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A multicenter prospective study on the management of hepatoblastoma in children:a report from the Chinese Children's Cancer Group

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World Journal of Pediatrics 2024年第6期20卷 590-601页

作者： Meng-Jie Tang Xiao-Li Ma Xiang-Ling He wei-Hua Pan Xiao-Hong Zhang Sha-Yi Jiang Ju Gao Fu Li wei Yao Song Gu wei-Ling Zhang Qiang Zhao Shi-Hao huang Yong-Jun Fang wei Liu Hui-Zhong Niu Chun-Mei Wang Li-rong Sun Hui Gao Yun-Peng Dai Shun-Gen huang Zhi-Yong Zhong Xi-Ge Wang Zhong-rong Li Liang-Chun Yang Ye-Ming Wu Huan-Min Wang Xin Sun Xiao-Jun Yuan Department of Pediatric Hematology/Oncology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineNo.1665Kongjiang RoadYangpu DistrictShanghai 200092China Medical Oncology Department Pediatric Oncology CenterBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China Department of Hematology/Oncology Children's Medical CenterHunan Provincial People's HospitalThe First Affiliated Hospital of Hunan Normal UniversityChangsha 41005China Department of Pediatric Surgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Hematology/Oncology Guangzhou Women and Children's Medical CenterNational Children's Medical Center for South Central RegionGuangzhou 510623China Department of Hematology Shanghai Children's HospitalShanghai Jiao Tong UniversityShanghai 200062China Department of Pediatrics West China Second University HospitalSichuan UniversityChengdu 610041China Department of Hematology/Oncology Qilu Children's Hospital of Shandong UniversityJinan 250022China Department of Pediatric Surgery Children's Hospital of Fudan UniversityShanghai 201102China Department of General Surgery Shanghai Children's Medical Center(National Children's Medical Center-Shanghai)Shanghai Jiao Tong University School of MedicineShanghai 200127China Department of Pediatrics Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Pediatric Oncology Tianjin Medical University Cancer Institute and HospitalTianjin 300060China Department of Hematology/Oncology Children's Hospital of Nanjing Medical UniversityNanjing 210008China Department of Hematology/Oncology Henan Children's HospitalZhengzhou 450018China Department of Pediatric General Surgery Hebei Children's Hospital of Hebei Medical UniversityShijiazhuang City 050031China Children's Hospital the First Affliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Paediatric

Background This study aimed to identify survival risk factors in Chinese children with hepatoblastoma(HB)and assess the effectiveness of the new treatment protocol proposed by the Chinese Children's Cancer Group(CCCG)in *** A multicenter,prospective study that included 399 patients with HB from January 2015 to June 2020 was *** demographics,treatment protocols,and other related information were *** regression models and Kaplan-Meier curve methods were *** The 4-year event-free survival(EFS)and overall survival(OS)were 76.9 and 93.5%,*** 4-year EFS rates for the very-low-risk,low-risk,intermediate-risk,and high-risk groups were 100%,91.6%,81.7%,and 51.0%,*** 4-year 0S was 100%,97.3%,94.4%,and 86.8%,*** regression analysis found that age,tumor rupture(R+),and extrahepatic tumor extension(E+)were independent prognostic factors.A total of 299 patients had complete remission,and 19 *** with declining alpha-fetoprotein(AFP)>75%after the first two cycles of neoadjuvant chemotherapy had a better EFS and OS than those≤75%.Conclusions The survival outcome of HB children has dramatically improved since the implementation of CCCG-HB-2016 ***≥8 years,R+,and E+were independent risk factors for *** with a declining AFP>75%after the first two cycles of neoadjuvant chemotherapy had better EFS and OS.

关键词： Alpha-fetoprotein Hepatoblastoma Multicenter Prospective study Survival

Structural effects of sulfonamides on the proliferation dynamics of sulfonamide resistance genes in the sequencing batch reactors and the mechanism

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Journal of Environmental Sciences 2024年第1期135卷 161-173页

作者： Ligui Wu Mingyu Wang Lingling rong Wenbiao Wang Linwei Chen Qiaofeng Wu Haoyu Sun Xiangfeng huang Xiaoming Zou College of Environmental Science and Engineering Tongji UniversityShanghai 200092China School of Life Science Jinggangshan UniversityJi’an 343009China Key Laboratory of Organic Compound Pollution Control Engineering(MOE) School of Environmental and Chemical EngineeringShanghai UniversityShanghai 200444China Fuzhou Urban and Rural Construction Group Co.Ltd. Fuzhou 350007China

