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Copper interactions with DNA of chromatin and its role in neurodegenerative disorders

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Journal of Pharmaceutical Analysis 2013年第5期3卷 354-359页

作者： M.Govindaraju H.s.shekar s.B.sateesha P.Vasudeva Raju k.R.sambasiva Rao k.s.J.Rao A.J.Rajamma Molecular Biophysics Unit Indian Institute of Science Department of Pharmacy Practice KIMS Hospital and Research CenterVIPS Department of Pharmaceutics Acharya & B.M.Reddy College of Pharmacy Department of Neuroscience Medical University of South Carolina Department of Biotechnology Acharya Nagarjuna University Centre for Neuroscience Institute for Scientifc Research and Technological services INDICASAT-AIP Department of Pharmacognosy KLEU's College of Pharmacy

In this study, we have demonstrated the conformational changes to DNA induced by abnormal interactions of copper using circular dichroism, in combination with UV-absorbance and fluorescence spectroscopy. Results confirm that binding of copper to bases of DNA in chromatin is concentration dependent. Binding efficiency of Cu2~ ions to DNA is increased in proportion to the degree of unwinding of the double helix induced by denaturation. Altered B-DNA conformation will alter the integrity of DNA which may affect the normal process of DNA replication and transcription. Copper induced DNA damage in the brain may cause neurotoxicity and the neuronal cell death and is implicated in Alzheimer＇s disease and other neurological disorders.

关键词： Human brain Chromatin DNA Copper Neurodegenerative disorders

Mechanical properties of friction stir welded armor grade Al-Zn-Mg alloy joints

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Transactions of Nonferrous Metals society of China 2017年第3期27卷 493-506页

作者： C.sHARMA V.UPADHYAY D.k.DWIVEDI P.kUMAR Rustamji Institute of Technology BSF AcademyTekanpurGwaliorMadhyapradesh 475005India Mechanical Engineering Department National Institute of Technology PatnaPatna 800005India Mechanical and Industrial Engineering Department I.I.T.RoorkeeUttarkhand 247667India

The influence of different welding speeds and rotary speeds on the formation and mechanical properties of friction stirweld joints of armor grade aluminum alloy was *** developed weld joints were characterized by bend tests,micro-hardness tests,tensile tests,optical and scanning electron *** properties(i.e.,micro-hardness,ultimatetensile strength and elongation to fracture)increased with the increase in rotary speed or decrease in welding *** effect ofwelding speed on micro-hardness of heat affected zones was more profound than the rotary *** welding speeds and rotaryspeeds influenced the mechanical properties and their effects on various mechanical properties of the friction stir welded joints canbe predicted with the help of regression models.

关键词： friction stir welding welding parameters mechanical properties fractography regression modeling

Plasma and platelet serotonin levels in patients with liver cirrhosis

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World Journal of Gastroenterology 2007年第43期13卷 5750-5753页

作者： ■or■e M ulafi Duko s Mirkovi Miodrag D Vukevi Jelena s Rudi Clinic of Gastroenterology and Hepatology Institute of Digestive Diseases Institute of Medical Biochemistry Institute of Pulmonary Diseases Clinical Center of serbia Medical Faculty Belgrade

AIM: To analyze the relationship between plasma and platelet serotonin levels and the degree of liver insufficiency. METHODs: The prospective study included 30 patients with liver cirrhosis and 30 healthy controls. The degree of liver failure was assessed according to the Child-Pugh classification. Platelet and platelet poor plasma serotonin levels were determined. REsULTs: The mean plasma serotonin level was higher in liver cirrhosis patients than in healthy subjects (215.0 ± 26.1 vs 63.1 ± 18.1 nmol/L; P serotonin content was not significantly different in patients with liver cirrhosis compared with healthy individuals (4.8 ± 0.6; 4.2 ± 0.3 nmol/platelet; P > 0.05). Plasma serotonin levels were significantly higher in Child- Pugh grade A/B than in grade C patients (246.8 ± 35.0 vs 132.3 ± 30.7 nmol/L; P serotonin content was not significantly different between Child-Pugh grade C and grade A/B (4.6 ± 0.7 vs 5.2 ± 0.8 nmol/platelet; P > 0.05). CONCLUsION: Plasma serotonin levels are significantly higher in patients with cirrhosis than in the controls and represent the degree of liver insufficiency. In addition, platelet poor plasma serotonin estimation is a better marker for liver insufficiency than platelet serotonin content.

