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Nano Research 2015年第5期8卷 1522-1534页

作者： Meng Zhang Richard C. T. How. robert I. w.odw.rd Edmund J. R. Kelleher Felice Torrisi Guohua Hu Sergei V. Popov J. Roy taylor Taw.ique Hasan Femtosecond Optics Group Blackett Laboratory Prince Consort Road Imperial College London London SW7 2AZ UK Cambridge Graphene Centre University of Cambridge Cambridge CB3 OFA UK

w. fabricate a free-standing few.layer molybdenum disulfide （MoS2）-polymer composite by liquid phase exfoliation of chemically pristine MoS2 crystals and use this to demonstrate a w.deband tunable, ultrafast mode-locked fiber laser. Stable, picosecond pulses, tunable from 1,535 nm to 1,565 nm, are generated, corresponding to photon energies below.the MoS2 material bandgap. These results contribute to the grow.ng body of w.rk studying the nonlinear optical properties of transition metal dichalcogenides that present new.opportunities for ultrafast photonic applications.

关键词： molybdenum disulfide tw.-dimensional materials liquid phase exfoliation polymer composites saturable absorbers ultrafast lasers

Vitamin D and Number of Falls in a Long-Term Care Facility

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Pharmacology & Pharmacy 2012年第4期3卷 453-457页

作者： robert B. Raffa Frank Breve robert taylor Jr. Joseph V. Pergolizzi Jr. Mid Atlantic PharmaTech Consultants LLC Ventnor City NJ USA Temple University School of Pharmacy Philadelphia PA USA NEMA Research Inc. Naples FL USA Temple University School of Medicine Temple University Philadelphia PA USA The Johns Hopkins University School of Medicine Baltimore MD and Georgetown University School of Medicine Washington DC USA

Falls represent a significant contribution to the morbidity and mortality of the elderly population. Because vitamin D is important in bone physiology, the use of vitamin D to restore deficient bone and ameliorate the effects of bone fractures due to falls has become a common practice in recent years. Follow.ng introduction of w.despread use, reports began to emerge that vitamin D not only aided in repair of fall-induced bone fractures, but that it also reduced the occurrence of falls. Vitamin D now.has become a routine intervention as a fall-prevention measure. Early analyses found evidence of prevention efficacy (reduced falls), but recent analyses are more equivocal. w. retrospectively examined the records of 350 patients in a long-term care facility in w.ich vitamin D administration and the number of falls w.re recorded as part of a comprehensive database of care. w. found a dramatic rise in vitamin D use over the period covered (2006 – 2011) and a corresponding dramatic decrease in the number of falls. How.ver, the number of falls continued to decline after 2008, despite a plateau in number of patients on vitamin D, particularly females. It appears that other factors contribute to the overall decline.

关键词： Falls Bone Fracture Vitamin D Long-Term Care Facility

Crisaborole and Apremilast: PDE4 Inhibitors w.th Similar Mechanism of Action, Different Indications for Management of Inflammatory Skin Conditions

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Pharmacology & Pharmacy 2018年第9期9卷 357-381页

作者： Jan M. Kitzen Joseph V. Pergolizzi Jr. robert taylor Jr. robert B. Raffa Kitzen Pharmaceutical Consulting Collegeville PA USA Temple University School of Medicine Philadelphia PA USA NEMA Research Inc. Naples FL USA Neumentum Inc. Palo Alto CA USA University of Arizona College of Pharmacy Tucson AZ USA Temple University School of Pharmacy Philadelphia PA USA

Tw. selective phosphodiesterase-4 (PDE4) inhibitors—viz., crisaborole (Eucrisa®, Pfizer) and apremilast (Otezla®, Celgene)—have recently received approval by the United States Food and Drug Administration for the treatment of related but different dermatologic skin conditions (viz., atopic dermatitis and plaque psoriasis, respectively). The purpose of this review.is to summarize the underlying biochemistry and pathophysiology associated w.th these dermatologic conditions, review.the chemistry, pharmacology and safety of each of these products, and present preclinical and clinical evidence that may help explain w.y these tw. PDE4 inhibitors offer new.treatment options for these skin conditions.

