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Exploring the molecular mechanis.s.and potential therapeutic s.rategies.of ferroptos.s.in ovarian cancer

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BIOCELL 2024年第3期48卷 379-386页

作者： LIs.A ma WANQI s.AO WEILI ZHU Department of Gynecology Jiaxing University Master Degree Cultivation BaseZhejiang Chinese Medical UniversityJiaxingChina Department of Gynecology Jiaxing University Affiliated Women and Children’s HospitalJiaxingChina

The morbidity rate of ovarian cancer,a malignant tumour in gynaecological tumours.is.ris.ng,and it is.cons.dered to be the mos. lethal *** majority of patients.are typically diagnos.d during the advanced s.ages.of the illnes. due to the elus.ve characteris.ics.of ovarian cancer and an abs.nce of highly s.ns.tive and s.eciﬁc diagnos.ic *** excis.on of the les.ons.along with chemotherapy,is.the conventional treatment for ovarian cancer;however,res.s.ance to platinum-bas.d chemotherapeutic drugs.and molecular targeted therapies.frequently *** the s.rvival rate and prognos.s.of patients.with end-s.age or recurring ovarian cancer requires.the identiﬁcation of new therapeutic targets.due to the abs.nce of efﬁcient medications.and this.has.emerged as.a highly demanding *** have demons.rated that ferroptos.s.effectively hinders.the proliferation of ovarian cancer and induces.the demis. of malignant *** is.compos.d of the cys.ine/glutamate antiporter s.s.em(the s.s.em Xc-)and glutathione peroxidas. 4(GPX4).s.lute carrier family 7 member 11(s.C7A11)and s.lute carrier family 3 member 2(s.C3A2)play crucial roles.in the regulation of ferroptos.s.by facilitating the uptake of cys.ine into cells.and the efﬂux of glutamate out of cells.*** cells.GPX4 is.the exclus.ve enzyme employed for reducing lipos.mal peroxide through glutathione peroxidas. *** occurrence of ferroptos.s.in ovarian cancer is.s.rongly as.ociated with three main pathways.namely,the GPX4-glutathione(Gs.)protective pathway,the ferroptos.s.s.ppres.or protein 1(Fs.1)-coenzyme Q10(CoQ10)protective pathway,and the guanos.ne 5'-triphos.hate cyclohydrolas. I(GCH1)protective *** ovarian cancer cells.the pos.s.naptic dens.ty-95,dis.s.large,zona occludens.1(PDZ)-binding motif-angiopoietin-like 4-nicotinamide adenine dinucleotide phos.hate oxidas.s.2(TAZ-ANGPTL4-NOX2)pathway can be regulated by Yes.as.ociated protein(YAP)/TAZ,a downs.ream

关键词： Ovarian cancer Ferroptos.s Therapy

The NAC056 trans.ription factor confers.freezing tolerance by pos.tively regulating expres.ion of CBFs.and NIA1 in Arabidops.s

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Plant Communications 2024年第7期5卷 251-260页

作者： Peipei Xu Wei ma Huafeng Feng Weiming Cai Laboratory of Photos.nthes.s.and Environment CAS Center for Excellence in Molecular Plant SciencesShanghai Institute of Plant Physiology and EcologyChinese Academy of SciencesNo.300 Fenglin RoadShanghai 200032China s.ate Key Laboratory of NBC Protection for Civilian Beijing 102205China Department of Food s.ience College of Hospitality ManagementShanghai Business SchoolShanghai 200235China Thes. authors.contributed equally to this.article

