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Combinatorial therapies for spinal cord injury repair

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Neural Regeneration Research 2025年第5期20卷 1293-1308页

作者： carla s.sousa Andreia Monteiro António J.salgado Nuno A.silva Life and Health sciences Research Institute(ICVs) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVs/3B’s Associate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for spinal cord injury recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord injury pathophysiology, have been extensively tested in the last decade. These approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration. Thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord injury pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord injury

The emerging role of mesenchymal stem cell-derived extracellular vesicles to ameliorate hippocampal NLRP3 inflammation induced by binge-like ethanol treatment in adolescence

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Neural Regeneration Research 2025年第4期20卷 1153-1163页

作者： susana Mellado María JoséMorillo-Bargues carla Perpiñá-Clérigues Francisco García-García Victoria Moreno-Manzano Consuelo Guerri María Pascual Department of Physiology School of Medicine and DentistryUniversity of ValenciaValenciaSpain Bioinformatics and Biostatistics Unit Príncipe Felipe Research CenterValenciaSpain Neuronal and Tissue Regeneration Laboratory Príncipe Felipe Research CenterValenciaSpain

Our previous studies have reported that activation of the NLRP3(NOD-,LRR-and pyrin domain-containing protein 3)-inflammasome complex in ethanol-treated astrocytes and chronic alcohol-fed mice could be associated with neuroinflammation and brain *** stem cell-derived extracellular vesicles(MsC-EVs)have been shown to restore the neuroinflammatory response,along with myelin and synaptic structural alterations in the prefrontal cortex,and alleviate cognitive and memory dysfunctions induced by binge-like ethanol treatment in adolescent *** the therapeutic role of the molecules contained in mesenchymal stem cell-derived extracellular vesicles,the present study analyzed whether the administration of mesenchymal stem cell-derived extracellular vesicles isolated from adipose tissue,which inhibited the activation of the NLRP3 inflammasome,was capable of reducing hippocampal neuroinflammation in adolescent mice treated with binge *** demonstrated that the administration of mesenchymal stem cell-derived extracellular vesicles ameliorated the activation of the hippocampal NLRP3 inflammasome complex and other NLRs inflammasomes(e.g.,pyrin domain-containing 1,caspase recruitment domain-containing 4,and absent in melanoma 2,as well as the alterations in inflammatory genes(interleukin-1β,interleukin-18,inducible nitric oxide synthase,nuclear factor-kappa B,monocyte chemoattractant protein-1,and C–X3–C motif chemokine ligand 1)and miRNAs(miR-21a-5p,miR-146a-5p,and miR-141-5p)induced by binge-like ethanol treatment in adolescent *** analysis further revealed the involvement of miR-21a-5p and miR-146a-5p with inflammatory target genes and NOD-like receptor signaling *** together,these findings provide novel evidence of the therapeutic potential of MsC-derived EVs to ameliorate the hippocampal neuroinflammatory response associated with NLRP3 inflammasome activation induced by binge drinking in adolescence.

关键词： adolescence binge-like ethanol treatment extracellular vesicles hippocampus mesenchymal stem cells neuroinflammation NOD-,LRR-and pyrin domain-containing protein 3(NLRP3)

Combined Effect of Honey from Central West Brazil on Bacterial Membrane Permeability

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Journal of Biosciences and Medicines 2025年第1期13卷 316-337页

作者： Mariana Lenina Menezes Aleixo Joziane da Cruz Mendonça Rafael Bruno Rocha Benevides Larissa Maria scalon Lemos carla Galbiati Graduate Program in Environmental sciences (PPGCA) Office of Research and Graduate Studies State University of Mato Grosso (UNEMAT) Cceres Mato Grosso Brazil Faculty of Agrarian sciences State University of Mato Grosso (UNEMAT) Cceres Mato Grosso Brazil Departament of Nursing Faculty of Health Sciences State University of Mato Grosso (UNEMAT) Cceres Mato Grosso Brazil

Honey, an apicultural product with a complex chemical composition, contains numerous bioactive compounds with potential antimicrobial effects. This study investigated the effect of Apis mellifera honey from Brazil’s Central-West Region, combined with antibiotics, on bacterial membrane permeability, exploring the contributions of bioactive compounds and the botanical origin of honey. six fresh Apis mellifera honey samples and their fractions (hexane and ethyl acetate) were analyzed, for a total of 18 samples. The bacteria staphylococcus epidermidis, Helicobacter pylori and Enterococcus faecalis were used for antibacterial activity tests, which included minimum inhibitory concentration (MIC) determination and synergistic effect (checkerboard) assays. The total polyphenol and flavonoid contents were quantified, and the botanical origin was determined based on pollen analysis. The tested honey samples significantly affected bacterial membrane permeability when combined with rifampicin and clarithromycin. Although many honey-derived bioactive compounds, when isolated, did not exhibit significant activity against these bacteria, the additive or synergistic effect of multiple compounds acting on different targets appears to potentiate the antibacterial action. Descriptive statistical analysis, including means and 95% confidence intervals, confirmed the relevance of the findings. This study has provided an important discovery: Honey has an effect on bacterial membrane permeability, although the specific mechanisms involved in this process require further investigation.

