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Gut microbiota-astrocyte axis: new insights into age-related cognitive decline

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Neural Regeneration Research 2025年第4期20卷 990-1008页

作者： Lan Zhang Jingge Wei Xilei liu Dai li Xiaoqi Pang Fanglian Chen Hailong Cao ping Lei Haihe Laboratory of Cell Ecosystem Department of GeriatricsTianjin Medical University General HospitalTianjinChina Tianjin Geriatrics Institute Tianjin Medical University General HospitalTianjinChina Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalNational Key Clinical SpecialtyTianjin Institute of Digestive DiseasesTianjin Key Laboratory of Digestive DiseasesTianjinChina Department of Urology Tianjin Medical University General HospitalTianjinChina Tianjin Neurological Institution Tianjin Medical University General HospitalTianjinChina

With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent *** is considered the main risk factor for cognitive decline and acts through alterations in the composition of the gut microbiota,microbial metabolites,and the functions of *** microbiota–gut–brain axis has been the focus of multiple studies and is closely associated with cognitive *** article provides a comprehensive review of the specific changes that occur in the composition of the gut microbiota and microbial metabolites in older individuals and discusses how the aging of astrocytes and reactive astrocytosis are closely related to age-related cognitive decline and neurodegenerative *** article also summarizes the gut microbiota components that affect astrocyte function,mainly through the vagus nerve,immune responses,circadian rhythms,and microbial ***,this article summarizes the mechanism by which the gut microbiota–astrocyte axis plays a role in Alzheimer’s and Parkinson’s *** findings have revealed the critical role of the microbiota–astrocyte axis in age-related cognitive decline,aiding in a deeper understanding of potential gut microbiome-based adjuvant therapy strategies for this condition.

关键词： age aging Alzheimer’s disease astrocytes cognitive decline dementia gut microbiota gut–brain axis microbial metabolites neuroinflammation Parkinson’s disease

Development of CaP nanocomposites as photothermal actuators for doxorubicin delivery to enhance breast cancer treatment

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Journal of Materials Science & Technology 2021年第4期63卷 73-80页

作者： Jie liu li li run Zhang Zhi ping Xu Australian Institute for Bioengineering and Nanotechnology The University of QueenslandSt LuciaQLD4072Australia

Breast cancer is the most common one in women worldwide and doxorubicin(Dox)is one of the most commonly used and effective drugs for breast cancer ***,Dox-based chemotherapy faces irreversible cardiotoxicity and unsatisfactory therapy *** is desirable to devise Dox nanoformulations with less adverse effects and greater therapeutic efficacy for this cancer *** this work,a multifunctional calcium phosphate nanoformulation(ICG-Dox/DNA@CaP)was developed by co-loading Dox/DNA complexes and indocyanine green(ICG)molecules for photothermal therapy(PTT)-enhanced *** this nanocomposite,using DNA as Dox carrier facilitated Dox loading into the CaP matrix,and significantly reduced Dox leakage as well as cytotoxicity in comparison with that of free Dox in physiological medium(pH 7.4).In specific,ICG-Dox/DNA@CaP only released Dox in a weakly acidic nuclease-containing environment,such as tumor microenvironment and endosome/***,Dox/DNA complexes exhibited synergistic interactions with ICG-based photothermal effect on tumor cell apoptosis in this ICG-Dox/DNA@CaP *** work has demonstrated a new strategy to combine FDA-approved therapeutics(Dox and ICG)in CaP-based nanomaterials for reduced cytotoxicity and enhanced therapeutic effect,and provided a new way to engineer CaP carriers as multifunctional delivery systems for clinical anti-cancer therapy.

