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Limosilactobacillus mucosae FZJTZ26M3 prevents NAFLD in mice through modulation of lipid metabolism and gut microbiota dysbiosis

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Food Science and Human Wellness 2024年第3期13卷 1589-1601页

作者： Danting Dang Bowen Li Mengfan Ding RPaul ross catherine Stanton Jianxin Zhao Bo Yang Wei chen State Key Laboratory of Food Science and Resources Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China International Joint Research center for Probiotics&Gut Health Jiangnan UniversityWuxi 214122China APc Microbiome Ireland University College CorkCork T12 YT20Ireland Teagasc Food Research centre MooreparkFermoyCork T12 YT20Ireland National Engineering Research center for Functional Food Jiangnan UniversityWuxi 214122China

Lactobacillus are considered promising therapeutic methods for nonalcoholic fatty liver disease(NAFLD).The effects of two strains of Ltmosilactobacillus mucosae on NAFLD were investigated in this ***-old male c57BL/6J mice were divided into 4 groups(n=8 per group,control,Model,FZJTZ26M3,FGSYc17L3).*** FZJTZ26M3 reduced the mice 's body weight,liver weight,and adipose tissue weight after 12 weeks of *** to serum analysis,total cholesterol,triacylglycerol,and low-density lipoprotein cholesterol significantly decreased after *** FZJTZ26M3 *** pathology showed that *** FZJTZ26M3 was effective to ameliorate lipid deposition in NAFLD ***,the expression of the gene related to lipid metabolism in the liver and adipose tissue was analyzed,and the results indicated that *** FZJTZ26M3 could alleviate NAFLD by regulating lipid ***,the results of 16S rRNA gene sequencing revealed a drop in the relative abundance of Ruminococcaceae,which is linked to inflammation,but the relative abundance of a potential probiotic Akkermansia significantly increased after *** FZJTZ26M3 ***,*** FZJTZ26M3 could be a candidate to prevent NAFLD.

关键词： Limosilactobacillus mucosae Nonalcoholic fatty liver disease(NAFLD) Probiotic Lipid metabolism Gut microbiota

Bifidobacterium breve ccFM1078 regulates bone development in growing BALB/c mice via gut microbiota and metabolites to balance bone formation and resorption

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Food Science and Human Wellness 2024年

作者： Bowen Li Mengfan Ding Xiaoming Liu Haiqin chen Jianxin Zhao R.Paul ross catherine Stanton Shilong Jiang Wei chen Bo Yang Nutrition and Metabolism Research Division， Innovation center， Heilongjiang Feihe Dairy co.， Ltd. National Engineering Research center for Functional Food， Jiangnan University State Key Laboratory of Food Science and Technology， Jiangnan University PKUHSc-china Feihe Joint Research Institute of Nutrition and Healthy Lifespan Development APc Microbiome Ireland， University college cork School of Food Science and Technology， Jiangnan University International Joint Research center for Probiotics & Gut Health， Jiangnan University Teagasc Food Research centre

This study endeavors to investigate the effects of Bifidobacterium breve ccFM1078 on bone formation and resorption balance in growing BALB/c mice. Newborn BALB/c mice were assigned to the control group (administration saline) and the ccFM1078 group (administration B. breve ccFM1078， 3 × 109cFU/day) in 3-， 4-， and 5-week tests. All the groups have male and female distinctions. Our findings demonstrate that B. breve ccFM1078 exerts on the dynamic equilibrium between bone formation and resorption during the critical period of growth in mice by modulating the composition of gut microbiota and metabolites (hexadecanamide， linoleoyl ethanolamide， and palmitoyl ethanolamide)， the genes and proteins expression related to the GH/IGF-1 axis and Gs/PKA/cREB signaling pathways， as well as downstream osteogenic and osteoclastic differentiation factors. The effects of B. breve ccFM1078 were different with age and gender dependent. This finding suggests B. breve ccFM1078 may have potential applications in regulating bone metabolism in the growth period population.

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Seeing through a new lens: exploring the potential of city walking tour videos for urban analytics

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International Journal of Digital Earth 2023年第1期16卷 2555-2573页

作者： Maximilian c.Hartmann ross S.Purves Department of Geography University of ZurichZurichSwitzerland

city Walking Tour Videos(cWTVs)are a novel source of Volunteered Geographic Information providing street-level imagery through video sharing platforms such as *** demonstrate that these videos contain rich information for urban analytical applications,by conducting a mobility *** detect transport modes with a focus on active(pedestrians and cyclists)and motorised mobility(cars,motorcyclists and trucks).We chose the city of Paris as our area of interest given the rapid expansion of the bicycle network as a response to the covid-19 pandemic and compiled a video corpus encompassing more than 66 hours of video *** the detection of street names in the video and placename containing timestamps we extracted and georeferenced 1169 locations at which we summarise the detected transport *** results show high potential of cWTVs for studying urban mobility *** detected significant shifts in the mobility mix before and during the pandemic as well as weather effects on the volumes of pedestrians and *** with the observed increase in data availability over the years we suggest that cWTVs have considerable potential for other applications in the field of urban analytics.

