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Gas-propelled nanomotors alleviate colitis through the regulation of intestinal immunoenvironment-hematopexis-microbiota circuits

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2732-2747页

作者： Bo Xiao Yuqi Liang Ga Liu Lingshuang Wang Zhan Zhang Libin Qiu Haiting Xu Sean Carr Xiaoxiao Shi rui lreis Subhas CKundu Zhenghua Zhu Department of Gastroenterology the First Affiliated Hospital of Nanchang UniversityNanchang 330006China College of Sericulture Textileand Biomass SciencesSouthwest UniversityChongqing 400715China Department of Neurology School of MedicineEmory UniversityAtlantaGA 30322USA Atlanta Veterans Affairs Medical Center DecaturGA 30033USA Department of Surgery School of MedicineEmory UniversityAtlantaGA 30322USA Bs Research Group I3Bs—Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkBarcoGuimaraes 4805-017Portugal

The progression of ulcerative colitis(UC)is associated with immunologic derangement,intestinal hemorrhage,and microbiota *** traditional medications mainly focus on mitigating inflammation,it remains challenging to address multiple ***,a versatile gas-propelled nanomotor was constructed by mild fusion of post-ultrasonic CaO_(2) nanospheres with Cu_(2)O *** resulting CaO_(2)–Cu_(2)O possessed a desirable diameter(291.3 nm)and a uniform size *** could be efficiently internalized by colonic epithelial cells and macrophages,scavenge intracellular reactive oxygen/nitrogen species,and alleviate immune reactions by pro-polarizing macrophages to the anti-inflammatory M2 *** nanomotor was found to penetrate through the mucus barrier and accumulate in the colitis mucosa due to the driving force of the generated oxygen *** administration of CaO_(2)–Cu_(2)O could stanch the bleeding,repair the disrupted colonic epithelial layer,and reduce the inflammatory responses through its interaction with the genes relevant to blood coagulation,anti-oxidation,wound healing,and ***,it restored intestinal microbiota balance by elevating the proportions of beneficial bacteria(e.g.,Odoribacter and Bifidobacterium)and decreasing the abundances of harmful bacteria(e.g.,Prevotellaceae and Helicobacter).Our gas-driven CaO_(2)–Cu_(2)O offers a promising therapeutic platform for robust treatment of UC via the rectal route.

关键词： Nanomotor Anti-inflammation Blood coagulation Immune regulation Hematopexis Microbiota rebalance Ulcerative colitis Rectal administration

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Author correction to“Gas-propelled nanomotors alleviate colitis through the regulation of intestinal immunoenvironmenthematopexis-microbiota circuits”[Acta Pharm Sin B 14(2024)2732e2747]

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Acta Pharmaceutica Sinica B 2024年第9期14卷 4193-4193页

作者： Bo Xiao Yuqi Liang Ga Liu Lingshuang Wang Zhan Zhang Libin Qiu Haiting Xu Sean Carr Xiaoxiao Shi rui lreis Subhas CKundu Zhenhua Zhu Department of Gastroenterology the First Affiliated Hospital of Nanchang UniversityNanchang 330006China College of Sericulture Textileand Biomass SciencesSouthwest UniversityChongqing 400715China Department of Neurology School of MedicineEmory UniversityAtlantaGA 30322USA Atlanta Veterans Affairs Medical Center DecaturGA 30033USA Department of Surgery School of MedicineEmory UniversityAtlantaGA 30322USA 3Bs Research Group I3Bs d Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkBarcoGuimaraes 4805-017Portugal

The authors regret that there are errors in the author information and author *** name of the corresponding author,Zhenghua Zhu,should be corrected to Zhenhua *** modification does not affect the results of the *** au... 详细信息

关键词： journal correction contributions

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Adaptable hydrogel with reversible linkages for regenerative medicine:Dynamic mechanical microenvironment for cells

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Bioactive Materials 2021年第5期6卷 1375-1387页

作者： Zongrui Tong Lulu Jin Joaquim Miguel Oliveira rui lreis Qi Zhong Zhengwei Mao Changyou Gao MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027China 3B’s Research Group I3Bs-Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkZona Industrial da Gandra4805-017Barco GMRPortugal ICVS/3B’s-PT Government Associate Laboratory Braga/GuimarãesPortugal The Discoveries Centre for Regenerative and Precision Medicine Headquarters at University of MinhoAvepark4805-017BarcoGuimarãesPortugal Key Laboratory of Advanced Textile Materials&Manufacturing Technology Ministry of EducationNational Base for International Science and Technology Cooperation in Textiles and Consumer-Goods ChemistryZhejiang Sci-Tech University310018HangzhouChina

Hydrogels are three-dimensional platforms that serve as substitutes for native extracellular *** materials are starting to play important roles in regenerative medicine because of their similarities to native matrix in water content and *** would be very advantagoues for researchers to be able to regulate cell behavior and fate with specific hydrogels that have tunable mechanical properties as biophysical *** developments in dynamic chemistry have yielded designs of adaptable hydrogels that mimic dynamic nature of extracellular *** current review provides a comprehensive overview for adaptable hydrogel in regenerative medicine as ***,we outline strategies to design adaptable hydrogel network with reversible linkages according to previous findings in supramolecular chemistry and dynamic covalent ***,we describe the mechanism of dynamic mechanical microenvironment influence cell behaviors and fate,including how stress relaxation influences on cell behavior and how mechanosignals regulate matrix ***,we highlight techniques such as bioprinting which utilize adaptable hydrogel in regenerative *** conclude by discussing the limitations and challenges for adaptable hydrogel,and we present perspectives for future studies.

