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Combined collision-induced dissociation and photo-selected reaction monitoring mass spectrometry modes for simultaneous analysis of coagulation factors and estrogens

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Journal of Pharmaceutical Analysis 2014年第3期4卷 183-189页

作者： Quentin Enjalbert Marion Girod Jérémy Jeudy Jordane Biarc Romain Simon rodolphe Antoine Philippe Dugourd Jér?me Lemoine Arnaud Salvador Université Lyon 1 CNRS Université de Lyon 69622 Villeurbanne cedexFrance Institut Lumière Matière UMR5306France Institut des Sciences Analytiques UMR 5280France

Oral estrogens are directly associated with changes in plasma levels of coagulation proteins. Thus, the detection of any variation in protein concentrations due to estrogen contraceptives, by a simultaneous analysis of both coagulation proteins and estrogens, would be a very informative tool. In the present study, the merit of photo-selected reaction monitoring （SRM）, a new analytical tool, was evaluated towards estrogens detection in plasma. Then, SRM and photo-SRM detection modes were combined for the simultaneous analysis of estrogen molecules together with heparin co-factor and factor XIIa, two proteins involved in the coagulation cascade. This study shows that photo-SRM could open new multiplexed analytical routes.

关键词： Estrogen Coagulation factorprotein Metabolite Photo-dissociation fragmentation SRM

Cross-Layer Energy Analysis and Proposal of a MAC Protocol for Wireless Sensor Networks Dedicated to Building Monitoring Systems

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Wireless Sensor Network 2013年第5期5卷 91-104页

作者： Denis Dessales Noel Richard Anne-Marie Poussard rodolphe Vauzelle Christophe Martinsons XLIM Laboratory SIC departmentUniversity of PoitiersPoitiersFrance Department of Health and Comfort Centre Scientifique et Technique du BatimentSt Martin d’HèresFrance

In a sustainable development context, the monitoring systems are essential to study the building energy performances. With the recent technology advances, these systems can be based on wireless sensor networks, where the energy efficiency is the main design challenge. To this end, most of the studies focus on low power Medium Access Control (MAC) protocols to reduce the overall energy consumption of a network. Nevertheless, the performances assessment of these protocols is generally not performed in a realistic way, and does not take into account the performances of the other layers of the OSI model. In this paper, we propose a cross-layer methodology to assess the real performances of a MAC protocol by taking into account the traffic volume, the synchronization losses and more particularly the physical layer performances through a Bit Error Rate (BER) criterion. The simulation results demonstrate clearly the physical layer impact on a sensor lifetime. Finally, the proposal of an energy efficient MAC protocol for a wireless sensor network dedicated to an application of building monitoring is proposed.

关键词： WSN Physical Layer MAC Layer Energy Consumption Cross-Layer Analysis

Content-Based Image Unequal Error Protection Strategies for an Open Loop MIMO System

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International Journal of Communications, Network and System Sciences 2012年第1期5卷 72-80页

作者： Rebeca Colda Clency Perrine Jean-Pierre Cances rodolphe Vauzelle Tudor Palade 不详

The paper deals with strategies for optimizing the transmission of JPEG2000 coded images over a MIMO quasi-static Rayleigh fading channel, by exploiting different available MIMO STBC (Space Time Block Codes), as well as the image content to be transmitted. The aim is to propose a link adaptation scheme based on the variable radio channel’s conditions, by establishing an UEP (Unequal Error Protection) scheme that leads to the best tradeoff between the robustness to errors and the image visual quality. Comparisons are made with the EEP (Equal Error Protection) case, in terms of the PSNR (Peak Signal to Noise Ratio) fidelity metric, as well as the subjective image quality.

关键词： EEP UEP MIMO STBCs JPEG2000 Wireless (JPWL)

Impact of body mass index on hepatocellular carcinoma recurrence after liver transplantation through long-term follow-up

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Hepatobiliary Surgery and Nutrition 2021年第5期10卷 598-609页

作者： Nada El-Domiaty Faouzi Saliba Vincent Karam rodolphe Sobesky Wafaa Ibrahim Eric Vibert Gabriella Pittau Khaled Amer Maysaa ASaeed Jihan AShawky Daniel Cherqui RenéAdam Didier Samuel AP-HP Hôpital Paul Brousse Hepato-Biliary CentreINSERM UMR 1193UniversitéParis SaclayVillejuifFrance Tropical Medicine Department Faculty of MedicineZagazig UniversityZagazigEgypt Statistics Department Faculty of Economics and Political ScienceCairo UniversityCairoEgypt Hepato-Biliary and Liver Transplant Department International Medical CenterCairoEgypt

