检索结果-南通市图书馆

A semi-supervised hierarchical approach： two-dimensional clustering of microarray gene expr.s.ion data

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Computer.s.ience 2013年第2期7卷 204-213页

作者： r Pr.s.ILLA s sWAMYNATHAN Department of Information and science and Technology The College of Engineering Guindy Campus Anna UniversityIndia Chennai 600025

Micro array technologies have become a widespread r.s.arch technique for biomedical r.s.archers to assess tens of thousands of gene expr.s.ion values simul- taneously in a single experiment. Micro array data analysis for biological discovery requir.s.computational tools. In this r.s.arch a novel two-dimensional hierarchical clustering is pr.s.nted. From the review, it is evident that the previous r.s.arch wor.s.have used clustering which have been ap- plied in gene expr.s.ion data to create only one cluster for a gene that leads to biological complexity. This is mainly because of the nature of proteins and their interactions. since proteins normally interact with different groups of proteins in Order to serve different biological roles, the genes that produce these proteins are therefore expected to co expr.s. with more than one group of genes. This constructs that in micro array gene expr.s.ion data, a gene may makes its pr.s. ence in more than one cluster. In this r.s.arch, multi-level micro array clustering, performed in two dimensions by the proposed two-dimensional hierarchical clustering technique can be used to repr.s.nt the existence of genes in one or more clusters consistent with the nature of the gene and its attributes and prevent biological complexities.

关键词： clustering hierarchical clustering supervisedclustering overlapping clustering

Novel functional association of rat testicular membrane-associated cytosolic glutathione s transfer.s.s and cyclooxygenase in vitro

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2005年第2期7卷 171-178,页

作者： s.Neeraja B.ramakr.s.na A.s.sreenath G.V.reddy P.r.K.reddy P.reddanna Department of Animal sciences School of Life SciencesUniversity of HyderabadHyderabad 500046India

Aim:To analyze the role of cytosolic glutathione s-transfer.s.s (cGsTs) and membrane-associated cytosolic GsTs (macGsTs) in pr.s.aglandin biosynthesis and to evaluate the possible interaction between glutathione s-transfer.s.s (GsTs) and cyclooxygenase (COX) in ***:sDs-PAGE analysis was undertaken for characterization of GsTs,thin layer chromatography (TLC) to monitor the effect of GsTs on pr.s.aglandin biosynthesis from arachi- donic acid (AA) and spectrophotometric assays were done for measuring activity levels of COX and ***: sDs-PAGE analysis indicates that macGsTs have molecular weights in the range of 25-28 *** a coupled assay involving GsTs,arachidonic acid and cyclooxygenase-1,rat testicular macGsTs produced pr.s.aglandin E2 and F2~, while the cGsTs caused the generation of pr.s.aglandin D2,E2 and F_(2α).In vitro interaction studies on GsTs and COX at the protein level have shown dose-dependent inhibition of COX activity by macGsTs and vice *** effect, however,is not seen with *** inhibitory effect of COX on macGsT activity was relieved with increasing concentrations of reduced glutathione (GsH) but not with 1-chloro 2,4-dinitrobenzene (CDNB).The inhibition of COX by macGsTs,on the other hand,was potentiated by ***:We isolated and purified macGsTs and cGsTs from rat testis and analyzed their involvement in pr.s.aglandin *** studies reveal a revers- ible functional interaction between macGsTs and COX in vitro,with possible interactions between them at the GsH binding site of macGsTs.

关键词： glutathione s-transfer.s. cyclooxygenase arachidonic acid glutathione pr.s.aglandins

Chemical expansion of solid oxide fuel cell materials: A brief overview

在线全文

学校读者我要写书评

暂无评论

Acta Mechanica sinica 2013年第3期29卷 312-317页

作者： s.r.Bishop International Institute for Carbon Neutral Energy r.s.arch Kyushu University

The importance of oxygen non-stoichiometry induced expansion, known as chemical expansion, for the mechanical properties of solid oxide fuel cells （sOFCs） is discussed. The methods used to measure chemical expansion and the defects r.s.onsible for its existence are introduced. recent work demonstrating the origin of chemical expansion in fluorite structured oxides for.s.FCs is pr.s.nted. Models used to predict str.s. induced by chemical expansion in sOFCs, highlighting the necessity of considering electro-chemo-mechanical coupling relationships, are discussed.

