“Six-and-twelve” score for outcome prediction of hepatocellular carcinoma following transarterial chemoembolization. In-depth analysis from a multicenter French cohort

作     者：Xavier Adhoute Guillaume Pénaranda Jean-Luc Raoul Jean-Pierre Bronowicki Rodolphe Anty MarcBourlière 

作者机构：Department of Gastroenterology and HepatologyHôpital Saint-JosephMarseille 13008France AlphaBio LaboratoryMarseille 13003France Department of Medical OncologyInstitut de Cancérologie de l'OuestNantes 44805France Department of Gastroenterology and HepatologyCentre Hospitalo-Universitaire deNancy 54511France Department of Gastroenterology and HepatologyHôpital Universitaire de l’ArchetNice 06200France 

出 版 物：《World Journal of Hepatology》 (世界肝病学杂志（英文版）（电子版）)

年 卷 期：2020年第12卷第8期

页      面：525-532页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Hepatocellular carcinoma Transarterial chemoembolization “Six-and-twelve”score Prognosis Albumin-Bilirubin grade Tumor nodularity,infiltrative nature of the tumor,alpha-fetoprotein,Child-Pugh class,and performance status score 

摘      要：The“six-and-twelve(6&12)score is a new hepatocellular carcinoma(HCC)prognostic index designed for recommended transarterial chemoembolization(TACE)*** and easy to use by the sum of tumor size(cm)and number,this model identifies three groups with different survival time(the sum is≤6;or6 but≤12;or12);a survival benefit with TACE can be expected for HCC patients with a score not exceeding ***,Wang ZW et al showed that the“6&12model was the best system correlated with radiological response after the first ***,we wanted to assess its survival prediction ability as well as its prognostic value and compared it to other systems(Barcelona Clinic Liver Cancer,Hong Kong Liver Cancer(HKLC)staging,Albumin-Bilirubin grade,tumor nodularity,infiltrative nature of the tumor,alpha-fetoprotein,Child-Pugh class,and Performance Status score,Cancer of the Liver Italian Program,Model to Estimate Survival for HCC scores,up-to-seven criteria)different from Wang ZW et al study in a multicenter French cohort of HCC including only recommended TACE candidates retrospectively *** previously demonstrated,we show that the6&12score can classify survival within this French cohort,with a prognostic value comparable to that of other systems,except HKLC *** importantly,the“6&12score simplicity and ability in patients’stratification outperform other systems for a routine clinical practice.