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World Journal of Gastroenterology 2017年第6期23卷 935-948页

作者： Hiroyuki Matsubayashi Kyoichi Takaori Chigusa Morizane Hiroyuki Maguchi Masamichi Mizuma Hideaki Takahashi Keita Wada Hiroko Hosoi shinichi Yachida Masami suzuki Risa Usui Toru Furukawa Junji Furuse Takamitsu sato Makoto Ueno Yoshimi Kiyozumi susumu Hijioka Nobumasa Mizuno Takeshi Terashima Masaki Mizumoto Yuzo kodama Masako Torishima Takahisa Kawaguchi Reiko Ashida Masayuki Kitano Keiji Hanada Masayuki Furukawa Ken Kawabe Yoshiyuki Majima Toru shimosegawa Division of Endoscopy Shizuoka Cancer Center Clinic of Genetic Medicine Shizuoka Cancer Center Department of surgery Kyoto University Graduate School of Medicine Division of Hepatobiliary and Pancreatic Oncology National Cancer Center Hospital Center for Gastroenterology Teine-Keijinkai Hospital Department of surgery Tohoku University Graduate School of Medicine Department of Hepatobiliary and Pancreatic Oncology National Cancer Center Hospital East Department of surgery Teikyo University School of Medicine Division of Cancer Genomics National Cancer Center Research Institute Institute for Integrated Medical sciences Tokyo Women’s Medical University Department of Internal Medicine Kyorin University School of Medicine Division of Gastroenterology Yokohama City University Graduate School of Medicine Division of Hepatobiliary and Pancreatic Medical Oncology Kanagawa Cancer Center Department of Gastroenterology Aichi Cancer Center Hospital Department of Gastroenterology Kanazawa University Graduate School of Medicine Department of surgery Japan Bapist Hospital Department of Gastroenterology and Hepatology Kyoto University Graduate School of Medicine Clinical Genetics Unit Kyoto University Graduate School of Medicine Center for Genomic Medicine Kyoto University Graduate School of Medicine Osaka Medical Center for Cancer and Cardiovascular Diseases second Department of Internal Medicine Wakayama Medical University Department of Gastroenterology Onomichi General Hospital Department of Gastroenterology NationalKyushu Cancer Center Department of Medicine and Bioregulatory sciences Kyushu University Graduate School of Medical Science Pancreatic Cancer Action Network Department of Gastroenterology Tohoku University Graduate School of Medicine

Familial pancreatic cancer (FPC) is broadly defined as two first-degree-relatives with pancreatic cancer (PC) and accounts for 4%-10% of PC. several genetic syndromes, including Peutz-Jeghers syndrome, hereditary pancreatitis, hereditary breast-ovarian cancer syndrome(HBOC), Lynch syndrome, and familial adenomatous polyposis (FAP), also have increased risks of PC, but the narrowest definition of FPC excludes these known syndromes. When compared with other familial tumors, proven genetic alterations are limited to a small proportion (s usually modest. However, an ethnic deviation (Ashkenazi Jewish>Caucasian) and a younger onset are common also in FPC. In European countries, "anticipation" is reported in FPC families, as with other hereditary syndromes; a trend toward younger age and worse prognosis is recognized in the late years. The resected pancreases of FPC kindred often show multiple pancreatic intraepithelial neoplasia (Pan IN) foci, with various K-ras mutations, similar to colorectal polyposis seen in the FAP patients. As with HBOC patients, a patient who is a BRCA mutation carrier with unresectable pancreatic cancer (accounting for 0%-19% of FPC patients) demonstrated better outcome following platinum and Poly (ADP-ribose) polymerase inhibitor treatment. Western countries have established FPC registries since the 1990 s and several surveillance projects for highrisk individuals are now ongoing to detect early PCs. Improvement in lifestyle habits, including non-smoking, is recommended for individuals at risk. In Japan, the FPC study group was initiated in 2013 and the Japanese FPC registry was established in 2014 by the Japan Pancreas society.

