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Multi-omics analysis reveals therapeutic effects of Bacillus subtilis-fermenting Astragalus membranaceus in hyperuricemia via modulation of gut microbiota

Multi-omics analysis reveals therapeutic effects of Bacillus...

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中国营养学会第十五届全国营养科学大会

作者： ruoyu wang Department of Nutrition and Food Hygiene School of Public Health Peking University

This study generated a hyperuricemic mouse model to explore the potent therapeutic ability and mechanism of Bacillus subtilis-fermenting Astragalus membranaceus to alleviate hyperuricemia by multi-omics analysis. Methods Eighty mice were randomly divided into 8 groups(n=10): the normal control group(the NC group), the hyperuricemia group(the HUA group), the benzbromarone group(the BEN group), the Bacillus subtilis-fermenting Astragalus group(0.25, 0.5 and 1 g/kg Astragalus, the BFA group), the unfermented Astragalus group(the UFA group), and the Bacillus subtilis group(the BAC group). Animals were treated by oral gavage for 6 consecutive weeks, and then sacrificed to collect different tissues for different studies. Results Compared with the NC group, the serum uric acid(SUA) level in the HUA group increased significantly(P<0.05). Compared with the HUA group, the SUA level was decreased to varying degrees in all BFA groups(P<0.05). Above all, we found intestinal wall injury in hyperuricemic mice using morphological observations. The intestinal mucosal villi were increased and lengthened, inflammation was diminished significantly, and red-stained particles was reduced after BFA treatment. Moreover, we used the western blotting method to observe that HUA could drive endotoxins into the bloodstream and activate the TLR4/NF-κB signaling pathway, resulting in the release of a downstream cascade of proinflammatory factors, such as IL-1β and IL-6. Interestingly, our study found that BFA effectively attenuated renal inflammation by protecting the intestinal mucosa barrier and reducing the production of LBP and NF-κB phosphorylation(P<0.05). A total of 1142 metabolites were identified by LC/MS. Lipids, vitamins and cofactors, and peptides were the predominant types of metabolites. Metabolomics differences among groups were assessed by PCA. A clear separation between the NC and HUA groups was observed in the PCA score plot. The BFA group was separated from the HUA group. Then,

关键词： Bacillus subtilis fermentation Astragalus membranaceus hyperuricemia gut microbiota

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pUGTdb:A comprehensive database of plant UDP-dependent glycosyltransferases

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Molecular Plant 2023年第4期16卷 643-646页

作者： Yuqian Liu Qian wang Xiaonan Liu Jian Chengi Lei Zhang Huanyu Chu ruoyu wang Haoran Li Hong Chang Nida Ahmed Zhonghua wang Xiaoping Liao Huifeng Jiang Key Laboratory of Engineering Biology for Low-carbon Manufacturing Tianjin Institute of Industrial BiotechnologyChinese Academy of SciencesTianjin 300308China National Center of Technology Innovation for Synthetic Biology Tianjin 300308China University of Chinese Academy of Sciences Beijing 100049China BGl-Shenzhen Shenzhen 518083China Academy of Life Science Wuhan Polytechnic UniversityWuhan 430040China These authors contributed equally to this article

Dear Editor,Plant UDP-dependent glycosyltransferases(UGTs),belonging to the carbohydrate-active enzyme glycosyltransferase 1 family(Louveau and Osbourn,2019),not only play important roles in adaptation to various environments(Cai et al.,2020;Pastorczyk-Szlenkier and Bednarek,2021)but also endow plant natural products with great pharmaceutical and ecological significance(Margolin et al.,2020).In recent years,an increasing number of plant UGTs have been characterized to function in the biosynthesis of many bioactive compounds such as ginsenosides(Wei et al.,2015),breviscapine(Liu et al.,2018),and rubusoside(Xu et al.,2022).

关键词： UDP database environments

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Endangered Wildlife Conservation Enhances Regional Economic Development: A Case Study of Tibetan Macaque (<i>Macaca thibetana</i>) and Fuxi Village in Mount Huangshan, China

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Open Journal of Ecology 2021年第9期11卷 635-644页

作者： ruoyu wang Linkun Ma Zirui wang Dongpo Xia Longzhu Li International Department Hefei No. 8 High School Hefei China School of Life Sciences Anhui University Hefei China International Collaborative Research Center for Huangshan Biodiversity and Tibetan Macaque Behavioral Ecology Hefei China Biology Teaching and Research Group Hefei No. 8 High School Hefei China

The economic development of key biodiversity conservation areas and their conservation measures are underpinned by a mutually complementary and synergistic development model. Regional economic development depends on conservation awareness in biodiversity conservation areas. Moreover, the effectiveness of biodiversity conservation can be indicated by endangered wildlife conservation. This study investigated the current conservation of Huangshan Tibetan macaque (Macaca thibetana)—an endemic endangered species in the Mount Huangshan Scenic Area located in a biodiversity conservation hotspot in China, the conservation awareness of residents and visitors, and changes in local economic income through field survey. It provides inspiration and a characteristic demonstration to build a synergistic model of endangered wildlife conservation, biodiversity maintenance, and sustainable regional economic development.