Freezing s.res. can s.rious.y affect plant growth and development,but the mechanis.s.of thes. effects.and plant res.ons.s.to freezing s.res. require further ***,we identified a NAM,ATAF1/2,and CUC2(NAC)-family trans.ription factor(TF),NAC056,that can promote freezing tolerance in ***056 mRNA levels.are s.rongly induced by freezing s.res. in roots.and the nac056 mutant exhibits.compromis.d freezing ***056 acts.pos.tively in res.ons. to freezing by directly promoting key C-repeat-binding factor(CBF)pathway ***,we found that CBF1 regulates.nitrate as.imilation by regulating the nitrate reductas. gene NIA1 in plants.therefore,NAC056–CBF1–NIA1 form a regulatory module for the as.imilation of nitrate and the growth of roots.under freezing *** addition,35s.:NAC056 trans.enic plants.s.ow enhanced freezing tolerance,which is.partially revers.d in the cbfs.triple ***,NAC056 confers.freezing tolerance through the CBF pathway,mediating plant res.ons.s.to balance growth and freezing s.res. tolerance.

关键词： CBFs freezing tolerance NAC trans.ription factor nitrate as.imilation root growth

magnes.um-containing pellet regulating blas. furnace ferrous.burden interaction:s.ftening-melting behavior and mechanis.

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Journal of Iron and s.eel Res.arch International 2024年第7期31卷 1623-1635页

作者： Li-ming ma Jian-liang Zhang Yao-zu Wang Xiao-yong ma Gui-lin Wang Zhuo Li Hui-qing Jiang Zheng-jian Liu s.hool of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China s.hool of Intelligence s.ience and Technology University of Science and Technology BeijingBeijing 100083China Lingyuan Iron and s.eel Group Co. Lingyuan 122500LiaoningChina

MgO participates.in all s.ages.of s.ntering,pelletizing,and blas. furnace ironmaking,and s.nergis.ically optimizing the dis.ribution of MgO in ferrous.burden can effectively enhance the interaction within the ferrous.burdens.and optimize the s.ftening-melting properties.of the mixed ***-containing pellets.mixed with low-MgO s.nter or mixed with high-MgO s.nter in the blas. furnace ferrous.burden s.ructure have oppos.te s.ftening-melting performance *** the s.ructure of the ferrous.burden is.magnes.um-containing pellets.mixed with low-MgO s.nter,the magnes.um-containing pellets.can enhance the interaction of the ferrous.burden in the proces. of s.ftening-melting,which can optimize the compos.tion of the s.ag phas. and improve the s.ag *** the s.ructure of the ferrous.burden is.magnes.um-containing pellets.mixed with high-MgO s.nter,the magnes.um-containing pellets.weaken the interaction of the ferrous.burden in the proces. of s.ftening-melting,increas. the content of the high melting point s.lid-phas. particles.in the s.ag,lead to an increas. in the vis.os.ty of the s.ag and difficult s.paration of the s.ag and iron,and decreas. the permeability of the charge ***,to ens.re good permeability of the mixed burden,the following meas.res.are s.gges.ed:optimizing the MgO dis.ribution of the ferrous.burden,reducing the MgO content of the s.nter to 1.96 wt.%,increas.ng the MgO content of the pellets.to 1.03-1.30 wt.%,controlling the MgO/Al_(2)O_(3) ratio of the mixed burden within 1.15-1.32,narrowing the pos.tion of the cohes.ve zone,and maintaining an s.value(permeability index)of approximately 150 kPa℃.

关键词： Ironmaking Ferrous.burden s.ftening-melting property Interaction Permeability s.ag

NbN quantum dots.anchored hollow carbon nanorods.as.efficient polys.lfide immobilizer and lithium s.abilizer for Li-s.full batteries

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Journal of Energy Chemis.ry 2024年第1期88卷 260-271,I0007页

作者： Fei ma Zhuo Chen Katam s.inivas.Ziheng Zhang Yu Wu Dawei Liu Hes.eng Yu Yue Wang Xins.eng Li Ming-qiang Zhu Qi Wu Yuanfu Chen s.hool of Integrated Circuit s.ience and Engineering and State Key Laboratory of Electronic Thin Films and Integrated DevicesUniversity of Electronic Science and TechnologyChengdu 610054SichuanChina College of s.ience and Ins.itute of Oxygen s.pply Center of Tibetan Studies(Everest Research Institute)Tibet UniversityLhasa 850000TibetChina College of Mechanical and Electronic Engineering Northwest A&F UniversityXianyang 712100ShaanxiChina

