检索结果-南通市图书馆

Precision Chemistry 2024年第2期2卷 81-87页

作者： Xiushang Xu Amogh Kinikar Marco di Giovannantonio carlo A.Pignedoli Pascal Ruffieux Klaus Müllen Roman Fasel Akimitsu Narita Max Planck Institute for Polymer Research 55128 MainzGermany Organic and Carbon Nanomaterials Unit Okinawa Institute of Science and Technology Graduate UniversityKunigami-gunOkinawa 904-0495Japan Empa Swiss Federal Laboratories for Materials Science and Technologynanotech@surfaces Laboratory8600 DübendorfSwitzerland Institute of structure of Matter-CNR(IsM-CNR) 00133 RomaItaly Institute of Physical Chemistry Johannes Gutenberg University Mainz55128 MainzGermany Department of Chemistry Biochemistry and Pharmaceutical SciencesUniversity of Bern3012 BernSwitzerland

On-surface synthesis has emerged as a powerful strategy to fabricate unprecedented forms of atomically precise graphene nanoribbons(GNRs).However,the on-surface synthesis of zigzag GNRs(ZGNR)has met with only limited ***,we report the synthesis and on-surface reactions of 2,7-dibromo-9,9′-bianthryl as the precursor towardπ-extended *** by scanning tunneling microscopy and high-resolution noncontact atomic force microscopy clearly demonstrated the formation of anthracene-fused *** skeletal rearrangements were also observed,which could be explained by intramolecular diels-Alder *** calculations of the electronic properties of the anthracene-fused ZGNRs revealed spin-polarized edge-states and a narrow bandgap of 0.20 eV.

关键词： On-surface synthesis Graphene nanoribbon On-surface reaction Rearrangement Edge state

Witness for resolution: post-conflict quadratic affiliation in semi-free ranging pigs

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Zoology 2024年第2期70卷 233-243页

作者： Ivan Norscia Edoardo Collarini carlo Robino Elena Chierto Giada Cordoni Department of Life sciences and systems Biology University of TorinoVia Accademia Albertina 1310123 TorinoItaly Department of Public Health sciences and Pediatric s University of TorinoC.So Galileo Galilei 2210126 TorinoItaly

In social mammals,post-conflict resolution can involve the reunion of former opponents(reconciliation),spontaneous/solicited post-conflict affliation of a third party with either opponent(triadic contacts),and affiliation between other individuals(hereafter bystanders;quadratic contacts).Quadratic contacts-possibly informing complex cognitive abilities-have been neglected in post-conflict *** investi-gated quadratic affliation in semi-free ranging pigs sus scrofa,at the ethical farm Parva-Domus(Cavagnolo,Italy).Kinship was *** collected behavioral data on adult pigs(n=104)via video recordings(43 h)followed by video *** and anxiety behaviors between bystanders were collected under post-conflict(PC;following a conflict between non-bystanders)and matched-control(MC;no conflict)*** affiliation was present in pigs,as bystanders affliated more in PC than MC,and such affiliation was followed by a decrease in the anxiety behaviors of both the interacting ***,quadratic contacts may be partly aimed at reducing one's own anxiety(intrinsic regulation).Quadratic affiliation was highest between closely related bystanders,which suggests that such affiliation may be most effective when close kin is *** affiliation was lowest after reconciliation and spontaneous triadic *** suggests that direct peacemaking between opponents and spontaneous triadic contacts with close kin may most likely replace quadratic ***,pigs can be influenced by the negative events that affect other pigs-but not themselves-and their response may be modulated by social *** non-random quadratic affiliation may point toward the presence of elements of social appraisal abilities inpigs.

关键词： anxiety reduction emotional regulation reconciliation social appraisal triadic contacts.

Current status of magnetic resonance imaging radiomics in hepatocellular carcinoma:A quantitative review with Radiomics Quality score

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第4期30卷 381-417页

作者： Valentina Brancato Marco Cerrone Nunzia Garbino Marco salvatore carlo Cavaliere Department of Information Technology IRCCS SYNLAB SDNNaples 80143Italy Department of Radiology IRCCS SYNLAB SDNNaples 80143Italy