关键词： familial pancreatic cancer registry high risk genetic surveillance

Development of new diagnostics based on LiF detector for pump-probe experiments

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Matter and Radiation at Extremes 2018年第4期3卷 197-206页

作者： T.Pikuz A.Faenov NOzaki T.Matsuoka B.Albertazzi N.J.Hartley K.Miyanishi K.Katagiri s.Matsuyama K.Yamauchi H.Habara Y.Inubushi T.Togashi H.Yumoto H.Ohashi Y.Tange T.Yabuuchi M.Yabashi A.N.Grum-Grzhimailo A.Casner I.skobelev s.Makarov s.Pikuz G.Rigon M.Koenig K.A.Tanaka T.Ishikawa R.kodama Graduate school of Engineering Osaka UniversitySuitaOsaka 565-0871Japan Joint Institute for High Temperatures Russian Academy of SciencesMoscow 125412Russia Open and Transdisciplinary Research Initiatives Osaka UniversitySuitaOsaka 565-0871Japan Photon Pioneers Center Osaka UniversitySuitaOsaka 565-0871Japan LULI e CNRs Ecole PolytechniqueCEA:Universite Paris-SaclayUPMC Univ Paris 06:Sorbonne Universites-F-91128 Palaiseau cedexFrance Helmholtz-Zentrum Dresden-Rossendorf Dresden 01328Germany Japan synchrotron Radiation Research Institute Sayo-choSayo-gunHyogo 679-5198Japan RIKEN spring-8 Center Sayo-choSayo-gunHyogo 679-5148Japan skobeltsyn Institute of Nuclear Physics Lomonosov Moscow State UniversityMoscow 119991Russia Universite de Bordeaux-CNRs-CEA CELIA(Center Lasers Intenses et Applications)UMR 5107F-33405 TalenceFrance National Research Nuclear University MEPhI Moscow 115409Russia ELI-NP/IFN-HH Maqurele-Bucharest 077125 Romania ILE Osaka UniversitySuitaOsaka 565-0871Japan

We present new diagnostics for use in optical laser pump-X-ray Free Electron Laser(XFEL)probe experiments to monitor dimensions,intensity profile and focusability of the XFEL beam and to control initial quality and homogeneity of targets to be driven by optical laser *** developing X-ray imaging,based on the use of an LiF crystal detector,we were able to measure the distribution of energy inside a hard X-ray beam with unprecedented high spatial resolution(~1 mm)and across a field of view larger than some *** diagnostic can be used in situ,provides a very high dynamic range,has an extremely limited cost,and is relatively easy to be implemented in pump-probe *** proposed methods were successfully applied in pump-probe experiments at the sPring-8 Angstrom Compact free electron LAser(sACLA)XFEL facility and its potential was demonstrated for current and future High Energy Density science experiments.

关键词： XFEL shock waves Pump-probe experiments High energy density science X-ray spectroscopy X-ray imaging

利多卡因通过增加细胞周期素依赖的蛋白激酶抑制剂1A（p21）表达抑制NIH-3T3细胞的增殖

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麻醉与镇痛 2012年第2期8卷 97-102页

作者： sukumar P. Desai Koji Kojima Charles A. Vacanti shohta kodama 苑亚静（译）郭曲练（校） Department of Anesthesiology Perioperative and Pain Medicine Laboratory for Tissue Engi-neering and Regenerative Medicine Brigham and Women＇s Hospital Harvard MedicalSchool Boston Massachusetts

背景研究利多卡因抑制大鼠胚胎成纤维细胞株NIH-3T3增殖的分子机制。体外实验中，局麻药可抑制细胞增殖，但它们对伤口愈合的影响目前尚存在争议。我们观察了利多卡因对体外大鼠成纤维细胞株NIH一3T3增殖的作用及机制。方法将NIH-3T3细... 详细信息

