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Cellular & Molecular Immunology 2020年第4期17卷 410-411页

作者： Maria Pia Pistillo roberta Carosio Barbara Banelli Anna Morabito Luca Mastracci Paola Ferro Serena Varesano roberta Venè Alessandro Poggi Silvio Roncella Tumor Epigenetics Unit IRCCS Ospedale Policlinico San Martino16132 GenoaItaly Department of Surgical Sciences and Integrated Diagnostics(DISC) University of Genoa16132 GenoaItaly Anatomic Pathology IRCCS Ospedale Policlinico San Martino16132 GenoaItaly Histopathology and Cytopathology Division Azienda Sanitaria Locale 519121 La SpeziaItaly Molecular Oncology and Angiogenesis Unit IRCCS Ospedale Policlinico San Martino16132 GenoaItaly AIL Associazione italiana contro le leucemielinfomi e mieloma19121 La SpeziaItaly

Programmed death-ligand-1(PD-L1)plays a crucial role in the suppression of the antitumor immune response upon interaction with programmed cell death protein-1(PD-1)on cytotoxic T ***-L1 is constitutively expressed on antigen-presenting cells or tumor ***,PD-L1 has been detected by immunohistochemistry in a variety of tumors,including malignant pleural mesothelioma(MPM),in which it has emerged as a predictive biomarker for PD-1/PD-L1 immune checkpoint blockers(ICBs).1,2 PD-L1 expression on tumor cells can be upregulated by several factors including the interferon gamma(IFN-γ)cytokine produced by tumor-infiltrating lymphocytes(TILs).3 In MPM cells,it has been reported that IFN-γupregulates PD-L1 mRNA expression due to the activation of the interferon regulatory factor 1(IRF1)transcription factor,4 but no data have been shown regarding cell surface PD-L1 that is functionally relevant for its contact with PD-1-positive cells.

关键词： interferon death pleural

AUTOMATED DETECTION OF FAST PULSATIONS IN SOLAR DYNAMIC RADIO SPECTRA USING WAVELET ANALYSIS

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AUTOMATED DETECTION OF FAST PULSATIONS IN SOLAR DYNAMIC RADI...

Paradoxical relationship between proton pump inhibitors and COVID-19: A systematic review and meta-analysis

第十一届全国日地空间物理学术讨论会

作者： R.A.sych Institute of Solar-Terrestrial Physics 126 Lermontov Street Irkutsk Russia 664033

＜正＞This paper applies 1D and 2D wavelet transform method to detection of sporadic signals in solar dynamic radio spectra. We investigate the problem of fast and accurate classification and selection of the bright details with different frequencies widths. Wavelet analysis is suitable for researching pulsations, such as spikes, zebra structure, U-burst, which are limited in both time and frequency. Use this technique, for first time, we have developed an algorithm to detect this pulsations. We tested the algorithm and found that the results of detection are consistent with those obtained by visual inspection. For practical realization we developed new software on IDL, included next output: histograms of the distribution spikes in clusters, construction of the filtered radio spectra for different frequency widths, correlation and cross-correlation of the frequency strips. We describe the structure of these algorithms and report experimental results of their performance. The algorithm is applied in a joint Russian-Chinese project which aim is investigating of the spikes clusters structure. In this project we use the radio spectrogram, with a sampling rate of 10 ms, obtained at Huairou station （5.2-7.6 HGz）. We plan to expand applying this method among other station and observatories.

