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Laparoscopic hepatectomy reduces postoperative complications and hospital stay in overweight and obese patients

World Journal of Gastrointestinal Surgery 2021年第1期13卷 19-29页

作者： Daniel Heise Jan Bednarsch Andreas Kroh Sandra Schipper Roman Eickhoff Marielle Coolsen ronald van dam Sven Lang Ulf Neumann Florian Ulmer Department of Surgery and Transplantation University Hospital RWTH AachenAachen 52074Germany Department of Surgery Maastricht University Medical CenterMaastricht 6229 HXNetherlands

BACKGROUND Laparoscopic liver surgery is currently considered the standard of care for various liver ***,studies focusing on perioperative outcome after laparoscopic hepatectomy(LH)in overweight patients are still sparse and its benefit compared to open hepatectomy(OH)is a matter of *** To analyze postoperative outcomes in overweight[body mass index(BMI)over 25 kg/m²]and obese(BMI over 30 kg/m²)patients undergoing LH and compare postoperative outcome with patients undergoing *** Perioperative data of 68 overweight(BMI over 25 kg/m²)including a subcohort of obese(BMI over 30 kg/m²)patients(n=27)who underwent LH at our institution between 2015 and 2019 were retrospectively analyzed regarding surgical outcome and compared to an equal number of patients undergoing *** The mean BMI was 29.8±4.9 kg/m2 in the LH group and 29.7±3.6 kg/m2 in the OH group with major resections performed in 20.6%(LH)and 26.5%(OH)of cases,*** time(194±88 min vs 275±131 min;P<0.001)as well as intensive care(0.8±0.7 d vs 1.1±0.8 d;P=0.031)and hospital stay(7.3±3.6 d vs 15.7±13.5 d;P<0.001)were significant shorter in the LH ***,overall complications(20.6%vs 45.6%;P=0.005)and major complications(1.5%vs 14.7%,P=0.002)were observed less frequently after *** additional investigation analyzing the subgroup of obese patients who underwent LH(n=27)and OH(n=29)showed a shorter operative time(194±81 min vs 260±137 min;P=0.009)and a reduced length of hospitalization(7.7±4.3 d vs 17.2±17 d;P<0.001)but no difference in postoperative complications or overall *** LH is safe and cost-effective in overweight and obese ***,LH is significantly associated with fewer postoperative complications and reduced hospital stay compared to OH in these patients.

关键词： Laparoscopic hepatectomy Obesity Overweight Morbidity Postoperative outcome Cost

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胆道胆泥铸形物阻塞

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中国普通外科杂志 2015年第8期24卷 1065-1066页

作者： Stefan HEM.Clermonts ronald M.van dam 蔡权宇荷兰里赫特大学医学中心外科

62岁女性,因化脓性胆管炎来急诊科就诊。患者因结肠癌肝转移行左半肝切除,术后肝门区局部复发接受过放化疗。肝脏磁共振成像检查显示肝内多发液性区/脓肿,合并明显的肝内胆管扩张,因严重肝功能损伤接受了抗生素治疗和经皮穿刺引流。鉴... 详细信息

62岁女性,因化脓性胆管炎来急诊科就诊。患者因结肠癌肝转移行左半肝切除,术后肝门区局部复发接受过放化疗。肝脏磁共振成像检查显示肝内多发液性区/脓肿,合并明显的肝内胆管扩张,因严重肝功能损伤接受了抗生素治疗和经皮穿刺引流。鉴别诊断包括肿瘤局部复发或放疗后纤维化引起肝门区胆道梗阻。在治疗期间血清胆红素值不断上升。术中外科医生决定行胆肠吻合术。术中肝切开术后,见绿-褐色油灰状物质。胆管内大部分铸型被取出。

关键词：胆管阻塞铸形物黄疸胆管炎,化脓性

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Single-emitter super-resolved imaging of radiative decay rate enhancement in dielectric gap nanoantennas

