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Improving the radiopacity of Fe-Mn biodegradable metals by magnetron-sputtered W-Fe-Mn-C coatings:Application for thinner stents

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Bioactive Materials 2022年第6期7卷 64-70页

作者： Samira Ravanbakhsh Carlo Paternoster Gianni Barucca Paolo Mengucci Sofia Gambaro Theophraste Lescot Pascale Chevallier a Marc-Andre Fortin Diego mantovani Laboratory for Biomaterials and Bioengineering Canada Research Chair I in Biomaterials and Bioengineering for the Innovation in SurgeryDepartment of Min-Met-Materials EngineeringResearch Center of CHU de QuebecDivision of Regenerative MedicineLaval UniversityQuebec CityQuebec G1V 0A6Canada Laboratory for Biomaterials in Imaging(BIM) Axe Medecine RegeneratriceCentre Hospitalier Universitaire(CHU)de Quebec-Universite Laval2705boul.Laurier(T1-61a)QuebecG1V 4G2Canada Department of Materials Environmental Sciences and Urban PlanningUniversita Politecnica delle Marchevia Brecce Bianche 1260131AnconaItaly National Research Council Institute of Condensed Matter Chemistry and EnergyCNR-ICMATEVia de Marini 616149GenovaItaly Departement de Genie des Mines de la Metallurgie et des MateriauxCentre de Recherche sur les Materiaux Avances(CERMA)Universite LavalQuebecG1V 0A6Canada Axe Medecine Regeneratrice Centre Hospitalier Universitaire(CHU)de Quebec-Universite Laval2705boul.Laurier(T1-61a)QuebecG1V 4G2Canada

In this exploratory work,micrometric radiopaque W-Fe-Mn-C coatings were produced by magnetron sputtering plasma deposition,for the first time,with the aim to make very thin Fe-Mn stents trackable by *** power of Fe-13Mn-1.2C target was kept constant at 400 W while that of W target varied from 100 to 400 W producing three different coatings referred to as P100,P200,*** effect of the increased W power on coatings thickness,roughness,structure,corrosion behavior and radiopacity was *** coatings showed a power-dependent thickness and W concentration,different roughness values while a similar and uniform columnar *** amorphous phase was detected for both P100 and P200 coatings while γ-Fe,bcc-W and W_(3)C phases found for ***,P200 and P400 showed a significantly higher corrosion rate(CR)compared to *** presence of W,W_(3)C as well as the Fe amount variation determined two different micro-galvanic corrosion mechanisms significantly changing the CR of coatings,0.26±0.02,59.68±1.21 and 59.06±1.16μm/year for P100,P200 and P400,*** P200 with its most uniform morphology,lowest roughness(RMS=3.9±0.4 nm)and good radiopacity(~6%)appeared the most suitable radiopaque biodegradable coating investigated in this study.

关键词： Fe-Mn-Based alloys Degradable coatings W-Fe-Mn-C coatings Magnetron sputtering Radiopacity Stent fluoroscopy

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Senescence in adipose-derived stem cells and its implications in nerve regeneration

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Neural Regeneration Research 2014年第1期9卷 10-15页

作者： Cristina mantovani Giorgio Terenghi Valerio Magnaghi Dipartimento di Scienze Farmacologiche e Biomolecolari Universitàdegli Studi di Milano Blond McIndoe Laboratories Faculty of Medical and Human SciencesThe University of Manchester

Adult mesenchymal stem cells, specifically adipose-derived stem cells have self-renewal and multiple differentiation potentials and have shown to be the ideal candidate for therapeutic applications in regenerative medicine, particularly in peripheral nerve regeneration. Adipose-de- rived stem cells are easily harvested, although they may show the effects of aging, hence their potential in nerve repair may be limited by cellular senescence or donor age. Cellular senescence is a complex process whereby stem cells grow old as consequence of intrinsic events （e.g., DNA damage） or environmental cues （e.g., stressful stimuli or diseases）, which determine a permanent growth arrest. Several mechanisms are implicated in stem cell senescence, although no one is exclusive of the others. In this review we report some of the most important factors modulating the senescence process, which can influence adipose-derived stem cell morphology and function, and compromise their clinical application for peripheral nerve regenerative cell therapy.