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World Journal of Clinical Cases 2021年第12期9卷 2763-2777页

作者： Maddalena Zippi Sirio Fiorino roberta Budriesi Matteo Micucci Ivan Corazza roberta Pica Dario de Biase Claudio Giuseppe Gallo Wandong Hong Unit of Gastroenterology and Digestive Endoscopy Sandro Pertini HospitalRome 00157Italy Unit of Internal Medicine Maggiore HospitalLocal Health Unit of BolognaBologna 40133Italy Food Chemistry and Nutraceuticals Laboratory Department of Pharmacy and Biotechnology(FaBiT)Alma Mater StudiorumUniversity of BolognaBologna 40133Italy Experimental Diagnostic and Speciality Medicine DepartmentUniversity of BolognaBologna 40138Italy Department of Pharmacy and Biotechnology University of BolognaBologna 40138Italy Internal Medicine Unit Budrio Hospital Azienda USLBologna 40138Italy Department of Gastroenterology and Hepatology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

BACKGROUND The proton pump inhibitors(PPIs),used to reduce gastric acid secretion,represent one of the most widely used pharmaceutical classes in the *** consumption as a risk factor for the evolution of severe forms of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has been investigated as well as the mortality of these *** risks also appear to be linked to the duration and the *** the other hand,several studies have emerged with regard to the protective or therapeutic effects of these *** and more evidence underlines the immunomodulatory and anti-fibrotic role of *** addition,their ability to alkalize the contents of endosomes and lysosomes serves as an obstacle to the entry of the virus into the host *** To identify studies on the relationship between the intake of PPIs and coronavirus disease 2019(COVID-19)in patients affected by SARS-CoV-2 infection,with the main objective of evaluating the outcomes related to severity and *** A literature review was performed in November *** MEDLINE/PubMed,Cochrane Library,EMBASE and Google Scholar databases were searched for all relevant articles published in English on this *** search terms were identified by means of controlled vocabularies,such as the National Library of Medicine’s MESH(Medical Subject Headings)and *** MESH terms and keywords used were as follows:“COVID-19”,“proton pump inhibitors”,“PPIs”,“SARS-CoV-2”,“outcomes”,“severity”and“mortality”.The inclusion criteria regarding the studies considered in our analysis were:meta-analysis,casecontrol,hospital-based case-control,population-based case-control,retrospective studies,online survey,as well as cohort-studies,while articles not published as full reports,such as conference abstracts,case reports and editorials were *** tried to summarize and pool all the data if *** A total of 9 studies were found that described the use of PPIs,of which only 5

关键词： COVID-19 Proton pump inhibitors SARS-CoV-2,Severity Mortality

Can adiponectin have an additional effect on the regulation of food intake by inducing gastric motor changes?

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World Journal of Gastroenterology 2020年第20期26卷 2472-2478页

作者： Eglantina Idrizaj Rachele Garella roberta Squecco Maria Caterina Baccari Department of Experimental and Clinical Medicine Section of Physiological SciencesUniversity of FlorenceFlorence 50134Italy

The regulation of food intake is a complex mechanism,and the hypothalamus is the main central structure *** particular,the arcuate nucleus appears to be the most critical area in the integration of multiple peripheral *** these signals,those originating from the white adipose tissue and the gastrointestinal tract are known to be involved in the regulation of food *** present paper focuses on adiponectin,an adipokine secreted by white adipose tissue,which is reported to have a role in the control of feeding by acting *** recent observation that adiponectin is also able to influence gastric motility raises the question of whether this action represents an additional peripheral mechanism that concurs with the central effects of the hormone on food *** possibility,which represents an emerging aspect correlating the central and peripheral effects of adiponectin in the hunger-satiety cycle,is discussed in the present paper.

关键词： Adipokines Adiponectin Adipose tissue Food intake Gastric motility Satiety signals

Local ablation of pancreatic tumors: State of the art and future perspectives

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World Journal of Gastroenterology 2021年第23期27卷 3413-3428页

作者： Vincenza Granata roberta Grassi roberta Fusco Andrea Belli Raffaele Palaia Gianpaolo Carrafiello Vittorio Miele Roberto Grassi Antonella Petrillo Francesco Izzo Department of Radiology Istituto Nazionale Tumori–IRCCS-Fondazione G.PascaleNaples 80131Italy Department of Radiology Universitàdegli Studi della Campania Luigi VanvitelliNaples 80127Italy Department of Surgery Istituto Nazionale Tumori–IRCCS-Fondazione G.PascaleNaples 80131Italy Department of Surgery Universitàdegli Studi di MilanoMilano 20122Italy Italian Society of Medical and Interventional Radiology SIRM SIRM Foundation Milan 20122Italy Department of Emergency Radiology San Camillo HospitalFirenze 50139Italy

