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Flow Dynamics around Two Side by Side Circular Cylinders with Alternating Movements

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World Journal of Mechanics 2023年第1期13卷 1-19页

作者： Alice rosa da Silva Faculty of Civil Engineering Federal University of Uberlandia Uberlandia-MG Brazil

The flow dynamics is analyzed through two-dimensional numerical simulations around two circular cylinders arranged side by side, with 4 combinations of alternating motions. All simulations are performed for Re = 1000, amplitude of oscillation (A) equal to 3, frequency ratio (fr) of 0.5, specific rotation (α) equal to 0.5 and different values of spacing ratio (L/D). It is verified that the combination of the type of movement, together with the position of one cylinder in relation to the other, exerts significant influence on the flow dynamics, as well as on the pressure distribution around the cylinder surface and on the average values of the fluid dynamics coefficients. The smallest value of the average pressure coefficient (Cp = -3.3), is obtained for the oscillating cylinder when placed side by side with the clockwise rotation cylinder, case 3 and L/D = 1.5. On the other hand, the lowest mean drag coefficient (Cd = 1.0788), is obtained for the cylinder with counterclockwise rotation, located in the lower position in relation to oscillating cylinder in the upper position, with spacing between them of 1.5. Furthermore, it is observed that the rotation movement is more effective in reducing drag than the rotation-oscillation movement, for the studied frequency ratio.

关键词： Rotation Rotation-Oscillation Flow Dynamic Circular Cylinder

Case series in Indonesia:B.1.617.2(delta)variant of SARS-CoV-2 infection after a second dose of vaccine

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World Journal of Clinical Cases 2022年第36期10卷 13216-13226页

作者： Anis Karuniawati Ari F Syam Armand Achmadsyah Fera Ibrahim Yulia rosa Pratiwi Sudarmono Fadilah Fadilah Menaldi Rasmin Department of Clinical Microbiology Faculty of MedicineUniversitas Indonesia/Cipto Mangunkusumo Jakarta IndonesiaJakarta 10430DKI JayaIndonesia Division of Gastroenterology Department of Internal MedicineFaculty of MedicineUniversitas Indonesia/Cipto Mangunkusumo Jakarta IndonesiaJakarta PUsat 10430DKI JayaIndonesia Faculty of Medicine Universits IndonesiaJakarta Pusat 10430DKI JayaIndonesia Department of Medical Chemistry Faculty of MedicineUniversitas IndonesiaJakarta IndonesiaFaculty of MedicineUniversitas IndonesiaJakarta 10430DKI JayaIndonesia Department of Pulmonology and Respiratory Medicine Faculty of MedicineUniversitas Indonesia/Persahabatan HospitalJakarta IndonesiaJakarta Pusat 10430DKI JayaIndonesia

BACKGROUND The B.1.617.2(delta)variant of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)was first discovered in Maharashtra in late 2020 and has rapidly expanded across India and *** took only 2 mo for this variant to spread in Indonesia,making the country the new epicenter of the delta variant as of July *** efforts made by accelerating massive rollouts of current vaccines to protect against infection,cases of fully-vaccinated people infected with the delta variant have been *** To describe the demographic statistics and clinical presentation of the delta variant infection after the second dose of vaccine in *** A retrospective,single-centre case series of the general consecutive population that worked or studied at Faculty of Medicine,Universitas Indonesia with confirmed Delta Variant Infection after a second dose of vaccine from 24 June and 25 June *** were collected retrospectively based on a combination of author recall,reverse transcription-polymerase chain reaction(RT-PCR),and whole genome sequencing results from the Clinical Microbiology Laboratory,Faculty of Medicine,Universitas *** Between 24 June and 25 June 2021,15 subjects were confirmed with the B.1.617.2(delta)variant infection after a second dose of the *** subjects were vaccinated with CoronaVac(Sinovac)and one subject with ChAdOx1 nCoV-19(Oxford-AstraZeneca).All of the subjects remained in home isolation,with fever being the most common symptom at the onset of illness(n=10,66.67%).The mean duration of symptoms was 7.73 d(±5.444).The mean time that elapsed from the first positive swab to a negative RT-PCR test for SARS-CoV-2 was 17.93 d(±6.3464).The median time that elapsed from the second dose of vaccine to the first positive swab was 87 d(interquartile range:86-128).CONCLUSION Although this case shows that after two doses of vaccine,subjects are still susceptible to the delta variant infection,currently availab

关键词： COVID-19/SARS-CoV-2 infection B.1.617.2(delta)variant Fully vaccinated Case series

In vitro Metabolomic Approaches to Investigating the Potential Biological Effects of Phenolic Compounds:An Update

