Magnesium:pathophysiological mechanisms and potential therapeutic roles in intracerebral hemorrhage

作     者：Jason J.Chang Rocco Armonda Nitin Goyal Adam S.Arthur 

作者机构：Department of Critical Care MedicineMedStar Washington Hospital Center Department of NeurologyGeorgetown University School of Medicine Department of NeurosurgeryGeorgetown University School of Medicine Department of NeurologyUniversity of Tennessee Health Science Center Semmes Murphey Clinic Department of NeurosurgeryUniversity of Tennessee Health Science Center 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2019年第14卷第7期

页      面：1116-1121页

核心收录：

学科分类：10[医学] 

主　　题：intracerebral hemorrhage stroke,magnesium vasodilation hemostasis blood-brain barrier perihematomal edema 

摘      要：Intracerebral hemorrhage(ICH) remains the second-most common form of stroke with high morbidity and *** can be divided into two pathophysiological stages:an acute primary phase,including hematoma volume expansion,and a subacute secondary phase consisting of blood-brain barrier disruption and perihematomal edema *** date,all major trials for ICH have targeted the primary phase with therapies designed to reduce hematoma expansion through blood pressure control,surgical evacuation,and ***,none of these trials has resulted in improved clinical *** is a ubiquitous element that also plays roles in vasodilation,hemostasis,and blood-brain barrier *** models have highlighted potential therapeutic roles for magnesium in neurological diseases specifically targeting these pathophysiological *** studies have also demonstrated inverse associations between admission magnesium levels and hematoma volume,hematoma expansion,and clinical outcome in patients with *** associations,coupled with the multifactorial role of magnesium that targets both primary and secondary phases of ICH,suggest that magnesium may be a viable target of study in future ICH studies.