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Optimization of stealthwatch Network security system for the Detection and Mitigation of Distributed Denial of service (DDos) Attack: Application to smart Grid system

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Communications and Network 2024年第3期16卷 108-134页

作者： Emmanuel s. Kolawole Penrose s. Cofie John h. Fuller Cajetan M. Akujuobi Emmanuel A. Dada Justin F. Foreman Pamela h. Obiomon Electrical and Computer Engineering Department Prairie View A&M University Prairie View TX USA

The smart Grid is an enhancement of the traditional grid system and employs new technologies and sophisticated communication techniques for electrical power transmission and distribution. The smart Grid’s communication network shares information about status of its several integrated IEDs (Intelligent Electronic Devices). however, the IEDs connected throughout the smart Grid, open opportunities for attackers to interfere with the communications and utilities resources or take clients’ private data. This development has introduced new cyber-security challenges for the smart Grid and is a very concerning issue because of emerging cyber-threats and security incidents that have occurred recently all over the world. The purpose of this research is to detect and mitigate Distributed Denial of service [DDos] with application to the Electrical smart Grid system by deploying an optimized stealthwatch secure Network analytics tool. In this paper, the DDos attack in the smart Grid communication networks was modeled using stealthwatch tool. The simulated network consisted of secure Network Analytic tools virtual machines (VMs), electrical Grid network communication topology, attackers and Target VMs. Finally, the experiments and simulations were performed, and the research results showed that stealthwatch analytic tool is very effective in detecting and mitigating DDos attacks in the smart Grid system without causing any blackout or shutdown of any internal systems as compared to other tools such as GNs3, Nessi2, NIssT Framework, OMNeT++, INET Framework, ReasE, Ns2, Ns3, M5 simulator, OPNET, PLC & TIA Portal management software which do not have the capability to do so. Also, using stealthwatch tool to create a security baseline for smart Grid environment, contributes to risk mitigation and sound security hygiene.

关键词： smart Grid system Distributed Denial of service (DDos) Attack Intrusion Detection and Prevention systems Detection Mitigation and stealthwatch

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A novel saliva-based miRNA profile to diagnose and predict oral cancer

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International Journal of Oral science 2024年第1期16卷 97-109页

作者： Jaikrishna Balakittnen Chameera Ekanayake Weeramange Daniel F.Wallace Pascal h.G.Duijf Alexandre s.Cristino Gunter hartel Roberto A.Barrero Touraj Taheri Liz Kenny sarju Vasani Martin Batstone Omar Breik Chamindie Punyadeera saliva&Liquid Biopsy Translational Laboratory Griffith Institute for Drug DiscoveryGriffith UniversityNathanQLDAustralia Department of Medical Laboratory sciences Faculty of Allied Health SciencesUniversity of JaffnaJaffnaSri Lanka Menzies health Institute Griffith UniversityGold CoastQLDAustralia school of Biomedical sciences Faculty of HealthQueensland University of TechnologyBrisbaneQLDAustralia Centre for Cancer Biology Clinical and Health SciencesUniversity of South Australia&SA PathologyAdelaideSAAustralia Institute of Clinical Medicine Faculty of MedicineUniversity of OsloOsloNorway Department of Medical Genetics Oslo University HospitalOsloNorway Griffith Institute for Drug Discovery Griffith UniversityNathanQLDAustralia QIMR Berghofer Medical Research Institute Statistics UnitBrisbaneQLDAustralia school of Public health The University of QueenslandBrisbaneQLDAustralia school of Nursing Queensland University of TechnologyBrisbaneQLDAustralia eResearch Research InfrastructureAcademic DivisionQueensland University of TechnologyBrisbaneQLDAustralia Department of Anatomical Pathology Royal Brisbane and Women’s HospitalHerstonQLDAustralia Faculty of Medicine The University of QueenslandBrisbaneQLDAustralia Royal Brisbane and Women’s hospital Cancer Care ServicesHerstonQLDAustralia Department of Otolaryngology Royal Brisbane and Women’s HospitalHerstonQLDAustralia Department of Oral and Maxillofacial surgery Royal Brisbane and Women’s HospitalHerstonQLDAustralia

