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A Disruptive Treatment to Prevent Amputation and Enhance Limb Salvage in an Elderly Patient

Journal of Cosmetics, Dermatological Sciences and Applications 2019年第2期9卷 129-154页

作者： Sarah Cristina Castillo Benitez rosa alduey duran Pilar Matos-Ruiz Madalene C. Y. Heng Thomas L. Vander Laan Department of Medicine/Dermatology UCLA School of Medicine Los Angeles USA

Background: Chronic wounds are a growing problem internationally, termed a silent epidemic. To combat this epidemic, it is not sufficient to rely on traditional wound care treatments alone, but to look to innovative and alternative therapies. The indispensable role of oxygen in wound healing is well-discussed in the literature, and in the past two decades the topical application of oxygen has shown promising results in the healing of chronic wounds. However, the toxic effects of oxygen are usually not appreciated and can often lead to wound necrosis and gangrene in wounds with compromised blood supply. While wounds with adequate blood supply contain free radical quenchers (catalase, superoxide dismutase and reduced glutathione) which neutralize the free radicals (reactive oxygen species) released as a by-product of the Krebs cycle, wounds with deficient blood supply are deficient in free radical quenchers and are further damaged by exposure to oxygen as a result of reperfusion injury/oxygen toxicity. Topical hyperbaric oxygen (THOT®) uses low oxygen tensions in the hyperbaric range to stimulate angiogenesis, while preventing excessive oxygen toxicity. The result is the induction of marked angiogenesis, with increasing capacity for quenching reactive oxygen species, resulting in wound healing of ischemic wounds. Case Presentation: This case report describes a 95-year-old Caucasian female who presented with a stage IV chronic necrotic ulcer on her lower left leg. Surgical pathology results revealed calcifying vasculopathy, which is thought to be responsible for deficient blood supply to the leg, leading to a necrotic, chronic leg ulcer of her left leg. After traditional wound therapies were unsuccessful, she was considered for leg amputation. The introduction of adjunctive treatment with topical hyperbaric oxygen therapy saw complete healing of the wound within 15 weeks. The wound remained closed, without the presence of scar tissue, with no signs of wound breakdo

关键词： Limb Salvage Necrotic Leg Ulcers Topical Hyperbaric Oxygen Angiogenesis Hypoxic Wounds TcPO2

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Two viral proteins translated from one open reading frame target different layers of plant defense

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Plant Communications 2024年第4期5卷 177-193页

作者： Yuzhen Mei Tao Hu Yaqin Wang rosa Lozano-duran Xiuling Yang Xueping Zhou State Key Laboratory of Rice Biology Institute of BiotechnologyZhejiang UniversityHangzhouZhejiang 310058China State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China Department of Plant Biochemistry Center for Plant Molecular Biology(ZMBP)Eberhard Karls University72076 TubingenGermany

Multilayered defense responses are activated upon pathogen *** utilize a number of strategies to maximize the coding capacity of their small genomes and produce viral proteins for infection,including suppression of host ***,we reveal translation leakage as one of these strategies:two viral effec-tors encoded by tomato golden mosaic virus,chloroplast-localized C4(cC4)and membrane-associated C4(mC4),are translated from two in-frame start codons and function cooperatively to suppress ***4 localizes in chloroplasts,to which it recruits NbPUB4 to induce ubiquitination of the outer membrane;as a result,this organelle is degraded,and chloroplast-mediated defenses are ***,chloroplast-localized cC4 induces the production of singlet oxygen(1O2),which in turn promotes translo-cation of the 1O2 sensor NbMBS1 from the cytosol to the nucleus,where it activates expression of the CERK1 ***,an antiviral effect exerted by CERK1 is countered by mC4,localized at the plasma ***4,like cC4,recruits NbPUB4 and promotes the ubiquitination and subsequent degradation of CERK1,suppressing membrane-based,receptor-like kinase-dependent ***,this translation leakage strategy seems to be conserved in multiple viral species and is related to host *** suggests that stacking of different cellular antiviral responses could be an effective way to abrogate viral infection and engineer sustainable resistance to major crop viral diseases in thefield.