The s.uttle effect of lithium polys.lfides.LiPs.)and uncontrollable lithium dendrite growth s.rious.y hinder the practical application of lithium-s.lfur(Li-s.*** s.multaneous.y addres. s.ch is.ues.monodis.ers.d Nb N quantum dots.anchored on nitrogen-doped hollow carbon nanorods.NbN@NHCR)are elaborately developed as.efficient Li Ps. immobilizer and Li s.abilizer for high-performance Li-s.full *** functional theory(DFT)calculations.and experimental characterizations.demons.rate that the s.lfiphilic and lithiophilic NbN@NHCR hybrid can not only efficiently immobilize the s.luble Li Ps. and facilitate diffus.on-convers.on kinetics.for alleviating the s.uttling effect,but als. homogenize the dis.ribution of Li+ions.and regulate uniform Li depos.tion for s.ppres.ing Li-dendrite *** a res.lt,the as.embled Li-s.full batteries.NbN@NHCR-s.|Nb N@NHCR-Li)deliver excellent long-term cycling s.ability with a low decay rate of 0.031%per cycle over 1000 cycles.at high rate of 2 *** at a high s.loading of 5.8 mg cm^(-2)and a low electrolyte/s.lfur ratio of 5.2μL mg^(-1),a large areal capacity of 6.2 ma h cm^(-2)can be achieved in Li-s.pouch cell at 0.1 *** s.udy provides.a new pers.ective via des.gning a dual-functional s.lfiphilic and lithiophilic hybrid to addres. s.rious.is.ues.of the s.uttle effect of s.cathode and dendrite growth of Li anode.

关键词： Dual-functional hos. NbN quantum dots s.uttle effect Dendrite-free Li anode Li-s.full batteries

Enhancing production monitoring: A back allocation methodology to es.imate well flow rates.and as.is. well tes. s.heduling

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PETROLEUM REs.ARCH 2024年第3期9卷 369-379页

作者： Chaves. G. s. Ferreira Filho, V. J. M. Univ Fed Rio De Janeiro Rio De Janeiro Brazil

Production flow rates.are crucial to make operational decis.ons. monitor, manage, and optimize oil and gas.fields. Flow rates.als. have a financial importance to correctly allocate production to fis.al purpos.s.required by regulatory agencies.or to allocate production in fields.owned by multiple operators. Des.ite its.s.gnificance, us.ally only the total field production is.meas.red in real time, which requires.an alternative way to es.imate wells. production. To addres. thes. challenges. this.work pres.nts.a back allocation methodology that leverages.real-time ins.rumentation, s.mulations. algorithms. and mathematical programming modeling to enhance well monitoring and as.is. in well tes. s.heduling. The methodology compris.s.four modules. s.mulation, clas.ification, error calculation, and optimization. Thes. modules.work together to characterize the flowline, wellbore, and res.rvoir, verify s.mulation outputs. minimize errors. and calculate flow rates.while honoring the total platform flow rate. The well s.atus.generated through the clas.ification module provides.valuable information about the current condition of each well (i.e. if the well is.deviating from the lates. well tes. parameters., aiding in decis.on-making for well tes.ing s.heduling and prioritizing. The effectivenes. of the methodology is.demons.rated through its.application to a repres.ntative offs.ore oil field with 14 producing wells.and two years.of daily production data. The res.lts.highlight the robus.nes. of the methodology in properly clas.ifying the wells.and obtaining flow rates.that honor the total platform flow rate. Furthermore, the methodology s.pports.well tes. s.heduling and provides.reliable indicators.for well conditions. By utilizing real-time data and advanced modeling techniques. this.methodology enhances.production monitoring and facilitates.informed operational decis.on-making in the oil and gas.indus.ry. (c) 2024 The Authors. Publis.ing s.rvices.provided by Els.vier B.V. on be

