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Petiveria alliacea Suppresses Airway Inflammation and Allergen-Specific Th2 Responses in Ovalbumin-Sensitized Murine Model of Asthma

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Chinese Journal of Integrative Medicine 2018年第12期24卷 912-919页

作者： rosa Martha perez Gutierrez Jose Maria Mota Flores Natural Products Research Laboratory Higher School of Chemical Engineering and Extractive IndustriesInstituto Politecnico Nacional (IPN) Professional Unit Adolfo Lopez Mateos Av. Instituto Politécnico NacionalS/N

Objective： To examine the effect of metanol extract of Petiveria alliacea （PM） on airway inflammation in a murine model of chronic asthma. Methods： Two-month-old male BALB/c mice （n=6-8/group） were sensitized on days 0 and 14 by intraperitoneal injection of 20μg ovalbumin （OVA）. On day 25, the mice received an airway challenge with OVA （3%, w/v, in phosphate buffered saline）. PM was administered orally by oral gavage to mice at doses of 100, 200 and 400 mg/kg body weight once daily from days 18 to 23. Control mice were orally administered phosphate buffered saline （PBS） to induce a model of asthma. At the end of the test, respiratory reactivity was assayed, the total cell number, interleukin-4 （IL-4）, IL-5, IL-13, tumor necrosis factor-alpha （TNF-α） and reactive oxygen species （ROS） in the bronchoalveolar lavage fluid （BALF） were determined and the levels of serum IgE, intercellular cell adhesion molecule 1 （ICAM-1） and eotoxin were measured. In addition, lung tissue was used to qualify the IL-4, IL-5, IL-13, TNF-α and transforming growth factor beta 1 （TGF-β1）. Histologic examination was performed to observe inflammatory cellular infiltration. Results： The administration of PM in comparison with the OVA-only treated group significantly attenuated the infiltration of eosinophUs and other inflammatory cells （P〈0.01）. Airway resistance （RI） in the OVA-only induced group was significantly higher than that of the PBS control group （P〈0.01） when methacholine was added. TNF-α, IgE, TGF-β1 and cytokine levels IL-4, IL-5, IL-β in the BALF decreased compared to control mice （P〈0.01 or P〈0.05）. PM treatment also inhibited the production of chemokines, eotaxin and ICAM-1 in BALF （P〈0.01）, which improved lung function. Histopathological examination revealed that the sensitized treated PM groups had significant lower in inflammatory scores similar to dexamethasone treatments and the untreated group. Conclusion： Administration of PM could inhibit airway inflammation, regulate cyt

关键词： Petiveria alliacea allergy antiinflammation asthma

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Effects of bixin in high-fat diet-fed-induced fatty liver in C57BL/6J mice

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Asian Pacific Journal of Tropical Biomedicine 2016年第12期6卷 1015-1021页

作者： rosa Martha perez Gutierrez Rita Valadez Romero Research Laboratory of Natural Products School of Chemical Engineering and Extractive IndustriesNational Polytechnic InstituteAv.Instituto Politecnico Nacional S/NUnidad Profesional Adolfo Lopez Mateos

Objective:To evaluate the anti-obesity activity of bixin(BIX) on C57BL/6J mice which were fed a high-fat diet(HFD) and to determine the mechanism of this ***:C57BL/6J mice were separately fed a high-calorie diet or a normal diet for 8weeks,then they were treated with BIX for another 13 *** administration for 13 weeks,the animals were *** adiposity,serum lipid level,and insulin resistance were *** addition,a histological assay of pancreas and liver,an evaluation of the inhibitory properties on pancreatic lipase,and a-amylase were ***:Administration of BIX significantly decreased the body weight gain,adipocyte size,fat pad weights,hepatic lipid levels in HFD-induced obese *** addition,reduced liver weight exhibited decreased serum leptin levels,malic enzyme,glucose-6-phosphate dehydrogenase,hepatic fatty acid synthase,aspartate aminotransferase,alanine aminotransferase and hepatic phosphatidate phosphohydrolase ***,superoxide dismutase,catalase,glutathione peroxidase,and glutathione levels were increased in hepatic *** also decreased lipid and carbohydrates absorption due to inhibition of pancreatic lipase and *** term supplementation of BIX significantly decreased hyperlipidemia,insulin resistance and glucose *** levels of hepatic steatosis and the islets of Langerhans appeared less shrunken in HFD-fed ***:The antiobesity effect of BIX appears to be associated at least in part,to its inhibitory effect on lipids and carbohydrate digestion enzymes such as pancreatic lipase,a-glucosidase,and *** results suggested that BIX also act as an antioxidant and may treat visceral obesity normalizing glucose levels,improving insulin resistance and increasing energy ***,achiote which has a main component,the carotenoid BIX,could be a viable food for the treatment of obesity and diabetes.

