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Long-term prognosis and its associated predictive factors in patients with eosinophilic gastroenteritis

World Journal of Gastroenterology 2024年第2期30卷 146-157页

作者： Kai-Wen Li Ge-Chong ruan shuang Liu Tian-Ming Xu Ye Ma Wei-Xun Zhou Wei Liu Peng-Yu zhao Zhi-Rong Du Ji Li Jing-Nan Li Department of Gastroenterology Chinese Academy of Medical Sciences and Peking Union Medical College HospitalBeijing 100730China Department of Allergy Chinese Academy of Medical Sciences and Peking Union Medical College HospitalBeijing 100730China Department of Pathology Chinese Academy of Medical Sciences and Peking Union Medical College HospitalBeijing 100730China Department of Radiology Chinese Academy of Medical Sciences and Peking Union Medical College HospitalBeijing 100730China Affairs Office Chinese Academy of Medical Sciences and Peking Union Medical College Hospital(West campus)Beijing 100032China

BACKGROUND Eosinophilic gastroenteritis(EGE)is a chronic recurrent disease with abnormal eosinophilic infiltration in the gastrointestinal *** remain the most common treatment ***,disease relapse and glucocorticoid dependence remain notable *** date,few studies have illuminated the prognosis of EGE and risk factors for disease *** To describe the clinical characteristics of EGE and possible predictive factors for disease relapse based on long-term *** This was a retrospective cohort study of 55 patients diagnosed with EGE admitted to one medical center between 2013 and *** records were collected and ***-Meier curves and log-rank tests were conducted to reveal the risk factors for long-term relapse-free survival(RFS).RESULTS EGE showed a median onset age of 38 years and a slight female predominance(56.4%).The main clinical symptoms were abdominal pain(89.1%),diarrhea(61.8%),nausea(52.7%),distension(49.1%)and vomiting(47.3%).Forty-three(78.2%)patients received glucocorticoid treatment,and compared with patients without glucocorticoid treatments,they were more likely to have elevated serum immunoglobin E(IgE)(86.8%vs 50.0%,P=0.022)and descending duodenal involvement(62.8%vs 27.3%,P=0.046)at *** a median follow-up of 67 mo,all patients survived,and 56.4%had at least one *** variables at baseline might have been associated with the overall RFS rate,including age at diagnosis24 kg/m^(2)(HR 0.3922,95%CI:0.1916-0.8027,P=0.014),disease duration from symptom onset to diagnosis>3.5 mo(HR 2.4725,95%CI:1.220-5.0110,P=0.011),vomiting(HR 3.1259,95%CI:1.5246-6.4093,P=0.001),total serum IgE>300 KU/L at diagnosis(HR 0.2773,95%CI:0.1204-0.6384,P=0.022)and glucocorticoid treatment(HR 6.1434,95%CI:2.8446-13.2676,P=0.003).CONCLUSION In patients with EGE,younger onset age,longer disease c

关键词： Eosinophilic gastroenteritis Prognosis Relapse Glucocorticoid Glucocorticoid dependence

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A lateral AlGaN/GaN Schottky barrier diode with 0.36-V turn-on voltage and 10-kV breakdown voltage by using double-barrier anode structure

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Chip 2024年第1期3卷 35-42页

作者： ru Xu Peng Chen Xiancheng Liu Jianguo zhao Tinggang Zhu Dunjun Chen Zili Xie Jiandong Ye Xiangqian Xiu Fayu Wan Jianhua Chang Rong Zhang Youdou Zheng The Key Laboratory of Advanced Photonic and Electronic Materials School of Electronic Science and EngineeringNanjing UniversityNanjing 210023China School of Electronic and Information Engineering Nanjing University of Information Science and TechnologyNanjing 210044China Corenergy Semiconductor Incorporation Suzhou 215600China

GaN power electronic devices,such as the lateral AlGaN/GaN Schottky barrier diode(SBD),have received significant attention in recent *** studies have focused on optimizing the breakdown voltage(BV)of the device,with a particular emphasis on achieving ultra-high-voltage(UHV,>10 kV)***,another important question arises:can the device maintain a BV of 10 kV while having a low turn-on voltage(V_(on))?In this study,the fabrication of UHV AlGaN/GaN SBDs was demonstrated on sapphire with a BV exceeding 10 ***,by utilizing a doublebarrier anode(DBA)structure consisting of platinum(Pt)and tantalum(Ta),a remarkably low Von of 0.36 V was *** achievement highlights the great potential of these devices for UHV applications.

