检索结果-南通市图书馆

Optimizing laser coupling,matter heating,and particle acceleration from solids us.ng multiplexed ultraintense lasers

在线全文

学校读者我要写书评

暂无评论

Matter and Radiation at Extremes 2024年第4期9卷 16-28页

作者： Weipeng Yao Motoaki nakatsutsumi sébastien Buffechoux Patrizio Antici Marco Borghesi Andrea Ciardi sophia n.Chen Emmanuel d’Humières Laurent Gremillet robert Heathcote Vojtech Horny Paul McKenna Mark n.Quinn Lorenzo Romagnani Ryan Royle Gianluca sarri Yasuhiko s.ntoku Hans-Peter schlenvoigt Toma Toncian Olivier Tresca Laura Vassura Oswald Willi Julien Fuchs LULI-CnRs CEASorbonne UniversitéEcole PolytechniqueInstitut Polytechnique de ParisF-91128 Palaiseau CedexFrance sorbonne Université Observatoire de ParisUniversité PSLCNRSLERMAF-75005 ParisFrance InRs-EMT 1650 BoulLionel-BouletVarennesQuebec J3X 1S2Canada Center for Plasma Physics School of Mathematics and PhysicsQueen’s University BelfastBelfast BT71NNUnited Kingdom “Horia Hulubei”national Institute for Physics and nuclear Engineering 30 Reactorului StreetRO-077125 Bucharest-MagureleRomania University of Bordeaux Centre Lasers Intenses et ApplicationsCNRSCEAUMR 5107F-33405 TalenceFrance CEA DAMDIFF-91297 ArpajonFrance Université Paris-saclay CEALMCE91680 Bruyères-le-ChatelFrance Central Laser Facility STFC Rutherford Appleton LaboratoryDidcotUnited Kingdom sUPA Department of PhysicsUniversity of StrathclydeGlasgow G40NGUnited Kingdom department of Physics University of NevadaRenoNevada 89557USA Institute of Laser Engineering Osaka University2-6 YamadaokaSuitaOsaka 565-0871Japan Institut fur Laser und Plasmaphysik Heinrich Heine Universitat DusseldorfDusseldorfGermany

Realizing the full potential of ultrahigh-intensity lasers for particle and radiation generation will require multi-beam arrangements due to technology ***,we investigate how to optimize their coupling with solid ***,we show that overlapping two intense lasers in a mirror-like configuration onto a solid with a large preplasma can greatly improve the generation of hot electrons at the target front and ion acceleration at the target *** underlying mechanisms are analyzed through multidimensional particle-in-cell simulations,revealing that the self-induced magnetic fields driven by the two laser beams at the target front are susceptible to reconnection,which is one possible mechanism to boost electron *** addition,the resistive magnetic field generated during the transport of the hot electrons in the target bulk tends to improve their *** simulations also indicate that such effects can be further enhanced by overlapping more than two laser beams.

关键词： laser acceleration particle

Public health importance of light intensity physical activity

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of sport and Health science 2024年第5期13卷 674-675页

作者： robert Ross Ian Janss.n Mark s.Tremblay school of Kinesiology and Health studies Queen’s UniversityKingstonON K7L 3N6Canada school of Medicine Division of Endocrinology and MetabolismQueen’s UniversityKingstonON K7L 3N6Canada Healthy Active Living and Obesity Research Group Children’s Hospital of Eastern Ontario Research InstituteOttawaON K1H 8L1Canada department of Pediatrics University of OttawaOttawaON K1H 8L1Canada

*** intensity physical activity(PA)benefits health PA guidelines worldwide recommend that adults accumulate 150 min of moderate intensity or 75 min of vigorous intensity PA(moderate-to-vigorous PA(MVPA))weekly to achieve health benefits.1-3 Abs.nt from these guidelines are recommendations for light intensity PA(LPA,e.g.,walking at a leisurely pace of 3 km/h or less,equivalent to 1.5-2.9 metabolic equivalents).

