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Biomedical and Environmental Sciences 2021年第7期34卷 577-580页

作者： SU Liang TIAN Yan FU Ming ZHANG rui zhong OU Xiu Fei XIA Hui Min LI rui Zhuo Provincial Key Laboratory of Research in Structure Birth Defect Disease and Department of Pediatric Surgery Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623GuangdongChina

Biliary atresia(BA)is one of the most common and enigmatic forms of neonatal cholestasis and is characterized by inflammation and obstruction of extrahepatic bile ducts resulting in biliary cirrhosis,which occurs in 1 in 8,000 to 1 in 18,000 live *** of the mechanisms underlying BA is crucial for early diagnosis,intervention,and better *** etiology of BA remains unclear,and currently,noncoding and epigenetic factors,rather than classic genetic alterations,are assumed to be responsible for genetic predisposition to BA.

关键词： res alterations diagnosis

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鸭骨髓源树突状细胞的诱导培养及功能分析

畜牧与兽医 2024年第4期56卷 61-65页

作者：李玲祝博森朱婷钟睿郭子杰李睿婷洪伟鸣徐海江苏农牧科技职业学院江苏泰州225300

旨在建立鸭骨髓源树突状细胞(DC)体外诱导培养方法,分析DC基本生物学功能。在无菌条件下分离鸭骨髓单核细胞,优化粒细胞-巨噬细胞集落刺激因子(GM-CSF)和白细胞介素4(IL-4)工作浓度,在体外进行诱导培养,然后通过形态学观察、吞噬活性检... 详细信息

旨在建立鸭骨髓源树突状细胞(DC)体外诱导培养方法,分析DC基本生物学功能。在无菌条件下分离鸭骨髓单核细胞,优化粒细胞-巨噬细胞集落刺激因子(GM-CSF)和白细胞介素4(IL-4)工作浓度,在体外进行诱导培养,然后通过形态学观察、吞噬活性检测、表面标志物流式鉴定、分泌细胞因子和刺激淋巴细胞增殖能力的测定,对制备的DC进行形态和生物功能评价。结果:添加20 ng/mL的IL-4和40 ng/mL的GM-CSF可以诱导出高吞噬活性的DC,诱导培养后3 d可见菱形、有纤突的细胞;经脂多糖(LPS)刺激成熟的DC,呈现典型的树突状结构,细胞表面CD11c、CD80和MHCⅡ分子表达量分别为80.08%、81.27%和91.47%;DC培养体系中白细胞介素2(IL-2)、γ干扰素(IFN-γ)分泌量随着培养时间延长而增加,并在成熟后分泌量显著升高(P<0.05);CCK-8法检测结果显示成熟后的DC以1∶5比例与淋巴细胞混合培养,能够显著刺激淋巴细胞增殖。本试验成功建立鸭骨髓源DC体外诱导培养方法,制备细胞具备了树突状细胞的基本生物学功能。

关键词：鸭树突状细胞体外培养功能分析

Promising natural lysine specific demethylase 1 inhibitors for cancer treatment:advances and outlooks

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Chinese Journal of Natural Medicines 2022年第4期20卷 241-257页

作者： LI zhong-rui GU Meng-Zhen XU Xiao ZHANG Jing-Han ZHANG Hai-Li HAN Chao Department of Medicinal Chemistry School of PharmacyNanjing Medical UniversityNanjing 211166China State Key Laboratory of Natural Medicines Jiangsu Key Laboratory of Bioactive Natural Product ResearchSchool of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 210009China

Lysine specific demethylase 1(LSD1),a transcriptional corepressor or coactivator that serves as a demethylase of histone 3 lysine 4 and 9,has become a potential therapeutic target for cancer ***1 mediates many cellular signaling pathways and regulates cancer cell proliferation,invasion,migration,and *** research has focused on the exploration of its pharmacological *** products are a major source of compounds with abundant scaffold diversity and structural complexity,which have made a major contribution to drug discovery,particularly anticancer *** this review,we briefly highlight recent advances in natural LSD1 inhibitors over the past *** present a comprehensive review on their discovery and identification process,natural plant sources,chemical structures,anticancer effects,and structure-activity relationships,and finally provide our perspective on the development of novel natural LSD1 inhibitors for cancer therapy.

关键词： Histone lysine demethylase LSD1 inhibitor Natural product Anticancer

800MPa高强钢T形截面轴压构件极限承载力有限元分析

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安徽工业大学学报（自然科学版） 2024年第5期41卷 552-560页

作者：陶征强曹现雷钟锐王培陶清林陈云旭安徽工业大学建筑工程学院安徽马鞍山243032 广西壮族自治区应用数学中心(玉林师范学院) 广西玉林537000

针对800MPa高强钢T形截面轴压构件失稳问题,基于ABAQUS软件建立有限元计算模型,分析残余应力、几何初始缺陷、翼缘宽厚比、腹板高厚比和构件长细比对构件极限承载力的影响,建立正则化长细比与整体稳定系数关系曲线,并将高强钢T形截面轴... 详细信息

