Peninsular Malaysia

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Asian Pacific Journal of Tropical Medicine 2024年第2期17卷 84-90页

作者： Eric Tzyy Jiann Chong Joveen Wan fen Neoh Tiek Ying Lau Kek heng Chua Yvonne Ai-Lian Lim Ping-Chin Lee Biotechnology Research Institute Universiti Malaysia SabahJalan UMS88400 Kota KinabaluSabahMalaysia Department of Biomedical science Faculty of Medicine BuildingUniversity of Malaya50603 Kuala LumpurMalaysia Centre of Excellence for Research in AIDs(CERiA) University of Malaya50603 Kuala LumpurMalaysia Faculty of science and Natural Resources Universiti Malaysia SabahJalan UMS88400 Kota KinabaluSabahMalaysia

Objective:To determine the genetic diversity of Plasmodium(P.)knowlesi isolates from sabah,Malaysian Borneo and Peninsular Malaysia,targeting the s-type ssU rRNA gene and including aspects of natural selection and ***:Thirty-nine blood samples infected with *** were collected in sabah,Malaysian Borneo and Peninsular *** s-type ssU rRNA gene was amplified using polymerase chain reaction,cloned into a vector,and *** natural selection and haplotype of the s-type ssU rRNA gene sequences were determined using DnasP v6 and illustrated using NETWORK *** study's 39 s-type ssU rRNA sequences and eight sequences from the Genbank database were subjected to phylogenetic analysis using MEGA ***:Overall,the phylogenetic analysis showed no evidence of a geographical cluster of *** isolates from different areas in Malaysia based on the s-type ssU rRNA gene *** s-type ssU rRNA gene sequences were relatively conserved and with a purifying *** sharing of the s-type ssU rRNA gene was observed between the *** isolates in sabah,Malaysian Borneo,but not between sabah,Malaysian Borneo and Peninsular ***:This study suggests that the s-type ssU rRNA gene of *** isolates in sabah,Malaysian Borneo,and Peninsular Malaysia has fewer polymorphic sites,representing the conservation of the *** features make the s-type ssU rRNA gene suitable for comparative studies,such as determining the evolutionary relationships and common ancestry among *** species.

关键词： Plasmodium knowlesi s-type small subunit ribosomal RNA Genetic diversity Natural selection haplotype