BACKGROUND Currently,the technologies most commonly used to treat locally advanced pancreatic cancer are radiofrequency ablation(RFA),microwave ablation,and irreversible(IRE)or reversible electroporation combined with low doses of chemotherapeutic *** To report an overview and updates on ablative techniques in pancreatic *** Several electronic databases were *** search covered the years from January 2000 to January ***,the reference lists of the found papers were analysed for papers not indexed in the electronic *** titles and abstracts were *** We found 30 studies(14 studies for RFA,3 for microwave therapy,10 for IRE,and 3 for electrochemotherapy),comprising 1047 patients,which were analysed *** randomized trials were found for *** and laparotomy approaches were *** the assessed patients,the median maximal diameter of the lesions was in the range of 2.8 to 4.5 *** series included patients unfit for surgical treatment,but Martin et al assessed a subgroup of patients with borderline resectable tumours who underwent resection with margin attenuation with *** studies administered chemotherapy prior to ablative ***,several studies suggest that the key determinant of improved survival is attributable to ablative treatment ***,the authors suggested chemotherapy before local therapies for several *** strategy may not only downstage a subgroup of patients to curative-intent surgery but also support to recognize patients with biologically unfavourable tumours who would likely not benefit from ablation *** therapies seem safe based on the 1047 patients assessed in this *** mortality rate ranged from 1.8%to 2%.However,despite the low mortality,the reported rates of severe post procedural complications ranged from 0%-42%.Most reported complications have been self-limiting and *** overall survival varied betwe

关键词： Pancreatic cancer Ablation treatment Radiofrequency ablation Microwave ablation Irreversible Electrochemotherapy

Bacterial symbiosis in Bactrocera oleae,an Achilles’heel for its pest control

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Insect Science 2021年第4期28卷 874-884页

作者： Gaia Bigiotti Patrizia Sacchetti roberta Pastorelli Carol R.Lauzon Antonio Belcari Department of Agriculture FoodEnvironment and Forestry(DAGRI)University of FlorenceItaly Research Centre for Agriculture and Environment Consiglio perlaricerca in agricoltura e I'analisi dell'economia agraria(CREA-AA)FlorenceItaly Department of Biological Sciences California State UniversityHaywardUSA

Investigations on microbial symbioses in Tephritidae have increased over the past 30 years owing to the potential use of these relationships in developing new control strategies for economically important fruit *** oleae(Rossi)—the olive fruit fly—is a monophagous species strictly associated with the olive tree,and among all the tephritids,its symbionts are the most *** bacterium Candidatus Erwinia dacicola is the major persistent resident endosymbiont in wild *** *** relationship with *** has been investigated since being identified in *** endosymbiont is vertically transmitted through generations from the female to the *** exists at every developmental stage,although it is more abundant in larvae and ovipositing females,and is necessary for both larvae and *** ***–***,or other ***–microbe interactions,will allow us to develop modern biological control systems for area-wide olive protection and set an example for similar programs in other important food *** review summarizes the information available on tephritid–microbe interactions and investigates relationships among fruit flies,bacteria and host plants;however,its focus is on *** and its strict association with *** to promote environmentally friendly control strategies for area-wide pest management.