针对800MPa高强钢T形截面轴压构件失稳问题,基于ABAQUS软件建立有限元计算模型,分析残余应力、几何初始缺陷、翼缘宽厚比、腹板高厚比和构件长细比对构件极限承载力的影响,建立正则化长细比与整体稳定系数关系曲线,并将高强钢T形截面轴压构件极限承载力的模拟结果与GB50017—2017系列设计规范进行比较分析。结果表明:建立的有限元模型能够准确模拟试验构件的屈曲行为,残余应力峰值对短柱承载力影响较小,对大长细比构件的承载力影响较大;试件初弯曲和板件翘曲对小长细比构件极限承载力影响较大,随构件长细比增加,构件极限承载力随着翼缘宽厚比变化表现为敏感度降低,腹板的高厚比变化规律与之类似。计算得到的稳定系数与GB50017—2017中b类柱子曲线吻合较好,建议采用b类柱子曲线计算800MPa高强钢焊接T形截面轴压构件的极限承载力。

关键词：高强钢有限元分析 T形截面轴压构件极限承载力柱子曲线

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甘蔗/花生间作对根系生理及根际土壤养分的影响

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中国油料作物学报 2024年第4期46卷 889-896页

作者：邱江梅吴海宁黄志鹏贺梁琼李忠钟瑞春韩柱强蒋菁黎冰唐秀梅唐荣华广西壮族自治区农业科学院经济作物研究所广西南宁530007 广西作物遗传改良生物技术重点开放实验室广西南宁530007 贺州学院广西贺州542800

为探明甘蔗/花生间作对根系生理及根际土壤养分的影响,本文设置了甘蔗单作、花生单作、甘蔗/花生间作模式,系统分析了不同种植模式下根系分泌物、根系浸提物和根际土壤养分的变化及其相关性。结果表明:间作甘蔗根系分泌的总氨基酸及根... 详细信息

为探明甘蔗/花生间作对根系生理及根际土壤养分的影响,本文设置了甘蔗单作、花生单作、甘蔗/花生间作模式,系统分析了不同种植模式下根系分泌物、根系浸提物和根际土壤养分的变化及其相关性。结果表明:间作甘蔗根系分泌的总氨基酸及根系浸提液中的总糖显著高于单作,间作花生根系分泌的总糖显著高于单作。间作甘蔗根际土壤的碱解氮(alkali-hydrolyzed nitrogen,AN)、有效磷(available phosphorus,AP)、速效钾(available potassium,AK)和土壤有机质(soil organic matter,SOM)显著高于单作甘蔗,间作种植显著降低了花生根际土壤的有效磷、速效钾和pH。间作和单作甘蔗的酸性磷酸酶、过氧化氢酶、脲酶和蔗糖酶差异不显著,间作花生的过氧化氢酶显著高于单作花生。根系分泌的酚酸与土壤有机质呈显著负相关,总糖与蔗糖酶呈显著正相关,氨基酸与脲酶呈显著正相关;根系浸提液中的有机酸与pH呈显著正相关,氨基酸与SOM呈显著负相关、与AK呈极显著负相关。脲酶与AK呈显著负相关,蔗糖酶与SOM呈极显著负相关。综上,甘蔗/花生间作主要影响根系分泌氨基酸、总糖和酚酸的代谢活动,且可显著提高甘蔗的土壤有效养分。

关键词：间作系统根系分泌物根系浸提物土壤养分土壤酶

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Robust global motion estimation

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Optoelectronics Letters 2007年第4期3卷 303-307页

作者： DING Jia-rui LI zhong-jian AN Jin-wen College of Automation Nonhwestern Polytechnical UniversityXi’an710072China

A global motion estimation method based on robust statistics is presented in this paper. By using tracked feature points instead of whole image pixels to estimate parameters the process speeds up. To further speed up the process and avoid numerical instability, an alterative description of the problem is given, and three types of solution to the problem are compared. By using a two step process, the robustness of the estimator is also improved. Automatic initial value selection is an advantage of this method. The proposed approach is illustrated by a set of examples, which shows good results with high speed.

关键词：运动估计鲁棒性鲁棒统计学轨迹特征点

基于动力学递推算法的绳系卫星系统刚柔耦合多体模型

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北京航空航天大学学报 2015年第7期41卷 1188-1195页

作者：钟睿北京航空航天大学宇航学院北京100191

利用动力学递推算法建立了空间绳系卫星系统(TSS)的铰接柔性杆动力学模型.所研究的绳系系统包含两颗刚体绳端卫星和一段连接两颗卫星的柔绳,柔绳离散为一系列球铰连接的弹性杆,考虑杆不均匀的纵向一维形变,并利用球铰的运动模拟柔绳的... 详细信息

利用动力学递推算法建立了空间绳系卫星系统(TSS)的铰接柔性杆动力学模型.所研究的绳系系统包含两颗刚体绳端卫星和一段连接两颗卫星的柔绳,柔绳离散为一系列球铰连接的弹性杆,考虑杆不均匀的纵向一维形变,并利用球铰的运动模拟柔绳的弯曲和扭转;然后基于递推算法推导得出了该刚柔混合离散模型的动力学方程.数值仿真结果表明:所建立的绳系卫星系统模型能够很好地模拟空间系绳的各向摆振和扭转,此外,递推算法的引入能够有效地减少离散模型动力学方程的维数,从而大幅减少计算量.