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Genomics, Proteomics & Bioinformatics 2017年第4期15卷 236-245页

作者： Ursula Catalan Laura Barrubes rosa Maria Vails rosa Soila Laura Rubio Functional Nutrition Oxidation and Cardiovascular Diseases Group(NFOC-Salut)Technological Center of Nutrition and Health(CTNS)lnstitut d'lnvestigacio Sanitaria Pere Virgili(IISPV)Faculty of Medicine and ttealth SciencesUniversitat Rovira i VirgiliReus 43201Spain Food Technology Department Universitat de Lleida-AGROTECNIO CenterLleida 25198Spain

Dietary phenolic compounds （PCs） have been receiving intercst lor their presumcd roles ill disease prevention. However, there is a lack of studies on the underlying molecular mechanisnls. In this regard, in vitro metabolomic approaches are suitable for the investigation o1 the molecular changes in response to PC exposure. Up to date, the biological effects of PCs have only been cxalnined for PCs from rosemary （Rosmarinus officinalis）, olive oil, and reSVCl-atrol using cell-based mctabolomic approach, although transcriptomic and/or proteomic studies have also been conducted in the same in vi[ro cell experiment in some cases. Our integral analysis of the reviewed studies suggest that PCs may be involved not only in basic cellular processes or macro-and micro-nutrient meta- bolism, but also in specific metabolic pathways that have been thoroughly investigated. These modulated pathways could have a clinical impact on neurodegenerativc diseases, type 2 diabetes, cancer, and cardiovascular diseases. In conclusion, the in vitro metabolomic approaches provide additional information of the molecular mechanisms involved in disease risk reduction of dietary PCs. In order to elucidate the mechanisms of action of PCs, more metabolomic cell-based studies are nccdcd and testing the physiological conjugated forms of PCs in these cell systems could be of special interest.

关键词： Cell-based Metabolomics Phenolic compounds Mechanism of action Disease prevention

Analysis of hydrodynamic effects on biofilm thickness in fluidized-bed tapered bioreactors

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Particuology 2021年第5期19卷 48-57页

作者： Daniela Maria Koerich Leonardo Machado da rosa Chemical Engineering Department University of Blumenau(FURB)3250 Sao Paulo Street89030-000 BlumenauSanta CatarinaBrazil

Fluidized beds in tapered geometries provide advantages such as a broad range of optimum operating ***,the dynamics of the flow inside these bioreactors is significantly more complex,as they promote non-uniform bioparticles *** this end,the CFD technique can give a detailed description of the flow in the ***,the aim of this work is to assess the influence of the hydrodynamic on the steady-state biofilm thickness through numerical simulations of liquid–solid fluidized *** geometries of tapered bioreactors in the operating conditions used to develop *** were run to solve the two-phase RANS equations using the open-source software OpenFOAM in *** SST k−ω model was used to estimate the turbulent features of the *** and bioparticles distribution inside the reactor were analyzed for different inlet velocities,while bioparticles collision frequency and shear stresses were evaluated for various operating *** comparison between the turbulent kinetic energy and the granular temperature indicated that the fluid flow is more turbulent than the bioparticles *** hydrodynamics influence on the steady-state biofilm thickness was assessed,and results led to the conclusion that biofilm is more sensitive to hydrodynamic shear stress than bioparticles collisions.

关键词： Liquid-solid fluidization Shear stress Particles collisions Computational fluid dynamics Biofilm Tapered bioreactors

Targeting neuronal nitric oxide synthase as a valuable strategy for the therapy of neurological disorders

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Neural Regeneration Research 2016年第11期11卷 1731-1734页

作者： Cristina Maccallini rosa Amoroso Department of Pharmacy University "G.d'Annunzio" of Chieti-Pescara

The management of neurological disorders have huge and increasing human and economic costs. Despite this, there is a scarcity of effective therapeutics, and there is an extreme urgency for new and real treatments. In this short review we analyze some promising advancements in the search of new bioactive molecules targeting neuronal nitric oxide synthase （nNOS）, an enzyme deputed to the biosynthesis of nitric oxide （NO）. In different conditions of neuronal damages, this molecule is overproduced, contributing to the pathogenesis and progression of neuronal diseases. Two main approaches to modulate nNOS are discussed： a first one consisting in the direct inhibition of the enzyme by means of small organic molecules, which can be also active against other different targets involved in such diseases. A second section is dedicated to molecules able to prevent the formation of the ternary complex N-methyl-D-aspartate （NMDA）type glutamate receptors, postsynaptic density-95 （PSD95） protein-nNOS, which is necessary to activate the latter for the biosynthesis of NO.