关键词： geminivirus C4 PUB4 CERK1 subcellular localization antiviral defense

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Chloroplast immunity: A cornerstone of plant defense

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Molecular Plant 2024年第5期17卷 686-688页

作者： Jie Liu Pan Gong Ruobin Lu rosa Lozano-duran Xueping Zhou Fangfang Li State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100081China State Key Laboratory of Rice Biology Institute of BiotechnologyZhejiang UniversityHangzhouZhejiang 310058China Department of Plant Biochemistry Centre for Plant Molecular Biology(ZMBP)Eberhard Karls UniversityTubingen 72076Germany

Increasing evidence supports the notion that pattern-recognition-receptor-mediated immunity goes beyond plasma membrane-to-nucleus *** the findings of the pathways linking plasma membrane and chloroplasts and the functions of stromules and perinuclear chloroplast clustering(PCC)in plant defense,chloroplast immunity has emerged as a cornerstone of plant defense and a target of plant pathogens.

关键词： plant immunity corners

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Plant biotic interactions: From fundamental research toward sustainable agriculture

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Journal of Integrative Plant Biology 2021年第2期63卷 275-276页

作者： rosa Lozano-duran Suomeng Dong Shanghai Center for Plant Stress Biology CAS Center for Excellence in Molecular Plant Sciencesthe Chinese Academy of SciencesShanghai 201602China Department of Plant Biochemistry Centre for Plant Molecular Biology(ZMBP)Eberhard Karls UniversityD-72076 TubingenGermany The Key Laboratory of Plant Immunity and Department of Plant Pathology Nanjing Agricultural UniversityNanjing 210095China

Plants not only provide food and natural materials for humankind, but also constitute an indispensable part of the ecological system of this planet:without plants, life as we know it would simply not be possible. Through their lifespans,plants interact with a plethora of other organisms, including beneficial microbes and potential pathogens. Dissecting the underlying mechanisms determining the outcome of plant biotic interactions is a cornerstone for the design of rational management strategies to secure global food production and ecological balance.

关键词： corners planet rational

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Nucieocytoplasmic Shuttling of Geminivirus C4 Protein Mediated by Phosphorylation and Myristoylation Is Critical for Viral Pathogenicity

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Molecular Plant 2018年第12期11卷 1466-1481页

作者： Yuzhen Mei Yaqin Wang Tao Hu Xiuling Yang rosa Lozano-duran Garry Sunter Xueping Zhou State Key Laboratory of Rice Biology Institute of Biotechnology Zhejiang University Hangzhou Zhejiang 310058 China State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant Protection Chinese Academy of Agricultural Sciences Beijing 100193 China Shanghai Center for Plant Stress Biology CAS Center for Excellence in Molecular Plant Sciences Chinese Academy of Sciences Shanghai 201602 China Department of Biology University of Texas at San Antonio San Antonio TX 78249 USA

Many geminivirus C4 proteins induce severe developmental abnormalities in *** previously demon- strated that Tomato leaf curl Yunnan virus (TLCYnV)C4 induces plant developmental abnormalities at least partically by decreasing the accumulation of NbSKη,an ortholog of Arabidopsis BIN2 kinase involved in the brassinosteroid signaling pathway,in the nucleus through directing it to the plasma ***, the molecular mechanism by which the membrane-associated C4 modifies the localization of NbSKη in the host cell remains ***,we show that TLCYnV C4 is a nucleocytoplasmic shuttle protein,and that C4 shuttling is accompanied by nuclear export of *** C4 is phosphorylated by NbSKη in the nucleus,which promotes myristoylation of the viral *** of phosphorylated C4 favors its interaction with exportin-α(XPO I);which in turn facilitates nuclear export of the C4/NbSKTI complex. Supporting this model,chemical inhibition of N-myristoyltransferases or exportin-α enhanced nuclear retention of C4,and mutations of the putative phosphorylation or myristoylation sites in C4 resulted in increased nuclear retention ofrC4 and thus decreased severity of C4-induced developmental abnormalities. The impact of C4 on development is also lessened when a nuclear localization signal or a nuclear export signal is added to its C-terminus,restricting it to a specific cellular niche and therefore impairing nucleocytoplasmic *** together,our results suggest that nucleocytoplasmic shuttling of TLCYnV C4,enabled by phosphorylation by NbSKη,myristoylation,and interaction with exportin-α is critical for its function as a pathogenicity factor.