关键词： bacterial symbiosis esophageal bulb IPM olive fly Tephritid

It is time to mate: population-level plasticity of wild boar reproductive timing and synchrony in a changing environment

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Current Zoology 2022年第4期68卷 371-380页

作者： Rudy Brogi Enrico Merli Stefano Grignolio roberta Chirichella Elisa Bottero Marco Apollonio Department of Veterinary Medicine University of Sassarivia Vienna 2Sassari I-07100Italy

On a population level,individual plasticity in reproductive phenology can provoke either anticipations or delays in the average reproductive timing in response to environmental ***,a rigid reliance on photoperiodism can constraint such plastic responses in populations inhabiting temperate *** regulation of breeding season length may represent a further tool for populations facing changing ***,this skill was reported only for equatorial,nonphotoperiodic *** goal was to evaluate whether species living in temperate regions and relying on photoperiodism to trigger their reproduction may also be able to regulate breeding season *** 10 years,we collected 2,500 female reproductive traits of a mammal model species(wild boar Sus scrofa)and applied a novel analytical approach to reproductive patterns in order to observe population-level variations of reproductive timing and synchrony under different weather and resources availability *** favorable conditions,breeding seasons were anticipated and population synchrony increased(i.e.,shorter breeding seasons).Conversely,poor conditions induced delayed and less synchronous(i.e.,longer)breeding *** potential to regulate breeding season length depending on environmental conditions may entail a high resilience of the population reproductive patterns against environmental changes,as highlighted by the fact that almost all mature females were reproductive every year.

关键词： breeding season length phenology photoperiodism population ecology reproduction wild boar

Dispersive liquid-liquid microextraction,an effective tool for the determination of synthetic cannabinoids in oral fluid by liquid chromatography-tandem mass spectrometry

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Journal of Pharmaceutical Analysis 2021年第3期11卷 292-298页

作者： Pierpaolo Tomai Alessandra Gentili roberta Curini Rossella Gottardo Franco Tagliaro Salvatore Fanali Department of Chemistry Sapienza UniversityP.le Aldo Moro 500185RomeItaly Department of Diagnostics and Public Health University of VeronaVeronaItaly and Institute of Translational Medicine and BiotechnologySechenov First Moscow State Medical UniversityMoscowRussia Teaching Committee of Ph.D.School in Natural Science and Engineering University of Verona VeronaItaly

In the present work,dispersive liquid-liquid microextraction(DLLME)was used to extract six synthetic cannabinoids(JWH-018,JWH-019,JWH-073,JWH-200,or WIN 55,225,JWH-250,and AM-694)from oral fluids.A rapid baseline separation of the analytes was achieved on a bidentate octadecyl silica hydride phase(Cogent Bidentate C18;4.6 mm×250 mm,4μm)maintained at 37℃,by eluting in isocratic conditions(water:acetonitrile(25:75,V/V)).Detection was performed using positive electrospray ionization-tandem mass *** parameters affecting DLLME(pH and ionic strength of the aqueous phase,type and volume of the extractant and dispersive solvent,vortex and centrifugation time)were optimized for maximizing *** particular,using 0.5 mL of oral fluid,acetonitrile(1 mL),was identified as the best option,both as a solvent to precipitate proteins and as a dispersing solvent in the DLLME *** select an extraction solvent,a low transition temperature mixture(LTTM;composed of sesamol and chlorine chloride with a molar ratio of 1:3)and dichloromethane were compared;the latter(100μL)was proved to be a better extractant,with recoveries ranging from 73%to 101%by vortexing for 2 *** method was validated according to the guidelines of Food and Drug Administration bioanalytical methods:intra-day and inter-day precisions ranged between 4%and 18%depending on the spike level and analyte;limits of detection spanned from 2 to 18 ng/mL;matrixmatched calibration curves were characterized by determination coefficients greater than ***,the extraction procedure was compared with previous methods and with innovative techniques,presenting superior reliability,rapidity,simplicity,inexpensiveness,and efficiency.