背景研究利多卡因抑制大鼠胚胎成纤维细胞株NIH-3T3增殖的分子机制。体外实验中，局麻药可抑制细胞增殖，但它们对伤口愈合的影响目前尚存在争议。我们观察了利多卡因对体外大鼠成纤维细胞株NIH一3T3增殖的作用及机制。方法将NIH-3T3细胞置于含利多卡因（O、0．05、0．5、1、2、5rIM）的培养液中生长。细胞计数反映细胞增殖水平，并测定溴脱氧尿苷的摄取来反映利多卡因的抑制作用，基因表达和蛋白增殖水平分别采用PcR和westem测定。结果利多卡因呈浓度依赖性地抑制NIH—313细胞增殖，其抑制程度从无（Q05和Q5mM）到轻微（1mM）到很强（2mM和5mM）（P=0．006）。第3．5天，2mM利多卡因组明显抑制溴脱氧尿苷的摄取（与对照组相比P=0．02，与lmM利多卡因组相比P=Q0495）。第1．5天，利多卡因可上调细胞周期蛋白D1和细胞周期素依赖性蛋白激酶抑制剂1A（p21）的表达。第2．5天，利多卡因增加了p21蛋白水平。结论在脊髓麻醉、硬膜外麻醉和神经阻滞时，血浆中利多卡因浓度较低，其对成纤维细胞的增殖无明显影响，而高浓度的利多卡因可升高p21蛋白水平，使细胞增殖停止在细胞周期的s期，从而抑制细胞增殖。组织渗透后可能达到的高浓度利多卡因可能通过抑制成纤维细胞增殖而阻碍伤口的愈合。

关键词： NIH-3T3细胞抑制细胞增殖蛋白激酶抑制剂细胞周期素利多卡因成纤维细胞株浓度依赖性细胞周期蛋白D1

和1995年神户地震有关的同震泉水日流量变化

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世界地震译丛 2001年第3期32卷 81-84页

作者： T. sato R. sakai K. Furuya T. kodama 杨国栋王建荣中国地震局兰州地震研究所

1995年神户地震以后,很多泉的流量迅速增加,这可能是由渗透率增加引起的。淡路岛距离神户不远,从1995年到1998年,岛上9个泉的流量变化显示出,增加的流量在两年之内逐渐呈指数衰减。我们用一个很简单的扩散模型来估算蓄水层增强了的水压... 详细信息

1995年神户地震以后,很多泉的流量迅速增加,这可能是由渗透率增加引起的。淡路岛距离神户不远,从1995年到1998年,岛上9个泉的流量变化显示出,增加的流量在两年之内逐渐呈指数衰减。我们用一个很简单的扩散模型来估算蓄水层增强了的水压扩散率,其值为130～2300 cm^2/s。根据分析,我们推测本次地震使渗透率和泉水流量增加了约7倍。

关键词：神户地震水压日流量同震流量变化泉水流量扩散率

Experimental platform for the investigation of magnetized-reverse-shock dynamics in the context of POLAR

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High Power Laser science and Engineering 2018年第3期6卷 36-49页

作者： B. Albertazzi E. Falize A. Pelka E Brack E Kroll R. Yurchak E. Brambrink E Mabey N. Ozaki s. Pikuz L. Van Box som J. M. Bonnet-Bidaud J. E. Cross E. Filippov G. Gregori R. kodama M. Mouchet T. Morita Y. sakawa R. E Drake C. C. Kuranz M. J.-E. Manuel C. Li E Tzeferacos D. Lamb U. schramm M. Koenig LULI- CNRs Ecole Polytechnique CEA: Universite Paris-Saclay UPMC Univ Paris 06: sorbonne Universites- F-91128 Palaiseau cedex France CEA-DAM-DIF F-91297 Arpajon France CEA saclay DSM/Irfu/Service d'Astrophysique F-91191 Gif-sur- Yvette France Helmholtz-Zentrum Dresden - Rossendorf HZDR Bautzner Landstrαβe 400 01328 Dresden Germany Department of Atmospheric Oceanic and Space Sciences University of Michigan Ann Arbor M148109 USA Graduate school of Engineering Osaka University Suita Osaka 565-0871 Japan JIHT-RAs 13-2 lzhorskaya st. Moscow 125412 Russia National Research Nuclear University MEPhl Moscow 115409 Russia Department of Physics University of Oxford Parks Road Oxford OX1 3PU UK Institute of Laser Engineering Osaka University Suita Osaka 565-0871 Japan LUTH Observatoire de Paris UMR CNRS 8102 Universite Paris Diderot 92190 Meudon France Department of Energy Engineering science Faculty of Engineering Sciences Kyushu University Japan General Atomics San Diego CA 92121 USA Plasma science and Fusion Center Massachusetts Institute of Technology 77 Massachusetts Avenue Cambridge MA 02139 USA Flash Center for Computational science University of Chicago IL 60637 USA