关键词： serotonin Plasma Platelet Liver cirrhosis

Catalytic role of Cu(I) species in Cu_2O/CuI supported on MWCNTs in the oxidative amidation of aryl aldehydes with 2-aminopyridines

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Chinese Journal of Catalysis 2015年第11期36卷 1825-1836页

作者： H. N. Hareesh k. U. Minchitha N. Nagaraju N. kathyayini 耆那大学纳米生物科学系新兴技术中心印度卡纳塔克邦格讷格布尔圣约学院及研究中心化学系催化研究实验室印度卡纳塔克邦班加罗尔

Cu2O and Cul were supported on multiwalled carbon nanotubes （MWCNTs） using a wet impregna- tion method, and the resulting materials were fully characterized by powder X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy with energy dispersive X-ray spectroscopy, transmission electron microscopy, and temperature-programmed desorption with ammonia analysis. The results of these experiments revealed that Cu2O and CuI were deposited on the MWCNTs in the cubic and γ phases, respectively. These results also showed that the Cu-containing MWCNTs exhibited weak to strong electron-accepting （Lewis acidic） properties. The catalytic activities of these materials were studied for the synthesis of biologically significant N-（pyridin-2-yl）benzamides via the oxidative amidation of aryl aldehydes with 2-aminopyridines. The yields of the products were in the range 50%-95% with 100% selectivity. Notably, the CuI/MWCNT catalyst was much more effective than the Cu2O/MWCNT catalyst with respect to the isolated yield of the product, although the latter of these two catalysts exhibited much better recyclability. A preferential interaction was observed between the polar nature of the acid-activated MWCNTs and the ionic Cu2O compared with covalent CuL The differences in these interactions had a significant impact on the rate of the nucleophilic attack of the amino group of 2-aminopyridine substrate on the carbonyl group of the aryl aldehyde.

关键词： Cuprous oxide Cuprous iodide Multiwalled carbon nanotube2-Aminopyridine Oxidative amidation

Optical properties of sr_(x)Ba_(1−x)Nb_(2)O_(6)nanoscale films(x=0.5 and 0.61)grown by RF-cathode sputtering in an oxygen atmosphere

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Journal of Advanced Dielectrics 2021年第5期11卷 48-53页

作者： s.V.kara-Murza k.M.Zhidel N.V.korchikova Yu.V.Tekhtelev A.V.Pavlenko L.I.kiseleva Lugansk state Pedagogical University No.2 Oboronnaya street Lugansk 91000Ukraine Research Institute of Physics Southern Federal University No.194 Stachki AvenueRostov-on-Don 344090Russia Federal state Budgetary Institution of science“Federal Research Centre The southern scientific Centre of the Russian Academy of sciences”No.41 Chekhova street Rostov-on-Don 344090Russia

The research findings of the phase composition,nanostructure and optical properties of strontium-barium niobate thin films are ***_(x)Ba_(1−x)Nb_(2)O_(6)nanosized films(x=0.5 and 0.61)were characterized by XRD,sEM and AFM *** multi-angle ellipsometry and spectrophotometry were used to determine the optical parameters(refractive index,its dispersion,and thickness of the damaged surface layer)of thin *** was shown that sBN-50 and sBN-61 thin films were grown c-oriented on Al_(2)O_(3)(0001)and heteroepitaxial on MgO(001)*** increase of refractive index,approaching its maximum value in the bulk material for a given composition as the film thickness increases,is observed.

关键词： Ellipsometry optical parameters strontium-barium niobates thin films

三洋LCD-32A88PFC型液晶彩电三无故障应急维修

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家电维修 2018年第2期 I0043-I0043页

作者：孔德因

故障现象：上电后，面板指示灯不亮。分析检修：拆机检查，电源保险丝已烧断，PFC开关管已短路。并且开关管旁边一只470pF／2kV瓷片电容烧焦，开关管s极两只0．2212电流取样电阻烧坏，G极驱动限流电阻（1012）开路，

关键词：应急维修三无故障 FC型彩电三洋电源保险丝开关管故障现象

多级缓冲区的土地使用和车站层次的可达性对轨道客流量的影响

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城市规划学刊 2016年第3期 121-121页

作者： sUNG H CHOI k LEE s 许劼

该论文采用空间回归分析方法,分析了首尔大都市区中土地使用、轨道服务覆盖范围(研究中划分为缓冲区)和铁路车站可达性等要素对轨道客流影响的实证研究。1、研究背景已有研究肯定了TOD发展模式和公交客流量之间的积极关系,但是较少关注... 详细信息