Background:Obesity is associated with increased oncological risk and outcomes but the evidence surrounding the effect of body mass index(BMI)on increased risk of hepatocellular carcinoma(HCC)recurrence after liver transplantation(LT)is still *** purpose of this retrospective study of a large cohort of adult patients transplanted for HCC was to investigate the effect of BMI on the incidence of HCC recurrence and ***:Data from 427 adult recipients transplanted for HCC between 2000 and 2017 were *** were classified at time of LT according to the World Health Organization BMI classification into 3 groups;group 1:BMI<25(n=166),group 2:BMI 25-29.9(n=150)and group 3:BMI≥30(n=111).Results:There were no significant changes of mean BMI overtime 26.8±5.0 kg/m2 at time of LT and 28.8±23.1 at 5 *** recurrence rates of HCC after LT in the three groups were 19%,16%and 17%*** 5,10 and 15-year recurrence free survival(RFS)rates were respectively 68.6%,47.3%and 40.8%in group 1,73.3%,66.2%and 49.5%in group 2 and 68.8%,57.5%and 47.7%in group 3(log rank P=0.47).Conclusions:Recipient BMI at time of transplant and during follow-up didn’t impact the incidence of HCC recurrence nor long-term patient survival,irrespective to the status of the patients and their tumor characteristic at time of *** present study clearly confirms that obesity should not be considered,when selecting patients with HCC to LT,as a predictive factor of recurrence.

关键词： Hepatocellular carcinoma(HCC) obesity body mass index(BMI) nutrition liver transplantation(LT) hepatocellular carcinoma recurrence(HCC recurrence)

Expected outcomes and patients’selection before chemoembolization—“Six-and-Twelve or Pre-TACE-Predict”scores may help clinicians:Real-life French cohorts results

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World Journal of Clinical Cases 2021年第18期9卷 4559-4572页

作者： Xavier Adhoute Edouard Larrey rodolphe Anty Patrick Chevallier Guillaume Penaranda Albert Tran Jean-Pierre Bronowicki Jean-Luc Raoul Paul Castellani HervéPerrier Olivier Bayle Olivier Monnet Bernard Pol Marc Bourliere Department of Gastroenterology and Hepatology Hôpital Saint-JosephMarseille 13008France Department of Gastroenterology and Hepatology Hôpital Universitaire de l’ArchetNice 06000France Department of Radiology Hôpital Universitaire de l’ArchetNice 06000France Statistics Department AlphaBio LaboratoryMarseille 13003France Department of Gastroenterology and Hepatology Centre Hospitalo-Universitaire de NancyVandoeuvre les Nancy 54511France Department of Medical Oncology Institut de Cancérologie de l’OuestSite de NantesNantes 44805France Department of Radiology Hôpital Saint-JosephMarseille 13008France Department of Hepatobiliary Surgery Hôpital Saint-JosephMarseille 13008France

BACKGROUND Careful selection of hepatocellular carcinoma(HCC)patients prior to chemoembolization treatment is a daily reality,and is even more necessary with new available therapeutic options in *** propose two new models to better stratify patients and maximize clinical benefit:“6 and 12”and“pre/post-TACE-predict”(TACE,transarterial chemoembolization).METHODS We evaluated and compared their performance in predicting overall survival with other systems{Barcelona Clinic Liver Cancer(BCLC),Albumin-Bilirubin(ALBI)and NIACE[Number of tumor(s),Infiltrative HCC,alpha-fetoprotein,Child-Pugh(CP),and performance status]}in two HCC French cohorts of different stages enrolled between 2010 and *** The cohorts included 324 patients classified as BCLC stages A/B(cohort 1)and 137 patients classified as BCLC stages B/C(cohort 2).The majority of the patients had cirrhosis with preserved liver function.“Pre-TACE-predict”and“6 and 12”models identified three distinct categories of patients exhibiting different prognosis in cohort ***,their prognostic value was no better than the BCLC system or NIACE *** function based on CP and ALBI grades significantly impacted patient ***,the“post-TACE-predict”model had a higher predictive value than other *** stratification ability as well as predictive performance of these new models in an intermediate/advanced stage population was less efficient(cohort 2).CONCLUSION The newly proposed“Pre-TACE-predict”and“6 and 12”models offer an interesting stratification into three categories in a recommended TACE population,as they identify poor candidates,those with partial control and durable *** models'contribution was reduced in a population with advanced stage HCCs.

关键词： Hepatocellular carcinoma Transarterial chemoembolization Pre-TACEpredict Six-and-twelve Barcelona Clinic Liver Cancer Prognosis

Adsorption and desorption phenomena on thermally annealed multi-walled carbon nanotubes by XANES study

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Chinese Physics B 2019年第9期28卷 145-149页

作者： Camile rodolphe Tchenguem Kamto Bridinette Thiodjio Sendja Jeannot Mane Mane University of Yaounde Ⅰ Faculty of ScienceDepartment of PhysicsYaoundeCameroon University of Yaounde Ⅰ National Advanced School of EngineeringDepartment of Mathematic and Physical ScienceYaoundeCameroon University of Dschang DschangCameroon

The multi-walled carbon nanotubes(MWCNTs) studied in this work were synthesized by the catalytic chemical vapor deposition(CCVD) process, and were thermally annealed by the hot filament plasma enhanced(HF PE) method at 550℃ for two *** x-ray absorption near edge structure(XANES) technique was used to investigate the adsorption and desorption phenomena of the MWCNTs at normal and grazing incidence *** adsorbates were found to have different sensitivities to the thermal *** geometry of the incident beam consistently gave information about the adsorption and desorption *** addition, the adsorption of non-intrinsic potassium quantitatively affected the intrinsic adsorbates and contributed to increase the conductivity of the *** desorption of potassium was almost 70% greater after the thermal *** potassium non-intrinsic adsorbates are from a physisorption mechanism whereas the intrinsic adsorbates result from chemisorption.