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Light(Science & Applications) 2024年第1期13卷 47-54页

作者： R.Margoth Córdova-Castro Bart van dam Alberto Lauri Stefan A.Maier Riccardo Sapienza Yannick De Wilde Ignacio Izeddin Valentina Krachmalnicoff Institut Langevin ESPCI ParisPSL UniversityCNRSParisFrance The Blackett Laboratory Department of PhysicsImperial College LondonLondonUK School of Physics and Astronomy Monash UniversityClaytonVictoriaAustralia Chair in Hybrid Nanosystems Ludwig-Maximilians Universität MünchenMuenchenGermany Department of Physics University of OttawaOttawaONCanada

High refractive index dielectric nanoantennas strongly modify the decay rate via the Purcell effect through the design of radiative *** to their dielectric nature,the field is mainly confined inside the nanostructure and in the gap,which is hard to probe with scanning probe *** we use single-molecule fluorescence lifetime imaging microscopy(smFLIM)to map the decay rate enhancement in dielectric GaP nanoantenna dimers with a median localization precision of 14 *** measure,in the gap of the nanoantenna,decay rates that are almost 30 times larger than on a glass *** comparing experimental results with numerical simulations we show that this large enhancement is essentially radiative,contrary to the case of plasmonic nanoantennas,and therefore has great potential for applications such as quantum optics and biosensing.

关键词： dielectric decay radiative

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Quadruple[6]Helicene Featuring Pyrene Core:Unraveling Contorted Aromatic Core with Larger Effective Conjugation

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Precision Chemistry 2024年第9期2卷 488-494页

作者： Christopher Wallerius Otgonbayar Erdene-Ochir Eva van Doeselar ronald Alle Anh Tu Nguyen Marvin F.Schumacher Arne Lützen Klaus Meerholz Sai Ho Pun Department of Chemistry University of CologneCologne 50939Germany Kekulé-Institute of Organic Chemistry and Biochemistry University of BonnBonn 53121Germany Department of Chemistry Hong Kong University of Science and TechnologyClean Water BayHong KongChina

Multiple helicenes display distinct aromatic cores characterized by highly twisted rings that are shared or fused with constituent helicene *** these aromatic cores unlocks avenues for creating multiple helicenes with distinct properties and *** we report the synthesis of a quadruple[6]helicene featuring pyrene as the aromatic *** synthesis involved key steps of the annulativeπ-extension reaction and Scholl *** extending multiple helicenes along the axial direction,the degree of contortion of the aromatic core can be controlled from nearly flat to highly ***,quadruple[6]-helicene exhibits a significant red-shift of 0.49 eV compared to quadruple[4]-helicenes,of which the red-shift arises from bothπ-extension and augmented effective conjugation due to enhanced *** chemical calculations demonstrate that the degree of contortion in the pyrene core adeptly governs the energy levels of the HOMO and LUMO,which offers an alternative strategy beyond mere enlargement of theπ*** intriguing serendipitous finding reveals the formation of one-molecule-thick supramolecular homochiral nanosheets through selfinterlocking interactions of enantiomers in single crystals,a rare packing motif for multiple helicenes.

关键词： Helicenes Polycyclic aromatics Pyrene Core contortion Effective conjugation

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Balanced Monitoring of Flow Phenomena in Moving Mesh Methods

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Communications in Computational Physics 2010年第1期7卷 138-170页

作者： A.van dam P.A.Zegeling Department of Mathematics Utrecht UniversityP.O.Box 80.0103508 TA UtrechtThe Netherlands

