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1091例有症状的确诊COVID-19病人胸部CT表现正常：发生率、特点和转归

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国际医学放射学杂志 2021年第5期 610-610页

作者： I.L.Lorant F.Severac P.Bilbault J.Muller P.Leyendecker C.roy 高丹

摘要目的有症状的新型冠状病毒肺炎(COVID-19)病人的胸部CT表现正常的发生率及预后尚不清楚。研究旨在评估一组连续确诊的有呼吸道症状的COVID-19病人最初

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2 - 22 Isospin effect on Transverse Flow for Isobaric Fragments from Nuclear Collisions at Intermediate energy

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IMP & HIRFL Annual Report 2012年第1期 57-59页

作者： Liu Xingquan Wada roy Chen Zhiqiang Huang Meirong Lin Weiping Zhang Suyalatu Jin Zengxue Han Rui Liu Jianli Shi Fudong

2 - 23 Fragment Charge Dependence of Transverse Flow in Heavy-ion Collisions at Intermediate energy

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IMP & HIRFL Annual Report 2012年第1期 60-61页

作者： Liu Xingquan Wada roy Chen Zhiqiang Huang Meirong Lin Weiping Zhang'Suyalatu Jin Zengxue Han Rui Liu Jianli Shi Fudong

可注射CGF凝胶联合支架材料在牙髓再生中的应用研究

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可注射CGF凝胶联合支架材料在牙髓再生中的应用研究

第十六次全国牙体牙髓病学学术大会

作者：王明浩郭倩付乙代子寒朱晓茹朱小苗王志华王胜朝 Paul roy Cooper 蒋文凯何文喜口颌系统重建与再生全国重点实验室国家口腔疾病临床医学研究中心陕西省口腔医学重点实验室第四军医大学口腔医院牙体牙髓病科遵义医科大学附属口腔医院空军特色医学中心口腔科奥塔哥大学牙学院约翰·沃尔什爵士研究所口腔科学系

目的探究可注射浓缩生长因子(CGF)凝胶单独或联合胶原蛋白、PHA和PLGA三种支架材料对比格犬牙髓再生的影响。方法建立比格犬牙髓炎模型,建模后进行根管预备和消毒。将3只比格犬的42颗牙齿分为7组:(1) CGF组(n=6)、(2)胶原海绵(CS)组(n=6...

目的探究可注射浓缩生长因子(CGF)凝胶单独或联合胶原蛋白、PHA和PLGA三种支架材料对比格犬牙髓再生的影响。方法建立比格犬牙髓炎模型,建模后进行根管预备和消毒。将3只比格犬的42颗牙齿分为7组:(1) CGF组(n=6)、(2)胶原海绵(CS)组(n=6)、(3) BioO-Oss胶原(BO)组(n=6)、(4)CGF+胶原海绵(CGF+CS)组(n=6)、(5) CGF+Bio-Oss胶原(CGF+BO)组(n=6)、(6) CGF+PHA组(n=6)和(7) CGF+PLGA组(n=6);用iRoot-BP Plus封闭根管口,冠部填充光固化树脂。术前及术后3个月拍摄CBCT,进行影像学检查,术后3个月取材行组织学观察。结果组织学分析显示,CGF组和CGF+CS组均有新生牙髓样组织产生,CGF+CS组根管内炎症细胞较少;BO组和CGF+BO组根管内形成少量牙髓样组织;CS组、CGF+PHA组和CGF+PLGA组均未形成牙髓样组织。CGF组、CGF+CS组、CGF+BO组和CGF+PLGA组中均可见成牙本质细胞样细胞。所有组的样本中有不同程度的根尖闭合。结论 CGF与胶原支架的联合应用实现了牙髓-牙本质复合体的原位再生。单独应用支架材料不能诱导根管内形成新的牙髓样组织。人工合成材料在牙髓再生中的应用仍需进一步研究。本研究的结果为未来的根管治疗提供了一种很有前途的治疗策略。

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中国面临土改挑战

财经文摘 2008年第7期 57-57页

作者： Zhu Ketiang roy Prosterman 段醒予（编译）

中国宪法规定，土地集体所有制是社会主义制度的基础。然而，成千上万的农民正要求土地私有化，并且正单方面地在内部分割集体土地。

关键词：中国土地集体所有制土改社会主义制度土地私有化集体土地农民

Radiation signature on exposed cells: Relevance in dose estimation

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World Journal of Radiology 2015年第9期7卷 266-278页

作者： Venkatachalam Perumal Tamizh Selvan Gnana Sekaran Venkateswarlu Raavi Safa Abdul Syed Basheerudeen Karthik Kanagaraj Amith roy Chowdhury Solomon FD Paul Department of Human Genetics College of BiomedicalSciences Technology and Research Sri Ramachandra University