Oral cancer (OC) is the most common form of head and neck cancer. Despite the high incidence and unfavourable patient outcomes, currently, there are no biomarkers for the early detection of OC. This study aims to discover, develop, and validate a novel saliva-based microRNA signature for early diagnosis and prediction of OC risk in oral potentially malignant disorders (OPMD).The Cancer Genome Atlas (TCGA) miRNA sequencing data and small RNA sequencing data of saliva samples were used to discover differentially expressed miRNAs. Identified miRNAs were validated in saliva samples of OC (n=50), OPMD (n=52), and controls(n=60) using quantitative real-time PCR. Eight differentially expressed miRNAs (miR-7-5p, miR-10b-5p, miR-182-5p, miR-215-5p,miR-431-5p, miR-486-3p, miR-3614-5p, and miR-4707-3p) were identified in the discovery phase and were validated. The efficiency of our eight-miRNA signature to discriminate OC and controls was:area under curve (AUC):0.954, sensitivity:86%, specificity:90%,positive predictive value (PPV):87.8%and negative predictive value (NPV):88.5%whereas between OC and OPMD was:AUC:0.911,sensitivity:90%, specificity:82.7%, PPV:74.2%and NPV:89.6%. We have developed a risk probability score to predict the presence or risk of OC in OPMD patients. We established a salivary miRNA signature that can aid in diagnosing and predicting OC,revolutionising the management of patients with OPMD. Together, our results shed new light on the management of OC by salivary miRNAs to the clinical utility of using miRNAs derived from saliva samples.

关键词： specificity salivary diagnosis

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Connections Between Induction Generator Effect and Open-loop Modal Proximity to Cause sub-synchronous Oscillations in series-compensated Power system

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CsEE Journal of Power and Energy systems 2024年第3期10卷 963-973页

作者： Wenjuan Du Yang Wang h.F.Wang Tao Zhao Tim Littler College of Electrical Engineering Sichuan UniversityChengduChina school of Electrical Engineering the Queen’s University of BelfastBelfastUK IEEE

The induction generator effect(IGE)and the openloop modal proximity(OLMP)are two different reasons why subsynchronous oscillations(ssOs)in a series-compensated power system(sCPs)may *** IGE attributes the growing ssOs to negative resistance,while the OLMP explains the ssO mechanism from the standpoint of modal *** this paper,we investigate the connections between the IGE and the OLMP through equivalent RLC circuit and open-loop modal *** investigation is conducted for two types of seriescompensated power systems where either a synchronous generator or a DFIG is connected at the sending *** investigation reveals the conditions,in which the IGE and the OLMP may jointly cause the growing ssOs,i.e.,both the IGE and the OLMP can explain why the growing ssOs ***,the investigation indicates that the IGE and the OLMP may be totally irrelevant and lead to growing ssOs *** implies that it is possible that in a sCPs,the growing ssOs are only due to the IGE,and the OLMP is non-existent,and vice ***,when the growing ssOs occurs in a sCPs,examination based on both the IGE and the OLMP should be carefully conducted in order to find if the oscillatory instability is due to the IGE,or the OLMP,or both of them.

关键词： Induction generator effect open-loop modal proximity series compensation sub-synchronous oscillations

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Dispersion effect of nano-structure pyrolytic carbon on mechanical,electrical,and microstructural characteristics of cement mortar composite

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International Journal of smart and Nano Materials 2024年第3期15卷 534-578页

作者： N.K.Karthikeyan s.Elavenil school of Civil Engineering Vellore Institute of TechnologyChennaiIndia

In material science,converting waste into nanomaterials by green technologies highlights the interest in producing sus-tainable carbon nanomaterial(sCN).This study first-ever uti-lized tyre-char as a Nano-structure Pyrolytic Carbon(NsPC)to develop electrically conductive *** other car-bon nanomaterials,the efficiency of NsPC particle as an sCN in developing electrically conductive composites was investi-gated in terms of dispersion,mechanical,water absorption,electrical resistivity,and *** results of sedi-mentation and zeta potential(-19 mV)showed the excellent dispersion of NsPC particle in water with the combined effect of superplasticizer and *** compressive(40.37%)and flexural strength(10.76%)than that of plain cement mortar composite(CMC)is achieved with 2 wt.%and 1.5 wt.%of NsPC particle,*** water absorption rate and volume of permeable voids were reduced,exhibiting less *** percolation zone of AC and DC resis-tivity of NsPC composite ranges between 1 and 2 wt.%,and the established percolation threshold is at 2 wt.%.XRD analysis showed C-s-h formation consistently increased with curing age,and hR-sEM with EDAX analysis exhibits the dense micro-structure and well-distributed NsPC particle at the *** experimental outcomes significantly enhanced the relia-bility and provided a framework for tailoring NsPC particle as sCN for developing electrically conductive composite.