关键词： multi-walled carbon nanotubes thermal annealing adsorption desorption

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剥蚀对活动逆冲断层地震活动性的影响

地壳构造与地壳应力 2018年第1期5卷 23-32页

作者： Philippe Steer Martine Simoes rodolphe Cattin J.Bruce H.Shyu 王璞(翻译) 黄禄渊(校对) Geosciences Rennes Universite Rennes 1 and CNRS UMR 6118RennesFrance Institut de Physique du Globe de Paris Sorbonne Paris CiteUniversity Paris DiderotUMR 7154 CNRSF-75005 ParisFrance Geosciences Montpellier Universite Montpellier Ⅱ and CNRS UMR 5243France Department of Geosciences National Taiwan UniversityTaipei 10617Taiwan 不详

评估地震危害仍然是地球科学中最具挑战性的科学问题之一。经典理论认为深部构造运动是驱动地震活动断层上的应力持续加载的唯一机制。这里我们通过一个力学模型显示,在一个地震周期的时间范围内,剥蚀也会显著影响逆冲断层的应力加载。... 详细信息

评估地震危害仍然是地球科学中最具挑战性的科学问题之一。经典理论认为深部构造运动是驱动地震活动断层上的应力持续加载的唯一机制。这里我们通过一个力学模型显示,在一个地震周期的时间范围内,剥蚀也会显著影响逆冲断层的应力加载。事实上,例如台湾和其他活动逆冲造山带约0.1~20mm/a的剥蚀率就可以将震中附近的逆冲断层的库仑应力提高约0.1~10bar。在连续的或短暂和强烈的地震过程中,地表所发生的物质转移是地表附近断层的震间应力加载的主要机制。这种应力可能足以引发浅层地震活动或促进大陆深部地震的破裂一直延续到地表。

关键词：地震活动性逆冲断层剥蚀率库仑应力深部地震科学问题地球科学地震危害

“Six-and-twelve” score for outcome prediction of hepatocellular carcinoma following transarterial chemoembolization. In-depth analysis from a multicenter French cohort

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World Journal of Hepatology 2020年第8期12卷 525-532页

作者： Xavier Adhoute Guillaume Pénaranda Jean-Luc Raoul Jean-Pierre Bronowicki rodolphe Anty MarcBourlière Department of Gastroenterology and Hepatology Hôpital Saint-JosephMarseille 13008France AlphaBio Laboratory Marseille 13003France Department of Medical Oncology Institut de Cancérologie de l'OuestNantes 44805France Department of Gastroenterology and Hepatology Centre Hospitalo-Universitaire deNancy 54511France Department of Gastroenterology and Hepatology Hôpital Universitaire de l’ArchetNice 06200France

The“six-and-twelve”(6&12)score is a new hepatocellular carcinoma(HCC)prognostic index designed for recommended transarterial chemoembolization(TACE)*** and easy to use by the sum of tumor size(cm)and number,this model identifies three groups with different survival time(the sum is≤6;or>6 but≤12;or>12);a survival benefit with TACE can be expected for HCC patients with a score not exceeding ***,Wang ZW et al showed that the“6&12”model was the best system correlated with radiological response after the first ***,we wanted to assess its survival prediction ability as well as its prognostic value and compared it to other systems(Barcelona Clinic Liver Cancer,Hong Kong Liver Cancer(HKLC)staging,Albumin-Bilirubin grade,tumor nodularity,infiltrative nature of the tumor,alpha-fetoprotein,Child-Pugh class,and Performance Status score,Cancer of the Liver Italian Program,Model to Estimate Survival for HCC scores,up-to-seven criteria)different from Wang ZW et al study in a multicenter French cohort of HCC including only recommended TACE candidates retrospectively *** previously demonstrated,we show that the"6&12”score can classify survival within this French cohort,with a prognostic value comparable to that of other systems,except HKLC *** importantly,the“6&12”score simplicity and ability in patients’stratification outperform other systems for a routine clinical practice.

关键词： Hepatocellular carcinoma Transarterial chemoembolization “Six-and-twelve”score Prognosis Albumin-Bilirubin grade Tumor nodularity,infiltrative nature of the tumor,alpha-fetoprotein,Child-Pugh class,and performance status score

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大位阻二茂铁盐单分子磁体性质研究

大位阻二茂铁盐单分子磁体性质研究