关键词： intensity light benefits

The energetics of cellular life transitions

在线全文

学校读者我要写书评

暂无评论

Life Metabolism 2024年第3期3卷 12-20页

作者： Anna s.Monzel Michael Levin Martin Picard department of Psychiatry Division of Behavioral MedicineCollege of Physicians and SurgeonsColumbia University Irving Medical CenterNew YorkNY 10032United States department of Biology Tufts UniversityMedfordMA 02155United States Allen discovery Center at Tufts University MedfordMA 02155United States Wyss Institute for Biologically Inspired Engineering Harvard UniversityBostonMA 02115United States department of neurology H.Houston Merritt CenterColumbia Translational Neuroscience InitiativeCollege of Physicians and SurgeonsColumbia University Irving Medical CenterNew YorkNY 10032United States new York state Psychiatric Institute New YorkNY 10032United States robert n Butler Columbia Aging Center Columbia University Mailman School of Public HealthNew YorkNY 10032United States

Major life transitions are always difficult because change costs *** findings have demonstrated how mitochondrial oxidative phosphorylation(OxPhos)defects increase the energetic cost of living and that excessive integrated stress response(IsR)signaling may prevent cellular identity transitions during *** this perspective,we discuss general bioenergetic principles of life transitions and the costly molecular processes involved in reprograming the cellular hardware/software as cells shift *** energetic cost of cellular differentiation has.not been directly quantified,repres.nting a gap in *** propose that the IsR is an energetic checkpoint evolved to(i)prevent OxPhos-deficient cells from engaging in excessively costly transitions and(ii)allow IsR-positive cells to recruit systemic energetic resources by signaling via GdF15 and the brain.

关键词： energy mitochondria signaling pathway growth differentiation factor 15 energy balance development

storylines of family medicine Ⅹ:standing up for diversity,equity and inclusion

在线全文

学校读者我要写书评

暂无评论

Family Medicine and Community Health 2024年第S3期12卷 89-98页

作者： William B Ventres Leslie A stone Wayne W Bryant Jr Mario F Pacheco Edgar Figueroa Francis.n Chu shailendra Prasad david n Blane na'amah Razon Ranit Mishori robert L Ferrer Garrett s Kneese Family and Preventive Medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Family and Community Medicine University of New Mexico School of MedicineAlbuquerqueNew MexicoUSA Medicine Weill Cornell Medical CollegeNew YorkNew YorkUSA s.n Jose Family Medicine Residency Kaiser PermanenteSan JoseCaliforniaUSA Family Medicine and Community Health University of Minnesota Medical School—Twin Cities CampusMinneapolisMinnesotaUSA school of Health and Wellbeing University of GlasgowGlasgowUK Family and Community Medicine University of CaliforniaDavisSacramentoCaliforniaUSA Family Medicine Georgetown University School of MedicineWashingtonDistrict of ColumbiaUSA Family and Community Medicine UT Health San Antonio Long School of MedicineSan AntonioTexasUSA UC s.n diego Family Medicine Residency Program San DiegoCaliforniaUSA

storylines of Family Medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine as interpreted by individual family physicians and medical educators in the UsA and elsewhere around the ***‘Ⅹ:standing up for diversity,equity and inclusion’,authors address the following themes:‘The power of diversity—why inclusivity is ess.ntial to equity in healthcare’,‘Medical education for whom?’,‘Growing a diverse and inclusive workforce’,‘Therapeutic judo—an inclusive approach to patient care’,‘Global family medicine—seeing the world“upside down”’,‘The inverse care law‘,‘social determinants of health as a lens for care’,‘Why family physicians should care about human rights’and‘Toward health equity—the opportunome’.May the essays that follow inspire readers to promote change.

关键词： illustration education family

strong invariance principle for a counterbalanced random walk

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 370-380页

作者： TAn Hui-qun HU Zhi-shui dOnG Liang International Institute of Finance School of ManagementUniversity of Science and Technology of ChinaHefei 230026China Center for Basic Teaching and Experiment Nanjing University of Science and TechnologyJiangyin 214443China

We study a counterbalanced random walks_(n)=X_(1)+…+X_(n),which is a discrete time non-Markovian process andX_(n) are given recursively as *** n≥2,X_(n) is a new independent sample from some fixed law̸=0 with a fixed probability p,andX_(n)=−X_(v(n))with probability 1−p,where v(n)is a uniform random variable on{1;…;n−1}.We apply martingale method to obtain a strong invariance principle fors_(n).