关键词： AlGaN/GaN Schottky barrier diode Double-barrier anode Turn-on voltage Ultra-high-voltage

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Quantum generative adversarial networks based on a readout error mitigation method with fault tolerant mechanism

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Chinese Physics B 2024年第4期33卷 285-295页

作者：赵润盛马鸿洋程涛王爽范兴奎 School of Sciences Qingdao University of TechnologyQingdao 266033China School of Information and Control Engineering Qingdao University of TechnologyQingdao 266033China

Readout errors caused by measurement noise are a significant source of errors in quantum circuits,which severely affect the output results and are an urgent problem to be solved in noisy-intermediate scale quantum(NISQ)*** this paper,we use the bit-flip averaging(BFA)method to mitigate frequent readout errors in quantum generative adversarial networks(QGAN)for image generation,which simplifies the response matrix structure by averaging the qubits for each random bit-flip in advance,successfully solving problems with high cost of measurement for traditional error mitigation *** experiments were simulated in Qiskit using the handwritten digit image recognition dataset under the BFA-based method,the Kullback-Leibler(KL)divergence of the generated images converges to 0.04,0.05,and 0.1 for readout error probabilities of p=0.01,p=0.05,and p=0.1,***,by evaluating the fidelity of the quantum states representing the images,we observe average fidelity values of 0.97,0.96,and 0.95 for the three readout error probabilities,*** results demonstrate the robustness of the model in mitigating readout errors and provide a highly fault tolerant mechanism for image generation models.

关键词： readout errors quantum generative adversarial networks bit-flip averaging method fault tolerant mechanisms

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Heme oxygenase 1-mediated ferroptosis in Kupffer cells initiates liver injury during heat stroke

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Acta Pharmaceutica Sinica B 2024年第9期14卷 3983-4000页

作者： ru Li Riqing Wei Chenxin Liu Keying Zhang Sixiao He Zhifeng Liu Junhao Huang Youyong Tang Qiyuan An Ligen Lin Lishe Gan Liying zhao Xiaoming Zou Fudi Wang Yuan Ping Qiang Ma The Seventh Affiliated Hospital Southern Medical UniversityFoshan 528244China Department of Biopharmaceutics School of Laboratory Medicine and BiotechnologySouthern Medical UniversityGuangzhou 510000China Medical Critical Care Medicine General Hospital of Southern Theatre Command of PLAGuangzhou 510000China Guangdong Branch Center National Clinical Research Center for Geriatric Diseases(Chinese PLA General Hospital)Guangzhou 510000China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoAvenida da UniversidadeTaip1Macao 999078China School of Pharmaceutical Sciences Zhejiang Chinese Medical UniversityHangzhou 311402China Department of General Surgery Nanfang Hospitalthe First School of Clinical MedicineSouthern Medical UniversityGuangzhou 510000China The Fourth Affiliated Hospital the First Affiliated HospitalSchool of Public HealthInstitute of Translational MedicineCancer CenterState Key Laboratory of Experimental HematologyZhejiang University School of MedicineHangzhou 310000China The First Affiliated Hospital the Second Affiliated HospitalBasic Medical SciencesSchool of Public HealthHengyang Medical SchoolUniversity of South ChinaHengyang 421200China College of Pharmaceutical Sciences Zhejiang UniversityHangzhou 310000China Liangzhu Laboratory Zhejiang University Medical CenterHangzhou 310000China Guangdong Provincial Key Laboratory of Immune Regulation and Immunotherapy School of Laboratory Medicine and BiotechnologySouthern Medical UniversityGuangzhou 510000China

