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Synthesis of New Ointment-like Poly(ortho esters)

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Chinese Chemical Letters 1997年第2期8卷 114-116页

作者： Zheng rong lu Jia Hui YU Ren Xi ZHUO.(Department of Chemistry, Wuhan University, Wuhan 430072) Department of Chemistry Wuhan University Wuhan 430072 China

Ointment-like poly(ortho esters) were synthesized from the reaction of 3,9-bis (methylene)-2,4,8,10-tetraoxaspiro[5.5]undecane with PEG-400,N,N-bis(2-hydroxyethyl)-n-hexadecylamine and N,N-bis(2-hydroxyethyl) palmitam... 详细信息

关键词： ppm CCH Synthesis of New Ointment-like Poly ortho esters OCH

Biliary stent combined with iodine-125 seed strand implantation in malignant obstructive jaundice

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World Journal of Clinical Cases 2021年第4期9卷 801-811页

作者： Hui-Wen Wang Xiao-Jing Li Shi-Jie Li Jun-rong lu Dong-Feng He Department of Interventional Harbin Medical University Cancer HospitalHarbin 150081Heilongjiang ProvinceChina

BACKGROUND Malignant obstructive jaundice is mainly caused by *** a few patients are indicated for surgical resection,and the 3-year survival rate is<50%.For patients who are not eligible for surgery,biliary stent pla... 详细信息

BACKGROUND Malignant obstructive jaundice is mainly caused by *** a few patients are indicated for surgical resection,and the 3-year survival rate isluate the safety and efficacy of biliary stent combined with 125I seed strand implantation in malignant obstructive *** We enrolled 67 patients between January 2016 and June 2018 with malignant obstructive jaundice and randomized them into a biliary stent combined with 125I seed strand treatment(combined)group(n=32)and biliary stent(control)group(n=35).All patients underwent enhanced computed tomography and magnetic resonance imaging and were tested for biochemical and cancer *** patients underwent pathological examination before *** patients were followed up by telephone or clinical *** liver function improvement,postoperative complications,stent patency time,and survival time were compared between the two *** risk factors were *** Technical success was achieved in all patients in both *** liver function improved significantly in all patients(total bilirubin,direct bilirubin,alanine aminotransferase,and aspartate aminotransferase decreased significantly in all patients,the P values were less than 0.05).There was no significant difference in preoperative or postoperative indexes between the two groups for changes in total bilirubin(P=0.147),direct bilirubin(P=0.448),alanine aminotransferase(P=0.120),and aspartate aminotransferase(P=0.387)between the two *** median stent patency time of the combined group was 9.0±1.4 mo[95%confidence interval(CI):6

关键词： Biliary stent 125I Obstructive jaundice Malignant tumor Clinical research Surgery

Novel Recombinant Seneca Valley Virus Isolated from Slaughtered Pigs in Guangdong Province

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Virologica Sinica 2019年第6期34卷 722-724页

作者： Jianxin Liu Yunfeng Zha Huizi Li Yanwei Sun Fuguang Wang rong lu Zhangyong Ning College of Veterinary Medicine South China Agricultural UniversityGuangzhou 510642China Center of Animal Diseases Control and Prevention in Guangdong Province Guangzhou 510230China

Dear Editor,Since the first outbreak in Brazil in 2015,Seneca Valley virus(SVV)associated with porcine idiopathic vesicular disease,has shown increasing geographic *** of SVV have been reported from several countries including the United States(US),Colombia,Thailand,Canada,and China(Pasma et al.2008;Zhang et al.2015;Sun et al.2017;Wu et al.2017;Liu et al.2018;Saeng-Chuto et al.2018).SVV was first identified in the US in 2002 and is the only member of the genus Senecavirus in the family Picomaviridae(Hales et al.2008;Leme et al.2017).The SVV genome contains a large open reading frame(ORF)encoding a polyprotein,which is cleaved into various mature viral proteins including the leader protein(L),structural proteins(VP1,VP2,VP3,and VP4),and non-structural proteins(2A,2B,2C,3A,3B,3C,and 3D)(Hales et al 2008).Structural proteins bind to their receptor,anthrax toxin receptor 1,to mediate viral invasion and stimulate specific immunity of the host(Jayawardena et al.2018).Non-structural proteins such as 3C suppress innate immune responses by degrading interferon regulatory factor 3(IRF 3)and IRF7 and inhibit the activation of RIG-1,TBK1,and TRAF3 through deubiquitination(Xue et al 2018).