Adaptive moving mesh research usually focuses either on analytical deriva-tions for prescribed solutions or on pragmatic solvers with challenging physical appli-cations. In the latter case, the monitor functions that steer mesh adaptation are oftendefined in an ad-hoc way. In this paper we generalize our previously used moni-tor function to a balanced sum of any number of monitor components. This avoidsthe trial-and-error parameter fine-tuning that is often used in monitor functions. Thekey reason for the new balancing method is that the ratio between the maximum andaverage value of a monitor component should ideally be equal for all *** as a monitor component is a good motivating example for this. Entropy alsoturns out to be a very informative monitor component. We incorporate the monitorfunction in an adaptive moving mesh higher-order finite volume solver with HLLCfluxes, which is suitable for nonlinear hyperbolic systems of conservation laws. Whenapplied to compressible gas flow it produces very sharp results for shocks and otherdiscontinuities. Moreover, it captures small instabilities (Richtmyer-Meshkov, Kelvin-Helmholtz). Thus showing the rich nature of the example problems and the effective-ness of the new monitor balancing.

关键词： Moving mesh method conservative interpolation balanced monitor function direc-tional adaptation hydrodynamics implosion problem

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Effects of turbulence on carbon emission in shallow lakes

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Journal of Environmental Sciences 2018年第7期30卷 166-172页

作者： Lin Zhu Boqiang Qin Jian Zhou Bryce van dam Wenqing Shi Taihu Lake Laboratory Ecosystem Station State Key Laboratory of Lake Science and Environment Nanjing Institute of Geography and Limnology Chinese Academy of Sciences Institute of Marine Sciences University of North Carolina at Chapel Hill Center for Eco-Environmental Research Nanjing Hydraulics Research Institute

Turbulent mixing is enhanced in shallow lakes. As a result, exchanges across the air–water and sediment–water interfaces are increased, causing these systems to be large sources of greenhouse gases. This study investigated the effects of turbulence on carbon dioxide（CO2）and methane（CH4） emissions in shallow lakes using simulated mesocosm *** demonstrated that turbulence increased CO2 emissions, while simultaneously decreasing CH4 emissions by altering microbial processes. Under turbulent conditions, a greater fraction of organic carbon was recycled as CO2 instead of CH4, potentially reducing the net global warming effect because of the lower global warming potential of CO2 relative to CH4. The CH4/CO2 flux ratio was approximately 0.006 under turbulent conditions, but reached 0.078 in the control. The real-time quantitative PCR analysis indicated that methanogen abundance decreased and methanotroph abundance increased under turbulent conditions, inhibiting CH4 production and favoring the oxidation of CH4 to *** findings suggest that turbulence may play an important role in the global carbon cycle by limiting CH4 emissions, thereby reducing the net global warming effect of shallow lakes.

关键词： Turbulence Carbon dioxide Methane Methanogen Methanotroph

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Building Expertise on FAIR Through Evolving Bring Your Own Data(BYOD) Workshops: Describing the Data, Software, and Management-focused Approaches and Their Evolution

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Data Intelligence 2024年第2期6卷 429-456页