关键词： random walk martingale invariance principle

Airway management of a patient with linear immunoglobulin A bullous dermatosis:A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第13期12卷 2263-2268页

作者： Olga C nin robert Hutnik neil n Chheda david Hutchins.n department of Anesthesiology University of Florida College of MedicineGainesvilleFL 32610United States department of Otolaryngology University of Florida College of MedicineGainesvilleFL 32610United States

BACKGROUnd There is limited literature on managing the airway of patients with linear immunoglobulin A(IgA)bullous dermatosis,a rare mucocutaneous disorder that leads to the development of friable *** clinical decision making is.necessary when there is a risk of bleeding into the airway,and a multidisciplinary team approach may lead to decreased patient morbidity during these high-risk scenarios,especially when confronted with an unusual cause for *** sUMMARY A 45-year-old African American female pres.nted to our ambulatory surgical center for right corneal transplantation due to corneal perforation after blunt trauma in the setting of cicatricial conjunctivitis and diffuse corneal neovascularization from linear IgA bullous *** diagnosis of IgA dermatosis was recent,and the patient had been lost to *** severity of the disease and extent of airway involvement was unknown at the time of the *** airway bleeding was.noticed upon intubation and the otorhinolaryngology team had to be called to the operating *** patient required transfer to the intensive care unit where a multidisciplinary team was involved in her *** patient was extubated on postoperative day *** A multidisciplinary approach to treating this disease is the best course of action before a surgical *** our case,key communication between the surgery,anesthesia,and dermatology teams led to the quick and safe treatment of our patient’s *** surgery should not be considered for these cases unless they are in full remission and there is.no mucous membrane involvement.

关键词： Airway management Bleeding risk Linear immunoglobulin A bullous dermatosis Multidisciplinary approach Outpatient procedure Case report

Unfolding rates of 1:1 and 2:1 complex of CX-5461 and c-MYC promoter G-quadruplexes revealed by s.ngle-molecule force spectroscopy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biophysics Reports 2024年第3期10卷 180-189页

作者： Hui Peng Yashuo Zhang qun Luo Xinyu Wang Huijuan You Hubei Key Laboratory of natural Medicinal Chemistry and Resource Evaluation School of Pharmacy Tongji Medical College Huazhong University of Science and Technology College of Physics science and Technology Yangzhou University

CX-5461, also known as pidnarulex, is a strong G4 stabilizer and has received FdA fast-track designation for BRCA1-and BRCA2-mutated cancers. However, quantitative measurements of the unfolding rates of CX-5461-G4 complexes which are important for the regulation function of G4s, remain ***, we employ s.ngle-molecule magnetic tweezers to measure the unfolding force distributions of c-MYC G4s in the pres.nce of different concentrations of CX-5461. The unfolding force distributions exhibit three discrete levels of unfolding force peaks, corresponding to three binding modes. In combination with a fluorescent quenching assay and molecular docking to previously reported ligand-c-MYC G4 structure, we assigned the ～69 pn peak corresponding to the 1:1（ligand:G4） complex where CX-5461binds at the G4's 5'-end. The ～84 p n peak is attributed to the 2:1 complex where CX-5461 occupies both the 5' and 3'. Furthermore, us.ng the Bell-Arrhenius model to fit the unfolding force distributions,we determined the zero-force unfolding rates of 1:1, and 2:1 complexes to be（2.4 ± 0.9） × 10-8s-1and（1.4 ± 1.0） × 10-9s-1respectively. These findings provide valuable insights for the development of G4-targeted ligands to combat c-MYC-driven cancers.

关键词： s.ngle-molecule G-quadruplex Magnetic tweezers stoichiometry Force spectroscopy Pidnarulex

Modulatory effects of Lactiplantibacillus plantarum on chronic metabolic diseases

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Food science and Human Wellness 2023年第4期12卷 959-974页