关键词： Canada immunity invasion

Effects of attribution retraining on the perceived career barriers of undergraduate nursing students

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International Journal of Nursing Sciences 2015年第1期2卷 99-104页

作者： Mei-chun Wu Yan-ping Wu Yan-ping Wan Ying Zeng Xi-rong Tang lu-rong Wang School of Nursing University of South ChinaHengyangHunan421001China The First Hospital Affiliated to University of South China HengyangHunan421001China

Background/purpose:To evaluate the effects of attribution retraining on the perceived career barriers of undergraduate nursing students and to foster positive attributional ***:Ninety-four undergraduate nursing students were recruited and randomly divided into two groups:the attribution retraining group and the control *** students were assessed by the perceived career barriers inventory before and after the eight-week ***:Attribution retraining significantly influenced the students'perceived career *** mean scores of vocational knowledge,professional knowledge,and social ability of the experimental group were significantly reduced compared to the control group(plusion:Attribution retraining provides opportunities for improving the undergraduate nursing students'vocational knowledge,professional knowledge,and social *** retraining should be encouraged in undergraduate nursing programs in order to reduce the nursing shortage in China's Mainland.

关键词： Attribution retraining Nursing students Perceived career barriers

Systemic immune-inflammation index,neutrophilto-lymphocyte ratio,and platelet-to-lymphocyte ratio in patients with type 2 diabetes at different stages of diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 877-882页

作者： Ying Gao rong-Xin lu Yun Tang Xin-Yi Yang Hu Meng Chang-Lin Zhao Yi-lu Chen Feng Yan Qian Cao Department of Ophthalmology Sir Run Run HospitalNanjing Medical UniversityNanjing 211112Jiangsu ProvinceChina Department of Ophthalmology Affiliated Jinling HospitalMedical School of Nanjing UniversityNanjing 210002Jiangsu ProvinceChina Department of Thoracic Surgery the First Affiliated Hospital with Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina Medical School Nanjing UniversityNanjing 210093Jiangsu ProvinceChina Department of Ophthalmology Taikang Xianlin Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210046Jiangsu ProvinceChina

AIM:To investigate systemic immune-inflammation index(SII),neutrophil-to-lymphocyte ratio(NLR),and plateletto-lymphocyte ratio(PLR)levels in patients with type 2 diabetes at different stages of diabetic retinopathy(DR).METHODS:This retrospective study included 141 patients with type 2 diabetes mellitus(DM):45 without diabetic retinopathy(NDR),47 with non-proliferative diabetic retinopathy(NPDR),and 49 with proliferative diabetic retinopathy(PDR).Complete blood counts were obtained,and NLR,PLR,and SII were *** study analysed the ability of inflammatory markers to predict DR using receiver operating characteristic(ROC)*** relationships between DR stages and SII,PLR,and NLP were assessed using multivariate logistic ***:The average NLR,PLR,and SII were higher in the PDR group than in the NPDR group(P=0.011,0.043,0.009,respectively);higher in the NPDR group than in the NDR group(PluSION:The NLR,PLR,and SII may be used as predictors of DR.

关键词： diabetic retinopathy neutrophil-tolymphocyte ratio platelet-to-lymphocyte ratio systemic immune-inflammation index

A 95 GHz methanol emission survey toward eight small supernova remnants

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Research in Astronomy and Astrophysics 2017年第12期17卷 65-76页

作者： Ying-Jie Li Ye Xu Xi Chen Deng-rong lu Yan Sun Xin-Yu Du Zhi-Qiang Shen Purple Mountain Observatory Chinese Academy of SciencesNanjing 210008China University of Science and Technology of China Chinese Academy of SciencesHefei 230026China Center for Astrophysics Guangzhou UniversityGuangzhou 51006China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China University of the Chinese Academy of Sciences Beijing 100049China

We report on a 95 GHz（80-71A＋） methanol（CH3OH） emission survey with the Purple Mountain Observatory Delingha 13.7 m telescope. Eight supernova remnants（SNRs） with angular size〈10′ were observed, but emission was only detected in three SNRs near the Galactic center（Sgr A East,G 0.1–0.1 and G 359.92–0.09）. CH3OH emission mainly surrounds the SNRs and can be decomposed into nine spatial peaks with the velocity range of eight peaks being（-30, 70） km s-1, and the other is（70, 120） km s-1. They are probably excited by interaction with these SNRs and adjacent molecular gas in the central molecular zone（CMZ）, although star formation may play an important role in exciting CH3OH emission in some regions of CMZ. We infer that tidal action is unlikely to be an excitation source for CH3OH emission.