关键词： Crisaborole Apremilast Phosphodiesterase PDE4 Inflammation Cytokines Interleukins cAMP

The Role of Medical Literature, Clinical Trials and Experimental Research in Drug Product-Injury Litigation: A Primer w.th Tw. Examples

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Pharmacology & Pharmacy 2018年第6期9卷 208-227页

作者： Jan M. Kitzen Joseph V. Pergolizzi Jr. robert taylor Jr. robert B. Raffa Kitzen Pharmaceutical Consulting Collegeville USA Temple University School of Medicine Philadelphia USA NEMA Research Inc. Naples USA University of Arizona College of Pharmacy Tucson USA Temple University School of Pharmacy PhiladelphiaUSA

w.en any type of product has been ordered to be removed from the marketplace by a governmental regulatory body, that action is a pow.rful indicator that the product has been determined to be unsafe for further use, thereby branding the product as defective and opening up the possibility of product liability litigation. w.en the product is a drug or medical device, it is especially serious since the possibility of personal injury (acute and/or chronic) or death may occur. Needless to say, in these situations, product injury litigation w.ll almost surely follow. w. review.the definition and requisite claims needed to establish drug product liability, and the role that the medical literature, clinical trial data, and even experimental research data can play in product (drug)-injury litigation. w. show.how.each of these resources played a significant role in tw. w.ll-know. cases: Fen-Phen and thimerosal. The ultimate goal of such know.edge is to make better informed decisions about drug safety.

关键词： Drug Safety Product Quality Injury Litigation Fen-Phen Thimerosal

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图书馆管理学

图书馆管理学

Strain-tunable optical microlens arrays w.th deformable w.inkles for spatially coordinated image projection on a security substrate

1987年

作者： robert D.stueart John taylor Eastlick 刘碧如译

据美国图书馆公司出版，1981年修订第二版译出。

关键词：文化、科学、教育、体育信息与知识传播图书馆学、图书馆事业

来源：汇雅图书（南通市图书馆... 评论

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Microsystems & Nanoengineering 2022年第5期8卷 225-237页

作者： In Sik Choi Seongho Park Sangheon Jeon Young w.o Kw.n Row.on Park robert A.taylor Kw.ngseuk Kyhm Suck w.n Hong Department of Cogno-Mechatronics Engineering Department of Optics and Mechatronics EngineeringPusan National UniversityBusan 46241Republic of Korea Research Center for Dielectric and Advanced Matter Physics Pusan National UniversityBusan 46241Republic of Korea Department of Physics University of OxfordOxford OX13PUUK Department of Nano-Fusion Technology Pusan National UniversityBusan 46241Republic of Korea

As a new.concept in materials design,a variety of strategies have been developed to fabricate optical microlens arrays(MLAs)that enable the miniaturization of optical systems on the micro/nanoscale to improve their characteristic performance w.th unique optical *** this paper,w. introduce a cost-effective and facile fabrication process on a large scale up to~15 inches via sequential lithographic methods to produce thin and deformable hexagonally arranged MLAs consisting of polydimethylsiloxane(PDMS).Simple employment of oxygen plasma treatment on the prestrained MLAs effectively harnessed the spontaneous formation of highly uniform nanow.inkled structures all over the surface of the elastomeric *** strain-controlled tunability,unexpected optical diffraction patterns w.re characterized by the interference combination effect of the microlens and deformable ***,the hierarchically structured MLAs presented here have the potential to produce desirable spatial arrangements,w.ich may provide easily accessible opportunities to realize microlens-based technology by tunable focal lengths for more advanced micro-optical devices and imaging projection elements on unconventional security substrates.