关键词： sustainable nanomaterial dispersion mechanical properties electrical resistivity microstructure analysis

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Astrocytic calcium waves:unveiling their roles in sleep and arousal modulation

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Neural Regeneration Research 2024年第5期19卷 984-987页

作者： Erxi Wu Dan Qi Damir Nizamutdinov Jason h.huang Department of Neurosurgery and Neuroscience Institute Baylor Scott&White HealthTempleTXUSA Texas A&M University school of Medicine TempleTXUSA Texas A&M University school of Pharmacy College StationTXUSA LIVEsTRONG Cancer Institutes and Department of Oncology Dell Medical Schoolthe University of Texas at AustinAustinTXUSA Department of Neurosurgery Baylor College of MedicineTempleTXUSA

Neuron-astrocyte interactions are vital for the brain’s *** astrocyte activities is crucial for comprehending the complex neural network,particularly the population-level functions of neurons in different cortical states and associated behaviors in *** on animal sleep and wakefulness have revealed distinct cortical synchrony patterns between ***,outnumbering neurons by nearly fivefold,support and regulate neuronal and synaptic *** research on astrocyte activation during cortical state transitions has emphasized the influence of norepinephrine as a neurotransmitter and calcium waves as key components of ion channel *** summary focuses on a few recent studies investigating astrocyte-neuron interactions in mouse models during sleep,wakefulness,and arousal levels,exploring the involvement of noradrenaline signaling,ion channels,and glutamatergic signaling in different cortical *** findings highlight the significant impact of astrocytes on large-scale neuronal networks,influencing brain activity and *** astrocytic signaling pathways shows promise for treating sleep disorders and arousal *** research is needed to understand astrocytic calcium signaling in different brain regions and its implications for dysregulated brain states,requiring future human studies to comprehensively investigate neuron-astrocyte interactions and pave the way for therapeutic interventions in sleep-and arousal-related disorders.

关键词： arousal astrocyte calcium waves locus coeruleus neuron-astrocyte interaction norepinephrine sleep wakefulness

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Optimizing oncolytic virus design:a“swiss army knife”approach to create a systemically delivered therapeutic

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signal Transduction and Targeted Therapy 2024年第5期9卷 1791-1792页

作者： Carolina s.Ilkow John Cameron Bell Ottawa hospital Research Institute 501 Smyth RoadOttawaONK1H 8L6Canada

In a recent paper published in Nature Biotechnology,Chen et al.1 describe a multiplex oncolytic virus platform that coupled with adoptive T cell therapy could solve the problem of repeat,systemic delivery of virus based *** is widely accepted that multi-targeted therapeutic approaches attacking several facets of cancer biology are necessary to effectively deal with the tumor heterogeneity that exists within and between patients.

关键词： therapeutic al. targeted

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Message Verification Protocol Based on Bilinear Pairings and Elliptic Curves for Enhanced security in Vehicular Ad hoc Networks

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Computers, Materials and Continua 2024年第1期81卷 1029-1057页

作者： Nyangaresi V.O. Ghaib A.A. Jasim h.M. Abduljabbar Z.A. Ma J. Al sibahee M.A. Aldarwish A.J.Y. Ali A.h. Neamah h.A. Department of Computer science and software Engineering Jaramogi Oginga Odinga University of Science and Technology Bondo 40601 Kenya Department of Applied Electronics Saveetha School of Engineering SIMATS Tamilnadu Chennai 602105 India Information Technology Department Management Technical College Southern Technical University Basrah 61004 Iraq Department of Computer science College of Education for Pure Sciences University of Basrah Basrah 61004 Iraq College of Big Data and Internet Shenzhen Technology University Shenzhen 518118 China huazhong University of science and Technology Shenzhen Institute Shenzhen 518000 China National Engineering Laboratory for Big Data system Computing Technology Shenzhen University Shenzhen 518060 China Computer Technology Engineering Department Iraq University College Basrah 61004 Iraq Department of Mathematics College of Education for Pure Sciences University of Basrah Basrah 61004 Iraq Institute of Mathematics University of Debrecen Debrecen H-4002 Hungary Department of Electrical Engineering and Mechatronics Faculty of Engineering University of Debrecen Debrecen 4028 Hungary

Vehicular ad hoc networks (VANETs) provide intelligent navigation and efficient route management, resulting in time savings and cost reductions in the transportation sector. however, the exchange of beacons and messages over public channels among vehicles and roadside units renders these networks vulnerable to numerous attacks and privacy violations. To address these challenges, several privacy and security preservation protocols based on blockchain and public key cryptography have been proposed recently. however, most of these schemes are limited by a long execution time and massive communication costs, which make them inefficient for on-board units (OBUs).Additionally, some of them are still susceptible tomany *** such, this study presents a novel protocol based on the fusion of elliptic curve cryptography (ECC) and bilinear pairing (BP) operations. The formal security analysis is accomplished using the Burrows-Abadi-Needham(BAN) logic, demonstrating that our scheme is verifiably secure. The proposed scheme's informal security assessment also shows that it provides salient security features, such as non-repudiation, anonymity, and unlinkability. Moreover, the scheme is shown to be resilient against attacks, such as packet replays, forgeries,message falsifications, and impersonations. Fromthe performance perspective, this protocol yields a 37.88% reduction in communication overheads and a 44.44% improvement in the supported security features. Therefore, the proposed scheme can be deployed in VANETs to provide robust security at low overheads. © 2024 The Authors. Published by Tech science Press.