关键词： amidines carbonic anhydrase inhibitors neurological diseases neuronal nitric oxide synthase NMDAR PSD95

Intestinal inflammation and the microbiota:Beyond diversity

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World Journal of Gastroenterology 2022年第26期28卷 3274-3278页

作者： Gabriela Gama Freire Alberca Naiane Samira Souza Cardoso rosa Liliana Solis-Castro Viviane Nakano Ricardo Wesley Alberca Department of Microbiology Institute of Biomedical SciencesUniversity of São PauloSão Paulo 05508-000Brazil Departamento Académico de Biología Bioquímica Facultad de Ciencias de la SaludUniversidad Nacional de TumbesPampa Grande 24000TumbesPeru Laboratorio de Dermatologia e Imunodeficiencias Departamento de DermatologiaFaculdade de Medicina FMUSPUniversidade de São PauloSão Paulo 01246-903Brazil

The recent manuscript entitled“Relationship between clinical features and intestinal microbiota in Chinese patients with ulcerative colitis”reported a difference in the intestinal microbiota of patients with ulcerative colitis according to the severity of the *** influence of the intestinal microbiota on the development and progress of gastrointestinal disorders is well *** the diversity in the microbiome,the presence of virulence factors and toxins by commensal bacteria may affect an extensive variety of cellular processes,contributing to the induction of a proinflammatory environment.

关键词： Inflammation Microbiota Toxins Intestinal Ulcerative Colitis Cancer

Searching for alternatives to brain regeneration

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Neural Regeneration Research 2021年第11期16卷 2198-2200页

作者： Chiara La rosa Luca Bonfanti Neuroscience Institute Cavalieri Ottolenghi(NICO) OrbassanoItaly Department of Veterinary Sciences University of TurinGrugliascoItaly

Brain regeneration from an evolutionary perspective:Brain regeneration(the full restoration of tissue after loss from injury or disease)is the most sought after goal for researchers working in developmental *** also appears to be the most challenging to achieve when considering the mammalian *** remarkable regenerative capacities can be present in the central nervous systems of many non-mammalian vertebrates(e.g.,fish,amphibians),these kinds of processes appear to be dramatically reduced in mammals(Bonfanti,2011).

关键词： regeneration sought injury

Contribution of purinergic receptors to spinal cord injury repair:stem cellbased neuroregeneration

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Neural Regeneration Research 2016年第3期11卷 418-419页

作者： rosa Gomez-Villafuertes Department of Biochemistry and Molecular Biology IV Veterinary SchoolUniversidad Complutense of Madrid

Traumatic spinal cord injury（SCI）,defined as physical trauma to the spinal column yielding altered motor,sensory,or autonomic function,is a devastating neurological disease causing major impact at both personal and societal *** is characterized by a primary insult（compression,contusion or laceration）followed by a secondary pathologicalcascade that propagates further injury disrupting motor,

关键词： repair devastating progenitor autonomic neurological altered sensory trauma yielding embryonic

Lipid catabolism and mitochondrial uncoupling are stimulated in brown adipose tissue of amyotrophic lateral sclerosis mouse models

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Genes & Diseases 2023年第2期10卷 321-324页

作者： Fabio Ciccarone Serena Castelli Giacomo Lazzarino Silvia Scaricamazza Renata Mangione Sergio Bernardini Savina Apolloni Nadia D'Ambrosi Alberto Ferri Maria rosa Ciriolo Department of Biology University of Rome “Tor Vergata”00133 RomeItaly IRCCS San Raffaele Roma 00166 RomeItaly UniCamillus-Saint Camillus International University of Health Sciences 00131 RomeItaly IRCCS Fondazione Santa Lucia 00179 RomeItaly Department of Basic Biotechnological Sciences Intensive and Perioperative ClinicsCatholic University of Rome00168 RomeItaly Fondazione Policlinico Universitario A. Gemelli IRCCS 00168 RomeItaly Institute of Translational Pharmacology IFT-CNR 00133 RomeItaly

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease typically leading to death within 5 years from symptom onset. ALS familial forms are associated with mutations in several genes, including Superoxide Dismutase 1 (SOD1) and Fused in Sarcoma (FUS). Although genes linked to ALS participate in disparate biological processes, ALS genetic variants largely trigger shared pathogenic events such as oxidative stress, protein aggregation and defects in RNA processing. Moreover, ALS patients show systemic hypermetabolism that leads to increased energy expenditure at rest and thus weight loss during the disease course.1 ALS hypermetabolic phenotype and weight loss have been extensively characterized in mice bearing the G93A substitution in SOD1 protein (SOD1-G93A), which exhibit skeletal-muscle metabolic reprogramming before disease onset.

关键词： Lipid metabolism aggregation