关键词： Biodiversity Huangshan Tibetan Macaque Regional Economy Ecosystem Services

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Cholesterol metabolism: physiological versus pathological aspects in intracerebral hemorrhage

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Neural Regeneration Research 2025年第4期20卷 1015-1030页

作者： ruoyu Huang Qiuyu Pang Lexin Zheng Jiaxi Lin Hanxi Li Lingbo Wan Tao wang Department of Forensic Science School of Basic Medicine and Biological SciencesSuzhou Medicine College of Soochow UniversitySuzhouJiangsu ProvinceChina

Cholesterol is an important component of plasma membranes and participates in many basic life functions,such as the maintenance of cell membrane stability,the synthesis of steroid hormones,and *** plays a key role in the establishment and maintenance of the central nervous *** brain contains 20%of the whole body’s cholesterol,80%of which is located within myelin.A huge number of processes(e.g.,the sterol regulatory element-binding protein pathway and liver X receptor pathway)participate in the regulation of cholesterol metabolism in the brain via mechanisms that include cholesterol biosynthesis,intracellular transport,and *** brain injuries or diseases involving crosstalk among the processes above can affect normal cholesterol metabolism to induce detrimental ***,we hypothesized that cholesterol-related molecules and pathways can serve as therapeutic targets for central nervous system *** hemorrhage is the most severe hemorrhagic stroke subtype,with high mortality and *** cholesterol levels are associated with the risk of intracerebral ***,secondary pathological changes after intracerebral hemorrhage are associated with cholesterol metabolism dysregulation,such as neuroinflammation,demyelination,and multiple types of programmed cell *** cholesterol accumulation in the brain has been found after intracerebral *** this paper,we review normal cholesterol metabolism in the central nervous system,the mechanisms known to participate in the disturbance of cholesterol metabolism after intracerebral hemorrhage,and the links between cholesterol metabolism and cell *** also review several possible and constructive therapeutic targets identified based on cholesterol metabolism to provide cholesterol-based perspectives and a reference for those interested in the treatment of intracerebral hemorrhage.

关键词： cell death cholesterol metabolism intracerebral hemorrhage myelination therapeutic target

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Fast and uniform growth of graphene glass using confined-flow chemical vapor deposition and its unique applications

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Nano Research 2016年第10期9卷 3048-3055页

作者： Zhaolong Chen Baolu Guan Xu-dong Chen Qing Zeng Li Lin ruoyu wang Manish Kr. Priydarshi Jingyu Sun Zhepeng Zhang Tongbo Wei Jinmin LI Yanfeng Zhang Yingying Zhang Zhongfan Liu Center for Nanochemistry (CNC) Beijing Science and Engineering Center for Nanocarbons College of Chemistry and Molecular Engineering Peking University Beijing 100871 China Key Laboratory of Opto-electronics Technology Ministry of Education Beijing University of Technology Beijing 100124 China ing 100083 China Department of Materials Science and Engineering College of Engineering Peking University Beijing 100871 China Department of Chemistry and Center for Nano and Micro Mechanics Tsinghua University Beijing 100084 China

Fast and uniform growth of high-quality graphene on conventional glass is of great importance for practical applications of graphene glass. We report herein a confined-flow chemical vapor deposition （CVD） approach for the high- efficiency fabrication of graphene glass. The key feature of our approach is the fabrication of a 2-4 μm wide gap above the glass substrate, with plenty of stumbling blocks; this gap was found to significantly increase the collision probability of the carbon precursors and reactive fragments between one another and with the glass surface. As a result, the growth rate of graphene glass increased remarkably, together with an improvement in the growth quality and uniformity as compared to those in the conventional gas flow CVD technique. These high-quality graphene glasses exhibited an excellent defogging performance with much higher defogging speed and higher stability compared to those previously reported. The graphene sapphire glass was found to be an ideal substrate for growing uniform and ultra-smooth aluminum nitride thin films without the tedious pre-deposition of a buffer layer. The presented confined- flow CVD approach offers a simple and low-cost route for the mass production of graphene glass, which is believed to promote the practical applications of various graphene glasses.

关键词： graphene glass confined-flow chemicalvapor deposition transparent heating device epitaxial A1N film

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The Higher Order Chromatin Reorganization during mammalian spermatogenesis

The Higher Order Chromatin Reorganization during mammalian s...