该论文采用空间回归分析方法,分析了首尔大都市区中土地使用、轨道服务覆盖范围(研究中划分为缓冲区)和铁路车站可达性等要素对轨道客流影响的实证研究。1、研究背景已有研究肯定了TOD发展模式和公交客流量之间的积极关系,但是较少关注在不同的服务覆盖范围内(缓冲区)用地特征和车站可达性与轨道客流量之间的关系。该项研究运用实证的方法来论证以上的关系。它与已有研究有三个方面的不同,第一是在多种服务覆盖范围(多级缓冲区)的背景下分

关键词：车站客流量可达性能达性覆盖范围土地使用

钙钛矿太阳能电池中CsPbBr3纳米晶界面修饰剂的作用机制

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物理化学学报 2022年第7期38卷 1-3页

作者： s.Wageh Ahmed A.Al-Ghamdi 赵丽 Department of Physics Faculty of ScienceKing Abdulaziz UniversityJeddah 21589Saudi Arabia 湖北大学材料科学与工程学院功能材料绿色制备与应用教育部重点实验室有机化工新材料湖北省协同创新中心武汉430062

During the past decade,organic-inorganic hybrid perovskite solar cell(PsC)has attracted great attention in the photovoltaic field 1,*** the third-generation solar cell,PsC in laboratory has already achieved certified power conversion efficiency(PCE)exceeding 25%.The superb photovoltaic performance of PsC is attributed to the unique optoelectronic properties of organic-inorganic halide perovskite light absorption layer,including low exciton binding energy,high absorption coefficients,and outstanding carrier mobility 3,***,the quality of perovskite film plays a decisive role in the photovoltaic performance of *** are inevitably formed on the surface and inside of polycrystalline perovskite film during the conventional preparation ***’s widely acknowledged that defects are the recombination centers of photogenerated electrons and holes,resulting in the loss of useful photogenerated charges 5,***,decreasing the charge loss is advantageous to improving the PCE of PsC.

关键词：钙钛矿太阳能电池界面修饰 perovskite

中国黑冠长臂猿的遗传多样性及其分子系统学研究——非损伤取样DNA序列分析

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中国科学（C辑） 1996年第5期26卷 414-419页

作者：宿兵 P.kressirer k.Monda 王文蒋学龙王应祥 D.s.Woodruff 张亚平中国科学院昆明动物研究所细胞与分子进化开放研究实验室美国加利福尼亚大学生物系中国科学院昆明动物研究所兽类学研究室昆明650223

采用非损伤性 DNA基因分型技术(Noninvasive DNA genotyping),对我国珍稀灵长类动物黑冠长臂猿11个个体的线粒体DNA(mtDNA)控制区159bp的片段进行了序列分析.在所得到的159bp的DNA序列中,发现39个核苷酸位点存在变异(24. 5％). DNA一级... 详细信息

采用非损伤性 DNA基因分型技术(Noninvasive DNA genotyping),对我国珍稀灵长类动物黑冠长臂猿11个个体的线粒体DNA(mtDNA)控制区159bp的片段进行了序列分析.在所得到的159bp的DNA序列中,发现39个核苷酸位点存在变异(24. 5％). DNA一级序列数据显示,中国黑冠长臂猿拥有丰富的线粒体 DNA序列变异.采用PAUP3.1.1(简约法)和PHYLIP3.5la(最大似然法)数据分析软件对序列数据进行聚类分析后,得到了中国黑冠长臂猿的分子系统树,并且两种分析方法给出了同样的分支结构,由线粒体DNA得到的分子系统树证实了形态学研究报道的中国黑冠长臂猿3个新亚种,同时DNA序列数据揭示长期以来被作为亚种的海南黑长臂猿(H.?.hainanus)可能是一个独立的种.根据分子系统树,结合形态学方面的资料,提出对中国黑冠长臂猿新的分类观点,即现生的中国黑冠长臂猿应为3个种( H. concalor; H. leucogenys ; H. hainanus),其中 H. concolor含 3个亚种( H. ***,***,***).同时,针对该类珍稀动物保护,提出将上述黑冠长臂猿的种和亚种作为不同的进化显著性单元(Evolutionarillysingificant Units, EsU)进行保护和遗传管理,以保存各类群在进化历史中积累的遗传变异及其进化潜力.此外,通过将非损伤性DNA分型技术?

关键词：黑冠长臂猿非损伤性DNA 分子系统遗传多样性