作者： César H.Bernabé Lieze Thielemans Rajaram Kaliyaperumal Claudio Carta Shuxin Zhang Celia W.G.van Gelder Nirupama Benis Luiz Olavo Bonino da Silva Santos ronald Cornet Bruna dos Santos Vieira Nawel Lalout Ines Henriques Alberto Camara Ballesteros Kees Burger Martijn G.Kersloot Friederike Ehrhart Esther van Enckevort Chris T.Evelo Alasdair J.G.Gray Marc Hanauer Kristina Hettne Joep de Ligt Arnaldo Pereira Nuria Queralt-Rosinach Erik Schultes Domenica Taruscio Andra Waagmeester Mark D.Wilkinson Egon L.Willighagen Mascha Jansen Barend Mons Marco Roos Annika Jacobsen Biosemantics Group Department of Human GeneticsLeiden University Medical CentreLeidenThe Netherlands NIHR Academic Fellow in General Practice University College London and The Royal Free NHS Foundation Trust National Centre for Rare Diseases Istituto Superiore di SanitaRomeItaly Department of Medical Informatics Amsterdam UMC location University of AmsterdamMeibergdreef 9AmsterdamThe Netherlands Amsterdam Public Health Methodology&Digital HealthAmsterdamThe Netherlands Health-Rl UtrechtThe Netherlands Semantics Services and Cybersecurity groupUniversity of TwenteEnschedeThe Netherlands Department of Medical Imaging Radboud Institute for Health SciencesRadboud University Medical CenterNijmegenThe Netherlands Department of Medical BioSciences Radboud University Medical CenterNijmegenThe Netherlands The Duchenne Parent Project VeneendaalThe Netherlands Departamento de Biotecnologia-Biologia Vegetal Escuela Tecnica Superior de Ingenieria AgronomicaAlimentaria y de BiosistemasCentro de Biotecnologia y Genomica de PlantasUniversidad Politecnica de Madrid(UPM)-Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria-CSIC(INIA-CSIC).Campus MontegancedoPozuelo de Alarcon(Madrid)Spain Castor AmsterdamThe Netherlands Department of Bioinformatics-BiGCaT Maastricht UniversityMaastrichtThe Netherlands University Medical Center Groningen University of GroningenGroningenThe Netherlands Maastricht Centre for Systems Biology(MaCSBio) Maastricht UniversityMaastrichtThe Netherlands Department of Computer Science Heriot-Watt UniversityEdinburghUK INSERM US14-OrphanetPlateforme Maladies RaresParisFrance Centre for Digital Scholarship Leiden University LibrariesThe Netherlands Center for Molecular Medicine Cancer Genomics NetherlandsDepartment of GeneticsUniversity Medical Center UtrechtUniversity UtrechtThe Netherlands University of Aveiro DETI/IEETAAveiroPortugal GO FAIR Foundation LeidenThe Netherlands The Leiden Academic Center for Drug Research LeidenThe Netherlands Micel

Since 2014,"Bring Your Own Data"workshops(BYODs)have been organised to inform people about the process and benefits of making resources Findable,Accessible,Interoperable,and Reusable(FAIR,and the FAIRification process).The BYOD workshops'content and format differ depending on their goal,context,and the background and needs of ***-focused BYODs educate domain experts on how to make their data FAIR to find new answers to research ***-focused BYODs promote the benefits of making data FAIR and instruct project managers and policy-makers on the characteristics of FAIRification ***-focused BYODs gather software developers and experts on FAIR to implement or improve software resources that are used to support ***,these BYODs intend to foster collaboration between different types of stakeholders involved in data management,curation,and reuse(*** experts,trainers,developers,data owners,data analysts,FAIR experts).The BYODs also serve as an opportunity to learn what kind of support for FAIRification is needed from different communities and to develop teaching materials based on practical examples and *** this paper,we detail the three different structures of the BYODs and describe examples of early BYODs related to plant breeding data,and rare disease registries and biobanks,which have shaped the structure of the *** discuss the latest insights into making BYODs more productive by leveraging our almost ten years of training experience in these workshops,including successes and encountered ***,we examine how the participants'feedback has motivated the research on FAIR,including the development of workflows and software.

关键词： FAIR FAIRification FAIR expertise Bring Your Own Data Workshop BYOD

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A review on the best practices in concrete pavement design and materials in wet-freeze climates similar to Michigan

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Journal of Traffic and Transportation Engineering(English Edition) 2019年第3期6卷 245-255页

作者： Naser P. Sharifi Siyu Chen Zhanping You Thomas van dam Christopher Gilbertson Department of Civil and Environmental Engineering Michigan Technological University Houghton MI 49931 USA Nichols Consulting Engineers Chtd. Reno NV 89509 USA