With the escalating prevalence of global heat waves,heat stroke has become a prominent health concern,leading to substantial liver *** other forms of liver injury,heat strokeinduced damage is characterized by heat cytotoxicity and heightened inflammation,directly contributing to elevated mortality *** clinical assessments have identified elevated bilirubin levels as indicative of Kupffer cell dysfunction,their specific correlation with heat stroke liver injury remains *** hypothesis proposes the involvement of Kupffer cell ferroptosis during heat stroke,initiating IL-1bmediated *** single-cell RNA sequencing of murine macrophages,a distinct and highly susceptible Kupffer cell subtype,Clec4Ft/CD206t,emerged,with heme oxygenase 1(HMOX-1)playing a pivotal ***,heat-induced HMOX-1,regulated by early growth response factor 1,mediated ferroptosis in Kupffer cells,specifically in the Clec4F t/CD206 t subtype(KC2),activating phosphatidylinositol 4-kinase beta and promoting PI4P *** cascade triggered NLRP3 inflammasome activation and maturation of *** findings underscore the critical role of targeted therapy against HMOX-1 in ferroptosis within Kupffer cells,particularly in Clec4F t/CD206 t *** an approach has the potential to mitigate inflammation and alleviate acute liver injury in the context of heat stroke,offering a promising avenue for future therapeutic interventions.

关键词： Heat stroke Liver injury Kupffer cells Ferroptosis Heme oxygenase 1 Phosphatidylinositol 4-kinase beta NLRP3 Early growth response factor 1

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关键核心技术识别方法研究进展

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情报杂志 2024年第4期43卷 68-77页

作者：赵建梁爽中国科学院文献情报中心北京100190 中国科学院大学经济与管理学院信息资源管理系北京100190

[研究目的]关键核心技术对推动我国经济高质量发展、保障国家安全、增强国际竞争力具有重要意义。梳理关键核心技术识别的主要方法,总结现有研究存在的不足,可以为后续关键核心技术的相关研究提供借鉴和参考。[研究方法]首先对关键核心... 详细信息

[研究目的]关键核心技术对推动我国经济高质量发展、保障国家安全、增强国际竞争力具有重要意义。梳理关键核心技术识别的主要方法,总结现有研究存在的不足,可以为后续关键核心技术的相关研究提供借鉴和参考。[研究方法]首先对关键核心技术的概念和特征进行辨析;其次对现有关键核心技术识别方法进行归纳和梳理,总结现有研究存在的不足与问题;最后对未来关键核心技术识别研究提出建议。[研究结论]从概念特征来看,关键核心技术具有地位垄断性、研发长期性以及技术主导性的特征。从识别方法来看,现有研究方法主要包括四种:基于专家经验的方法、基于专利指标的方法、基于专利关系网络的方法以及基于文本挖掘的方法。未来研究需强化对关键核心技术基础理论的探索,从特征层面进行多源数据的融合,借助人工智能技术提升识别过程的自动化程度,并进一步细化关键核心技术的识别粒度。

关键词：关键核心技术技术识别方法指标体系专利关系网络文本挖掘

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算法管理与员工创造力:借算法之势而创还是困数字牢笼而息

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系统管理学报 2024年第3期33卷 782-800页

作者：赵爽马君上海大学管理学院上海200444

算法管理替代传统经验管理已成为不可逆转的趋势。集成“最佳实践”智慧的算法管理是帮助员工站在“巨人肩上”从而拥有更多的时间和空间产生创造力,还是导致员工产生认知依赖或束缚于“数字牢笼”而使得创造力乏善可陈尚未得知。基于... 详细信息

算法管理替代传统经验管理已成为不可逆转的趋势。集成“最佳实践”智慧的算法管理是帮助员工站在“巨人肩上”从而拥有更多的时间和空间产生创造力,还是导致员工产生认知依赖或束缚于“数字牢笼”而使得创造力乏善可陈尚未得知。基于自我决定理论,构建了算法管理影响员工创造力的非线性框架。研究1(预研究)通过Python对社交媒体数据进行文本分析,获取社会大众对算法管理的情感倾向,并在此基础上提炼出增益效应和损耗效应两条不同的情感倾向,为探索算法管理对创造力的非线性效应奠定基础。研究2进一步探索了非线性成因以及员工“自下而上”的工作重塑在这一过程中所发挥的作用。结果发现:算法管理对创造力存在倒U型影响,内在动机起部分中介作用,工作重塑则可以缓解两者的倒U型关系。研究阐明了算法管理的“过犹不及”效应以及工作重塑促使算法管理“扬长补短”的内在机制,对企业优化算法管理从而推动创新发展具有重要意义。

关键词：算法管理员工创造力工作重塑自我决定理论文本分析倒U效应

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Design of a novel hybrid quantum deep neural network in INEQR images classification

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Chinese Physics B 2024年第6期33卷 230-238页