The influence of a strong external magnetic field on the collimation of a high Mach number plasma flow and its collision with a solid obstacle is investigated experimentally and numerically. The laser irradiation （I - 2 × 10^14 W. cm-2） of a multilayer target generates a shock wave that produces a rear side plasma expanding flow. Immersed in a homogeneous 10 T external magnetic field, this plasma flow propagates in vacuum and impacts an obstacle located a few mm from the main target. A reverse shock is then formed with typical velocities of the order of 15-20 4- 5 km/s. The experimental results are compared with 2D radiative magnetohydrodynamic simulations using the FLAsH code. This platform allows investigating the dynamics of reverse shock, mimicking the processes occurring in a cataclysmic variable of polar type.

关键词： accretion processes high-power laser hydrodynamics laboratory astrophysics polar radiative shocks

Petawatt and exawatt class lasers worldwide

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High Power Laser science and Engineering 2019年第3期7卷 168-221页

作者： Colin N.Danson Constantin Haefner Jake Bromage Thomas Butcher Jean-Christophe FChanteloup Enam A.Chowdhury Almantas Galvanauskas Leonida A.Gizzi Joachim Hein David I.Hillier Nicholas W.Hopps Yoshiaki Kato Efim A.Khazanov Ryosuke kodama Georg Korn Ruxin Li Yutong Li Jens Limpert Jingui Ma Chang Hee Nam David Neely Dimitrios Papadopoulos Rory R.Penman Liejia Qian Jorge J.Rocca andrey A.shaykin Craig W.siders Christopher spindloe sándor szatmári Raoul M.G.M.Trines Jianqiang Zhu Ping Zhu Jonathan D.Zuegel AWE AldermastonReadingUK OxCHEDs Clarendon LaboratoryDepartment of PhysicsUniversity of OxfordOxfordUK CIFs Blackett LaboratoryImperial CollegeLondonUK NIF&Photon science Directorate Lawrence Livermore National LaboratoryLivermoreUSA Fraunhofer Institute for Laser Technology(ILT) AachenGermany Chair for Laser Technology LLT RWTH Aachen UniversityAachenGermany University of Rochester Laboratory for Laser EnergeticsRochesterUSA Central Laser Facility STFC Rutherford Appleton LaboratoryChiltonDidcotUK LULI CNRSCEASorbonne UniversitesEcole PolytechniqueInstitut Polytechnique de ParisPalaiseauFrance Department of Physics The Ohio State UniversityColumbusUSA Centre for Ultrafast Optical science University of MichiganAnn ArborUSA Intense Laser Irradiation Laboratory Istituto Nazionale di Ottica(INO)CNRPisaItaly Institute of Optics and Quantum Electronics Friedrich-Schiller-University Jena and Helmholtz InstituteJenaGermany The Graduate school for the Creation of New Photonics Industries NishikuHamamatsuJapan Institute of Applied Physics Russian Academy of SciencesNizhny NovgorodRussia Institute of Laser Engineering Osaka UniversitySuitaOsakaJapan ELI-Beamlines Institute of PhysicsCzech Academy of SciencesPragueCzech Republic state Key Laboratory of High Field Laser Physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Institute for Applied Physics(IAP)at Friedrich-schiller-University Jena JenaGermany Helmholtz Institute Jena JenaGermany Fraunhofer Institute for Applied Optics and Precision Engineering(IOF) JenaGermany Key Laboratory for Laser Plasma(Ministry of Education) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Centre for Relativistic Laser science(CoReLs) Institute for Basic ScienceDepartment of Physics and Photon ScienceGwangju Institute of Science and Techno

In the 2015 review paper‘Petawatt Class Lasers Worldwide’a comprehensive overview of the current status of highpower facilities of>200 TW was *** was largely based on facility specifications,with some description of their uses,for instance in fundamental ultra-high-intensity interactions,secondary source generation,and inertial confinement fusion(ICF).With the 2018 Nobel Prize in Physics being awarded to Professors Donna strickland and Gerard Mourou for the development of the technique of chirped pulse amplification(CPA),which made these lasers possible,we celebrate by providing a comprehensive update of the current status of ultra-high-power lasers and demonstrate how the technology has *** are now in the era of multi-petawatt facilities coming online,with 100 PW lasers being proposed and even under *** addition to this there is a pull towards development of industrial and multi-disciplinary applications,which demands much higher repetition rates,delivering high-average powers with higher efficiencies and the use of alternative wavelengths:mid-IR *** apart from a comprehensive update of the current global status,we want to look at what technologies are to be deployed to get to these new regimes,and some of the critical issues facing their development.