关键词： Defect equilibria · sOFC mechanical properties · Chemical expansion

Dispersion sensitivity analysis&consistency im provement of APFsDs

在线全文

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2017年第4期13卷 316-322页

作者： sangeeta sharma Panda L.K. Gite A. Anandaraj r.s. Deodhar D.K. Joshi K.M. rajan Armament r.s.arch Development Establishment (ArDE) Defence Research Development Organization Ministry of Defence Government of India Pashan Pune Maharashtra 411 021 India

The purpose of this study is to investigate and quantify some possible sources of dispersion of 120 mm APFsDs tank ammunition both experimentally and *** paper aims to point out the most influential source during In-Bore Balloting Motion phase as well as in External Ballistics phase of the ammunition and quantifies its effect on *** obtained from flight trials is critically analysed and parameters affecting dispersion such as initial yaw/pitch rates,yaw/pitch dampening,plane start angle,launch spin,clearance,centre of gravity shift,dynamic imbalance angle,cr.s. wind,*** observed and,later on,studied in detail by extensive External Ballistics Monte Carlo(EBMC)simulation and six Degree of Freedom(6-DOF)trajectory *** Bore Balloting Motion simulation shows that reduction in r.s.dual spin by about 5%r.s.lts in dr.s.ic56%reduction in first maximum yaw.A correlation between first maximum yaw and r.s.dual spin is *** of data analysis are used in design modification for existing *** of designs are evaluated numerically before freezing five designs for further *** designs are critically assessed in ter.s.of their comparative performance during In-bore travel&external ballistics *** are validated by free flight trials for the finalised design.

关键词： APFsDs Dispersion Consistency Accuracy Yaw rate spin Muzzle jump factor In-bore dynamics Monte Carlo simulation

What′s new with the XYZ mesons?

在线全文

学校读者我要写书评

暂无评论

Chinese Physics C 2008年第6期32卷 455-462页

作者： s.L.Olsen Institute of High Energy Physics Chinese Academy of Sciences

I review some of the recent experimental r.s.lts on the so-called XYZ mesons.

关键词： charmonium multiquark mesons quark-gluon hybrids

remembering your A, B, C’s: Alzheimer.s.disease and ABCA1

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica sinica B 2022年第3期12卷 995-1018页

作者： Cutler T.Lewandowski Megan s.Laham Gregory r.J.Thatcher Department of Pharmaceutical sciences University of Illinois College of PharmacyChicagoIL 60612USA Department of Pharmacology and Toxicology University of Arizona College of PharmacyTucsonAZ 85721USA

The function of ATP binding cassette protein A1(ABCA1)is central to cholesterol *** ABCA1 expr.s.ion or activity is implicated in Alzheimer.s.disease(AD)and other *** approaches to boost ABCA1 activity have yet to be translated successfully to the *** r.s. factors for AD development and progr.s.ion,including comorbid disorders such as type2 diabetes and cardiovascular disease,highlight the intersection of cholesterol transport and *** of ABCA1 can positively impact APOE lipidation,insulin sensitivity,peripheral vascular and blood-brain barrier integrity,and anti-inflammatory *** strategies towar.s.ABCA1-boosting compounds have been described,with a bias toward nuclear hormone receptor(NHr)*** agonists display beneficial preclinical effects;however,important side effects have limited *** particular,ligands that bind liver X receptor(LXr),the primary NHr that controls ABCA1 expr.s.ion,have shown positive effects in AD mouse models;however,lipogenesis and unwanted increases in triglyceride production are often *** longstanding approach,focusing on LXrβ*** selectivity,is over.s.mplistic and has *** approaches such as phenotypic screening may lead to small molecule NHr modulators that elevate ABCA1 function without inducing lipogenesis and are clinically translatable.