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中国生理学会生殖科学专业委员会—中国动物学会生殖生物学分会第二次联合学术年会暨“生殖科学专业委员会第二次学术交流会”和“生殖生物学分会第十六次学术年会”

作者： Zhengyu Luo Xiaorong wang ruoyu wang Fei Sun Xiaoyuan Song CAS Key Laboratory of Brain Function and Disease CAS Center for Excellence in Molecular Cell ScienceSchool of Life SciencesUniversity of Science and Technology of China Institute of Reproductive Medicine School of MedicineNantong University

Spermatogensis is a key biological process in which spermatozoa are produced from spermatogonial stem cells by way of mitosis and *** higher order chromatin organization,which is critical for the transcriptional regulation and homologous recombination during spermatogensis,remains largely *** the advancement of genome wide chromatin conformation capture and

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“新课标”视域下义务教育英语教学转向与应对研究

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上海教育科研 2022年第6期 85-88页

作者：王若语重庆市教育科学研究院 400015

义务教育英语课程的变革表征为课堂教学的转向与应对。分别体现为:以核心素养指向的单元整体教学设计应对课程内容的变革;以英语活动观的教学活动组织形式应对学习方式的变革;从训练“解题”走向培养“解决问题”应对评价方式的变革;混... 详细信息

义务教育英语课程的变革表征为课堂教学的转向与应对。分别体现为:以核心素养指向的单元整体教学设计应对课程内容的变革;以英语活动观的教学活动组织形式应对学习方式的变革;从训练“解题”走向培养“解决问题”应对评价方式的变革;混合式学习与个性化学习结合应对教学工具的变革。最终指向新教学所具备的素养本位的单元设计、真实情境的深度学习、问题解决的进阶测评和混合学习的智能系统四大典型特征。

关键词：义务教育英语课程变革教学转向应对

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当代美国英语词汇的发展趋势

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外语教学 2002年第4期23卷 53-57页

作者：王若禹河南大学环境规划学院专业英语教研室河南开封475001

近半个世纪以来 ,随着美国政治、经济、文化的迅速发展 ,美国英语已取代了英国英语在世界范围内的主导地位。同时 ,美国英语本身也有了空前巨大的发展变化。美国英语的发展变化主要体现在词汇上 ,其发展趋势为 :1 )各行各类的新词大量出... 详细信息

近半个世纪以来 ,随着美国政治、经济、文化的迅速发展 ,美国英语已取代了英国英语在世界范围内的主导地位。同时 ,美国英语本身也有了空前巨大的发展变化。美国英语的发展变化主要体现在词汇上 ,其发展趋势为 :1 )各行各类的新词大量出现 ;2 )许多旧词的语义量不断扩大 ;3)词汇的拼写形式日趋简化。

关键词：美国英语词汇造词旧词新义拼写简化

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管道修复的一种非常规焊接方法

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焊接 2009年第1期 60-63页

作者：王若愚四川机电职业技术学院攀枝花市617000

管道安装及修复中采用的非常规焊接方法有镜子成像焊接法,双人配合施焊法,开窗口焊接法。文中以炼钢转炉余热锅炉水冷壁管道修复为例,介绍了开窗口这种非常规焊接法的应用。水冷壁管损坏漏水后需修复,由于它管径小,修复中位置狭窄,故焊... 详细信息

管道安装及修复中采用的非常规焊接方法有镜子成像焊接法,双人配合施焊法,开窗口焊接法。文中以炼钢转炉余热锅炉水冷壁管道修复为例,介绍了开窗口这种非常规焊接法的应用。水冷壁管损坏漏水后需修复,由于它管径小,修复中位置狭窄,故焊后质量很难保证。采用开窗口这种非常规焊接法,操作时从窗口伸入焊条焊接背面半圈,用手工TIG焊焊接窗口盖和正面半圈,能使管道修复质量得到保证。经应用表明,采用这种非常规焊接方法修复背面无法施焊的管道,能节省大量的人力、物力,这种方法值得在管道修复中推广。

关键词：管道焊接修复

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省级档案行政权力清单制度规范化策略探讨--以31张省级档案行政权力清单为样本

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档案学通讯 2022年第2期 75-81页

作者：张健汪若瑜江苏大学法学院镇江212013

推行档案行政权力清单制度是档案主管部门简政放权、实现依法行政的重要举措.对于推进档案事业治理体系和治理能力现代化具有重要意义。档案行政权力清单制度包含了“清权”“确权”“控权”“晒权”四项环节。当前,我国档案行政权力清... 详细信息

推行档案行政权力清单制度是档案主管部门简政放权、实现依法行政的重要举措.对于推进档案事业治理体系和治理能力现代化具有重要意义。档案行政权力清单制度包含了“清权”“确权”“控权”“晒权”四项环节。当前,我国档案行政权力清单制度建设取得了一定成效。不过,档案行政权力清单制度依旧存在“清权”“确权”环节不规范,清单制订与公布的规范性有待提高.责任清单建设不足,配套实施机制不完善等问题。未来应当推动权力清单制度标准化建设,重视权力清单的发布与动态调整工作,完善配套机制,推进权力清单制度落实。

关键词：档案行政权力清单档案主管部门权力清单制度规范化

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