关键词： chemotherapy doxorubicin breast

Cs阳离子掺杂对CH_(3)NH_(3)PbI_(3)钙钛矿电子性质的影响研究

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原子与分子物理学报 2025年第6期42卷 174-182页

作者：张平丽吉林师范大学物理学院四平136000

有机-无机杂化钙钛矿太阳能电池被报道具有极高的功率转换效率,是下一代太阳能电池材料有希望的候选者,但其化学性质极不稳定,在高温高湿条件下易分解.本研究采用无机Cs阳离子取代CH_(3)NH_(3)PbI_(3)结构中的CH_(3)NH_(3)有机阳离子,... 详细信息

有机-无机杂化钙钛矿太阳能电池被报道具有极高的功率转换效率,是下一代太阳能电池材料有希望的候选者,但其化学性质极不稳定,在高温高湿条件下易分解.本研究采用无机Cs阳离子取代CH_(3)NH_(3)PbI_(3)结构中的CH_(3)NH_(3)有机阳离子,利用第一性原理密度泛函理论,计算了未掺杂CH_(3)NH_(3)PbI_(3)钙钛矿和Cs阳离子掺杂钙钛矿的电子性质.结果表明,适当比例的Cs阳离子掺杂能够增强Pb-I的相互作用力,且Cs阳离子掺杂并未改变钙钛矿直接半导体的属性.Cs阳离子与Pb-I框架之间强的共价相互作用,导致Cs阳离子掺杂钙钛矿具有更加稳定的晶体结构.这项工作阐明了Cs阳离子掺杂钙钛矿材料高稳定性的潜在机理,可以为将来设计高效稳定的钙钛矿光伏材料提供一定的理论依据.

关键词：钙钛矿 Cs阳离子掺杂能带结构态密度

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高强度聚焦超声治疗子宫腺肌瘤28例

河南医学高等专科学校学报 2018年第2期30卷 103-105页

作者：郑媛媛郑素娟王润萍杨小丽登封市人民医院妇产科河南登封452470

目的了解高强度聚焦超声(high intensity focused ultrasound,HIFU)治疗子宫腺肌瘤的效果。方法对28例子宫腺肌瘤患者进行超声消融治疗,定期随访并评分,比较超声评价病灶消融情况。结果 28例患者中,术后1个月完全缓解3例(10.7%),明显缓... 详细信息

目的了解高强度聚焦超声(high intensity focused ultrasound,HIFU)治疗子宫腺肌瘤的效果。方法对28例子宫腺肌瘤患者进行超声消融治疗,定期随访并评分,比较超声评价病灶消融情况。结果 28例患者中,术后1个月完全缓解3例(10.7%),明显缓解18例(64.3%),部分缓解5例(17.9%),无效2例(7.1%)。术后3个月完全缓解7例(25.0%),明显缓解14例(50.0%),部分缓解7例(25.0%),无效0例(0.0%)。术后6个月完全缓解10例(35.7%),明显缓解14例(50.0%),部分缓解4例(14.3%),无效0例(0.0%)。HIFU治疗后1、3、6个月进行超声复查显示,治疗靶区病灶内血流信号明显减少或消失,病灶体积分别缩小26.9%、51.4%、72.2%,与术前比较差异有统计学意义(P<0.05)。结论 HIFU治疗子宫腺肌瘤,可有效缓解临床症状,为有效的保守治疗方法之一。

关键词：子宫腺肌瘤高强度聚焦超声超声消融疗效

Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan Cheng Zhaoli Han Bo Yan Pan liao Zhenyu Yin Xintong Ge Dai li Rongrong Zhong Qiang liu Fanglian Chen ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

On the Red Edge of the δ Scuti Instability Strip

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Chinese Journal of Astronomy and Astrophysics 2002年第5期2卷 441-448页

作者： Yan Xu Zhi-ping li li-Cai Deng Da-run Xiong National Astronomical Observatories Chinese Academy of SciencesBeijing 100012 Department of Physics Tianjin Normal UniversityTianjin 300073 Purple Mountain Observatory Chinese Academy of SciencesNanjing 210008

The δ Scuti star catalogue is used to derive the observational locations of such stars on the HR diagram. The theoretical and observational instability strips are compared to check the theoretical red edge obtained by considering nonlocal time-dependent convection theory. The observational instability strip almost overlaps with the theoretical one, but the observed blue and red envelopes are hotter than the theoretical edges. The distribution of δ Scuti stars in the pulsation strip is not uniform.

