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Neural Regeneration Research 2014年第10期9卷 1025-1030页

作者： Luigi Aloe Patrizia Bianchi Alberto De Bellis Marzia Soligo Maria Luisa rocco Cellular Biology and Neurobiology Institute National Research Council(CNR) Maria Rosaria Maglione Foundation Onlus NapoliItaly Intitute of Translational Pharmacology National Research Council(CNR)

The purpose of this work was to investigate whether, by intranasal administration, the nerve growth factor bypasses the blood-brain barrier and turns over the spinal cord neurons and if such therapeutic approach could be of value in the treatment of spinal cord injury. Adult Sprague-Dawley rats with intact and injured spinal cord received daily intranasal nerve growth factor administration in both nostrils for 1 day or for 3 consecutive weeks. We found an in-creased content of nerve growth factor and enhanced expression of nerve growth factor receptor in the spinal cord 24 hours after a single intranasal administration of nerve growth factor in healthy rats, while daily treatment for 3 weeks in a model of spinal cord injury improved the deifcits in locomotor behaviour and increased spinal content of both nerve growth factor and nerve growth factor receptors. These outcomes suggest that the intranasal nerve growth factor bypasses blood-brain barrier and affects spinal cord neurons in spinal cord injury. They also suggest exploiting the possible therapeutic role of intranasally delivered nerve growth factor for the neuroprotection of damaged spinal nerve cells.

关键词： nerve regeneration spinal cord injury nerve growth factor intranasal delivery blood-brain barrier motor function leptin neuroprotection rats neural regeneration

Large Brunner's gland adenoma:Case report and literature review

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World Journal of Gastroenterology 2006年第12期12卷 1966-1968页

作者： Alba rocco PasqualeBorriello Debora Compare Patrizia DeColibus LoredanaPica GerardoNardone Alessandro Iacono Department University"Federico Ⅱ" NaplesItaly

Brunner＇s gland adenoma （BGA） is a very rare benign tumour of the duodenum, which is usually asymptomatic and discovered incidentally at endoscopy. Occasionally, this lesion may be large, causing upper gastrointestinal haemorrhage or intestinal obstruction. The case had a large Brunner＇s gland adenoma, presenting melena that was managed by endoscopic excision.

关键词： Brunner's gland adenoma Endoscopic resection Giant brunneroma

Selective Gold Deposition on a Nanostructured Block Copolymer Film Crystallized by Epitaxy

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Nano Research 2011年第3期4卷 241-248页

作者： Claudio De Rosa Finizia Auriemma rocco Di Girolamo Rossella Aprea Annette Thierry Dipartimento di Chimica ＂P. Corradini＂ Universit~t di Napoli ＂Federico II＂ Complesso Monte S. Angelo Via Cintia 80126 Napoli Italy Institut Charles Sadron University de Strasbourg CNRS-UPR 22 B. E 84047 23 rue du Loess 67034 Strasbourg France

An ordered nanostructure formed by epitaxial crystallization of a semicrystalline block copolymer on a substrate has been used as a patterned template for the selective deposition of thermally evaporated gold nanoparticles, resulting in the formation of structure-guiding host nanocomposites in which the ordered distribution of the guest particles is guided by the ordering of the host nanostructured block copolymer matrix. This opens new perspectives in the field of polymeric composites related to the maximum enhancement of effective physical properties and to the numerous possible applications that arise due to the presence of long-range order in the spatial distribution of functional nanoparticles.

关键词： Crystalline block copolymers nanostructures nanocomposites gold deposition

Magnesium:pathophysiological mechanisms and potential therapeutic roles in intracerebral hemorrhage

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Neural Regeneration Research 2019年第7期14卷 1116-1121页

作者： Jason J.Chang rocco Armonda Nitin Goyal Adam S.Arthur Department of Critical Care Medicine MedStar Washington Hospital Center Department of Neurology Georgetown University School of Medicine Department of Neurosurgery Georgetown University School of Medicine Department of Neurology University of Tennessee Health Science Center Semmes Murphey Clinic Department of Neurosurgery University of Tennessee Health Science Center

Intracerebral hemorrhage(ICH) remains the second-most common form of stroke with high morbidity and *** can be divided into two pathophysiological stages:an acute primary phase,including hematoma volume expansion,and a subacute secondary phase consisting of blood-brain barrier disruption and perihematomal edema *** date,all major trials for ICH have targeted the primary phase with therapies designed to reduce hematoma expansion through blood pressure control,surgical evacuation,and ***,none of these trials has resulted in improved clinical *** is a ubiquitous element that also plays roles in vasodilation,hemostasis,and blood-brain barrier *** models have highlighted potential therapeutic roles for magnesium in neurological diseases specifically targeting these pathophysiological *** studies have also demonstrated inverse associations between admission magnesium levels and hematoma volume,hematoma expansion,and clinical outcome in patients with *** associations,coupled with the multifactorial role of magnesium that targets both primary and secondary phases of ICH,suggest that magnesium may be a viable target of study in future ICH studies.