关键词： Alzheimer.s.disease Cardiovascular disease Cholesterol Drug discovery Liver X receptor Nuclear hormone receptor Type 2 diabetes

Palladium installed copper-organic framework for C–C coupling reactions

在线全文

学校读者我要写书评

暂无评论

science China Chemistry 2025年

作者： Yu-Mei Wang Mei-Xia Tao Kai-Ming Mo Xu Chen shu-Hua Zhong Elena s shubina Guo-Hong Ning Dan Li College of Chemistry and Materials science Guangdong Provincial Key Laboratory of Supramolecular Coordination ChemistryJinan University A.N.Nesmeyanov Institute of Organoelement Compounds Russian Academy of Sciences

The formation of C–C bonds is a crucial aspect of organic synthesis. synthesists' long-term objective is to identify novel catalysts to optimize reaction systems based on traditional transition metal catalysis. This study explor.s.the synthesis and catalytic potential of palladium-installed covalent metal-organic framewor.s.CMOFs) based on copper cyclic trinuclear units(Cu-CTUs). By incorporating palladium ions into the imine-based framework JNM-7 through a straightforward immersion method, we achieved a notable enhancement in catalytic activity for critical C–C coupling reactions, including C–H arylation and sonogashira cr.s.-coupling. The r.s.lting JNM-7-Pd demonstrated remarkable stability and recyclability, maintaining its efficiency over at least three cycles without any decline in efficiency.

关键词：

study of a collisionless magnetized plasma sheath with nonextensively distributed species

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Plasma science and Technology 2023年第12期25卷 14-23页

作者： r PAUL K DEKA G sHArMA r MOULICK s ADHIKArI s s KAUsIK B K sAIKIA Centre of Plasma Physics Institute for Plasma ResearchAssam 782402India Institute for Energy Technology Instituttveien 8Kjeller 2007Norway

A weakly magnetized sheath for a collisionless, electronegative plasma compr.s.ng positive ions,electrons, and negative ions is investigated numerically using the fluid approach. The electrons are considered to be non-Maxwellian in nature and are described by Tsalli's distribution. such electrons have a substantial effect on the sheath properties. The study also reveals that non-Maxwellian distribution is the most realistic description for negative ions in the pr.s.nce of an oblique magnetic field. In addition to the negative ion temperature, the sheath potential is also affected by the nonextensive parameters. The pr.s.nt r.s.arch finds application in the plasma processing and semiconductor industry as well as in space plasmas.

关键词： magnetised plasma sheath electronegative plasma non-extensive distribution

Nanocr.s.allization of α-Fe Cr.s.als in Fe_(52)Cr_(18)Mo_7B_(16)C_4Nb_3 Bulk Amorphous Alloy

在线全文

学校读者我要写书评

暂无评论

Journal of Materials science & Technology 2011年第6期27卷 497-502页

作者： s. Ahmadi H.r. shahverdi s.s. saremi Faculty of Engineering Department of Materials Science Tarbiat Modares University

Cr.s.allization kinetics of Fe52Cr18Mo7B16C4Nb3 alloy was evaluated by X-ray diffraction（XrD）,differential scanning calorimetric（DsC） tests and transmission electron micr.s.opy（TEM） observations in this r.s.arch *** effect,cr.s.allization and growth mechanism were investigated by using DsC tests at four different heating rates（10,20,30,40 K/min）.r.s.lts showed that a two-step cr.s.allization process occurred in the alloy in which α-Fe and Fe3B phases were cr.s.allized,r.s.ectively in the structure after heat *** energy for the first step of cr.s.allization,i.e.α-Fe was measured to be 421 and 442 kJ/mol according to Kissinger.s.arink and Ozawa models,***,Avrami exponent calculated from DsC curves was 1.6 and a two-dimensional diffusion controlled growth mechanism with decreasing nucleation rate was observed in the ***,it was known from the TEM observations that cr.s.alline α-Fe phase nucleated in the structure of the alloy in an average size of 10 nm and completely mottled morphology.

关键词： Bulk metallic glasses (BMGs) structural amorphous steels (sAss) Avrami exponent Cr.s.allization and kinetic models