关键词： Street-level imagery city walking tour videos transport modes mobility object detection geolocation

Fit to fight——from military hygiene to wellbeing in the British Army

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Military Medical Research 2020年第4期7卷 482-488页

作者： Martin c.M.Bricknell colonel David A.ross Health and Military Medicine Conflict and Health Research GroupSchool of Security StudiesKing’s College LondonStrand CampusLondon WC2R 2LSUK Parkes Professor of Preventive Medicine Robertson HouseCamberley GU154NAUK

This paper reviews the historical evolution of the language and organization surrounding the health of personnel in the British Army from‘hygiene’through to‘wellbeing’.It starts by considering the health of the army in the midnineteenth century and the emergence of military hygiene as a professional *** continues by looking at advances in military hygiene in the two world *** was replaced by the term‘health’in the 1950 s as the collective noun used by professionals working in this *** unity split when the professions of occupational medicine and public health established separate faculties and training ***,the health issues for the armed forces remain fundamentally *** forward,the term‘wellbeing’is helping to refresh the close relationships between executives,their medical advisers and those within the population of health professions charged with keeping the British Army *** core theme is the collaborations between civil society,executive leadership and medical services in maximizing the health of the military population from recruitment through to life as a veteran.

关键词： Public health Hygiene Occupational medicine

Pyogenic liver abscess:An audit of 10 years’experience

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World Journal of Gastroenterology 2011年第12期17卷 1622-1630页

作者： Tony cY Pang Thomas Fung Jaswinder Samra Thomas J Hugh ross c Smith Upper Gastrointestinal Surgical Unit Royal North Shore HospitalUniversity of SydneySt Leonards NSW 2065Australia

AIM:To describe our own experience with pyogenic liver abscesses over the past 10 years and investigate the risk factors associated with failure of initial percutaneous ***:A retrospective study of records of 63 PLA patients presenting between 1998 and 2008 to Australian tertiary referral centre,were *** and hydatid abscesses were ***,clinical,radiological,and microbiological characteristics,as well as surgical/radiological interventions,were ***:Sixty-three patients(42 males,21 females) aged 65(±14) years[mean±(SD) ]had prodromal symptoms for a median(interquartile range;IQR) of 7(5-14) *** 59%of patients were febrile at presentation;however,the serum c-reactive protein was elevated in all 47 in whom it was *** function tests were non-specifically abnormal.67%of patients had a solitary abscess,while 32%had>3 abscesses with a median(IQR) diameter of 6.3(4-9) *** organisms were:Streptococcus milleri 25%,Klebsiella pneumoniae 21%,and Escherichia coli 16%.A presumptive cryptogenic cause was most common (34%).Four patients died in this series:one from sepsis,two from advanced cancer,and one from acute myocardial *** initial procedure was radiological aspiration±drainage in 54 and surgery in two patients.17%underwent surgical management during their *** hypoalbuminaemia[mean (95%cI) :32(29-35) g/L vs 28(25-31) g/L,P=0.045] on presentation was found to be the only factor related to failure of initial percutaneous therapy on univariate ***:PLA is a diagnostic challenge,because the presentation of this condition is *** antibiotics and radiological drainage in the first instance allows resolution of most PLAs;However,a small proportion of patients still require surgical drainage.

关键词： Pyogenic liver abscess Image guided drainage Surgical drainage c-reactive protein Hypoalbuminaemia

Use of non-timber forest products from invasive alien Prosopis species(mesquite) and native trees in South Africa: implications for management

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Forest Ecosystems 2015年第3期2卷 197-207页

作者： ross T Shackleton David c Le Maitre Brian W van Wilgen David M Richardson centre for Invasion Biology Department of Botany and ZoologyStellenbosch University centre for Invasion Biology Natural Resources and the EnvironmentCSIR

Background: Prosopis species have been introduced to many areas outside their native range to provide benefits to local communities. Several Prosopis species and their hybrids(hereafter "mesquite") have, however, become naturalised and invasive and now generate substantial costs. Management options are limited because of the complex conflicts of interest regarding benefits and costs. Management policies and strategies must take account of such conflicts, but further insights are needed on the dimensions of uses and impacts before such information can be usefully applied. current policy in South Africa allows for the growth and use of mesquite in one province,but not in others where its control is mandatory. We report on a study to quantify the direct use and perceptions of non-timber forest products(NTFPs) from mesquite and native trees in South ***: Semi-structures household interviews were conducted with various stakeholder groups to identify what tree products are used, to ascertain amounts used as well as to gauge perceptions of natural resource use between different tree species and use over ***: The direct household use value of native trees was higher than that of mesquite, and local stakeholders attached greater value to products from native trees than from mesquite. Therefore, native trees are and will still be preferentially harvested, and mesquite is unlikely to offer protection to native species by providing an alternative source of products. Mesquite pods do, however, provide valuable additional resources(fodder and medicinal products). The use of both native trees and mesquite is decreasing as the incomes of poorer households rise and as alternative energy sources become available. The benefits and reliance on mesquite are not as high as previously assumed and the impacts from mesquite invasions create large problems for local ***: This study provides further evidence that the impacts of mesquite exceed the benefi

