Partners in diabetes epidemic:A global perspective

作     者：Huan Wang Safoura Akbari-Alavijeh Ranjit S Parhar Randy Gaugler Sarwar Hashmi 

作者机构：College of Bioscience and BiotechnologyShenyang Agricultural UniversityShenyang 110866Liaoning ProvinceChina Rutgers Center for Vector BiologyRutgers UniversityNew BrunswickNJ 08901United States Department of Food Science and TechnologyCollege of AgricultureIsfahan University of TechnologyIsfahan 84156-83111Iran Department of Biological and Medical ResearchKing Faisal Specialist Hospital and Research CentreRiyadh 11211Saudi Arabia Research and DiagnosticsGhazala and Sanya Hashmi FoundationHolmdelNJ 07733United States 

出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)

年 卷 期：2023年第14卷第10期

页      面：1463-1477页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100205[医学-精神病与精神卫生学] 10[医学] 

主　　题：Diabetes Diabetes mellitus Endocrinology Genes Gut microbiota Environment Insulin signaling Metabolic disorder Mitochondria Obesity 

摘      要：There is a recent increase in the worldwide prevalence of both obesity and *** this review we assessed insulin signaling,genetics,environment,lipid metabolism dysfunction and mitochondria as the major determinants in diabetes and to identify the potential mechanism of gut microbiota in diabetes *** searched relevant articles,which have key information from laboratory experiments,epidemiological evidence,clinical trials,experimental models,metaanalysis and review articles,in PubMed,MEDLINE,EMBASE,Google scholars and Cochrane Controlled Trial *** selected 144 full-length articles that met our inclusion and exclusion criteria for complete *** have briefly discussed these associations,challenges,and the need for further research to manage and treat diabetes more *** involves the complex network of physiological dysfunction that can be attributed to insulin signaling,genetics,environment,obesity,mitochondria and *** recent years,there are intriguing findings regarding gut microbiome as the important regulator of *** approaches are necessary for speeding medical advances but we should find a solution sooner given the burden of the metabolic disorder―What we need is a collaborative venture that may involve laboratories both in academia and industries for the scientific progress and its application for the diabetes control.