作者：王爽王柯涵程涛赵润盛马鸿洋郭帅 School of Information and Control Engineering Qingdao University of TechnologyQingdao 266033China School of Sciences Qingdao University of TechnologyQingdao 266033China

We redesign the parameterized quantum circuit in the quantum deep neural network, construct a three-layer structure as the hidden layer, and then use classical optimization algorithms to train the parameterized quantum circuit, thereby propose a novel hybrid quantum deep neural network(HQDNN) used for image classification. After bilinear interpolation reduces the original image to a suitable size, an improved novel enhanced quantum representation(INEQR) is used to encode it into quantum states as the input of the HQDNN. Multi-layer parameterized quantum circuits are used as the main structure to implement feature extraction and classification. The output results of parameterized quantum circuits are converted into classical data through quantum measurements and then optimized on a classical computer. To verify the performance of the HQDNN, we conduct binary classification and three classification experiments on the MNIST(Modified National Institute of Standards and Technology) data set. In the first binary classification, the accuracy of 0 and 4 exceeds98%. Then we compare the performance of three classification with other algorithms, the results on two datasets show that the classification accuracy is higher than that of quantum deep neural network and general quantum convolutional neural network.

关键词： quantum computing image classification quantum–classical hybrid neural network quantum image representation interpolation

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Results of 23 yr of Pulsar Timing of PSR J1453-6413

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Research in Astronomy and Astrophysics 2023年第10期23卷 357-366页

作者： Wei Li Shi-Jun Dang Jian-Ping Yuan Lin Li Wei-Hua Wang Lun-Hua Shang Na Wang Qing-Ying Li Ji-Guang Lu Fei-Fei Kou shuang-Qiang Wang Shuo Xiao Qi-Jun Zhi Yu-Lan Liu ru-shuang zhao Ai-Jun Dong Bin Zhang Zi-Yi You Yan-Qing Cai Ya-Qin Yang Ying-Ying Ren Yu-Jia Liu Heng Xu School of Physics and Electronic Science Guizhou Normal UniversityGuiyang 550001China Guizhou Provincial Key Laboratory of Radio Astronomy and Data Processing Guizhou Normal UniversityGuiyang 550001China Guizhou Radio Astronomy Observatory Guizhou UniversityGuiyang 550025China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China School of Physics Science and Technology Xinjiang UniversityUrumqi 830046China College of Mathematics and Physics Wenzhou UniversityWenzhou 325035China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China CAS Key Laboratory of FAST National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China

In this paper,we presented the 23.3 yr of pulsar timing results of PSR J1456-6413 based on the observations of Parkes 64 m radio *** detected two new glitches at MJD 57093(3)and 59060(12)and confirmed its first glitch at MJD 54554(10).The relative sizes(Δν/ν)of these two new glitches are 0.9×10^(-9)and 1.16×10^(-9),*** the“Cholesky”timing analysis method,we have determined its position,proper motion,and two-dimensional transverse velocities from the data segments before and after the second glitch,***,we detected exponential recovery behavior after the first glitch,with a recovery timescale of approximately 200 days and a corresponding exponential recovery factor Q of approximately 0.15(2),while no exponential recovery was detected for the other two *** interestingly,we found that the leading component of the integral pulse profile after the second glitch became stronger,while the main component became *** results will expand the sample of pulsars with magnetosphere fluctuation triggered by the glitch event.

关键词： Stars (stars:)pulsars:individual(PSR J1453-6413) stars:neutron

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Efficacy and safety of low-dose tetracycline,amoxicillin quadruple therapy in Helicobacter pylori infection:A retrospective single center study

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World Journal of Gastroenterology 2024年第39期30卷 4295-4304页

作者： Yi-ru zhao Xin-Jie Wang Meng-Jia Zhu Ang-Li Chen Dian Zhang Qin Du John J Kim Wei-Ling Hu Department of Gastroenterology Sir Run Run Shaw HospitalMedical SchoolZhejiang UniversityHangzhou 310016Zhejiang ProvinceChina Department of Gastroenterology The First Affiliated HospitalMedical SchoolZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Keck School of Medicine University of Southern CaliforniaLos AngelesCA 90089-9021United States Institute of Gastroenterology Zhejiang UniversityHangzhou 310016Zhejiang ProvinceChina