关键词： Biological invasions conflicts of interests cost v

cytokines from the pig conceptus:roles in conceptus development in pigs

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Journal of Animal Science and Biotechnology 2015年第2期6卷 130-141页

作者： Rodney D Geisert Matthew c Lucy Jeffrey J Whyte Jason W ross Daniel J Mathew Animal Sciences Research center University of Missouri Department of Animal Science Iowa State University

Establishment of pregnancy in pigs involves maintaining progesterone secretion from the corpora lutea in addition to regulating a sensitive interplay between the maternal immune system and attachment of the rapidly expanding trophoblast for nutrient absorption. The peri-implantation period of rapid trophoblastic elongation followed by attachment to the maternal uterine endometrium is critical for establishing a sufficient placental-uterine interface for subsequent nutrient transport for fetal survival to term, but is also marked by the required conceptus release of factors involved with stimulating uterine secretion of histotroph and modulation of the maternal immune system. Many endometrial genes activated by the conceptus secretory factors stimulate a tightly controlled proinflammatory response within the uterus. A number of the cytokines released by the elongating conceptuses stimulate inducible transcription factors such as nuclear factor kappa B （NFKB） potentially regulating the maternal uterine proinflammatory and immune response. This review will establish the current knowledge for the role of conceptus cytokine production and release in early development and establishment of pregnancy in the pig.

关键词： cytokines Embryo development Porcine conceptus Pregnancy Prostaglandins uterus

Xi Jinping’s Analysis of “A common Future for Humanity”:Its Relation to Marx’s Das Kapital

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学术界 2019年第4期 185-189页

作者： John ross Renmin University of china

President Xi Jinping’s analysis of “a common future for humanity” is one of the most important and original features of china’s foreign policy and of “Xi Jinping’s Thought on Socialism with chinese characteristics for a New Era”.This concept is comprehensible not only in classical chinese but in Western philosophical ***,it is a creative development of Marxism whose accurate relation to economic reality,provides an exceptionally firm basis for china’s foreign policy and that of other countries.

关键词： Xi Jinping a common future for humanity Marx classical chinese thought Western thought

α1-antitrypsin increases interleukin-1 receptor antagonist production during pancreatic islet graft transplantation

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cellular & Molecular Immunology 2014年第4期11卷 377-386页

作者： Avishag Abecassis Ronen Schuster Galit Shahaf Eyal Ozeri ross Green David E Ochayon Peleg Rider Eli c Lewis Department of clinical Biochemistry and Pharmacology Faculty of Health Sciences Ben-Gurion University of the Negev Be'er-Sheva Israel

Although islet transplantation for individuals with type I diabetes has been shown to yield superior blood glucose control, it remains inadequate for long-term control. This is partly due to islet injuries and stresses that can lead to beta cell loss. Inhibition of excess IL-1β activity might minimize islet injuries, thus preserving function. The IL-1 receptor antagonist （IL-1Ra）, an endogenous inhibitor of IL-1β, protects islets from cytokine-induced necrosis and apoptosis. Therefore, an imbalance between IL-1β and IL-1Ra might influence the courses of allogeneic and autoimmune responses to islets. Our group previously demonstrated that the circulating serine-protease inhibitor human alpha-1-antitrypsin （hAAT）, the levels of which increase in circulation during acute-phase immune responses, exhibits anti-inflammatory and islet-protective properties, as well as immunomodulatory activity. In the present study, we sought to determine whether the pancreatic islet allograft-protective activity of hAAT was mediated by IL- 1Ra induction. Our results demonstrated that hAAT led to a 2.04-fold increase in IL-1Ra expression in stimulated macrophages and that hAAT-pre-treated islet grafts exhibited a 4.851-fold increase in IL-1Ra transcript levels, which were associated with a moderate inflammatory profile. Unexpectedly, islets that were isolated from IL-1Ra-knockout mice and pre-treated with hAAT before grafting into wild-type mice yielded an increase in intragraft IL-1Ra expression that was presumably derived from infiltrating host cells, albeit in the absence of hAAT treatment of the host. Indeed, hAAT-pre-treated islets generated hAAT-free conditioned medium that could induce IL-1Ra production in cultured macrophages. Finally, we demonstrated that hAAT promoted a distinct phosphorylation and nuclear translocation pattern for p65, a key transcription factor required for IL- 1Ra expression.

关键词： adaptive immunity inflammation innate immunity macrophages tolerance