关键词： Honey Mechanism of Action Antibacterial Bacterial Membrane Permeability Bioactive Compounds

The Role of Chilean Mountain Areas in Time of Drought and Energy Crisis:New Pressures and Challenges for Vulnerable Ecosystems

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Journal of Mountain science 2012年第4期9卷 451-462页

作者： Rafael sáNCHEZ carla MARCHANT Axel BORsDORF Institute for Geography Pontifical University Catholic of ChileAvenida Vicu a Mackenna 4860MaculSantiago de Chile Institute for Geography University of InnsbruckInnrain 526020 InnsbruckAustria Institute for Mountain Research:Man and Environment Austrian Academy of SciencesTechnikerstr.21a6020 InnsbruckAustria

In the summer of 2010/2011 Chile suffered the third most severe energy and water supply crisis in only one decade. This may be surprising as the Andes which accompany the country along 4,200 km are a water tower and could provide more electricity and water than needed. On top of that, it has to be mentioned that Chile also counts with sunny and windy climates and with excellent geothermal energy resources and thus has a huge potential as far as renewable energies are concerned. After analyzing the existing natural conditions, the infrastructure and the present challenges of climate change, it has to be asked in which way Chile can make use of this potential in the near future, considering the legal and political situation and the technological opportunities. It seems that the resources are still hidden in the Andes, and only the key is missing to realize the country＇s natural potential. This research has been based on the analysis of existing literature, media, quantitative data from government institutions and other antecedents obtained by the authors in field work done in the south of Chile in 2OLO. The added value of this compilation lies in the comprehensive perspective, linking the knowledge of climatologists, hydrologists, mountain researchers and energy experts in order to support a sustainable energy and water supply for the future in Chile. From this present research, it can be concluded that Chile necessarilyhas to adopt new energy-related strategies, particularly those aimed at diminishing the strong dependence on traditional sources of energy and establishing new techniques and technologies for generating electrieity and utilizing the vast potential that the country is ready to offer, such as that provided by the Andes along 4,200 kilometers.

关键词： Mountain region Andes Energy supply Chile

standardness and standard Automorphisms of Chevalley Groups,Ⅰ:the Case of Rank at Least Two

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Chinese Annals of Mathematics,series B 2012年第5期33卷 783-800页

作者： carla BARDINI Department of Mathematics University of Milanovia C.Saldini 5020133MilanoItaly.

The author studies the linkage between the standardness and the standard automorphisms of ChevMley groups over rings. It is proved that if H is any standard subgroup of G（R）, then each of its automorphisms can be extended to an automorphism of G（R, I）, restricted to an automorphism of E（R, I）, and an automorphism of E（R, I） can be extended to one of G（R, I）. The case of Chevalley groups of rank at least two is treated in this paper. Further results about the case of Chevalley groups of rank one, the case of nomcommutative ground ring and some others exceptions will appear elsewhere.

关键词： Chevalley groups standardness standard automorphism

Diagnostic tests for hepatitis C: Recent trends in electrochemical immunosensor and genosensor analysis

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World Journal of Gastroenterology 2014年第42期20卷 15476-15491页

作者： Carolina V Uliana carla s Riccardi Hideko Yamanaka Department of Chemistry Federal University of Sao Carlos Department of Physical Chemistry Institute of Chemistry Sao Paulo State University Department of Analytical Chemistry Institute of Chemistry of Araraquara Sao Paulo State University (UNESP)

Hepatitis C is a liver disease that is transmitted through contact with the blood of an infected person. An estimated 150 million individuals worldwide have been chronically infected with the hepatitis C virus(HCV). Hepatitis C shows significant genetic variation in the global population, due to the high rate of viral RNA mutation. There are six variants of the virus(HCV genotypes 1, 2, 3, 4, 5, and 6), with 15 recorded subtypes that vary in prevalence across different regions of the world. A variety of devices are used to diagnose hepatitis C, including HCV antibody test, HCV viral load test, HCV genotype test and liver biopsy. Rapid, inexpensive, sensitive, and robust analytical devices are therefore essential for effective diagnosis and monitoring of disease treatment. This review provides an overview of current electrochemical immunosensor and genosensortechnologies employed in HCV *** are a limited number of publications showing electrochemical biosensors being used for the detection of *** to their simplicity,specificity,and reliability,electrochemical biosensor devices have potential clinical applications in several viral infections.

