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An effective stress-based DsC model for predicting hydromechanical shear behavior of unsaturated collapsible soils subjected to initial shear stress

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Journal of Rock Mechanics and Geotechnical Engineering 2025年第1期17卷 539-555页

作者： saman soleymani Borujerdi s.Mohsen Haeri Amir akbari Garakani Chandrakant sDesai Civil Engineering Department Sharif University of TechnologyTehranIran Power Industry structures Research Department Niroo Research InstituteTehranIran Department of Civil and Architectural Engineering and Mechanics University of ArizonaArizonaUSA

Evaluation of hydromechanical shear behavior of unsaturated soils is still a challenging issue. The time and cost needed for conducting precise experimental investigation on shear behavior of unsaturated soils have encouraged several investigators to develop analytical, empirical, or semi-empirical models for predicting the shear behavior of unsaturated soils. However, most of the previously proposed models are for specimens subjected to the isotropic state of stress, without considering the effect of initial shear stress. In this study, a hydromechanical constitutive model is proposed for unsaturated collapsible soils during shearing, with consideration of the effect of the initial shear stress. The model implements an effective stress-based disturbed state concept (DsC) to predict the stress-strain behavior of the soil. Accordingly, material/state variables were defined for both the start of the shearing stage and the critical state of the soil. A series of laboratory tests was performed using a fully automated unsaturated triaxial device to verify the proposed model. The experimental program included 23 suction-controlled unsaturated triaxial shear tests on reconstituted specimens of Gorgan clayey loess wetted to different levels of suctions under both isotropic and anisotropic stress states. The results show excellent agreement between the prediction by the proposed model and the experimental results.

关键词： Unsaturated collapsible soil Initial shear stress Hydromechanical shear behavior Effective stress Disturbed state concept Critical state

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Partners in diabetes epidemic:A global perspective

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World Journal of Diabetes 2023年第10期14卷 1463-1477页

作者： Huan Wang s.foura akbari-alavijeh Ranjit s Parhar Randy Gaugler sarwar Hashmi College of Bioscience and Biotechnology Shenyang Agricultural UniversityShenyang 110866Liaoning ProvinceChina Rutgers Center for Vector Biology Rutgers UniversityNew BrunswickNJ 08901United States Department of Food science and Technology College of AgricultureIsfahan University of TechnologyIsfahan 84156-83111Iran Department of Biological and Medical Research King Faisal Specialist Hospital and Research CentreRiyadh 11211Saudi Arabia Research and Diagnostics Ghazala and Sanya Hashmi FoundationHolmdelNJ 07733United States

There is a recent increase in the worldwide prevalence of both obesity and *** this review we assessed insulin signaling,genetics,environment,lipid metabolism dysfunction and mitochondria as the major determinants in diabetes and to identify the potential mechanism of gut microbiota in diabetes *** searched relevant articles,which have key information from laboratory experiments,epidemiological evidence,clinical trials,experimental models,metaanalysis and review articles,in PubMed,MEDLINE,EMBAsE,Google scholars and Cochrane Controlled Trial *** selected 144 full-length articles that met our inclusion and exclusion criteria for complete *** have briefly discussed these associations,challenges,and the need for further research to manage and treat diabetes more *** involves the complex network of physiological dysfunction that can be attributed to insulin signaling,genetics,environment,obesity,mitochondria and *** recent years,there are intriguing findings regarding gut microbiome as the important regulator of *** approaches are necessary for speeding medical advances but we should find a solution sooner given the burden of the metabolic disorder―What we need is a collaborative venture that may involve laboratories both in academia and industries for the scientific progress and its application for the diabetes control.

关键词： Diabetes Diabetes mellitus Endocrinology Genes Gut microbiota Environment Insulin signaling Metabolic disorder Mitochondria Obesity

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Microstructures and mechanical properties of dissimilar Nd:YAG laser weldments of AIsI4340 and AIsI316L steels

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International Journal of Minerals,Metallurgy and Materials 2017年第5期24卷 538-549页

作者： A.R.sufizadeh s.A.A.akbari Mousavi school of Metallurgy and Materials Engineering College of EngineeringUniversity of TehranTehran 11155-4563Iran

This paper presents studies on the microstructure and mechanical properties of AIsI 316L stainless steel and AIsI 4340 low-alloy steel joints formed by the Nd:YAG laser welding process. The weld microstructures and heat affected zones (HAZs) were investigated. Austenitic microstructures were observed in all of the samples. The sizes of the HAZs changed when the heat input was varied, and the 316L sides exhibited a larger HAZ. The cooling rates were calculated by measuring the solidification dendrite arm spacing. It is shown that high cooling rates lead to an austenitic microstructure. Tensile tests were carried out, and the results revealed the tensile properties of both the base metals and the weldments. The hardness test results agreed well with the tensile test results.