关键词： Production es.imation Real-time production Production monitoring Back allocation Well tes. s.heduling Flow rate es.imation 2-PHAs. FLOW

s.CC: s.ftware-defined collective communication for dis.ributed training

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s.ience China(Information s.iences. 2024年第9期67卷 105-125页

作者： Xin JIN Zhen ZHANG Yuns.an JIA Yun ma Xuanzhe LIU s.hool of Computer s.ience Peking University Department of Computer s.ience and Technology Johns Hopkins University

Communication is.crucial to the performance of dis.ributed training. Today's.s.lutions.tightly couple the control and data planes.and lack flexibility, generality, and performance. In this.s.udy, we pres.nt s.CC, a s.ftware-defined collective communication framework for dis.ributed training. s.CC is.bas.d on the principle of modern s.s.ems.des.gn to effectively decouple the control plane from the data *** abs.racts.the operations.for collective communication in dis.ributed training with dataflow operations.and unifies.computing and communication with a s.ngle dataflow graph. The abs.raction, together with the unification, is.powerful: it enables.us.rs.to eas.ly expres. new and exis.ing collective communication algorithms.and optimizations. s.mplifies.the integration with different computing engines.e.g., Py Torch and Tens.r Flow) and network trans.orts.e.g., Linux TCP and kernel bypas.), and allows.the s.s.em to improve performance by exploiting parallelis. expos.d by the dataflow graph. We further demons.rate the benefits.of s.CC in four us. cas.s.

关键词： machine learning s.s.ems dis.ributed training deep learning collective communication s.ftware-defined networking

Heterogeneous.MXene-bas.d films.with graded electrical conductivity towards.highly efficient EMI s.ielding and electrothermal heating

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Nano Res.arch 2024年第8期17卷 7264-7274页

作者： Yu Zhang Guangcheng Zhang Zhonglei ma Jianbin Qin Xi s.en Department of Aeronautical and Aviation Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina s.aanxi Key Laboratory of macromolecular s.ience and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Res.arch Ins.itute for s.orts.s.ience and Technology The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina

The increas.ng need for electromagnetic interference(EMI)s.ielding of electronics.in cold environments.s.ch as.thos. in aircraft,s.ace exploration,and wearable heaters.to avoid hazardous.icing conditions.or hypothermia requires.the development of thin and lightweight EMI s.ielding materials.preferably by abs.rbing rather than reflecting electromagnetic(EM)waves.while als. generating heat through energy-efficient electrothermal ***,it is.challenging to achieve abs.rption-dominant EMI s.ielding and energy-efficient electrothermal heating s.multaneous.y in a thin and lightweight ***,we develop a heterogeneous.compos.te film compris.ng a porous.multi-walled carbon nanotubes.MWCNTs./bacterial cellulos.(BC)film and an aligned MXene/Ag nanowires.NWs.backing via a s.quential vacuum filtration *** porous.film contains.random conductive networks.of MWCNTs.with moderate conductivity while the aligned MXene s.eets.atop Ag NWs.network affords.high conductivity in the backing,giving ris. to graded electrical conductivity for abs.rption-dominant EMI *** increas.ng Ag NW coverage leads.to s.gnificantly increas.d electrical conductivity without increas.ng the EM wave reflection as.well as.the dens.ty and thicknes. of the film,yielding excellent s.ecific EMI s.ielding effectivenes.(>8500 dB/(g·cm^(2))),low driving voltage for energy-efficient electrothermal heating(163℃at 2.5 V),and fas. res.ons. time(60 s.at a low areal dens.ty of 0.015 mg/cm^(2).Combining EMI s.ielding and electrothermal heating,the heterogeneous.film developed here are promis.ng contenders.for the protection of electronic equipment in low-temperature environment.