关键词： Adaptable hydrogel Dynamic mechanical microenvironment Supramolecular chemistry Dynamic covalent chemistry Yes-associated protein

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Indirect printing of hierarchical patient-specific scaffolds for meniscus tissue engineering

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Bio-Design and Manufacturing 2019年第4期2卷 225-241页

作者： Joao BCosta Joana Silva-Correia Sandra Pina Alain da Silva Morais Sílvia Vieira Hélder Pereira Joao Espregueira-Mendes rui lreis Joaquim M.Oliveira B′s Research Group I3Bs-Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkZona Industrial da Gandra4805-017 Barco GmrPortugal ICVS/3B’s-PT Government Associate Laboratory Braga/GuimaraesPortugal The Discoveries Centre for Regenerative and Precision Medicine Headquarters at University of MinhoAvepark4805-017 BarcoGuimar'sPortugal Ripoll y De Prado Sports Clinic:Murcia-Madrid FIFA Medical Centre of Excellence MurciaSpain Orthopedic Department Centro Hospitalar Póvoa de Varzim Vila do CondePortugal Clínica do Dragao Espregueira-Mendes Sports CentreFIFA Medical Centre of ExcellencePortoPortugal Dom Henrique Research Centre PortoPortugal Orthopedic Department University of MinhoBragaPortugal

The complex meniscus tissue plays a critical role in the knee. The high susceptibility to injury has led to an intense pursuit for better tissue engineering regenerative strategies, where scaffolds play a major role. In this study, indirect printed hierarchical multilayered sca ffolds composed by a silk fibroin (SF) upper layer and an 80/20 (w/w) ratio of SF/ionic-doped β-tricalcium phosphate (TCP) bottom layer were developed. Furthermore, a comparative analysis between two types of sca ffolds pro- duced using di fferent SF concentrations, i.e., 8% (w/v) (Hi8) and 16% (w/v) (Hi16) was performed. In terms of architecture and morphology, the produced sca ffolds presented homogeneous porosity in both layers and no di fferences were observed when comparing both sca ffolds. A decrease in terms of mechanical performance of the sca ffolds was observed when SF concentration decreased from 16 to 8% (w/v). Hi16 revealed a static compressive modulus of 0.66 ± 0.05 MPa and dynamical mechanical properties ranging from 2.17 ± 0.25 to 3.19 ± 0.38 MPa. By its turn, Hi8 presented a compressive modulus of 0.27 ± 0.08 MPa and dynamical mechanical properties ranging from 1.03 ± 0.08 MPa to 1.56 ± 0.13 MPa. In vitro bioactivity studies showed formation of apatite crystals onto the surface of Hi8 and Hi16 bottom layers. Human meniscus cells (hMCs) and human primary osteoblasts were cultured separately onto the top layer (SF8 and SF16) and bottom layer (SF8/TCP and SF16/TCP) of the hierarchical sca ffolds Hi8 and Hi16, respectively. Both cell types showed good adhesion and proliferation as denoted by the live/dead staining, Alamar Blue assay and DNA quanti fication analysis. Subcutaneous implantation in mice revealed weak in flammation and sca ffold’s integrity. The hierarchical indirect printed SF sca ffolds can be promising candidate for meniscus TE sca ffolding applications due their suitable mechanical properties, good biological performance and possibility of being applied in a patie

关键词： Patient-specific Indirect printing Hierarchical Silk fibroin Enzymatic-cross-linking Meniscus

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融合多源地理数据与高分辨率遥感影像的尾矿库识别与监测——以云南省个旧市为例

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自然资源遥感 2024年第1期36卷 103-109页

作者：刘晓亮王志华邢江河周睿杨晓梅刘岳明张俊瑶孟丹中国科学院地理科学与资源研究所资源与环境信息系统国家重点实验室北京100101 中国科学院大学北京100049 中国矿业大学(北京)地球科学与测绘工程学院北京100083 京师天启(北京)科技有限公司北京100086

尾矿库是具有高势能的重大危险源,对尾矿库空间范围开展快速识别与监测,及时掌握尾矿库数量及分布情况,对我国尾矿库的环境监管与治理具有重要意义。现有单纯基于遥感影像识别提取的思路,因缺乏尾矿库潜在目标针对性,易将裸露地表等混... 详细信息

尾矿库是具有高势能的重大危险源,对尾矿库空间范围开展快速识别与监测,及时掌握尾矿库数量及分布情况,对我国尾矿库的环境监管与治理具有重要意义。现有单纯基于遥感影像识别提取的思路,因缺乏尾矿库潜在目标针对性,易将裸露地表等混淆为尾矿库,给实际的尾矿库监测应用带来较大误差。为此,提出一种融合企业名录与空间分布点位、数字高程模型(digital elevation model,DEM)、道路网等多源地理数据与高分遥感影像的尾矿库提取方法。以云南省个旧市为研究区的应用验证结果表明:融合多源地理数据可有效排除不存在尾矿库的干扰区域,尾矿库提取结果的精确率和召回率分别为83.9%和72.4%。该技术方案在全国尺度的尾矿库高频次、自动化遥感监测中具有广阔的应用前景。

关键词：多源地理数据遥感面向对象分类尾矿库多尺度分割

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