关键词：绳系卫星系统(TSS) 多体系统动力学递推算法刚柔混合模型动力学仿真

Optimization of biotransformation from phytosterol to androstenedione by a mutant Mycobacterium neoaurum ZJUVN-08

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第2期14卷 132-143页

作者： Xiao-yan ZHANG Yong PENG zhong-rui SU Qi-he CHEN Hui RUAN Guo-qing HE Department of Food Science and Nutrition Zhejiang University Department of Food Science and Technology School of Agriculture and BiologyShanghai Jiao Tong University

Biotransformation of phytosterol(PS) by a newly isolated mutant Mycobacterium neoaurum ZJUVN-08 to produce androstenedione has been investigated in this *** parameters of the biotransformation process were optimized using fractional factorial design and response surface *** was the sole product in the fermentation broth catalyzed by the mutant *** ZJUVN-08 *** showed that molar ratio of hydroxypropyl-β-cyclodextrin(HP-β-CD) to PS and substrate concentrations were the two most significant factors affecting androstenedione *** analyzing the statistical model of three-dimensional surface plot,the optimal process conditions were observed at 0.1 g/L inducer,pH 7.0,molar ratio of HP-β-CD to PS 1.92:1,8.98 g/L PS,and at 120 h of incubation *** these conditions,the maximum androstenedione yield was 5.96 g/L and nearly the same with the non-optimized(5.99 g/L),while the maximum PS conversion rate was 94.69% which increased by 10.66% compared with the non-optimized(84.03%).The predicted optimum conditions from the mathematical model were in agreement with the verification experimental *** is considered that response surface methodology was a powerful and efficient method to optimize the parameters of PS biotransformation process.

关键词： Phytosterol Mycobacterium neoaurum ZJUVN-08 Androstenedione Hydroxypropyl-β-cyclodextrin

Social support for and features of Chinese adults with epilepsy

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Acta Epileptologica 2022年第3期5卷 169-174页

作者： rui zhong Hanyu Zhang Yujuan Han Xin Guo Weihong Lin Department of Neurology The First Hospital of Jilin UniversityChangchun 130012China

Background:The lack of social support for adults with epilepsy(AWEs)is receiving increased attention,as it may result in low quality of *** study was aimed to confirm the demographic characteristics of and clinical factors associated with social support for ***:AWEs were consecutively recruited from our *** 10-term Social Support Rating Scale(SSRS)was used to measure social support.A linear regression analysis with stepwise selection was performed to analyze the independent variables associated with social support for ***:In total,165 AWEs were consecutively included in the present *** regression analysis showed that the marital status(t=-3.550,β=-0.272,P=0.001),the age at onset(t=2.545,β=0.192,P=0.012),and the QOLIE-31 score(t=3.144,β=0.221,P=0.002)were independent variables associated with social support for ***:Our findings suggest that the poor social support is associated with childhood onset of epilepsy and the unmarried *** study also confirmed a negative influence of low social support on quality of life in AWEs.

关键词： Epilepsy Marital status Childhood-onset epilepsy Social support Quality of life

Study of an Early Silurian–Early Permian paleo-weathering profile in Zunyi, north Guizhou Province, China

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Chinese Journal Of Geochemistry 2015年第4期34卷 558-578页

作者： Xiao-hui Xiong Jia-fei Xiao rui-zhong Hu Yi Wang Jian Wang Xiu-gen Fu State Key Laboratory of Ore Deposit Geochemistry Institute of Geochemistry Chinese Academy of Sciences Chinese Academy of Geological Sciences Chengdu Institute of Geology and Mineral Resources Nanjing Institute of Geology and Palaeontology Chinese Academy of Sciences

To understand and help settle the controversy around the living time of Pinnatiramosus qianensis Geng, a paleo-weathering profile situated in the town of Yongle near the city of Zunyi, north Guizhou Province, China, was analyzed. The profile formed during a break in sedimentation between the Early Silurian and the Early *** developed with a depth of several meters. The fossil plant P. qianensis Geng is present, but only in the lower portions(Layer 2) of the paleosol. Another plant with an irregularly branching system is found in Layers 2and 3. The distinct geochemical characteristics of the lower and upper portions of the Gaojiayan paleosol indicate a compound genesis. Its lower portions(Layers 1 and 2)resulted from in situ weathering of silty mudstone of the lower Silurian Hanjiadian Formation. The upper portions(Layer 3) are allochthonous. Transgression brought substantial concentrations K and Na, and led to K- and Naenrichment in the profile. Pumping of vascular plants and downward leaching enhanced the K enrichment in the middle portions. A superior preservation of P. qianensis Geng was observed in an exposure of Layer 2. Mass balance calculation indicates a great K enrichment related to bioaccumulation in the top of Layer 2 and a K loss in Layer3. Fossil plants(e.g., P. qianensis Geng) preserved in the paleosol are Permian rooting systems growing down into the lower Silurian rocks.

关键词：风化剖面早二叠世早志留世中国北方贵州省遵义市化石植物地球化学特征