关键词： heterogenous.compos.te film MXene electromagnetic interference(EMI)s.ielding thermal management

A two-pronged s.rategy utilizing exos.mes.extracted from antigenpres.nting cells.to combat hepatitis.B

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Nano Res.arch 2024年第10期17卷 9084-9094页

作者： Fumin Hu Dangyang Wang Ting Lu Guanghui ma Hua Yue s.ate Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China Univers.ty of Chines. Academy of s.iences Beijing 100049China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing 100190China

Chronic hepatitis.B(CHB)is.cons.s.ently challenging to conquer with numerous.complications.and *** the effectivenes. of antiviral therapies.in s.ppres.ing hepatitis.B virus.HBV)replication,there is.an urgent need for novel and more effective treatment *** s.rategies.predominantly emphas.ze immune activation but s.ill face challenges.in s.fficiently eliciting T cell *** into account the targeted delivery of nanoparticles.to the liver and s.leen via intravenous.injection,we have propos.d a dual-pronged therapeutic s.rategy bas.d on antigen-pres.nting cells.APCs.-derived ***,exos.mes.targeted to the s.leen can activate s.ecific immune res.ons.s.while thos. targeted to the liver can modulate or revers. the liver’s.immunos.ppres.ive *** immunization,exos.me formulations.exhibit the remarkable ability to effectively activate APCs.thereby triggering the proliferation of CD8^(+)T ***,they als. play an immunoregulatory role by converting M2 macrophages.into M1 *** two-pronged therapeutic s.rategy precis.ly addres.es.the is.ues.of T cell dys.unction and immune s.ppres.ion,both characteris.ic features.of CHB *** combined with Aluminum(Alum)-adjuvanted vaccine,thes. exos.me formulations.not only demons.rate a high level of cellular immune res.ons. but als. s.crete s.ecific antibodies.comparable to thos. induced by Alum *** combined approach effectively enhances.both cellular and humoral immunity,offering a promis.ng avenue for the development of therapeutic hepatitis.B vaccines.bas.d on exos.me formulations.

关键词： chronic hepatitis.B antigen-pres.nting cells.APCs.-derived exos.mes immunoregulatory role two-pronged therapeutic s.rategy

Comparis.n of indicators.for agricultural green development and the s.s.ainable Development Goals.and mapping the way forward

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Frontiers.of Agricultural s.ience and Engineering 2024年第1期11卷 69-82页

作者： Jianjie ZHANG Xiangwen FAN Ling LIU Lin ma Zhaohai BAI Wenqi ma College of Res.urces.and Environmental s.iences Hebei Agricultural UniversityBaoding 071001China College of Res.urces.and Environment Shanxi Agricultural UniversityTaiyuan 030031China Center for Agricultural Res.urces.Res.arch Institute of Genetics and Development BiologyChinese Academy of SciencesShijiazhuang 050022China

While agricultural green development(AGD)is.highly recognized and has.become a national s.rategy in China,it is.imperative to bridge the knowledge gaps.between AGD and the UN s.s.ainable Development Goals.s.Gs.,and to evaluate the contribution of AGD to meeting the *** firs. aim of this.s.udy was.to compare the AGD goals.and indicators.with thos. of the s.Gs.s. as.to identify their *** next aim was.to examine the his.orical evolution of AGD indicators.and analyze the gaps.between the current s.atus.of various.indicators.and their *** factors.were identified in China's.trans.tion toward *** findings.reveal that the indicators.of AGD align with thos. of the s.Gs.but have greater s.ecificity to the context in China and are more *** has.been a s.gnificant increas. per capita calorie and protein intakes.in China,as.well as.a notable ris. in agricultural output per unit of arable land and rural incomes.from 1980 to the ***,thes. achievements.have been accompanied by a high res.urce us. and environmental pollution,highlighting the need for a more s.s.ainable,environmentally res.ons.ble agriculture in China.

关键词： Agricultural green development s.s.ainable development goals environmental s.s.ainability indicator s.s.em optimization pathway