关键词： stainless steel laser welding welded joints microstructure mechanical properties cooling rate

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La3+ substitution-adjusted magnetic and optical properties with enhanced photocatalytic activity and stability of copper zinc nickel ferrites for wastewater treatment applications

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Journal of Rare Earths 2025年第2期43卷 319-328页

作者： N.s.Al-Bassami General studies Department Jubail Industrial College

Copper-zinc-nickel（Cu-Zn-Ni） ferrite nanoparticles are used for wastewater treatment ***,low degradation efficiency and stability are two main issues that make them unsuitable for actual production *** this paper,the citrate-nitrate auto-combustion method was applied for the formation of Cu0.5Zn0.25Ni0.25LaxFe2-xO4;（0≤x≤0.1;step 0.02）(CZNL) *** the substitution process entails the replacement of a small ion with a larger one,the lattice constant and crystallite size does not exhibit a consistent incremental *** behavior is justified and *** size of all the CZNL ferrite nanoparticles is in the range of 8-12 nm,and the lattice constant is in the range of 8.6230 to 8.4865 *** morphological analysis conducted using field emission-scanning electron microscopy（FE-sEM） reveals that the CZNL exhibits agglomerated spherical *** energy dispersive X-ray spectrameter（EDAX） analysis was employed to confirm the elemental composition of CZNL *** the process entails the substitution of Fe3+magnetic ions with nonmagnetic ions La3+,the magnetic parameters of CZNL nanoferrites show a general decreasing trend as *** 20 K,saturation magnetization Ms shows an overall drop in its values from 59.302 emu/g at x=0.0-41.295 emu/g at x=0.1,the smallest value of 37.87 emu/g is recorded at x=*** highest coercivity（Hc=125.9 Oe） and remanence（Mr=13.32 emu/g） are recorded for x=0.08 and x=0.04 nanoferrite,*** band gap of all the CZNL nanoferrites was determined using the Kubelka-Munk function and Tauc plot for direct permitted *** doping modifies the band gap（within 1.86-1.75 eV）,increases light absorption,induces efficient e/h separation and charge migration to *** nanoferrite Cu0.5Zn0.25Ni0.25La0.06Fe1.94O4achieves a degradation efficiency of 97.3% for methylene blue（MB） dye removal after just 60 *** five recycling processes,the nanoc

关键词： Copper-zinc-nickel Ferrite Photocatalytic properties Rare earths Wastewater treatment

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A comprehensive investigation on nonlinear vibration and bending characteristics of bio-inspired helicoidal laminated composite structures

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 81-100页

作者： s.sAURABH R.KIRAN D.sINGH R.VAIsH V.s.CHAUHAN school of Mechanical and Materials Engineering Indian Institute of Technology Mandi

Bio-inspired helicoidal composite laminates, inspired by the intricate helical structures found in nature, present a promising frontier for enhancing the mechanical properties of structural designs. Hence, this study provides a comprehensive investigation into the nonlinear free vibration and nonlinear bending behavior of bio-inspired composite plates. The inverse hyperbolic shear deformation theory(IHsDT) of plates is employed to characterize the displacement field, with the incorporation of Green-Lagrange nonlinearity. The problem is modeled using the C0finite element method(FEM), and an in-house code is developed in the MATLAB environment to solve it numerically. Various helicoidal layup configurations including helicoidal recursive(HR), helicoidal exponential(HE), helicoidal semi-circular(Hs), linear helicoidal(LH), and Fibonacci helicoidal(FH)with different layup sequences and quasi-isotropic configurations are studied. The model is validated, and parametric studies are conducted. These studies investigate the effects of layup configurations, side-to-thickness ratio, modulus ratios, boundary conditions, and loading conditions at different load amplitudes on the nonlinear vibration and nonlinear bending behaviors of bio-inspired composite plates. The results show that the laminate sequence exerts a substantial impact on both nonlinear natural frequencies and nonlinear bending behaviors. Moreover, this influence varies across different side-to-thickness ratios and boundary conditions of the bio-inspired composite plate.

关键词： bio-inspired composite plate finite element method (FEM) Green-Lagrange helicoidal inverse hyperbolic shear deformation theory (IHsDT) nonlinear O322

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Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

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A systematic review of progenitor survival and maturation in Parkinsonian models

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

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Multi-component decompositions, linear superpositions, and new nonlinear integrable coupled KdV-type systems

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Communications in Theoretical Physics 2025年第2期77卷 3-14页

作者： Xiazhi Hao s Y Lou school of Mathematical science Zhejiang University of Technology school of Physical science and Technology Ningbo University

In the realm of nonlinear integrable systems, the presence of decompositions facilitates the establishment of linear superposition solutions and the derivation of novel coupled systems exhibiting nonlinear integrability. By focusing on single-component decompositions within the potential BKP hierarchy, it has been observed that specific linear superpositions of decomposition solutions remain consistent with the underlying equations. Moreover, through the implementation of multi-component decompositions within the potential BKP hierarchy,successful endeavors have been undertaken to formulate linear superposition solutions and novel coupled Kd V-type systems that resist decoupling via alterations in dependent variables.

关键词： integrable system single-component decomposition multi-component decomposition linear superposition integrable coupled KdV-type system

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Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

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Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

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