关键词： exawatt lasers high-power lasers petawatt lasers ultra-high intensity

Alignment of solid targets under extreme tight focus conditions generated by an ellipsoidal plasma mirror

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Matter and Radiation at Extremes 2019年第2期4卷 30-35页

作者： Deepak Kumar Michal smid sushil singh Alexander soloviev Hannes Bohlin Konstantin Burdonov Gashaw Fente Alexander Kotov Livia Lancia Vit Leedl sergey Makarov Michael Morrissey sergey Perevalov Denis Romanovsky sergey Pikuz Ryousuke kodama David Neely Paul McKenna Tomas Lastovicka Mikhail starodubtsev stefan Weber Motoaki Nakatsutsumi Julien Fuchs ELI Beamlines Institute of Physics5.kvetna 83525241 Dolni BrezanyCzech Republic Institute of Applied Physics of the Russian Academy of sciences(IAP RAs) 46 Ulyanov Street603950 Nizhny NovgorodRussia LULI-CNRs Ecole PolytechniqueCEA:Universite Paris-SaclayUPMC Univ Paris 06:Sorbonne UniversitiesF-91128 Palaiseau CedexFrance Research Center Toptec Institute of Plasma PhysicsSobotecka 166051101 TurnovCzech Republic Joint Institute for High Temperatures Russian Academy of science(JIHT RAs) Moscow 125412Russia Division of Electrical Electronic and Information EngineeringGraduate School of EngineeringOsaka UniversityOsakaJapan Central Laser Facility STFC Rutherford Appleton LaboratoryDidcot OX110QXUnited Kingdom Department of Physics sUPA University of StrathclydeGlasgow G40NGUnited Kingdom European XFEL GmbH Holzkoppel 422869 SchenefeldGermany

The design of ellipsoidal plasma mirrors(EPMs)for the PEARL laser facility is *** EPMs achieve a magnification of 0.32 in focal spot size,and the corresponding increase in focused intensity is expected to be about *** and implementing such focusing optics for short-pulse(s)systems paves the way for their use in future high-power facilities,where they can be used to achieve intensities beyond 1023W/cm^(2).A retro-imaging-based target alignment system is also described,which is used to align solid targets at the output of the ellispoidal mirrors(with a numerical aperture of 0.75 in this case).

关键词： beyond mirror extreme

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日本老年痴呆预防的社区护理研究现状

康复学报 2016年第2期26卷 51-56页

作者：李猛小玉城段亚梅井上清美庞书勤李绵利吴小玉兵庫県立大学看護学研究科日本明石673-8588 国立病院機構·大阪医療センター日本大阪540-0006 名寄市立大学保健福祉部日本名寄096-8641 神戸常盤大学保健科学部日本神户653-0838 福建中医药大学护理学院福建福州350122

人口老化呈现出世界趋势,日本和中国等东亚国家人口老化现状尤为严峻。人口老化使老年痴呆患者数量急剧增加,如何预防老年痴呆受到全世界的关注。作为长寿之国的日本,在老年痴呆的应对方面,从国家战略到地区所采取的预防策略,乃至社区... 详细信息

人口老化呈现出世界趋势,日本和中国等东亚国家人口老化现状尤为严峻。人口老化使老年痴呆患者数量急剧增加,如何预防老年痴呆受到全世界的关注。作为长寿之国的日本,在老年痴呆的应对方面,从国家战略到地区所采取的预防策略,乃至社区护理研究都积累了丰富的经验。本文介绍日本老年痴呆预防的国家战略、地区策略,分析社区护理的研究现状、存在的问题,以期为中国老龄化进程中的老年痴呆预防策略的构建提供参考。

关键词：老年痴呆症预防国家战略社区护理