关键词： aging adipose-derived stem cell DNA damage p38 p53 mitochondria Sirtuins pe- ripheral nervous system

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Local Role of Food Producers' Communities for a Global One-Health Framework: The Experience of Translational Research in an Italian Dairy Chain

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Journal of Agricultural Chemistry and Environment 2014年第2期3卷 14-19页

作者： Chiara Frazzoli Alberto mantovani roberto Dragone Department of Veterinary Public Health and Food Safety Istituto Superiore di Sanità Rome Italy Institute for Nanostructured Materials Consiglio Nazionale delle Ricerche Rome Italy

Community is the foundation of public health: the present paper reports the approach and strategy for intervention on the dairy production community developed by the Italian project ALERT (***), which implements the transfer of technical innovation and technological know-how from public research. Starting from the local role of primary producers, North-South and South-South networking (***) is needed to share solutions for transnational problems like climatic change, contaminated agro-farming sites and food waste and losses in the era of food crisis. Based on risk analysis, science-society dialogue and global health, the main drivers of this experience of translational research are One Health, i.e. the web of inter-relationships among environment, farm animals and human health, and sustainable food safety (prevention actions on diet of young women, today, to protect next generation’s health) to increase population life expectancy in good health.

关键词： Contaminated Sites Ecology Food Losses Sustainable Food Safety Technological Transfer Traceability

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Nonalcoholic Fatty Liver Disease (NAFLD) and Risk of Cardiac Arrhythmias: A New Aspect of the Liver-heart Axis

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Journal of Clinical and Translational Hepatology 2017年第2期5卷 134-141页

作者： Alessandro mantovani Section of Endocrinology Diabetes and Metabolism Department of Medicine University and Azienda Ospedaliera Universitaria Integrata of Verona Verona Italy

Nonalcoholic fatty liver disease (NAFLD) is a pathologic condition frequently observed in clinical *** date,the prevalence of NAFLD is approximately 25-30% among adults of the general population in Western countries but increases to approximately 70-75% among patients with type 2 diabetes *** the last decade,accumulating evidence has clearly demonstrated that patients with NAFLD have not only an increased liver-related morbidity and mortality but also an increased risk of fatal and non-fatal cardiovascular *** particular,several studies have documented the existence of an independent association among NAFLD and cardiac changes in structure and function in both non-diabetic and diabetic *** addition,mounting evidence also suggests that there is a strong relationship between NAFLD and cardiac arrhythmias,such as atrial fibrillation,QTc prolongation and ventricular *** is of clinical interest,as it could explain,at least in part,the increased risk of death for cardiovascular disease in patients with ***,seeing that cardiovascular disease complications are the leading cause of disability and death in NAFLD patients,the recent European clinical practice guidelines advised to check the cardiovascular system in all patients with *** clinical mini review will briefly describe the increasing body of evidence regarding the association between NAFLD and cardiac arrhythmias,and discuss the potential biological mechanisms underlying this association.

关键词： Nonalcoholic fatty liver disease Cardiovascular disease Cardiac arrhythmias Cardiac complications

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Generation and Disruption of Subducted Lithosphere in the Central-Western Mediterranean Region and Time-Space Distribution of Magmatic Activity Since the Late Miocene

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International Journal of Geosciences 2022年第9期13卷 830-854页

作者： Enzo mantovani Marcello Viti Caterina Tamburelli Daniele Babbucci Dipartimento di Scienze Fisiche Della Terra e dell’Ambiente Università di Siena Siena Italy

The long migration of the Balearic Arc (Alpine-Apennine and Alpine-Maghrebian belts) in the Early-Middle Miocene caused the formation of a subducted lithospheric edifice in the western and central Mediterranean regions. Then, since the Late Miocene, this slab was almost completely disrupted, only maintaining a narrow and deformed remnant beneath the southernmost Tyrrhenian basin. This work describes a tentative reconstruction of the tectonic processes that caused the formation of major tears and breakoffs in the original slabs and the consequent disruption of the subducted lithosphere. In particular, it is suggested that this relatively fast process was produced by the collision between the Anatolian-Aegean system and the continental Adriatic domain, which triggered a number of extrusion processes. Possible connections between the proposed tectonic evolution and the spatio-temporal distribution and geochemical signatures of magmatic activity are then discussed. It is supposed that such activity has been mainly conditioned by the occurrence of transtensional tectonics in the wake of escaping orogenic wedges.