关键词： Hepatitis C virus Immunosensors Genosensors Electrochemical detection Diagnostic tests

Validation and adaptation of the Physical Activity Enjoyment scale (PACEs) in fitness group exercisers

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Journal of sport and Health science 2020年第4期9卷 352-357页

作者： Pedro Teques Luıs Calmeiro Carlos silva carla Borrego N2i Polytechnic Institute of Maia Research CentreMaia 4475-690Portugal CIPER Interdisciplinary Centre for the Study of Human PerformanceCruz Quebrada 1499-002Portugal Abertay University School of Social and Health SciencesDundee DD11HGUK Polytechnic Institute of santarem Sport Sciences School of Rio MaiorSantarem 2001-904Portugal CIEQV—Life Quality Research Center Santarem 2001-904Portugal

Background:Recently,Mullen et al.(2011)presented an 8-item version of the Physical Activity Enjoyment scale(PACEs)that provides a valid instrument for assessing enjoyment in physical *** present paper investigated the psychometric properties of a Portuguese adaptation of ***:After a process of back-to-back translation into Portuguese,395 members of fitness centers who ranged in age from 18 to 66 years(31.11§8.90,mean§sD)completed the translated version of the *** average,participants had 3.2 years of experience in fitness group classes and practiced for approximately 3.3 times per ***:An initial exploratory factor analysis(n=139)revealed a unidimensional structure with factor loadings ranging from 0.79 to *** also showed acceptable internal consistency.A confirmatory factor analysis in an independent sample(n=256)provided additional support for the unidimensional structure of the *** addition,moderate positive correlations between enjoyment and intrinsic and identified regulation,and moderate negative correlations between enjoyment and external and amotivation,demonstrate the convergent validity of the ***,measurement invariance between 2 independent samples was also ***:The 8-item Portuguese version of PACEs is a valid and reliable instrument for measuring enjoyment of physical activity in Portuguese adult fitness exercisers,and it is therefore suitable to use as a measure of affect in exercise adherence interventions studies.

关键词： Confirmatory factor analysis Construct validity Enjoyment Exploratory factor analysis Fitness Measurement invariance self-determination theory

Outcomes and management of viral hepatitis and human immunodeficiency virus co-infection in liver transplantation

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World Journal of Gastroenterology 2014年第2期20卷 414-424页

作者： stephen E Congly Karen E Doucette carla s Coffin Liver Unit Division of Gastroenterology and HepatologyUniversity of CalgaryCalgaryAB T2N 4Z6Canada Division of Infectious Diseases University of AlbertaEdmontonAB T6G 2R3Canada

Liver transplantation for human immunodeficiency virus(HIV)positive patients with viral hepatitis co-infection is increasingly offered in many North American and European liver transplant *** studies have demonstrated acceptable post-transplant outcomes and no increased risk of HIV complications in patients coinfected with hepatitis B virus(HBV).However,liver transplantation in HIV positive patients with hepatitis C virus(HCV)has poorer outcomes overall,requiring careful selection of *** review aims to summarize the published literature on outcomes after transplant in HIV patients with HBV or HCV related end-stage liver disease and recommendations for *** particular the pre-transplant factors impacting outcomes in HCV/HIV co-infected candidates and importance of multidisciplinary management will be discussed.

关键词： Hepatitis B virus Human immunodeficiency virus co-infection Hepatitis C virus Co-infection Liver transplantation

Extremal Betti Numbers of some Cohen-Macaulay Binomial Edge Ideals

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Algebra Colloquium 2021年第3期28卷 415-430页

作者： carla Mascia Giancarlo Rinaldo Department of Mathematicsf University of Trento Via sommarive 14 38123PovoTrentoItaly

We provide the regularity and the Cohen-Macaulay type of binomial edge ideals of Cohen-Macaulay cones,and we show the extremal Betti numbers of some classes of Cohen-Macaulay binomial edge ideals:Cohen-Macaulay bipartite and fan *** addition,we compute the Hilbert-Poincare series of the binomial edge ideals of some Cohen-Macaulaybipartitegraphs.

关键词： binomial edge ideal Cohen-Macaulay type extremal Betti number