作者： Lei Tian Ruixiang Zhao Xinyi Xu Zhiwei Zhou Xiaofang Xu dongmei Luo Zhiqiang Zhou Yu Liu Ariel Kushmaro robert s.marks.and.ás.d.nnyés.qun s.n Key Laboratory of Bio-Resource and Eco-Environment of the Ministry of Education College of Life SciencesSichuan UniversityChengdu 610064China Institute for Marine and Antarctic studies University of TasmaniaNewnham 7248Australia College of Biomass science and Engineering Sichuan UniversityChengdu 610064China department of Urology Institute of Urology(Laboratory of Reconstructive Urology)West China HospitalSichuan UniversityChengdu 610041China Avram and stella Goldstein-Goren Department of Biotechnology EngineeringFaculty of Engineering SciencesBen Gurion University of the NegevBeer-Sheva 84105Israel BioTalentum Ltd. Gödöllő2100Hungary department of Cell Biology and Molecular Medicine University of SzegedSzeged H-6720Hungary Hungarian University of Agriculture and Life sciences Institute of Physiology and Animal NutritionDepartment of Physiology and Animal HealthGödöllő2100Hungary

The increased global incidence of chronic metabolic diseases,a vital threat to human health and a burden on our healthcare systems,includes a series of clinical metabolic s.ndromes such as obesity,diabetes,hypertension,and *** of the well-known probiotic microorganisms,Lactiplantibacillus plantarum plays an important role in promoting human health,including inhibiting the occurrence and development of a variety of chronic metabolic *** pres.nt study provides an overview of the preventive and therapeutic effects of *** on diabetes,obesity,non-alcoholic fatty liver disease,kidney stone disease,and cardiovascular diseases in animal models and human clinical *** *** demonstrated its ability to reduce inflammatory and oxidative stress levels by regulating the production of cytokines and short-chain fatty acids(sCFAs),the activity of antioxidant enzymes,and the balance of intestinal microbial communities to alleviate the symptoms of chronic metabolic ***,updated applications and technologies of *** in food and biopharmaceutical industries are also *** the characteristics and functions of *** will guide the development of related probiotic products and explore the modulatory benefit of *** supplementations on the prevention and treatment of multiple chronic metabolic diseases.

关键词： Lactiplantibacillus plantarum diabetes Obesity non-alcoholic fatty liver disease Kidney stone disease Cardiovascular diseases

double-confined nanoheterostructure sb/sb_(2)s_(3)@Ti_(3)C_(2)T_(x)@C toward ultra-stable Li-/na-ion batteries

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2024年第5期43卷 2067-2079页

作者： dan Wang qun Ma Huan He Zhi-Yuan Wang Run-Guo Zheng Hong-Yu s.n Yan-Guo Liu Chun-Li Liu school of Materials science and Engineering Northeastern UniversityShenyang110819China school of Resources and Materials Northeastern University at QinhuangdaoQinhuangdao 066004China Key Laboratory of dielectric and Electrolyte Functional Material Hebei Province Qinhuangdao 066004China department of Physics and Oxide Research Center Hankuk University of Foreign StudiesYongin 17035Korea

Antimony-based materials with high capacities and moderate potentials are promis.ng anodes for lithium-/-sodium-ion ***,their tremendous volume expansion and inferior conductivity lead to poor structural stability and sluggish reaction ***,a doubleconfined nanoheterostructure sb/sb_(2)s_(3)@Ti_(3)C_(2)T_(x)@C has been fabricated through a solvothermal method followed by low-temperature heat *** dual protection of“MXene”and“carbon”can better accommodate the volume expansion of sb/sb_(2)s_(3).The strong covalent bond(Ti-s,Ti-O-sb,C-O-sb)can firmly integrate sb-based material with Ti_(3)C_(2)T_(x)and carbon,which significantly improves the structure *** addition,the carbon layer can restrain the oxidation of MXenes,and the nano-sb/sb_(2)s_(3)can facilitate electron/ion transport and suppress the restacking of *** heterogeneous interface between sb and sb_(2)s_(3)can further promote interfacial charge *** MXene-sb/sb_(2)s_(3)@C-1 with the optimal sb content shows high specific capacities,comparable rate properties and ultra-stable cycling performances(250 m Ah·g^(-1)after 2500 cycles at 1 A·g^(-1)for sodium-ion batteries).Ex situ X-ray diffractometer(XRd)test reveals the storage mechanism including the conversion and alloying process of MXene-sb/sb_(2)s_(3)@*** voltammetry(CV)test results demonstrate that the pseudocapacitance behavior is dominant in MXene-sb/sb_(2)s_(3)@C-1,especially at large *** design paves the way for exploring high-performance alloy-based/conversion-type anode for energy storage devices.

关键词： sb/sb_(2)s_(3) MXene Carbon Anode Lithium-ion batteries sodium-ion batteries