关键词： Deep Tectonics Slab Tears and Slab Breakoffs Magmatism Central-Western Mediterranean

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Analysis of the genotoxic potential of low concentrations of Malathion on the Allium cepa cells and rat hepatoma tissue culture

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Journal of Environmental Sciences 2015年第10期27卷 102-111页

作者： Jaqueline Bianchi Mario Sérgio mantovani Maria Aparecida Marin-Morales Department of Biology Institute of BiosciencesSao Paulo State University(UNESP) Department of General Biology Biological Science CentreUniv Estadual de Londrina

Based on the concentration of Malathion used in the field, we evaluated the genotoxic potential of low concentrations of this insecticide on meristematic and F1 cells of Allium cepa and on rat hepatoma tissue culture（HTC cells）. In the A. cepa, chromosomal aberrations（CAs）, micronuclei（MN）, and mitotic index（MI） were evaluated by exposing the cells at 1.5,0.75, 0.37, and 0.18 mg/m L of Malathion for 24 and 48 hr of exposure and 48 hr of recovery time. The results showed that all concentrations were genotoxic to A. cepa cells. However,the analysis of the MI has showed non-relevant effects. Chromosomal bridges were the CA more frequently induced, indicating the clastogenic action of Malathion. After the recovery period, the higher concentrations continued to induce genotoxic effects, unlike the observed for the lowest concentrations tested. In HTC cells, the genotoxicity of Malathion was evaluated by the MN test and the comet assay by exposing the cells at 0.09, 0.009, and0.0009 mg/5 m L culture medium, for 24 hr of exposure. In the comet assay, all the concentrations induced genotoxicity in the HTC cells. In the MN test, no significant induction of MN was observed. The genotoxicity induced by the low concentrations of Malathion presented in this work highlights the importance of studying the effects of low concentrations of this pesticide and demonstrates the efficiency of these two test systems for the detection of genetic damage promoted by Malathion.

关键词： HTC Chromosomal aberration Micronuclei Comet assay Pesticide

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Glucagon-like peptide-1 receptor agonists for treatment of nonalcoholic steatohepatitis:new insights from subcutaneous semaglutide

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Hepatobiliary Surgery and Nutrition 2021年第4期10卷 518-521页

作者： Alessandro mantovani Giovanni Targher Section of Endocrinology Diabetes and MetabolismDepartment of MedicineUniversity and Azienda Ospedaliera Universitaria Integrata of VeronaVeronaItaly

Nonalcoholic fatty liver disease(NAFLD)is the commonest cause of chronic liver disease *** affects around 25%of the general adult population,and up to∼70-80%of patients,who are obese or have type 2 diabetes mellitus(T2DM)(1,2).Over the past decades,it has become increasingly clear that NAFLD is a“multisystem”disease,requiring a multidisciplinary and holistic approach(3).

关键词： NAFLD liver hepatitis

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Pramipexole, a dopamine D3/D2 receptor-preferring agonist, attenuates reserpine-induced fibromyalgia-like model in mice

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Neural Regeneration Research 2022年第2期17卷 450-458页

作者： Carlos Pereira Martins Rodrigo Sebben Paes Gabriela mantovani Baldasso Eduarda Gomes Ferrarini Rahisa Scussel Rubya Pereira Zaccaron Ricardo Andrez Machado-de-Avila Paulo Cesar Lock Silveira Rafael Cypriano Dutra Laboratory of Autoimmunity and Immunopharmacology Department of Health SciencesCampus AraranguaUniversidade Federal de Santa CatarinaAraranguáSCBrazil Post-Graduate Program of Neuroscience Center of Biological SciencesUniversidade Federal de Santa CatarinaFlorianópolisSCBrazil Laboratory of Experimental Physiopathology Program of Postgraduate in Science of HealthUniversidade do Extremo Sul CatarinenseCriciumaSCBrazil