关键词： Attacks bilinear elliptic curve cryptography (ECC) privacy security vehicular ad hoc network (VANET)

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On the Geometry of the Anti-canonical Bundle of the Bott–samelson–Demazure–hansen Varieties

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Acta Mathematica sinica,English series 2024年第8期40卷 1920-1940页

作者： Indranil BIsWAs s.senthamarai KANNAN Pinakinath sAhA school of Mathematics Tata Institute of Fundamental Research1 Homi Bhabha RoadMumbai 400005India Chennai Mathematical Institute Plot H1SIPCOT IT ParkSiruseriKelambakkam603103India

Let G be a semi-simple simply connected algebraic group over the field C of complex *** T be a maximal torus of G,and let W be the Weyl group of G with respect to *** Z(w,i)be the Bott–samelson–Demazure–hansen variety corresponding to a tuple i associated to a reduced expression of an element w∈*** prove that for the tuple i associated to any reduced expression of a minuscule Weyl group element w,the anti-canonical line bundle on Z(w,i)is globally *** consequence,we prove that Z(w,i)is weak *** that G is a simple algebraic group whose type is different from *** s={α1,...,αn}be the set of simple *** w be such that support of w is equal to *** prove that Z(w,i)is Fano for the tuple i associated to any reduced expression of w if and only if w is a Coxeter element and w^(−1)(Σ_(t=1)^(n)α_(t))∈−s.

关键词： Bott-samelson-Demazure-hansen variety Coxeter element anti-canonical line bundle Fano weak Fano

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Exploring Variability in sea Level at a Tide Gauge station through Control Charts

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Journal of Environmental & Earth sciences 2024年第1期6卷 11-18页

作者： h.Bâkiİz Independent scholar Boca Raton Florida33496USA

Monitoring temporal changes in sea level is important in assessing coastal *** level anomalies at a tide gauge station,if kinematically conceived,include systematic variations such as trend,acceleration,periodic oscillations,and random *** them,the non-stationary nature of the random sea level variations of known or unknown origin at coastal regions has been long recognized by the sea level *** study proposes the analyses of subgroups of random residual statistics of a rigorously formulated kinematic model solution of tide gauge variations using X-bar and s control *** approach is demonstrated using Key West,Florida tide gauge *** mean and standard errors of 5-year-long subgroups of the residuals revealed that sea level changes at this location have been progressively intensifying from 1913 to the *** oscillations in sea level at this locality may be attributed partly to the thermal expansion of seawater with increasing temperatures causing larger buoyancy-related sea level fluctuations as well as the intensification of atmospheric events including wind patterns and the impact of changes in inverted barometer effects that will alter coastal risk assessments for the future.

关键词： Climate change sea level variance X-bar s control charts

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Evaluation of the seismic behavior of reinforced concrete structures with flat slab-column gravity frame and shear walls through nonlinear analysis methods

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Earthquake Engineering and Engineering Vibration 2024年第3期23卷 713-726页

作者： M.A.Najafgholipour s.heidarian Radbakhsh E.Erfani Department of Civil and Environmental Engineering Shiraz University of TechnologyShiraz ***Iran Department of Building Civiland Environmental EngineeringConcordia UniversityMontréal H3G 1M8Canada

This paper presents an investigation of the seismic behavior of reinforced concrete(RC)structures in which shear walls are the main lateral load-resisting elements and the participation of flat slab floor systems is not considered in the seismic design *** this regard,the behavior of six prototype structures(with different heights and plan layouts)is investigated through nonlinear static and time history analyses,implemented in the Opensees *** results of the analyses are presented in terms of the behavior of the slab-column connections and their mode of failure at different loading ***,the global response of the buildings is discussed in terms of some parameters,such as lateral overstrength due to the gravity flat slab-column *** to the nonlinear static analyses,in structures in which the slab-column connections were designed only for gravity loads,the slab-column connections exhibited a punching mode of failure even in the early stages of ***,the punching failure was eliminated in structures in which a minimum transverse reinforcement recommended in ACI 318(2019)was provided in the slabs at joint ***,despite neglecting the contribution of gravity flat slab-column frames in the lateral load resistance of the structures,a relatively significant overstrength was imposed on the structures by the gravity frames.

关键词： RC flat slab-column frames seismic behavior nonlinear analysis time history analysis

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