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strategies for PET imaging of the receptor for advanced glycation endproducts(RAGE)

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Journal of Pharmaceutical Analysis 2020年第5期10卷 452-465页

作者： Lindsey R.Drake Allen F.Brooks Jenelle stauff Phillip s.sherman Janna Arteaga Robert A.Koeppe Aimee Reed Timothy J.Montavon Marc B.skaddan Peter J.H.scott Department of Radiology University of MichiganAnn ArborMI48109USA Department of Medicinal Chemistry University of MichiganAnn ArborMI48109USA AbbVie Process Chemistry North ChicagoIL60064USA AbbVie Centralized Medicinal Chemistry North ChicagoIL60064USA AbbVie Translational imaging North ChicagoIL60064USA

The implication of the receptor for advanced glycation end-products(RAGE)in numerous diseases and neurodegenerative disorders makes it interesting both as a therapeutic target and as an inflammatory *** the context of investigating RAGE as a biomarker,there is interest in developing radiotracers that will enable quantification of RAGE using positron emission tomography(PET)*** have synthesized potential small molecule radiotracers for both the intracellular([18F]inRAGER)and extracellular([18F]RAGER)domains of *** we report preclinical evaluation of both using in vitro(lead panel screens)and in vivo(rodent and nonhuman primate PET imaging)*** radiotracers have high affinity for RAGE and show good brain uptake,but suffer from off-target *** source of the off-target PET signal is not attributable to binding to melatonin receptors,but remains *** have also investigated use of lipopolysaccharide(LPs)-treated mice as a possible animal model with upregulated RAGE for evaluation of new imaging *** of the mouse brain sections revealed increases in RAGE in the male cohorts,but no difference in the female ***,it proves challenging to quantify the changes in RAGE due to off-target binding of the ***,they are appropriate lead scaffolds for future development of 2nd generation RAGE PET radiotracers because of their high affinity for the receptor and good CNs penetration.

关键词： RAGE Neuroimaging Positron emission tomography Radiochemistry Neuroinflammation

simultaneous Voltammetric Determination of Cd^(2+), Pb^(2+), and Hg^(2+) ions Using Aminosepiolite-Coated Glassy Carbon Electrode: Optimization of Detection Parameters via Response surface Methodology

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Journal of Analysis and Testing 2019年第4期3卷 295-305页

作者： Ervice Ymélé sherman Lesly Zambou Jiokeng Divine Bup Nde Théophile Kamgaing ignas Kenfack Tonlé Electrochemistry and Chemistry of Materials Department of ChemistryFaculty of ScienceUniversity of DschangP.O.Box 67DschangCameroon Higher institute of the sahel University of MarouaP.O.Box 46MarouaCameroon

Adsorptive stripping voltammetry using a glassy carbon electrode modified by a film of aminosepiolite was utilized for simultaneous pre-concentration and trace detection of cadmium,lead,and mercury ions in aqueous *** modified sepiolite exploited as electrode material was obtained by grafting on its surface of[(3-(2-aminoethylamino)propyl)]trimethoxysilane(AEPTMs).The results demonstrated that the amine groups on sepiolite efficiently affected the voltammetric detection of heavy *** full factorial design matrix and response surface methodology were applied in designing experiments,to determine the optimal conditions and to evaluate their mutual *** high values of adjusted R2 obtained of the fitted model show that the experiments data were well explained by the model,which then allowed to acquire optimum parameters for the electroanalysis and detection of the analytes by differential pulse *** pH 6.5 of accumulating medium,with an electrolysis potential of-0.9 V and in the concentration range of 10^(−8) M to 10^(−9) M,calibration plots were *** limits of detection(3sd/m)were 8.689×10^(−10) M,8.197×10^(−10) M,and 8.099×10^(−10) M,respectively,for Cd^(2+),Pb^(2+),and Hg^(2+)*** interference effect of several cations and anions on the response of the analytes was also evaluated,and finally,the sensor was applied to the simultaneous detection of metal ions in tap water with satisfactory recovery rates.