关键词： Bixa orellana Bixin Obesity Enzymes Metabolic disturbances Diabetic

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Immediate post-operative complications(I):Post-operative bleeding;vascular origin:Thrombosis pancreatitis

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World Journal of Transplantation 2020年第12期10卷 415-421页

作者： Jose Antonio perez Daga rosa perez Rodriguez Julio Santoyo Department of Surgery Hospital Regional de MálagaMalaga 29010Spain

Simultaneous pancreas-kidney transplantation is the treatment of choice forinsulin-dependent diabetes that associates end-stage diabetic nephropathy, sinceit achieves not only a clear improvement in the quality of life, but also provides along-term survival advantage over isolated kidney transplant. However, pancreastransplantation still has the highest rate of surgical complications among organtransplants. More than 70% of early graft losses are attributed to technical failures,that is, to a non-immunological cause. The so-called technical failures includegraft thrombosis, bleeding, infection, pancreatitis, anastomotic leak and pancreaticfistula. Pancreatic graft thrombosis leads these technical complications as the mostfrequent cause of early graft loss. Currently most recipients receive postoperativeanticoagulation with the aim of reducing the rate of thrombosis. Hemoperitoneumin the early postoperative period is a frequent cause of relaparotomy, but it is notusually associated with graft loss. The incidence of hemoperitoneum is clearlyrelated to the use of anticoagulation in the postoperative period. Post-transplantpancreatitis is another cause of early postoperative complications, less frequentthan the previous. In this review, we analyze the most common surgicalcomplications that determine pancreatic graft losses.

关键词： Pancreas transplantation Vascular graft thrombosis Postoperative hemorrhage Graft pancreatitis Reperfusion injury Tissue donors Risk factors

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The translabyrinthine approach in residency training.“Step by step”surgical anatomy from the dissection laboratory to the operative room

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Journal of Otology 2021年第2期16卷 99-108页

作者： Fabio Roberti Joshua J.Wind rosa perez Anthony J.Caputy Dept.of Neurological Surgery The George Washington UniversityWashington DCUSA

Surgical anatomy training in a dedicated research laboratory and attendance to focused“hands-on”dissection courses are of high educational importance in order to acquire and maintain surgical expertise in skull base surgery,both for young and more experienced ***,transitioning surgical skills and anatomic knowledge from the laboratory to the operative room it is not free of challenges,especially during skull base approaches where the three-dimensional surgical orientation can be quite *** present a“step-by-step”and“side-by-side”surgical anatomy report on a translabyrinthine approach that was practiced in the laboratory then performed in the operative room by the surgical team,and we compare surgical anatomy exposures while discussing intraoperative techniques,nuances and challenges,both in the laboratory and the operative room.

关键词： Skull base surgery Translabyrinthine approach Vestibular schwannomas

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Robust Fiber-Optic Sensor Networks

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Photonic Sensors 2012年第4期2卷 366-380页

作者： rosa Ana perez-HERRERA Montserrat FERNANDEZ-VALLEJO Manuel LOPEZ-AMO Department of Electric and Electronic Engineering Public University of Navarra 31006 Pamplona Spain

The ability to operate despite failure will become increasingly important as the use of optical sensor networks grows, and the amount of sensing information to be handled by a sensor network is increasing, especially for safety and security applications. In this review, the four categories of protection to allow service to be reestablished after a failure （dedicated/shared and line/path） are thoroughly discussed. This paper also presents an overview of the most representative robust fiber-optic sensor systems, discussing their schemes, pros and cons.

关键词： Self-healing robust resilience fiber-optic sensor multiplexing fiber Bragg gratings (FBGs) fiber-optic networks

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Does Muller Cell Differentiation Occur Prior to the Emergence of Synapses in Embryonic Turtle Retina？

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Journal of Life Sciences 2012年第11期6卷 1200-1205页

作者： Yolanda Segovia rosa Maria perez Norberto Mauricio Grzywacz Joaquin De Juan Departamento de Biotecnologia Universidad de Alicante Alicante 03080 Spain Departamento de Enfermeria Universidad de Alicante Alicante 03080 Spain Department of Biomedical Engineering University of Southern California Los Angeles CA 90089-111 USA

MOiler cells are the main glial cells in the retina, and are related to plexiform layer activity. Recent studies have demonstrated that Muller cells are involved in the synaptic conservation, plasticity, development and metabolism of glutamate. During turtle retinal development, layers, cells and synapses appear at different times. The aim of this research is to study the emergence of Muller cells during embryonic development and their relationship with the synaptogenesis. The authors used retinas from Trachemys scripta elegans embryos at stages S14, 18, 20, 23, and 26. Some retinas were processed with immunocytochemistry in order to detect the presence of glutamine synthetase in Muller cells, which was used as a marker of these ceils. Other retinas from the same stages were processed for ultrastructural studies. Samples were observed in confocal and transmission electron microscopes, respectively. The present results show that glutamine synthetase expression in MOiler cells occurs at S18, before the emergence of the retinal layers and the early synapses.

关键词： Synaptogenesis retinal development glutamine synthetase ultrastructure immunochemistry.

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Fiber Cavity Ring Down and Gain Amplification Effect

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Photonic Sensors 2016年第4期6卷 324-327页

作者： Susana SILVA Regina MAGALHAES rosa Ana perez-HERRERA Manuel LOPEZ-AMO M. B. MARQUES O. FRAZAO IINESC TEC Rua do Campo Alegre 687 4169-007 Porto Portugal Dept. de Fisica e Astronomia da Faculdade de Ciencias da Universidade do Porto Rua do Campo Alegre 687 4169-007 Porto Portugal public University of Navarra Dept. of Electric and Electronic Engineering Campus de Arrosadla Pamplona Spain.