BACKGROUND Radiomics is a promising tool that may increase the value of magnetic resonance imaging(MRI)for different tasks related to the management of patients with hepatocellular carcinoma(HCC).However,its implementation in clinical practice is still far,with many issues related to the methodological quality of radiomic *** To systematically review the current status of MRI radiomic studies concerning HCC using the Radiomics Quality score(RQs).METHODs A systematic literature search of PubMed,Google scholar,and Web of science databases was performed to identify original articles focusing on the use of MRI radiomics for HCC management published between 2017 and *** methodological quality of radiomic studies was assessed using the RQs ***’s correlation(ρ)analysis was performed to explore if RQs was correlated with journal metrics and characteristics of the *** level of statistical significance was set at Pseven articles were included,of which 43 focused on HCC prognosis,39 on prediction of pathological findings,16 on prediction of the expression of molecular markers outcomes,18 had a diagnostic purpose,and 11 had multiple *** mean RQs was 8±6.22,and the corresponding percentage was 24.15%±15.25%(ranging from 0.0% to 58.33%).RQs was positively correlated with journal impact factor(IF;ρ=0.36,P=2.98×10^(-5)),5-years IF(ρ=0.33,P=1.56×10^(-4)),number of patients included in the study(ρ=0.51,Pdiomics features extracted in the study(ρ=0.59,PsION Although MRI radiomics in HCC represents a promising tool to develop adequate personalized treatment as a noninvasive approach in HCC patients,our study revealed that studies in this field still lack the quality required to allow its introduction into clinical practice.

关键词： Hepatocellular carcinoma systematic review Magnetic resonance imaging Radiomics Radiomics quality score

Uveal melanoma:Recent advances in immunotherapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2024年第1期15卷 23-31页

作者： Francesco saverio sorrentino Francesco De Rosa Patrick di Terlizzi Giacomo Toneatto Andrea Gabai Lucia Finocchio carlo salati Leopoldo spadea Marco Zeppieri Department of surgical sciences Unit of OphthalmologyOspedale MaggioreBologna 40100Italy Department of Oncology IRCCS Istituto Romagnolo per lo Studio dei Tumori“Dino Amadori”Meldola 47014Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy Eye Clinic Policlinico Umberto I“Sapienza”University of RomeRome 00142Italy

Uveal melanoma(UM)is the most common primary intraocular cancer in *** incidence in Europe and the United states is 6-7 per million population per *** most primary UMs can be successfully treated and locally controlled by irradiation therapy or local tumor resection,up to 50%of UM patients develop metastases that usually involve the liver and are fatal within 1 *** date,chemotherapy and targeted treatments only obtain minimal responses in patients with metastatic UM,which is still characterized by poor *** standard therapeutic approaches for its prevention or treatment have been *** application of immunotherapy agents,such as immune checkpoint inhibitors that are effective in cutaneous melanoma,has shown limited effects in the treatment of ocular *** is due to UM’s.distinct genetics,natural history,and complex interaction with the immune *** cutaneous melanomas characterized mainly by BRAF or NRAs mutations,UMs are usually triggered by a mutation in GNAQ or *** a result,more effective immunotherapeutic approaches,such as cancer vaccines,adoptive cell transfer,and other new molecules are currently being *** this review,we examine novel immunotherapeutic strategies in clinical and preclinical studies and highlight the latest insight in immunotherapy and the development of tailored treatment of UM.

关键词： Uveal melanoma Immunotherapy Ocular oncology Tumor Metastatic disease Genetic mutations

Evaluation of ruminal methane and ammonia formation and microbiota composition as affected by supplements based on mixtures of tannins and essential oils using Rusitec

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Animal science and Biotechnology 2024年第4期15卷 1607-1622页

作者： Giulia Foggi Melissa Terranova Matteo Daghio sergej L.Amelchanka Giuseppe Conte simon Ineichen Monica Agnolucci carlo Viti Alberto Mantino Arianna Buccioni Michael Kreuzer Marcello Mele Department of Agriculture Food and Environment(DAFE)University of Pisa56124 PisaItaly AgroVet‑strickhof ETH ZurichLindauSwitzerland Department of Agriculture FoodEnvironment and ForestryUniversity of FlorenceFlorence 50144Italy Centro di Ricerche Agro‑Ambientali“E.Avanzi” University of PisaPisa 56122Italy school of Agricultural Forest and Food Sciences HAFLBern University of Applied SciencesZollikofenSwitzerland Institute of Agricultural sciences ETH ZurichLindauSwitzerland

Background dietary supplements based on tannin extracts or essential oil compounds(EOC)have been repeatedly reported as a promising feeding strategy to reduce the environmental impact of ruminant husbandry.A previous batch culture screening of various supplements identified selected mixtures with an enhanced potential to mitigate ruminal methane and ammonia *** these,Q-2(named after quebracho extract and EOC blend 2,composed of carvacrol,thymol,and eugenol)and C-10(chestnut extract and EOC blend 10,consisting of oregano and thyme essential oils and limonene)have been investigated in detail in the present study with the semi-continuous rumen simulation technique(Rusitec)in three independent *** this purpose,Q-2 and C-10,dosed according to the previous study,were compared with a non-supplemented diet(negative control,NC)and with one supplemented with the commercial EOC-based Agolin^(R) Ruminant(positive control,PC).Results From d 5 to 10 of fermentation incubation liquid was collected and analysed for pH,ammonia,protozoa count,and gas *** residues were collected for the determination of ruminal *** d 10,samples of incubation liquid were also characterised for bacterial,archaeal and fungal communities by high-throughput sequencing of 16s rRNA and 26s ribosomal large subunit gene *** of the duration of the fermentation period,Q-2 and C-10 were similarly efficient as PC in mitigating either ammonia(-37%by Q-2,-34%by PC)or methane formation(-12%by C-10,-12%by PC).The PC was also responsible for lower feed degradability and bacterial and fungal richness,whereas Q-2 and C-10 effects,particularly on microbiome diversities,were limited compared to *** All additives showed the potential to mitigate methane or ammonia formation,or both,in vitro over a period of 10 ***,several differences occurred between PC and Q-2/C-10,indicating different mechanisms of *** pronounced defaunation caused by PC a