The research presented in this paper aims to identify best practices of design and materials for concrete pavements in wet-freeze climates similar to the Michigan State. For the purposes of this paper, a best practice is a procedure that has been shown by field-validated research or experience to produce improved results and that is established or proposed as a standard suitable for widespread implementation. The local wet-freeze climate makes the requirements for Michigan's pavement system different from many other regions. Wetfreeze climates can result in various concrete pavement distress mechanisms such as thermally-induced cracking, freeze-thaw deterioration, accelerated cracking due to loss of support, frost heave, and material degradation. Therefore, appropriate procedures for design and material selection need to be selected to withstand high precipitation and freezing winter temperatures. Failure to take into account the climatic conditions may lead to inadequate or reduced pavement performance. However, utilizing appropriate techniques and materials could potentially improve the quality and increase the service life of the concrete pavement. Three design methods and five materials have been identified, and examples of their successful performance in wet-freeze climates are provided. In addition, the reasons that give them the superior performance in wet-freeze climates are discussed in detail.

关键词： Concrete pavements Pavement design Pavement materials Best practice Wet-freeze climate

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;he regulation of TGF-β/SMAD signaling by protein deubiquitination

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Protein & Cell 2014年第7期5卷 503-517页

作者： Juan Zhang Xiaofei Zhang Feng Xie Zhengkui Zhang Hans van dam Long Zhang Fangfang Zhou Life Sciences Institute Zhejiang University Hangzhou 310058 China Department of Molecular Cell Biology Cancer Genomics Centre Netherlands and Centre of Biomedical Genetics Leiden University Medical Center Postbus 9600 2300 RC Leiden The Netherlands

Transforming growth factor-β （TGF-β） members are key cytokines that control embryogenesis and tissue homeostasis via transmembrane TGF-β type II （TβR II） and type I （TβRI） and serine/threonine kinases receptors. Aberrant activation of TGF-β signaling leads to diseases, including cancer. In advanced cancer, the TGF-β/SMAD pathway can act as an oncogenic factor driving tumor cell invasion and metastasis, and thus is considered to be a therapeutic target. The activity of TGF-β/SMAD pathway is known to be regulated by ubiquitination at multiple levels. As ubiquitination is reversible, emerging studies have uncovered key roles for ubiquitin-removals on TGF-β signaling components by deubiquitinating enzymes （DUBs）. In this paper, we summarize the latest findings on the DUBs that control the activity of the TGF-β signaling pathway. The regula- tory roles of these DUBs as a driving force for cancer progression as well as their underlying working mech- anisms are also discussed.

关键词： TGF-β TβRI SMAD DUB ubiquitin deubiquitination

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地拉那金字塔

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世界建筑导报 2024年第4期39卷 121-125页

作者： ronald Hoogeveen Stavros Gargaretas Guido Boeters Angel Sanchez Navarro Boris Tikvarski Jasper van der Ven Mirco Facchinelli Manuel Magnaguagno Leo Stuckardt MVRDV

地拉那金字塔是一个新型的文化中心,位于阿尔巴尼亚首都的中心地带。地拉那金字塔最初是作为纪念共产主义者恩维尔·霍查(EnverHoxha)而建的博物馆,MVRDV对其进行了巨大的改造,现在的地拉那金字塔重新使用了混凝土结构,已经成为了一个... 详细信息

地拉那金字塔是一个新型的文化中心,位于阿尔巴尼亚首都的中心地带。地拉那金字塔最初是作为纪念共产主义者恩维尔·霍查(EnverHoxha)而建的博物馆,MVRDV对其进行了巨大的改造,现在的地拉那金字塔重新使用了混凝土结构,已经成为了一个新公园中的开放式雕塑。公园和雕塑中散布着一个个五颜六色的盒子,这些盒子散落在原来的建筑中及其周围,里面有咖啡馆、工作室、工作坊、创业办公室、孵化器、节庆活动,还有供阿尔巴尼亚青年免费学习各种技术和知识的教室。建筑倾斜的外墙还增加了台阶,让阿尔巴尼亚人民可以在这位前共产主义者的杰作上漫步。

关键词：工作坊金字塔节庆活动孵化器阿尔巴尼亚咖啡馆工作室混凝土结构

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