Antibiotic resistance genes(ARGs)can be easily promoted by antibiotics,however,the structural effects of antibiotics on the proliferation of ARGs dynamic and the associated mechanisms remain obscure in,especially,activated sludge sequencing batch *** the present study,the effects of 9 sulfonamides(SAs)with different structures on the proliferation dynamic of sulfonamide resistance genes(Suls)in the activated sludge sequencing batch reactors and the corresponding mechanisms were determined(30 days),and the results showed that the largest proliferation value(ΔA^(R))of Suls dynamic for SAs(sulfachloropyridazine)was approximately 2.9 times than that of the smallest one(sulfadiazine).The proliferation of Suls was significantly related to the structural features(minHBint6,SssNH,SHBd and SpMax2_Bhm)that represent the biological activity of *** interpret the phenomenon,a mechanistic model was developed and the results indicated that the biodegradation of SAs(T_(1/2))rather than conjugative transfer frequency or mutation frequency tends to be the key process for affecting Suls proliferation.T_(1/2)was proved to be dependent on the interactions between SAs and receptors(E_(binding)),the cleavage mode(bond dissociation energy),and the site of nucleophilic ***,the metagenomic analysis showed that SAs posed significant effect on antibiotic resistome and Tnp31 played a vital role in the proliferation of ***,our findings provide important insight into a theoretical basis for understanding the structural effects of SAs on the proliferation of ARGs in SBR systems.

关键词： Activated sludge Sulfonamides Suls Proliferation Mechanism

GCGR:novel potential therapeutic target for chronic kidney disease

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Science China(Life Sciences) 2024年第7期67卷 1542-1544页

作者： Yan Hu Hao huang rong Xiang Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE State Key Laboratory of BiotherapyWest China Second University HospitalSichuan UniversityChengdu 610041China Department of Nephrology Xiangya Hospital Central South UniversityChangsha 410008China Department of Cell Biology School of Life SciencesCentral South UniversityChangsha 410013China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China Hunan Key Laboratory of Organ Fibrosis Central South UniversityChangsha 410013China

The kidney,a central regulator of systemic homeostasis essential for human health,plays a vital role in various metabolic pathways,including fatty acid metabolism,gluconeogenesis,glycolysis,and mitochondrial *** kidney disease(CKD)manifests as a progressive decline in renal function,marked by reduced glomerular filtration rate(GFR)or persistent kidney damage persisting for more than three months.

关键词： kidney metabolism homeostasis

Evolution of chemistry and selection technology for DNA-encoded library

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Acta Pharmaceutica Sinica B 2024年第2期14卷 492-516页

作者： Peixiang Ma Shuning Zhang Qianping huang Yuang Gu Zhi Zhou wei Hou wei Yi Hongtao Xu Shanghai Key Laboratory of Orthopedic Implants Department of OrthopedicsShanghai Ninth People’s HospitalShanghai Jiao Tong UniversitySchool of MedicineShanghai 200025China Shanghai Institute for Advanced Immunochemical Studies ShanghaiTech UniversityShanghai 201210China Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target&Clinical Pharmacology The NMPA and State Key Laboratory of Respiratory DiseaseGuangzhou Medical UniversityGuangzhou 511436China College of Pharmaceutical Science and Institute of Drug Development&Chemical Biology Zhejiang University of TechnologyHangzhou 310014China

DNA-encoded chemical library(DEL)links the power of amplifiable genetics and the nonself-replicating chemical phenotypes,generating a diverse chemical *** analogy with the biological world,the DEL world can evolve by using a chemical central dogma,wherein DNA replicates using the PCR reactions to amplify the genetic codes,DNA sequencing transcripts the genetic information,and DNA-compatible synthesis translates into chemical ***,DNA-compatible synthesis is the key to expanding the DEL chemical ***,the evolution-driven selection system pushes the chemicals to evolve under the selective pressure,i.e.,desired selection *** this perspective,we summarized recent advances in expanding DEL synthetic toolbox and panning strategies,which will shed light on the drug discovery harnessing in vitro evolution of chemicals via DEL.

关键词： DNA-encoded library Drug discovery High-throughput selection DNA-compatible synthesis In vitro evolution Chemical central dogma

Conservation genomics of the critically endangered Chinese pangolin

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Science China(Life Sciences) 2024年第10期67卷 2051-2061页

作者： Shichao wei Huizhong Fan Wenliang Zhou Guangping huang Yan Hua Shibao Wu Xiao wei Yiting Chen Xinyue Tan Fuwen wei Jiangxi Province Key Laboratory of Conservation Biology College of ForestryJiangxi Agricultural UniversityNanchang 330045China Center for Evolution and Conservation Biology Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)Guangzhou 511458China Institute of Zoology Chinese Academy of SciencesBeijing 100101China Guangdong Provincial Key Laboratory of Silviculture Protection and UtilizationGuangdong Academy of ForestryGuangzhou 510520China School of Life Science South China Normal UniversityGuangzhou 510631China Terrestrial Wildlife Rescue and Epidemic Diseases Surveillance Center of Guangxi Nanning 530003China