关键词： ISM:molecules ISM:supernova remnants Galaxy:center ISM:kinematics and dynamics ISM:clouds

Pterygial body epithelium domination of pterygial proliferation with TCF4 as a potential key factor

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International Journal of Ophthalmology(English edition) 2018年第9期11卷 1467-1474页

作者： Cong Nie Xin-Chun Zhang Si-Ying Xu Ya-Dan Quan Zhi-Xin Tang rong lu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen University Department of Prosthodontics Hospital of StomatologyGuangdong Provincial Key Laboratory of StomatologyGuanghua School of StomatologySun Yat-sen University

AIM： To characterize the proliferative capacity of pterygial epithelium in different regions（head, neck and body） of pterygium and explore the function of transcription factor 4（TCF4） in pterygium ***： Thirty pterygium tissues and 10 normal conjunctival tissues were obtained from Zhongshan Ophthalmic Center（ZOC） and Guangdong Eye Bank, respectively. Proliferative capacity of head, neck and body in pterygial epithelium was measured using clonal analysis, fold growth analysis and expression profile of proliferative markers revealed by immunofluorescent staining and real-time PCR. The expression of TCF4 was highlighted by double immunofluorescent staining with other proliferation related markers such as proliferating cell nuclear antigen（PCNA） and ATP-binding cassette subfamily G member 2（ABCG2）.RESULTS： The proliferative potential of pterygial epithelium was higher than that of normal conjunctival epithelium. High expression levels of proliferative markers（P63α, PCNA and ABCG2） in pterygial body epithelium were observed in immunofluorescent staining and real-time PCR（P〈0.05）. Also, epithelial cells isolated from pterygial body demonstrated higher proliferative capacity in clonal analysis and fold growth analysis, than those isolated from the head and neck regions. The TCF4 expression in pterygial epithelium was similar to other proliferative markers（P63α, PCNA and ABCG2）, as higher in pterygial body than head and neck. Moreover, TCF4 showed coexpression with other proliferation-related markers（PCNA and ABCG2） in the double immunofluorescent staining ***： The proliferative capacity in pterygial body epithelium is prominent than the head and neck regions, and upregulated TCF4 may be associated with enhanced proliferation in the pterygium.

关键词： pterygium epithelium proliferation transcription factor 4

Hyperprogression after anti-programmed death-1 therapy in a patient with urothelial bladder carcinoma:A case report

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World Journal of Clinical Cases 2023年第28期11卷 6841-6849页

作者： Hong-Yu Yang Yu-Xuan Du Yu-Jia Hou Dian-rong lu Peng Xue Department of Oncology Wangjing HospitalChina Academy of Chinese Medical SciencesBeijing 100000China Department of Oncology Tianjin University of Chinese MedicineTianjin 300000China Traditional Chinese Medical Science Tianjin University of Chinese MedicineTianjin 300000China

BACKGROUND Immune checkpoint inhibitors,including programmed death-ligand 1(PD-L1)and programmed death-1(PD-1)have recently been approved to treat locally advanced and metastatic urothelial carcinoma(UC).However,some patients experience rapid tumor progression rather than any clinical benefit from anti-PDL1/PD-1 *** SUMMARY A 73-year-old woman with bladder UC showed the progression of multiple metastases after surgery and chemotherapy for over 12 *** patient could not tolerate further ***-generation sequencing was performed,and the results indicated that the tumor mutational burden was 6.4 mutations/*** patient received the anti-PD-L1 agent toripalimab combined with albuminbound *** with the baseline staging before immunotherapy,the patient had a treatment failure time of50%,and a>2-fold increase in progression,indicating *** Selecting patients most likely to respond to treatment with immunotherapeutic agents remains *** older patients with advanced UC who have already exhausted multi-line chemotherapy options,immunotherapy should be used prudently if no effective biomarker is *** studies are required to clarify the causes and mechanisms of hyperprogression.

关键词： Bladder urothelial carcinoma Hyperprogression Immunotherapy Toripalimab Case report

Epigenetic modification regulates both expression of tumor-associated genes and cell cycle progressing in human colon cancer cell lines: Colo-320 and SW1116

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Cell Research 2004年第3期14卷 217-226页

作者： Jing Yuan FANG, Ying Xuan CHEN, Juan lu, rong lu, Li YANG, Hong Yin ZHU, Wei Qi GU, lun Gen lu Shanghai Institute of Digestive Disease, Renji Hospital Shanghai Second Medical University, Shanghai 200001, China. Shanghai Institute of Digestive Disease Renji Hospital Shanghai Second Medical University Shanghai China

The aim of this study is to assess the effects of DNA methylation and historic acetylation, alone or in combination, on the expression of several tumor-associated genes and cell cycle progression in two established human colon cancer cell lines: Colo-320 and SW1116. Treatments with 5-aza-2’-deoxycytidine (5-aza-dC) and trichostatin A, alone or in combination, were applied respectively. The methylation status of the CDKN2A promoter was determined by methyla-tion-specific PCR, and the acetylated status of the histones associated with the p21WAF1 and CDKN2A genes was examined by chromatin immunoprecipitation. The expression of the CDKN2A, p21WAF1, p53, p73, APC, c-myc, c-Ki-ras and survivin genes was detected by real-time RT-PCR and RT-PCR. The cell cycle profile was established by flow cytometry. We found that along with the demethylation of the CDKN2A gene promoter in both cell lines induced by 5-aza-dC alone or in combination with TSA, the expression of both CDKN2A and APC genes increased. The treatment

关键词： human colon cancer cell lines tumor-associated genes DNA methylation histone acetylation cell cycle.