The radiation is considered as a double edged sword, as its beneficial and detrimental effects have been demonstrated. The potential benefits are being exploited to its maximum by adopting safe handling of radionuclide stipulated by the regulatory agencies. While the occupational workers are monitored by personnel monitoring devices, for general publics, it is not a regular practice. However, it can be achieved by using biomarkers with a potential for the radiation triage and medical management. An ideal biomarker to adopt in those situations should be rapid, specific, sensitive, reproducible, and able to categorize the nature of exposure and could provide a reliable dose estimation irrespective of the time of the exposures. Since cytogenetic markers shown to have many advantages relatively than other markers, the origins of various chromosomal abnormalities induced by ionizing radiations along with dose-response curves generated in the laboratory are presented. Current status of the gold standard dicentric chromosome assay, micronucleus assay, translocation measurement by fluorescence insitu hybridization and an emerging protein marker the g-H2 AX assay are discussed with our laboratory data. With the wide choice of methods, an appropriate assay can be employed based on the net.

关键词： Biomarker Dicentric chromosomes Micronucleus Fluor

习近平访美签下农业大单美国猎人借机进入中国

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商业周刊（中文版） 2012年第6期 35-35页

作者： Jeff Wilson Whitney McFerron Debarati roy Feiwen Rong

美国农业部4月份将带领有史以来最大贸易代表团前往中国“中国国家副主席在美国艾奥瓦的停留，让当地人感觉中国很重要”

关键词：美国农业部中国习近平猎人访美国家副主席代表团大贸易

帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析

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中国肺癌杂志 2021年第9期24卷 I0007-I0016页

作者： Sarah B GOLDBeRG Kurt A SCHALPeR Scott N GeTTINGeR Amit MAHAJAN roy S HeRBST Anne C CHANG Rogerio LILeNBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVeANU Thuy TRAN Kira PAVLIK elin ROWeN Heather GeRRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBeIRO Yuval KLUGeR Geyu ZHOU Wei WeI Veronica L CHANG Harriet M KLUGeR 董晓荣(翻译/校对) Department of Medicine(Medical Oncology) Yale School of MedicineNew HavenCTUSA Department of Pathology Yale School of MedicineNew HavenCTUSA Department of Radiology Yale School of MedicineNew HavenCTUSA Department of Neurosurgery Yale School of MedicineNew HavenCTUSA Department of Therapeutic Radiology Yale School of MedicineNew HavenCTUSA Interdepartmental Program in Computational Biology and Bioinformatics Yale School of MedicineNew HavenCTUSA Department of Biostatistics Yale School of Public HealthNew HavenCTUSA 华中科技大学同济医学院附属协和医院胸部肿瘤科

背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(ce... 详细信息

背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(eastern Cooperative Oncology Group,eCOG)ed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1erse events,Aes)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。

关键词：非小细胞肺癌脑转移免疫治疗帕博利珠单抗

Chromatin boundary elements organize genomic architecture and developmental gene regulation in Drosophila Hox clusters

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World Journal of Biological Chemistry 2016年第3期7卷 223-230页

作者： Zhibo Ma Mo Li Sharmila roy Kevin J Liu Matthew L Romine Derrick C Lane Sapna K Patel Haini N Cai Department of Cellular Biology University of Georgia

The three-dimensional(3D) organization of the eukaryotic genome is critical for its proper function. evidence suggests that extensive chromatin loops form the building blocks of the genomic architecture, separating genes and gene clusters into distinct functional domains. These loops are anchored in part by a special type of DNA elements called chromatin boundary elements(CBes). CBes were originally found to insulate neighboring genes by blocking influences of transcriptional enhancers or the spread of silent chromatin. However, recent results show that chromatin loops can also play a positive role in gene regulation by looping out intervening DNA and "delivering" remote enhancers to gene promoters. In addition, studies from human and model organisms indicate that the configuration of chromatin loops, many of which are tethered by CBes, is dynamically regulated during cell differentiation. In particular, a recent work by Li et al has shown that the SF1 boundary, located in the Drosophila Hox cluster, regulates local genes by tethering different subsets of chromatin loops: One subset enclose a neighboring gene ftz, limiting its access by the surrounding Scr enhancers and restrict the spread of repressive histones during early embryogenesis; and the other loops subdivide the Scr regulatory region into independent domains of enhancer accessibility. The enhancer-blocking activity of these CBe elements varies greatly in strength and tissue distribution. Further, tandem pairing of SF1 and SF2 facilitate the bypass of distal enhancers in transgenic flies, providing a mechanism for endogenous enhancers to circumvent genomic interruptions resulting from chromosomal rearrangement. This study demonstrates how a network of chromatin boundaries, centrally organized by SF1, can remodel the 3D genome to facilitate gene regulation during development.

关键词： Chromatin boundary element Insulator CTCF Chromatin loop domains Drosophila Hox genes