关键词： intracerebral hemorrhage stroke,magnesium vasodilation hemostasis blood-brain barrier perihematomal edema

Role of negative affects in pathophysiology and clinical expression of irritable bowel syndrome

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World Journal of Gastroenterology 2014年第24期20卷 7570-7586页

作者： Maria Rosaria A Muscatello Antonio Bruno Giuseppe Scimeca Gianluca Polfo rocco A Zoccali Psychiatry Unit Department of NeurosciencesUniversity of Messina98125 MessinaItaly

Irritable bowel syndrome(IBS)is regarded as a multifactorial disease in which alterations in the brain-gut axis signaling play a major *** biopsychosocial model applied to the understanding of IBS pathophysiology assumes that psychosocial factors,interacting with peripheral/central neuroendocrine and immune changes,may induce symptoms of IBS,modulate symptom severity,influence illness experience and quality of life,and affect *** present review focuses on the role of negative affects,including depression,anxiety,and anger,on pathogenesis and clinical expression of *** potential role of the autonomic nervous system,stress-hormone system,and immune system in the pathophysiology of both negative affects and IBS are taken into *** comorbidity and subclinical variations in levels of depression,anxiety,and anger are further discussed in relation to the main pathophysiological and symptomatic correlates of IBS,such as sensorimotor functions,gut microbiota,inflammation/immunity,and symptom reporting.

关键词： Depression Anxiety Anger Mood disorders Irritable bowel syndrome Neuroticism Stress Brain-gut axis Microbiota Hypothalamic-pituitary-adrenal axis

Alcoholic disease: Liver and beyond

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World Journal of Gastroenterology 2014年第40期20卷 14652-14659页

作者： Alba rocco Debora Compare Debora Angrisani Marco Sanduzzi Zamparelli Gerardo Nardone Gastroenterology Unit Department of Clinical Medicine and Surgery University Federico Ⅱ of Naples 80131 Naples Italy

The harmful use of alcohol is a worldwide problem. It has been estimated that alcohol abuse represents the world’s third largest risk factor for disease and disability; it is a causal factor of 60 types of diseases and injuries and a concurrent cause of at least 200 others. Liver is the main organ responsible for metabolizing ethanol, thus it has been considered for long time the major victim of the harmful use of alcohol. Ethanol and its bioactive products, acetaldehyde-acetate, fatty acid ethanol esters, ethanol-protein adducts, have been regarded as hepatotoxins that directly and indirectly exert their toxic effect on the liver. A similar mechanism has been postulated for the alcohol-related pancreatic damage. Alcohol and its metabolites directly injure acinar cells and elicit stellate cells to produce and deposit extracellular matrix thus triggering the “necrosis-fibrosis” sequence that finally leads to atrophy and fibrosis, morphological hallmarks of alcoholic chronic pancreatitis. Even if less attention has been paid to the upper and lower gastrointestinal tract, ethanol produces harmful effects by inducing: (1) direct damaging of the mucosa of the esophagus and stomach; (2) modification of the sphincterial pressure and impairment of motility; and (3) alteration of gastric acid output. In the intestine, ethanol can damage the intestinal mucosa directly or indirectly by altering the resident microflora and impairing the mucosal immune system. Notably, disruption of the intestinal mucosal barrier of the small and large intestine contribute to liver damage. This review summarizes the most clinically relevant alcohol-related diseases of the digestive tract focusing on the pathogenic mechanisms by which ethanol damages liver, pancreas and gastrointestinal tract.

关键词： Alcoholic liver disease Alcoholic pancreatitis Alcohol and gastrointestinal tract

A technique for promoting detonation transmission from a confined tube into larger area for pulse detonation engine applications

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Propulsion and Power Research 2014年第1期3卷 9-14页

作者： Navid Mehrjoo rocco Portaro Hoi Dick Ng Department of Mechanical and Industrial Engineering Concordia UniversityMontréalQCH3G 1M8Canada

A simple method of detonation transmission from a small tube to a large area is *** technique involves placing obstacles which create slight blockages at the exit of the confined tube before the planar detonation emerges into the larger space,thereby generating flow instability to promote the detonation *** this experimental study two mixtures of undiluted stoichiometric acetylene-oxygen and acetylene-nitrous oxide are *** mixtures can be characterized by a cellular detonation front that is irregular and representative of those potentially used in practical aerospace *** blockage ratio imposed by the obstacles is varied systematically to identify the optimal condition under which a significant reduction in critical pressure for transmission can be obtained.A new perturbation configuration for practical use in propulsion and power systems is also introduced and results are in good agreement with those obtained using thin needles as the blockage ratio is kept constant.