关键词： Microextraction techniques Dispersive liquid-liquid microextraction Illicit drugs Synthetic cannabinoids Silica C-based column

Identification of BRAF V600E mutation in odontogenic tumors by high-performance MALDI-TOF analysis

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International Journal of Oral Science 2022年第2期14卷 212-219页

作者： Lucrezia Togni Antonio Zizzi roberta Mazzucchelli Andrea Santarelli Corrado Rubini Marco Mascitti Department of Clinical Specialistic and Dental Sciences Marche Polytechnic Universityvia Tronto 10AnconaItaly Department of Biomedical Sciences and Public Health Marche Polytechnic Universityvia Tronto 10AnconaItaly Dentistry Clinic National Institute of Health and Science of AgingIRCCS INRCAvia Tronto 10AnconaItaly

Odontogenic tumors are rare lesions with unknown *** of them are benign,but local aggressiveness,infiltrative potential,and high recurrence rate characterize some *** MAP-kinase pathway activation can represent a primary critical event in odontogenic ***,the BRAF V600E mutation has been involved in 80%–90%of ameloblastic lesions,offering a biological rationale for developing new targeted *** study aims to evaluate the BRAF V600E mutation in odontogenic lesions,comparing three different detection methods and focusing on the Sequenom MassARRAY System.81 surgical samples of odontogenic lesions were subjected to immunohistochemical analysis,Sanger Sequencing,and Matrix-Assisted Laser Desorption/Ionization-Time of Flight mass spectrometry(Sequenom).The BRAF V600E mutation was revealed only in ameloblastoma ***,the presence of BRAF V600E was significantly associated with the mandibular site(ρ=0.627;P value<0.001)and the unicystic histotype(ρ=0.299,P value<0.001).However,any significant difference of 10-years disease-free survival time was not ***,Sequenom showed to be a 100%sensitive and 98.1%specific,suggesting its high-performance diagnostic *** results suggest the MAP-kinase pathway could contribute to ameloblastic ***,they could indicate the anatomical specificity of the driving mutations of mandibular ameloblastomas,providing a biological rational for developing new targeted ***,the high diagnostic accuracy of Sequenom was confirmed.

关键词： V600E BRAF specificity

Characterization of volatile organic compounds in grafted tomato plants upon potyvirus necrotic infection

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Journal of Integrative Agriculture 2023年第8期22卷 2426-2440页

作者： roberta SPANò Mariarosaria MASTROCHIRICO Francesco LONGOBARDI Salvatore CERVELLIERI Vincenzo LIPPOLIS Tiziana MASCIA Department of Soil Plant and Food SciencesUniversity of Bari“Aldo Moro”Via Amendola 165/ABari 70126Italy Department of Chemistry University of Bari“Aldo Moro”Via Orabona 4Bari 70126Italy National Research Council(CNR) Institute of Sciences of Food Production(ISPA)Via Amendola 122/OBari 70126Italy

A headspace solid-phase microextraction-gas chromatography-mass spectrometry(HS-SPME/GC-MS)method was used to study the volatile organic compounds(VOCs)associated with the differential immune response of tomato plants infected with the recombinant strain of potato virus Y(PVY^(C)-to),necrogenic to *** was carried out in UC82(UC),a virus susceptible tomato variety,comparing the same UC plants grafted or not onto a virus tolerant tomato ecotype,Manduria(Ma);the three types of samples used for the GC-MS analysis were mock-inoculated UC/Ma plants,UC/Ma+PVY^(C)-to and UC+PVY^(C)-to plants;the VOCs obtained were *** from symptomatic PVY^(C)-to-infected UC plants showed a VOCs composition enriched in alcohols,fatty acid derivates,benzenoids,and salicylic acid derivatives,while in mock-inoculated UC/Ma plants VOCs were mainly characterized by methyl ester *** VOC profile was in line with RNAseq data analyses,denoting that PVY^(C)-to viral RNA accumulation and disease symptoms induce the specific transcriptional activation of genes involved in VOCs ***,principal component analysis highlighted that VOCs of PVY^(C)-to-infected and mock-inoculated grafted plants were much closer each other than that of symptomatic PVY^(C)-to-infected non-grafted UC *** results suggest that VOCs profiles of tomato plants are related to the viral RNA accumulation,disease intensity and graft-derived tolerance to PVY^(C)-to infection.

关键词： tomato potyvirus VOCs defense grafted plants