The Chinese pangolin(Manis pentadactyla,MP)has been extensively exploited and is now on the brink of extinction,but its population structure,evolutionary history,and adaptive potential are ***,we analyzed 94 genomes from three subspecies of the Chinese pangolin and identified three distinct genetic clusters(MPA,MPB,and MPC),with MPB further divided into MPB1 and MPB2 *** divergence of these populations was driven by past climate *** MPB2 and MPC,recent human activities have caused dramatic population decline and small population size as well as increased inbreeding,but not decrease in genomic variation and increase in genetic load probably due to strong gene flow;therefore,it is crucial to strengthen in situ habitat management for these two *** contrast,although human activities have a milder impact on MPA,it is at high risk of extinction due to long-term contraction and isolation,and genetic rescue is urgently ***1 exhibited a relatively healthy population status and can potentially serve as a source ***,our findings provide novel insights into the conservation of the Chinese pangolin and biogeography of the mammals of eastern Asia.

关键词： Manis pentadactyla conservation genomics demographic history human activities conservation strategies

Integrated multi-omics analysis reveals liver metabolic reprogramming by fish iridovirus and antiviral function of alpha-linolenic acid

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Zoological Research 2024年第3期45卷 520-534页

作者： Lin Liu Ya Zhang Meng-Di Yuan Dong-Miao Xiao wei-Hua Xu Qi Zheng Qi-wei Qin You-Hua huang Xiao-Hong huang College of Marine Sciences South China Agricultural UniversityGuangdong Laboratory for Lingnan Modern AgricultureGuangzhouGuangdong 510642China Nansha-South China Agricultural University Fishery Research Institute GuangzhouGuangdong 511464China Southern Marine Science and Engineering Guangdong Laboratory ZhuhaiGuangdong 519082China

Iridovirus poses a substantial threat to global aquaculture due to its high mortality rate;however,the molecular mechanisms underpinning its pathogenesis are not well ***,a multi-omics approach was applied to groupers infected with Singapore grouper iridovirus(SGIV),focusing on the roles of key *** showed that SGIV induced obvious histopathological damage and changes in metabolic enzymes within the ***,SGIV significantly reduced the contents of lipid droplets,triglycerides,cholesterol,and *** analysis indicated that the altered metabolites were enriched in 19 pathways,with a notable down-regulation of lipid metabolites such as glycerophosphates and alpha-linolenic acid(ALA),consistent with disturbed lipid homeostasis in the *** of transcriptomic and metabolomic data revealed that the top enriched pathways were related to cell growth and death and nucleotide,carbohydrate,amino acid,and lipid metabolism,supporting the conclusion that SGIV infection induced liver metabolic *** integrative transcriptomic and proteomic analysis indicated that SGIV infection activated crucial molecular events in a phagosome-immune depression-metabolism dysregulation-necrosis signaling *** note,integrative multi-omics analysis demonstrated the consumption of ALA and linoleic acid(LA)metabolites,and the accumulation of L-glutamic acid(GA),accompanied by alterations in immune,inflammation,and cell death-related *** experimental data showed that ALA,but not GA,suppressed SGIV replication by activating antioxidant and anti-inflammatory responses in the ***,these findings provide a comprehensive resource for understanding host response dynamics during fish iridovirus infection and highlight the antiviral potential of ALA in the prevention and treatment of iridoviral diseases.

关键词： Iridovirus Liver damage Metabolic reprogramming SGIV Alpha-linolenic acid Antiinflammatory

Nanodiamond/Ti_(3)C_(2) MXene-coated quartz crystal microbalance humidity sensor with high sensitivity and high quality factor

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Rare Metals 2024年第6期43卷 2719-2729页

作者： Yao Yao Qiao Chen Yan-Qi Li Xian-He huang wei-wei Ling Zhe-MiaoXie Jia-QiWang Chang-Ming Chen College of Communication Engineering Chengdu University of Information TechnologyChengdu 610225China School of Automation Chongqing University of Posts and TelecommunicationsChongqing 400065China School of Automation Engineering University of Electronic Science and Technology of ChinaChengdu 611731China Advanced Micro-/Nano-Devices Lab Department of Systems Design EngineeringUniversity of WaterlooWaterlooON N2L 3GlCanada