关键词： Combustion Detonation Pulse detonation engines Diffraction Perturbation Reactive flow

Personality traits and emotional patterns in irritable bowel syndrome

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World Journal of Gastroenterology 2016年第28期22卷 6402-6415页

作者： Maria Rosaria A Muscatello Antonio Bruno Carmela Mento Gianluca Pandolfo rocco A Zoccali Psychiatry Unit Department of Biomedical and Dental Sciences and Morphofunctional Imaging University of Messina

The review focuses on those personality traits(neuroticism, extraversion, openness to experience, agreeableness, and conscientiousness), constructs(alexithymia and distressed- Type D personality) and emotional patterns(negative and positive) that are of particular concern in health psychology, with the aim to highlight their potential role on the pathogenesis, onset, symptom clusters, clinical course, and outcome of irritable bowel syndrome(IBS). Personality traits and emotional patterns play key roles in affecting autonomic, immune, inflammatory, and endocrine functions, thus contributing not only to IBS clinical expression and symptomatic burden, but also to disease physiopathology. In this sense, psychological treatments should address those personality traits and emotional features that are constitutive of, and integral to IBS. The biopsychosocial model of illness applied to IBS acknowledges the interaction between biological, psychological, environmental, and social factors in relation to pain and functional disability. A holistic approach to IBS should take into account the heterogeneous nature of the disorder, and differentiate treatments for different types of IBS, also considering the marked individual differences in prevalent personality traits and emotional patterns. Beyond medications, and lifestyle/dietary interventions, psychological and educational treatments may provide the optimal chance of addressing clinical symptoms, comorbid conditions, and quality of life in IBS patients.

关键词： Alexithymia Depression Anxiety Anger Conscientiousness Irritable bowel syndrome Emotions Personality Neuroticism Extraversion

Active suspension in railway vehicles:a literature survey

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Railway Engineering Science 2020年第1期28卷 3-35页

作者： Bin Fu rocco Libero Giossi Rickard Persson Sebastian Stichel Stefano Bruni Roger Goodall Dipartimento di Meccanica Politecnico di MilanoMilanItaly Division of Rail Vehicles KTH Royal Institute of TechnologyStockholmSweden Institute of Railway Research University of HuddersfieldHuddersfieldUK

Since the concept of active suspensions appeared,its large possible benefits has attracted continuous exploration in the field of railway *** new demands of higher speed,better ride comfort and lower maintenance cost for railway vehicles,active suspensions are very promising *** the starting point of commercial application of active suspensions in rail vehicles,tilting trains have become a great success in some *** increased technical maturity of sensors and actuators,active suspension has unprecedented development *** this work,the basic concepts are summarized with new theories and solutions that have appeared over the last *** studies and the implementation status of different active suspension technologies are described as ***,tilting trains are briefly ***,an indepth study for active secondary and primary suspensions is *** both topics,after an introductory section an explanation of possible solutions existing in the literature is *** implementation status is *** secondary suspensions are categorized into active and semi-active *** suspensions are instead divided between acting on solid-axle wheelsets and independently rotating ***,a brief summary and outlook is presented in terms of benefits,research status and *** potential for active suspensions in railway applications is outlined.

关键词： Active suspension Railway vehicle Mechatronics Control Active primary suspension Active secondary suspension

Retrobulbar administration of purified anti-nerve growth factor in developing rats induces structural and biochemical changes in the retina and cornea

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International Journal of Ophthalmology(English edition) 2021年第2期14卷 209-216页

作者： Luigi Aloe Maria Luisa rocco Bijorn Omar Balzamino Graziana Esposito Alessandra Micera Institute of Cell Biology and Neurobiology CNRLazio 00143RomeItaly Fondazione IRET Ozzano EmiliaBologna 40064Italy Institute of Translational Pharmacology CNRLazio 00133RomeItaly Research and Development Laboratory for Biochemical Molecular and Cellular Applications in Ophthalmological ScienceIRCCSFondazione BiettiRome 00182Italy

AIM:To develop an experimental model of endogenous nerve growth factor(NGF)deprivation by retrobulbar administration of purified neutralizing anti-NGF antibodies in young Sprague-Dawley rats and provide further information on NGF expression in the retina and ***:Sixty old pathogen-free Sprague Dawley rats(p14,post-natal days)were treated with repeated retrobulbar injections of neutralizing anti-NGF(2μL,100μg/m L,every 3 d).After 2 wk(p28),retinal and corneal tissues were investigated for morphological,biochemical,and molecular expression of trkANGFR by using Western blotting or *** as well as protein profile expression were also ***:Chronic retrobulbar neutralizing anti-NGF antibodies changed the distribution of trkANGFR immunoreactivity at retinal level,while no changes were detected for global trkANGFR protein *** contrary,the treatment resulted in the increase of corneal trkANGFR *** tissues showed a decreased rhodopsin expression as well as reduced number of both rhodopsin expressing and total retinal cells,as observed after single cell extraction.A decreased expression of ICAM-1,IL-17 and IL-13 as well as an increased expression of IL-21 typified retinal *** significant changes were observed for corneal ***:The reduced availability of endogenous NGF,as produced by chronic retrobulbar anti-NGF administration,produce a quick response from retinal tissues,with respect to corneal ones,suggesting the presence of early compensatory mechanisms to protect retinal networking.

关键词： anti-nerve growth factor trk^(ANGFR) retina cornea photoreceptors tissue response