关键词： stars: variables: δ Sct - stars: oscillations ?stars: HR diagram

An immortalized rat pancreatic stellate cell line RP-2 as a new cell model for evaluating pancreatic fibrosis,inflammation and immunity

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Hepatobiliary & Pancreatic Diseases International 2015年第6期14卷 651-659页

作者： Rong-li Piao Ming Xiu David R Brigstock run-ping Gao Department of Hepatic-biliary-pancreatic Medicine the First Hospital of Jilin University The Research Institute at Nationwide Children's Hospital Division of Pediatric Surgery Department of Surgerythe Ohio State University

BACKGROUND： Pancreatic stellate cells （PSCs） play a critical role in the pathogenesis of pancreatic fibrosis and have emerging functions as progenitor cells, immune cells or intermediaries in pancreatic exocrine secretion. Increasing evidence has shown that desmin as an exclusive cytoskeleton marker of PSC is only expressed in part of these cells. This study was to establish a desmin-positive PSC cell line and evaluate its actions on pancreatic fibrosis, inflammation and immunity.

关键词： pancreatic stellate cell pancreatic fibrosis Toll-like receptor 4 inflammation immunity

Clinical significance of connective tissue growth factor in hepatitis B virus-induced hepatic fibrosis

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World Journal of Gastroenterology 2012年第18期18卷 2280-2286页

作者： Rong-li Piao David R Brigstock Jie Zhu Man-li Zhang run-ping Gao Department of Hepatie-biliary-panereatie Medicine First Hospital Jilin University Changehun 130021 Jilin Province China Division of Pediatric Surgery Department of Surgery The Research Institute at Nationwide Children＇s Hospital The Ohio State University Columbus OH 43210 United States

AIM:To determine the utility of connective tissue growth factor(CCN2/CTGF) for assessing hepatic fibrosis in hepatitis B virus(HBV)-induced chronic liver diseases(CLD-B).METHODS:Enzyme-linked immunosorbent assay was used to measure CCN2 in sera from 107 patients with chronic hepatitis B(CHB) and 39 patients with HBVinduced active liver cirrhosis and 30 healthy *** samples from 31 patients with CHB,8 patients with HBV-induced liver cirrhosis and 8 HBV carriers with normal liver histology were examined for transforming growth factor β-1(TGF-β1) or CCN2 mRNA levels by in situ hybridization,and computer image analysis was performed to measure integrated optimal density(IOD) of CCN2 mRNA-positive cells in liver *** inflammation grading and fibrosis staging were evaluated by H and E staining and Van Gieson's ***:Serum CCN2 concentrations were,respectively,4.0-or 4.9-fold higher in patients with CHB or active liver cirrhosis as compared to healthy individuals(P liver tissues(r = 0.87,P liable marker for the assessment of liver fibrosis,with areas under the receiver operating characteristic(ROC) curves(AUC) of 0.94 or 0.85 for,respectively,distinguishing normal liver controls from patients with F1 stage liver fibrosis or discriminating between mild and significant ***:Detection of serum CCN2 in patients with CLD-B may have clinical significance for assessment of severity of hepatic fibrosis.

关键词： Connective tissue growth factor liver fibrosis Chronic hepatitis B Chronic liver disease Chronic hepatitis C

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Hepatobiliary & Pancreatic Diseases International 2017年第4期16卷 443-445页

作者： li Sun Hong-Yan li David R Brigstock run-ping Gao Department of Hepatic-biliary-pancreatic Medicine First Hospital of Jilin University The Research Institute at Nationwide Children’s Hospital and Division of Pediatric Surgery Department of SurgeryThe Ohio State University

To the Editor:IgG4-related sclerosing cholangitis（IgG4-SC）has re cently been recognized as a biliary manifestation of IgG4-related disease（IgG4-RD）.Type 3 IgG4-SC pre sented biliary strictures in both the porta hepatis and the distal common bile duct（CBD）.;Its manifestation especially in the absence of autoimmune pancreatitis,is extremely rare and very similar to that of cholangiocarci noma（CC）.

关键词： IgG4-related sclerosing cholangitis and chronic sclerosing sialadenitis mimicking cholangiocarcinoma and neck malignancy is it been of CBD in