Fibromyalgia(FM) is a complex pathology described as persistent hyperalgesia including somatic and mood dysfunctions, depression and anxiety. Although the etiology of FM is still unknown, a significant decrease in biogenic amines is a common characteristic in its pathogenesis. Here, our main objective was to investigate the role of dopamine D3/D2 receptor during the reserpine-induced pain in mice. Our results showed that pramipexole(PPX) – a dopaminergic D3/D2 receptor agonist – inhibited mechanical allodynia and thermal sensitivity induced by reserpine. Relevantly, PPX treatment decreased immobility time and increased the number of grooming in the forced swimming test and splash test, respectively. Animals that received PPX remained longer in the open arms than the reserpine group using elevated plusmaze apparatus. The repeated PPX administration, given daily for 4 days, significantly blocked the mechanical and thermal allodynia during FM model, similarly to pregabalin, although it failed to affect the reserpine-induced thermal nociception. Reserpine administration induced significant downregulation of dopamine concentration in the central nervous system, and repeated treatment with PPX restored dopamine levels in the frontal cortex and spinal cord tissues. Moreover, PPX treatment inhibited oxidants production such as DCFH(2′,7′-dichlorodihydrofluorescein) and nitrite, also decreased oxidative damage(carbonyl), and upregulated the activity of superoxide dismutase in the spinal cord. Together, our findings demonstrated the ability of dopamine D3/D2 receptor-preferring agonist in reducing pain and mood dysfunction allied to FM in mice. All experimental protocols were approved by the Universidade Federal de Santa Catarina(UFSC) Ethics Committee(approval No. 2572210218) on May 10, 2018.

关键词： dopamine dopaminergic system fibromyalgia hyperalgesia pain pramipexole reserpine

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The dawn of a new era for nonalcoholic fatty liver disease?

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Hepatobiliary Surgery and Nutrition 2019年第6期8卷 629-631页

作者： Alessandro mantovani Chiara Zusi Section of Endocrinology Diabetes and MetabolismDepartment of MedicineUniversity and Azienda Ospedaliera Universitaria Integrata of VeronaVeronaItaly

Non-alcoholic fatty liver disease(NAFLD)has become the most frequent chronic liver disease in several developed and developing countries,affecting roughly 30%of adults in the general population,65-70%of individuals with type 2 diabetes mellitus and,virtually,all patients with obesity(1).Of note,its prevalence is believed to rise dramatically over the next decade,along with an increase of prevalence in obesity,diabetes mellitus and metabolic syndrome.

关键词： obesity prevalence liver

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Obligatory parthenogenesis and TE load： Bacillus stick insects and the R2 non-LTR retrotransposon

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Insect Science 2017年第3期24卷 409-417页

作者： Livia Bonandin Claudia Scavariello Valentina Mingazzini Andrea Luchetti Barbara mantovani Dipartimento di Scienze Biologiche Geologiche e Ambientali Universit~ di Bologna Bologna Italy

Transposable elements （TEs） are selfish genetic elements whose self-replication is contrasted by the host genome. In this context, host reproductive strategies are predicted to impact on both TEs load and activity. The presence and insertion distribution of the non- LTR retrotransposon R2 was here studied in populations of the strictly bisexual Bacillus grandii maretimi and of the obligatory parthenogenetic Bacillus atticus atticus. Further- more, data were also obtained from the offspring of selected B. a. atticus females. At the population level, the gonochoric B. g. maretimi showed a significantly higher R2 load than the obligatory parthenogenetic B. a. atticus. The comparison with bisexual and unisexual Bacillus rossius populations showed that their values were higher than those recorded for B. a. atticus and similar, or even higher, than those of B. g. maretimi. Consistently, an R2 load reduction is scored in B. a. atticus offspring even if with a great variance. On the whole, data here produced indicate that in the obligatory unisexual B. a. atticus R2 is active and that mechanisms of molecular turnover are effective. Furthermore, progeny analyses show that, at variance of the facultative parthenogenetic B. rossius, the R2 activ- ity is held at a lower rate. Modeling parental-offspring inheritance, suggests that in B. a. atticus recombination plays a major role in eliminating insertions rather than selection, as previously suggested for unisexual B. rossius progeny, even if in both cases a high variance is observed. In addition to this, mechanisms of R2 silencing or chances of clonal selection cannot be ruled out.

关键词： insertion activity Muller's ratchet Phasmida recombination retrotranspo-son unisexuality

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