关键词： Additive Bacteria Continuous culture Degradability Fermentation Fungi Greenhouse gas In vitro Microbiome Rumen

stubborn Hypoxia in Neonates with D-Transposition of the Great Arteries after Arterial switch Operation: Central sleep Apnea as the Cause and Potential Indicator of Brain Immaturity

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Congenital Heart disease 2024年第2期19卷 185-195页

作者： Camden L.Hebson Kyle Bliton Amr Y.Hammouda Kaitlyn Barr W.Hampton Gray Mohini Gunnett Waldemar F.carlo Department of Pediatrics Division of Pediatric CardiologyUniversity of Alabama BirminghamBirmingham35233USA Department of Pediatrics Division of Pediatric PulmonologyUniversity of Alabama BirminghamBirmingham35233USA Department of Pediatrics University of Alabama BirminghamBirmingham35233USA Department of surgery Division of Cardiothoracic SurgeryUniversity of Alabama BirminghamBirmingham35233USA

D-transposition of the great arteries(d-TGA)is surgically repaired with the arterial switch operation(AsO)with excellent results,however short and long-term morbidities still develop including neurocognitive *** significant central sleep apnea is uncommon in non-premature infants,but when present indicates immature autonomic control of respiration likely due to a neurologic *** report the unanticipatedfinding of central sleep apnea in four-term neonates with d-TGA after uncomplicated AsO,with the short-term complication of delayed hospital discharge and long-term concerns regarding this early marker of brain immaturity and its hindrance to normal *** this report,we will review each patient’s clinical course and then examine the literature on pediatric central sleep apnea,neurodevelopmental outcomes after AsO,and the important overlap of these entities in the care of patients going forward.

关键词： Transposition congenital heart disease sleep apnea polysomnography

Impact of low-intensity extracorporeal shockwave therapy on vascular parameters and sexual function in patients with arteriogenic erectile dysfunction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2024年第4期26卷 344-348页

作者： Matteo Rubino Anna Ricapito Marco Finati Ugo G Falagario Pasquale Annese Vito Mancini Gian Maria Busetto Luigi Cormio Giuseppe Carrieri carlo Bettocchi Andrology Unit Department of Urology and Renal TransplantationUniversity of FoggiaFoggia 71122Italy Department of Molecular Medicine and surgery Karolinska InstitutetStockholm 17177Sweden Department of Urology Bonomo Teaching HospitalUniversity of FoggiaAndria 76123Italy.

Previous published studies have shown an improvement of penile hemodynamic parameters after low-intensity extracorporeal shockwave therapy(Li-EsWT).However,the clinical significance of these findings remains unclear,and definitive selection criteria for Li-EsWT based on preexisting comorbidities have yet to be *** was an observational study of 113 patients with ED,evaluated between January 2019 and December 2021 in Andrology Unit at the Department of Urology and Renal Transplantation,University of Foggia(Foggia,Italy).Penile dynamic Doppler was performed to evaluate vascular parameters and 5-item version of the International Index of Erectile Dysfunction(IIEF-5)questionnaire was administered to assess the severity of *** was repeated 1 month after *** with a peak systolic velocity(PsV)s−1 were considered eligible for *** protocol consisted of 8 weekly sessions with 1500 strokes.distributed in 5 different locations along the *** treatment,a significant mean(±standard deviation[s.d.])PsV increase of 5.0(±3.4)cm s−1 was recorded and 52/113(46.0%)patients reached a PsV>30 cm s−1 at posttherapeutic penile dynamic Doppler.A clinically significant IIEF-5 score improvement was observed in 7 patients,21 patients,and 2 patients with mild-to-moderate,moderate,and severe pretreatment ED,*** different outcomes were assessed based on smoking habits,previous pelvic surgery,or use of oral phosphodiesterase-5 inhibitor(PDE5i).On the other side,only 1(6.7%)in 15 patients with diabetes mellitus showed an IIEF-5 score improvement after *** treatment determined a significant increase in PsV and correlated IIEF-5 improvement in ED *** advantage seemed particularly evident for moderate ED and was not affected by smoking habits,previous pelvic surgery,and use of ***,diabetic patients.did not benefit from the treatment.