The effect of an erbium-doped fiber amplifier （EDFA） placed inside the fiber ring of a cavity ring down （CRD） configuration is studied. The limitations and advantages of this configuration are discussed, and the study of the ring-down time as a function of the current applied and gain to the EDFA is also presented. In this case, the power fluctuations in the output signal are strongly dependent on the cavity ring-down time with the EDFA gain.

关键词： Cavity ring down EDFA multimode laser optical fibers.

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西班牙渗出性老年性黄斑变性的相关流行病学因素(英文)

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国际眼科杂志 2008年第6期8卷 1070-1072页

作者： Javier A Montero Hortensia Sanchez-Tocino Maria Jo-sefa Marti Maldonado Concepcién Arnaiz Nifio rosa Mafia perez Bartolomé Antonio Valera Coomonte 西班牙巴利亚多利德Piodel Rio Hortega大学医院眼科西班牙阿利坎特眼科研究所视网膜科西班牙Castilla La Mancha大学阿利坎特医学院

目的：报告在西班牙Castilla-Leo地区患有渗出性老年性黄斑变性（AMD）的样本人群的流行病学特点，并与一组来自同一地区和相同年龄人群进行比较。方法：在本次观察性前瞻性调查中，我们访问了在一家地区性诊所接受光动力学疗法的AMD患... 详细信息

目的：报告在西班牙Castilla-Leo地区患有渗出性老年性黄斑变性（AMD）的样本人群的流行病学特点，并与一组来自同一地区和相同年龄人群进行比较。方法：在本次观察性前瞻性调查中，我们访问了在一家地区性诊所接受光动力学疗法的AMD患者。患者报告了高血压、高血脂、吸烟的病史，检查患者虹膜颜色并分为浅色（绿色、蓝色、灰色）和深色（淡褐色、褐色、黑色）。结果：共有343名患者接受了访问，平均年龄为74．9岁（55～93岁），其中64．5％为女性，35．5％为男性，有45．1％的患者虹膜颜色被划为浅色。这些患者中，有50％有动脉性高血压，15．3％接受高胆固醇血症治疗，30．2％吸烟或者已经戒烟（女性中占80．9％）。结论：在渗出性AMD患者中，虹膜颜色为浅色的频率较高。在我们的调查中，其他渗出性AMD其他的风险因素有男性的吸烟习惯、未接受高胆固醇血症治疗、患者为女性身份等。

关键词：渗出性老年性黄斑变性虹膜颜色吸烟血压高血脂吸烟史

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In vitro germination and shoot proliferation of the threatened species Cinchona officinalis L(Rubiaceae).

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Journal of Forestry Research 2016年第6期27卷 1229-1236页

作者： rosa Armijos-Gonzalez Cesar perez-Ruiz Departamento de Ciencias Naturales Universidad Tecnica Particular de LojaCP 1101 608 LojaEcuador Departamento de Biotecnologia y Biologia Vegetal E.T.S.Ingenieros AgronomosUniversidad Politecnica de MadridCP 728040 MadridSpain

Cinchona officinalis （Rubiaceae） is an endemic species of the Loja Valley in southern Ecuador with medicinal uses. Because of over-exploitation in the nine- teenth century and more recent disturbances to its ecosystem, C. officinalis populations are threatened. Currently, natural regeneration of the populations is low, despite its high plant regeneration and seed formation capacity. In the present study, an efficient protocol for germination, shoot proliferation and plantlets regeneration was developed for this species. Phenolic content and germination rate of C. officinalis seeds were compared with a control species, C. pubescens. Nodal segments from seedlings of C. officinalis were cultured on Gamborg medium supplemented with different combinations of plant growth regulators. Because the phenol content is high in C. officinalis, the phenolic should be removed with hydrogen peroxide or water washes to stimulate germination. Shoots and callus developed from nodal segments within 45 days using most of the tested combinations of plant growth regulators. The best rates of shoot proliferation, callus formation and adventitious buds were obtained in medium supplemented with 5.0 mg L^-1 6-benzyl-aminopurine and 3.0 mg L^-1 indole- 3-butyfic acid.

关键词： Callus Cinchona officinalis Germination Phenols Rubiaceae Shoot

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Protective effects of D-002 on experimentally induced gastroesophageal reflux in rats

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World Journal of Gastroenterology 2014年第8期20卷 2085-2090页

作者： Zullyt Zamora Vivian Molina rosa Mas Yazmin Ravelo Yohany perez Ambar Oyarzabal Department of Pharmacology Centre of Natural ProductsNational Centre for Scientific ResearchHavana 10600Cuba

AIM: To investigate the effects of beeswax alcohols (D-002) on the esophageal damage induced by gastroesophageal reflux (GER) in rats.

关键词： D-002 Beeswax alcohols Esophagitis Gastroesophageal reflux Oxidative stress

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