关键词： Aminosepiolite surface response methodology Factorial design Differential pulse voltammetry Heavy metals

increases in Mortality for All Causes and All Cancers Combined before and after startup of a Nuclear Power Plant in New Jersey, UsA

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Journal of Environmental Protection 2019年第4期10卷 488-499页

作者： Joseph Mangano Janette sherman Radiation and Public Health Project New York NY USA

The salem/Hope Creek nuclear plant in southern New Jersey is one of just four U.s. plants with three large reactors (all others consist of one or two). These reactors started operations in 1976, 1980, and 1986 and routinely released toxic radioactive gases and particles into the environment. Only a single study has been performed by federal officials on cancer near nuclear plants—a study now 30 years old. A review of official mortality data using four-year periods shows the salem County cancer death rate was consistently just below that of other New Jersey counties up to the mid-1980s. However, from 1983-1986 to 2015-2017, the county rate soared from -5.4% below the rest of the state to +32.6% above. The county/state mortality ratio for all causes also increased rapidly in these periods, from +0.6% above to +28.4% above the state. salem now has the highest cancer death rate, and the 2nd highest total death rate of any New Jersey county. Had the 1983-1986 county-state ratios not changed in the following 31 years, 3493 fewer deaths (1018 of them from cancer) would have occurred among salem County residents. The lack of any apparent etiologies that could have caused such a dramatic and unexpected change, plus the fact that the salem/Hope Creek reactors are aging, corroding, and more prone to leaking radionuclides, emphasizes the immediate need for more studies of this type, and the inclusion of local health as a crucial factor in public decisions on the plant’s future.

关键词： Radiation Nuclear Power Nuclear Reactors Radioactivity Cancer

Rising Thyroid Cancer incidence Proximate to a New York City-Area Nuclear Power Plant

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Journal of Environmental Protection 2017年第12期8卷 1446-1459页

作者： Joseph Mangano Janette sherman Radiation and Public Health Project New York NY USA

Thyroid cancer incidence has risen steadily in the Us for several decades. While any cause of this trend has yet to be clearly identified, most analyses have concluded that there are factors other than improved detection accounting for the increase. since exposure to radioactive iodine is the only acknowledged root cause of thyroid cancer, a review of temporal trends in incidence since the late 1970s near the indian Point nuclear power plant, just 23 miles from the New York City border, was conducted. Rates in the four counties closest to indian Point, where virtually the entire population resides within 20 miles of the plant, were compared with national trends in the Us. The relative ratio in the local area was 0.778 in the period 1976-1981, or 22.2 percent lower than the national rate. This ratio increased steadily, to 1.579 (57.9 percent greater than the Us) by the period 2000-2004, which slightly declined to 1.515 (51.5 percent greater) in the latest period available (2010-2014). significant increases occurred for both males and females, and in each of the four counties. Annual new cases diagnosed among residents of the four counties increased from 51 to 412 between 1976-1981 and 2010-2014. Because the two large reactors at indian Point began operations in 1973 and 1976, and exposures to radioiodine isotopes can manifest as cancer from five years to several decades after exposure, iodine emissions from indian Point emissions should be considered as a potential factor in these trends. More studies near indian Point and other nuclear installations should be conducted to further explore this potential association.

关键词： Thyroid Cancer Radiation iodine Nuclear Power Nuclear Reactor

Chen Yao-huang, integrate and Divide： The Communist Revolution in Hebei Area, 1921-1949 （in Chinese）

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Frontiers of History in China 2013年第4期8卷 621-624页

作者： sherman Xiaogang Lai Royal Military College of Canada

For decades, the victory of the Chinese Communist Party （CCP） has been fascinating historians of modem China who work outside of the People＇s Republic of China. After recognizing the complexity of the Chinese Revolution, they have tended to focus on specific regions, applying the approaches of a variety of disciplines including sociology, a trend that gave rise to the field of ＂base area studies,＂ marked by the publishing of Mark sheldon＇s The Yenan Way in 1971. This new book by Chen Yao-huang is another remarkable contribution to the study of base areas.