BACKGROUND Helicobacter pylori(***)eradication rates have declined with the rise of antibiotic-resistant strains in recent *** highly effective with a low prevalence of resistance,standard dose tetracycline is associated with frequent adverse *** efficacy and safety of low-dose tetracycline as part of tetra-cycline and amoxicillin-containing bismuth quadruple therapy are not well *** To compare the efficacy and safety of low-dose compared to standard dose tetracycline with combined amoxicillin-containing bismuth quadruple therapy in patients with *** *** Consecutive patients with *** infection receiving tetracycline,amoxicillin,proton pump inhibitor,and bismuth for 14 days at Sir run run Shaw Hospital(1/2022-6/2023)were *** low-dose tetracycline group received tetracycline 500 mg twice daily(bid)while the standard dose group received 750 mg bid or 500 mg three times daily(tid).Primary endpoints were *** eradication rate and treatment-related adverse events.

关键词： Helicobacter pylori Tetracycline Amoxicillin Eradication Adverse events Bismuth quadruple therapy

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GTF2H4 regulates partial EndMT via NF-κB activation through NCOA3 phosphorylation in ischemic diseases

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The Innovation 2024年第2期5卷 27-41页

作者： Zheyan Fang Gang zhao shuang zhao Xueting Yu runyang Feng You-en Zhang Haomin Li Lei Huang Zhenyang Guo Zhentao Zhang Mukaddas Abdurahman Hangnan Hong Peng Li Bing Wu Jinhang Zhu Xin Zhong Dong Huang Hao Lu Xin zhao zhaoyang Chen Wenbin Zhang Junjie Guo Hongchao Zheng Yue He Shengying Qin Haojie Lu Yun zhao Xiangdong Wang Junbo Ge Hua Li Department of Cardiology Zhongshan HospitalFudan UniversityShanghai Institute of Cardiovascular DiseasesShanghai 200032China Department of Cardiology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Medical Examination Shanghai Xuhui District Central HospitalShanghai 200031China Department of Cardiology and Institute of Clinical Medicine Renmin HospitalHubei University of MedicineShiyan 442000China Clinical Data Center Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Molecular Celland Cancer BiologyUniversity of Massachusetts Chan Medical SchoolWorcesterMA 01605USA Bio-X Institute Key Laboratory for The Genetics of Developmental and Neuropsychiatric DisordersShanghai Jiao Tong UniversityShanghai 200030China Department of Cardiology Heart Center of Fujian ProvinceFujian Medical University Union HospitalFuzhou 350001China Department of Cardiology Sir Run Run Shaw Hospitalaffiliated with Zhejiang University School of MedicineHangzhou 310020China Department of Cardiology The Affiliated Hospital of Qingdao UniversityQingdao 266003China Department of Cardiology Shanghai Xuhui District Central HospitalShanghai 200031China Department of Cardiology Shanghai Eighth People’s HospitalShanghai 200235China Department of Chemistry and Institutes of Biomedical Sciences Fudan UniversityShanghai 200032China State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China School of Life Science and Technology Shanghai Tech University100 Haike RoadShanghai 201210China Key Laboratory of Systems Health Science of Zhejiang Province School of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Department of Pulmonary and Critical Care Medicine Zhongshan Hospital

Partial endothelial-to-mesenchymal transition(EndMT)is an intermediate phenotype observed in endothelial cells(ECs)undergoing a transition toward a mesenchymal state to support neovascularization during(patho)physiological ***,we investigated the occurrence of partial EndMT in ECs under hypoxic/ischemic conditions and identified general transcription factor IIH subunit 4(GTF2H4)as a positive regulator of this *** addition,we discovered that GTF2H4 collaborates with its target protein excision repair cross-complementation group 3(ERCC3)to co-regulate partial ***,by using phosphorylation proteomics and site-directed mutagenesis,we demonstrated that GTF2H4 was involved in the phosphorylation of receptor coactivator 3(NCOA3)at serine 1330,which promoted the interaction between NCOA3 and p65,resulting in the transcriptional activation of NF-κB and the NF-kB/Snail signaling axis during partial *** vivo experiments confirmed that GTF2H4 significantly promoted partial EndMT and angiogenesis after ischemic ***,our findings reveal that targeting GTF2H4 is promising for tissue repair and offers potential opportunities for treating hypoxic/ischemic diseases.

关键词： ischemic activation GTF

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