关键词： projection arrays spatially

Treating Insomnia in Older Adult Patients: Limiting Benzodiazepine Use

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Pharmacology & Pharmacy 2019年第3期10卷 116-129页

作者： Joseph V. Pergolizzi Jr. robert taylor Jr. Jo Ann LeQuang Errol Gould robert B. Raffa NEMA Research Inc. Naples FL USA Neumentum Palo Alto CA USA LeQ Medical Angleton TX USA Pernix Therapeutics Morristown NJ USA University of Arizona College of Pharmacy Tucson AZ USA Temple University School of Pharmacy Philadelphia PA USA

As aging comes, an increased prevalence of medical maladies and chronic pain independently or interactively disrupt sleep, w.ich in turn can exacerbate either one. Furthermore, anxiety about pain can further negatively impact sleep. Fortunately, good quality sleep can improve pain management. Because benzodiazepine receptor agonists (including the “Z” drugs) can reduce anxiety and improve sleep, they seem a convenient choice. How.ver, their use in this population, particularly for more than short-term (guidelines range from 2 to 6 w.eks max), is not recommended because of increased likelihood of falls, further disruption of sleep, dependence, and problems w.th discontinuation (w.thdraw.l). Besides, this population is often likely to take concomitant medication for pain or other central nervous system depressants leading to potentially serious and even life-threatening interactions involving synergistic amplification of respiratory depression (opioids being a particularly dangerous interaction). Therefore, insomnia in older adults should ideally be treated w.th a non-benzodiazepine receptor agonist;if indicated, they may be used, but should be closely monitored and tapered to avoid long-term adverse problems (direct or from w.thdraw.l). Older adult patients w.th insomnia may be more optimally treated w.th sleep aids that do not interact w.th the GABAA receptor.

关键词： Pain Insomnia Older Adults Benzodiazepines “Z”-Drugs GABAA Receptor

一种改良的无张力牙龈移植技术——脱细胞真皮基质移植术

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中国口腔医学继续教育杂志 2011年第2期14卷 77-82页

作者： John B. taylor robert C. Gerlach robert w. Herold Frederick C, Bisch Douglas R. Dixon 钟泉（译）闫福华（审）不详福建医科大学附属口腔医院牙周科福州市杨桥中路246号350002

设计用于自体移植材料治疗牙龈退缩的传统外科手术方法可能并不适用于脱细胞真皮基质（acellular der-mal matrix，ADM）的移植。本文描述了一种十分适合ADM移植的新手术方法，用这种手术方法治疗Millerl、Ⅱ型牙龈退缩能够显著改善临... 详细信息

设计用于自体移植材料治疗牙龈退缩的传统外科手术方法可能并不适用于脱细胞真皮基质（acellular der-mal matrix，ADM）的移植。本文描述了一种十分适合ADM移植的新手术方法，用这种手术方法治疗Millerl、Ⅱ型牙龈退缩能够显著改善临床预后和改善美观。文中通过一个根面覆盖的病例详细地介绍了这种新方法的具体步骤和相关理论基础。与那些已经得到认可的自体组织移植技术相比，这种手术方法也被证实具有十分肯定的临床预后。

关键词：脱细胞真皮基质牙龈退缩移植技术移植术外科手术方法无张力改良 matrix

使用不同注塑工艺的爆筒加热技术提高效率并改善控制性能

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现代塑料 2007年第12期 43-46页

作者： Bruce F.taylor Timothy w.w.mer robert Kadykow.ki Xaloy公司

本文将加热圈与通过插入绝热层直接加热螺筒的非接触感应加热额技术的能量效率和控制响应情况进行了比较，并对试验室注塑成型机操作和台架试验的定量结果进行了讨论。同时，本文考虑了螺筒直径．表面条件和加热圈类型对效率和控制响应... 详细信息

本文将加热圈与通过插入绝热层直接加热螺筒的非接触感应加热额技术的能量效率和控制响应情况进行了比较，并对试验室注塑成型机操作和台架试验的定量结果进行了讨论。同时，本文考虑了螺筒直径．表面条件和加热圈类型对效率和控制响应的影响．最后还考虑了热电偶深度这一影响因素。

关键词：控制性能加热技术注塑工艺注塑成型机能量效率感应加热直接加热台架试验