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猫外膝体中继细胞低阈值钙通道的动力学特性

中国科学（C辑） 1997年第2期27卷 116-120页

作者：罗茀荪 s.M.sherman 中国科学院上海脑研究所 state University of New York at stony Brook Stony Brook 11794USA

在猫外膝体脑片上用单电极电压钳位的方法研究了低阈值T-型钙离子通道的动力学特性.采用阻断各种钾和钠离子通道、减小钙离子电流和选择适当的维持电位等方法,改善了脑片实验的空间钳位.所得结果与大鼠外膝体急性分离神经元的结果一致.... 详细信息

在猫外膝体脑片上用单电极电压钳位的方法研究了低阈值T-型钙离子通道的动力学特性.采用阻断各种钾和钠离子通道、减小钙离子电流和选择适当的维持电位等方法,改善了脑片实验的空间钳位.所得结果与大鼠外膝体急性分离神经元的结果一致.说明猫外膝体神经元T-型钙离子通道的动力学特性与大鼠的相同.

关键词：猫外膝体核钙离子通道动力学特性

spontaneous emergence of overgrown molar teeth in a colony of Prairie voles(Microtus ochrogaster)

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international Journal of Oral science 2015年第1期7卷 23-26页

作者： Andrew H Jheon Michaela Prochazkova Michael sherman Devanand s Manoli Nirao M shah Lawrence Carbone Ophir Klein Department of Orofacial sciences and Program in Craniofacial and Mesenchymal Biology University of California San Francisco (UCSF) Department of Anthropology and Human Genetics Faculty of Science Charles University in Prague Laboratory Animal Resource Center UCSF Department of Psychiatry UCSF Department of Anatomy UCSF

Continuously growing incisors are common to all rodents, which include the Microtus genus of voles. However, unlike many rodents, voles also possess continuously growing molars. Here, we report spontaneous molar defects in a population of Prairie voles （Microtus ochrogaster）. We identified bilateral protuberances on the ventral surface of the mandible in several voles in our colony. in some cases, the protuberances broke through the cortical bone. The mandibular molars became exposed and infected, and the maxillary molars entered the cranial vault. Visualisation upon soft tissue removal and microcomputed tomography （microCT） analyses confirmed that the protuberances were caused by the overgrowth of the apical ends of the molar teeth. We speculate that the unrestricted growth of the molars was due to the misregulation of the molar dental stem cell niche. Further study of this molar phenotype may yield additional insight into stem cell regulation and the evolution and development of continuously growing teeth.

关键词： continuously growing teeth molar phenotype mutation stem cell regulation voles

The West in the world :a mid-length narrative history .volume 1 ,to 1715 2nd ed. 2nd ed.

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Current endoscopic approach to indeterminate biliary strictures

2004年

作者： Dennis sherman Joyce salisbury

v1-To 1715

ISBN: (纸本)007281957X

v1-To 1715

关键词： Civilization Western

来源：畅想之星图书光盘版（南... 评论

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World Journal of Gastroenterology 2012年第43期18卷 6197-6205页

作者： David W Victor stuart sherman Tarkan Karakan Mouen A Khashab Department of Medicine Johns Hopkins Hospital Baltimore MD 21287 United States Department of Medicine Indiana University School of Medicine Indianapolis IN 46202 United States Department of Medicine Gazi University 06710 Ankara Turkey

Biliary strictures are considered indeterminate when basic work-up, including transabdominal imaging and endoscopic retrograde cholangiopancreatography with routine cytologic brushing, are non-diagnostic. indeterminate biliary strictures can easily be mischaracterized which may dramatically affect patient's outcome. Early and accurate diagnosis of malignancy impacts not only a patient's candidacy for surgery, but also potential timely targeted chemotherapies. A significant portion of patients with indeterminate biliary strictures have benign disease and accurate diagnosis is, thus, paramount to avoid unnecessary surgery. Current sampling strategies have suboptimal accuracy for the diagnosis of malignancy. Emerging data on other diagnostic modalities, such as ancillary cytology techniques, single operator cholangioscopy, and endoscopic ultrasonography-guided fine needle aspiration, revealed promising results with much improved sensitivity.

关键词： indeterminate stricture Bile duct single operator cholangioscope Cholangioscopy Endoscopic ultrasound Endoscopic retrograde cholangiopancrea-tography Bile duct stricture indeterminate biliary stricture Confocal microscopy Transpapillary biopsy Cholangiocarcinoma Primary sclerosing cholangitis spyglass