To address the challenge of achieving both high sensitivity and a high quality factor in quartz crystal microbalance(QCM)humidity sensors,a nanodiamond(ND)/Ti_(3)C_(2)MXene composite-coated QCM humidity sensor was *** material characteristics of ND,Ti_(3)C_(2)MXene,and ND/Ti_(3)C_(2)MXene composite were analyzed by transmission electron microscopy(TEM)and Fourier transform infrared(FTIR)*** experimental results demonstrated that the hydrophilic ND nanoparticles coated on Ti_(3)C_(2) MXene nanosheet prevented the self-stacking of Ti_(3)C_(2)MXene and enhanced the sensitivity of Ti_(3)C_(2) MXene-based QCM humidity ***,the high mechanical modulus of Ti_(3)C_(2) MXene material helped ND/Ti_(3)C_(2)MXene composite-coated QCM humidity sensor to achieve a high quality factor(>20,000).ND/Ti_(3)C_(2)MXene compositecoated QCM humidity sensor exhibited a sensitivity of 82.45 Hz/%RH,a humidity hysteresis of 1.1%RH,fast response/recovery times,acceptable repeatability,and good stability from 11.3%RH to 97.3%*** response mechanism of ND/Ti_(3)C_(2) MXene composite-coated QCM humidity sensor was analyzed in combination with a bi-exponential kinetic adsorption ***,the potential application of ND/Ti_(3)C_(2)MXene composite-coated QCM humidity sensor was demonstrated through its frequency response to wooden blocks with different moisture contents.

关键词： Humidity sensor Quartz crystal microbalance Nanodiamond Ti_(3)C_(2)MXene High quality factor

Study of baryon number transport dynamics and strangeness conservation effects using Ω-hadron correlations

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Nuclear Science and Techniques 2024年第7期35卷 147-156页

作者： wei-Jie Dong Xiao-Zhou Yu Si-Yuan Ping Xia-Tong Wu Gang Wang Huan-Zhong huang Zi-wei Lin Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Fudan UniversityShanghai 200433China Department of Physics and Astronomy University of CaliforniaLos AngelesCA 90095USA Department of Physics East Carolina UniversityGreenvilleNC 27858USA

In nuclear collisions at RHIC energies, an excess of Ω hyperons over ■ is observed, indicating that Ω has a net baryon number despite s and s quarks being produced in pairs. The baryon number in Ω may have been transported from the incident nuclei and/or produced in the baryon-pair production of Ω with other types of anti-hyperons such as Ξ. To investigate these two scenarios, we propose to measure the correlations between Ω and K and between Ω and anti-hyperons. We use two versions, the default and string-melting, of a multiphase transport(AMPT) model to illustrate the method for measuring the correlation and to demonstrate the general shape of the correlation. We present the Ω-hadron correlations from simulated Au+Au collisions at ■ =7.7 and 14.6 Ge V and discuss the dependence on the collision energy and on the hadronization scheme in these two AMPT versions. These correlations can be used to explore the mechanism of baryon number transport and the effects of baryon number and strangeness conservation on nuclear collisions.

关键词： Baryon number transport Strangeness conversation Correlation Gluon junction

Rapid surface texturing to achieve robust superhydrophobicity,controllable droplet impact,and anti-frosting performances

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Friction 2024年第2期12卷 291-304页

作者： Qingwen DAI Lei CHEN Jiabao PAN Liping SHI Dameng LIU wei huang Xiaolei WANG College of Mechanical and Electrical Engineering Nanjing University of Aeronautics&AstronauticsNanjing 210016China State Key Laboratory of Tribology in Advanced Equipment Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China School of Mechanical Engineering Anhui Polytechnic UniversityWuhu 241000China School of Mechanical Engineering Anhui University of TechnologyMa’anshan 243032China

Robust superhydrophobic surfaces with excellent capacities of repelling water and anti-frosting are of importance for many mechanical *** this work,wear-resistant superhydrophobic surfaces were fabricated by curing a mixture of polyurethane acrylate(PUA)coating and 1H,1H,2H,2H-Perfluorodecyltrichlorosilane(HFTCS)on titanium alloy(TC4)surfaces decorated with micropillars pattern,thus,composite functional surfaces with PUA coating in the valleys around the micropillars pattern of TC4 were *** contact angle on fabricated surfaces could reach 167°.Influences of the geometric parameters of micropillars pattern on the apparent contact angle were investigated,and the corresponding wear-resistant property was *** impact and anti-frosting performances on the prepared surfaces were *** optimized design of surface texture with robust superhydrophobicity,controllable droplet impact,and anti-frosting performances was *** design principle is of promising prospects for fabricating superhydrophobic surfaces in traditional mechanical systems.

关键词： surface texture robust superhydrophobic wear-resistant droplet impact anti-frosting