关键词： Geminivirus C4 phosphorylation myristoylation pathogenicity nucleocytoplasmic shuttling

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RNA-directed DNA methylation has an important developmental function in Arabidopsis that is masked by the chromatin remodeler PICKLE^FA

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Journal of Integrative Plant Biology 2020年第11期62卷 1647-1652页

作者： Rong Yang Li He Huan Huang Jian-Kang Zhu rosa Lozano-duran Heng Zhang Shanghai Center for Plant Stress Biology Center for Excellence for Molecular Plant Sciencesthe Chinese Academy of SciencesShanghai 201062China Department of Horticulture and Landscape Architecture Purdue UniversityWest LafayetteIndiana 47907USA National Key Laboratory of Plant Molecular Genetics Center for Excellence for Molecular Plant Sciencesthe Chinese Academy of SciencesShanghai 200032China

In Arabidopsis,RNA-directed DNA methylation(RdDM)is required for the maintenance of CHH methylation,and for denovo methylation in all(CG,CHG,and CHH)contexts,but no obvious effect of RdDM deficiency on plant developmenthas been found to *** show that the combination of mutations in the chromatin remodeler PKL and RdDMcomponents results in developmental alterations,which appear in a SUPPRESSOR OF DRMI DRM2 CMT3(SDC)dependent manner.

关键词： alterations directed Arabidopsis

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Plant viruses as probes to engineer tolerance to abiotic stress in crops

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Stress Biology 2022年第1期2卷 440-444页

作者： Emmanuel Aguilar rosa Lozano-duran Shanghai Center for Plant Stress Biology Chinese Academy of SciencesShanghai 201602China Center for Excellence in Molecular Plant Science Chinese Academy of SciencesBeijingChina Departamento de Biología Celular Genética y FisiologíaInstituto de Hortofruticultura Subtropical y Mediterránea“La Mayora”Universidad de Málaga-Consejo Superior de Investigaciones Científicas(IHSM-UMA-CSIC)Universidad de MálagaCampus Teatinos29071 MálagaSpain Department of Plant Biochemistry Centre for Plant Molecular Biology(ZMBP)Eberhard Karls UniversityD-72076 TübingenGermany

Main text Plants,as sessile organisms,have to deploy a vast array of mechanisms to cope with the always-changing environmental conditions that surround *** increasing accumulation of greenhouse gases in the atmosphere in the last century is responsible for a global warming of which the effects are predicted to be magnified in the near future.

关键词： Plants Plant crops

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Glycoprotein biomarkers for the detection of pancreatic ductal adenocarcinoma

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World Journal of Gastroenterology 2018年第24期24卷 2537-2554页

作者： Esther Llop Pedro E Guerrero Adriàduran Sílvia Barrabés Anna Massaguer María JoséFerri Maite Albiol-Quer Rafael de Llorens rosa Peracaula Department of Biology Biochemistry and Molecular Biology UnitUniversity of GironaGirona 17003Spain Biomedical Research Institute of Girona(IdIBGi).Parc Hospitalari Martíi Julià-Edifici M2 Salt 17190Spain Clinic Laboratory University Hospital Dr Josep TruetaGirona 17007Spain Department of Surgery Hepato-biliary and Pancreatic Surgery UnitUniversity Hospital Dr Josep TruetaGirona 17007Spain

Pancreatic cancer(Pa C) shows a clear tendency to increase in the next years and therefore represents an important health and social challenge. Currently, there is an important need to find biomarkers for PaC early detection because the existing ones are not useful for that purpose. Recent studies have indicated that there is a large window of time for PaC early detection, which opens the possibility to find early biomarkers that could greatly improve the dismal prognosis of this tumor. The present manuscript reviews the state of the art of the existing PaC biomarkers. It focuses on the anomalous glycosylation process and its role in PaC. Glycan structures of glycoconjugates such as glycoproteins are modified in tumors and these modifications can be detected in biological fluids of the cancer patients. Several studies have found serum glycoproteins with altered glycan chains in PaC patients, but they have not shown enough specificity for PaC. To find more specific cancer glycoproteins we propose to analyze the glycan moieties of a battery of glycoproteins that have been reported to increase in PaC tissues and that can also be found in serum. The combination of these new candidate glycoproteins with their aberrant glycosylation together with the existing biomarkers could result in a panel, which would expect to give better results as a new tool for early diagnosis of PaC and to monitor the disease.

