IFN-γ upregulates membranous and soluble PD-L1 in mesothelioma cells: potential implications for the clinical response to PD-1/PD-L1 blockade
作者机构：Tumor Epigenetics UnitIRCCS Ospedale Policlinico San Martino16132 GenoaItaly Department of Surgical Sciences and Integrated Diagnostics(DISC)University of Genoa16132 GenoaItaly Anatomic PathologyIRCCS Ospedale Policlinico San Martino16132 GenoaItaly Histopathology and Cytopathology DivisionAzienda Sanitaria Locale 519121 La SpeziaItaly Molecular Oncology and Angiogenesis UnitIRCCS Ospedale Policlinico San Martino16132 GenoaItaly AILAssociazione italiana contro le leucemielinfomi e mieloma19121 La SpeziaItaly
出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)
年 卷 期：2020年第17卷第4期
页 面：410-411页
核心收录：
学科分类：0710[理学-生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学]
基 金：supported by grants from the Italian Ministry of Health(5×1000 funds 2014 and 2015 Ricerca Corrente 2017)
主 题：interferon death pleural
摘 要：Programmed death-ligand-1(PD-L1)plays a crucial role in the suppression of the antitumor immune response upon interaction with programmed cell death protein-1(PD-1)on cytotoxic T ***-L1 is constitutively expressed on antigen-presenting cells or tumor ***,PD-L1 has been detected by immunohistochemistry in a variety of tumors,including malignant pleural mesothelioma(MPM),in which it has emerged as a predictive biomarker for PD-1/PD-L1 immune checkpoint blockers(ICBs).1,2 PD-L1 expression on tumor cells can be upregulated by several factors including the interferon gamma(IFN-γ)cytokine produced by tumor-infiltrating lymphocytes(TILs).3 In MPM cells,it has been reported that IFN-γupregulates PD-L1 mRNA expression due to the activation of the interferon regulatory factor 1(IRF1)transcription factor,4 but no data have been shown regarding cell surface PD-L1 that is functionally relevant for its contact with PD-1-positive cells.
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