关键词： arteriogenic erectile dysfunction International Index of Erectile Function low-intensity extracorporeal shockwave therapy peak systolic velocity

Machine learning-enhanced Monte carlo and subset simulations for advanced risk assessment in transportation infrastructure

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Mountain science 2024年第2期21卷 690-717页

作者： Furquan AHMAD Pijush sAMUI s.s.MIsHRA Department of Civil Engineering National Institute of TechnologyPatna 800006India

The maintenance of safety and dependability in rail and road embankments is of utmost importance in order to facilitate the smooth operation of transportation *** study introduces a comprehensive methodology for soil slope stability evaluation,employing Monte carlo simulation(MCs)and subset simulation(ss)with the"UPss 3.0 Add-in"in *** on an 11.693-meter embankment with a soil slope(inclination ratio of 2H:1V),the investigation considers earthquake coefficients(kh)and pore water pressure ratios(ru)following Indian zoning *** chance of slope failure showed a considerable increase as the Coefficient of Variation(COV),seismic coefficients(kh),and pore water pressure ratios(ru)experienced an *** ss approach showed exceptional efficacy in calculating odds of failure that are notably *** computational modeling,the study optimized the worst-case scenario using ANFIs-GA,ANFIs-GWO,ANFIs-PsO,and ANFIs-BBO *** ANFIs-PsO model exhibits exceptional accuracy(training R2=0.9011,RMsE=0.0549;testing R2=0.8968,RMsE=0.0615),emerging as the most *** study highlights the significance of conducting thorough risk assessments and offers practical insights into evaluating and improving the stability of soil slopes in transportation *** findings contribute to the enhancement of safety and reliability in real-world situations.

关键词： Monte carlo simulation subset simulation Machine Learning seismic coefficient

Herpes simplex keratitis:A brief clinical overview

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Virology 2024年第1期13卷 5-32页

作者： Mutali Musa Ehimare Enaholo Gladness Aluyi-Osa George Nnamdi Atuanya Leopoldo spadea carlo salati Marco Zeppieri Department of Optometry University of BeninBenin 300283Nigeria Department of Ophthalmology Africa Eye Laser CentreKm 7Benin 300105Nigeria Department of Ophthalmology Centre for Sight AfricaNkpor 434101Nigeria Eye Clinic Policlinico Umberto I"Sapienza"University of RomeRome 00142Italy of Ophthalmology University Hospital of UdineUdine 33100Italy

The aim of our minireview is to provide a brief overview of the diagnosis,clinical aspects,treatment options,management,and current literature available regarding herpes simplex keratitis(HsK).This type of corneal viral infection is caused by the herpes simplex virus(HsV),which can affect several tissues,including the *** significant aspect of HsK is its potential to cause recurrent episodes of inflammation and damage to the *** the initial infection,the HsV can establish a latent infection in the trigeminal ganglion,a nerve cluster near the *** virus may remain dormant for extended *** reactivation of the virus can occur,leading to recurrent episodes of *** triggering reactivation include stress,illness,immunosuppression,or *** episodes can manifest in different clinical patterns,ranging from mild epithelial involvement to more severe stromal or endothelial *** severity and frequency of recurrences vary among *** cases of HsK,especially those involving the stroma and leading to scarring,can result in vision impairment or even blindness in extreme *** cornea's clarity is crucial for good vision,and scarring can compromise this,potentially leading to visual *** management of HsK involves not only treating acute episodes but also implementing long-term strategies to prevent recurrences and attempt repairs of corneal nerve endings via *** medications,such as oral Acyclovir or topical Ganciclovir,may be prescribed for *** immune response to the virus can contribute to corneal ***,caused by the body's attempt to control the infection,may inadvertently harm the corneal *** should be informed about triggers and advised on measures to minimize the risk of *** summary,the recurrent nature of HsK underscores the importance of both acute and long-term management strategies to preserve corneal health and maintai

关键词： Herpes simplex virus Herpes simplex keratitis Acyclovir Neurotization Reactivation

stem cell-based 3D brain organoids for mimicking, investigating, and challenging Alzheimer's.diseases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第2期17卷 330-332页

作者： Federica Cordella carlo Brighi Alessandro soloperto silvia di Angelantonio Center for Life Nanoscience Istituto Italiano di TecnologiaRomeItaly Department of Physiology and Pharmacology Sapienza UniversityRomeItaly

Alzheimer's.disease(AD) is a progressive and irreversible neurodegene rative disorder that causes a decline of cognitive functions and a deterioration of behavioral and social performances. According to current estima... 详细信息

关键词： Alzheimer diseases irreversible