关键词： Pancreatic cancer Aberrant glycosylation Glycoproteins Biomarkers Diagnosis

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A novel protein complex that regulates active DNA demethylation in Arabidopsis

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Journal of Integrative Plant Biology 2021年第4期63卷 772-786页

作者： Pan Liu Wen-Feng Nie Xiansong Xiong Yuhua Wang Yuwei Jiang Pei Huang Xueqiang Lin Guochen Qin Huan Huang Qingfeng Niu Jiamu Du Zhaobo Lang rosa Lozano-duran Jian-Kang Zhu Shanghai Center for Plant Stress Biology Center of Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghai 201602China University of Chinese Academy of Sciences Beijing 100049China Department of Horticulture College of Horticulture and Plant ProtectionYangzhou UniversityYangzhou 225009China Department of Horticulture&Landscape Architecture Purdue UniversityWest LafayetteIndiana 47906USA

Active DNA demethylation is critical for altering DNA methylation patterns and regulating gene *** 5-methylcytosine DNA glycosylase/lyase ROS1 initiates a base-excision repair pathway for active DNA demethylation and is required for the prevention of DNA hypermethylation at 1000 s of genomic regions in *** ROS1 is regulated and targeted to specific genomic regions is not well ***,we report the discovery of an Arabidopsis protein complex that contains ROS1,regulates ROS1 gene expression,and likely targets the ROS1 protein to specific genomic ***1 physically interacts with a WD40 domain protein(RWD40),which in turn interacts with a methyl-DNA binding protein(RMB1)as well as with a zinc finger and homeobox domain protein(RHD1).RMB1 binds to DNA that is methylated in any sequence context,and this binding is necessary for its function in ***-of-function mutations in RWD40,RMB1,or RHD1 cause DNA hypermethylation at several tested genomic regions independently of the known ROS1 regulator *** the hypermethylated genomic regions include the DNA methylation monitoring sequence in the ROS1 promoter,plants mutated in RWD40,RMB1,or RHD1 show increased ROS1 ***,ROS1 binding to the ROS1 promoter requires RWD40,RMB1,and RHD1,suggesting that this complex dictates ROS1 targeting to this *** results demonstrate that ROS1 forms a protein complex with RWD40,RMB1,and RHD1,and that this novel complex regulates active DNA demethylation at several endogenous loci in Arabidopsis.

关键词： DNA demethylation DNA methylation methyl-DNA binding ROS1 WD40 domain

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The transcriptional regulator JAZ8 interacts with the C2 protein from geminiviruses and limits the geminiviral infection in Arabidopsis

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Journal of Integrative Plant Biology 2023年第7期65卷 1826-1840页

作者： Tabata rosas-Diaz Pepe Cana-Quijada Mengshi Wu Du Hui Gemma Fernandez-Barbero Alberto PMacho Roberto Solano Araceli GCastillo Xiao-Wei Wang rosa Lozano-duran Eduardo R.Bejarano Departamento de Biología Celular Genética y FisiologíaFacultad de CienciasInstituto de Hortofruticultura Subtropical y Mediterránea“La Mayora”(IHSM‐UMA‐CSIC)Universidad de MálagaMálagaSpain Shanghai Center for Plant Stress Biology CAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghai 201602China Institute of Insect Sciences Zhejiang UniversityHangzhou 310058China Departamento de Genética Molecular de Plantas Centro Nacional de Biotecnología‐Consejo Superior de Investigaciones CientíficasMadrid 28049Spain Department of Plant Biochemistry Centre for Plant Molecular BiologyEberhard Karls UniversityTübingen D‐72076Germany

Jasmonates(JAs) are phytohormones that finely regulate critical biological processes, including plant development and defense. JASMONATE ZIM-DOMAIN(JAZ) proteins are crucial transcriptional regulators that keep JA-responsive genes in a repressed state. In the presence of JA-Ile, JAZ repressors are ubiquitinated and targeted for degradation by the ubiquitin/proteasome system,allowing the activation of downstream transcription factors and, consequently, the induction of JA-responsive genes. A growing body of evidence has shown that JA signaling is crucial in defending against plant viruses and their insect vectors. Here, we describe the interaction of C2proteins from two tomato-infecting geminiviruses from the genus Begomovirus, tomato yellow leaf curl virus(TYLCV) and tomato yellow curl Sardinia virus(TYLCSaV), with the transcriptional repressor JAZ8 from Arabidopsis thaliana and its closest orthologue in tomato, SlJAZ9. Both JAZ and C2proteins colocalize in the nucleus, forming discrete nuclear speckles. Overexpression of JAZ8did not lead to altered responses to TYLCV infection in Arabidopsis;however, knock-down of JAZ8 favors geminiviral infection. Low levels of JAZ8 likely affect the viral infection specifically,since JAZ8-silenced plants neither display obvious developmental phenotypes nor present differences in their interaction with the viral insect vector. In summary, our results show that the geminivirus-encoded C2 interacts with JAZ8 in the nucleus, and suggest that this plant protein exerts an anti-geminiviral effect.

关键词： C2 protein geminivirus jasmonates JAZ8 transcriptional repressor TYLCV

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