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Elevated urine formaldehyde in elderly patients with primary open angle glaucoma

International Journal of Ophthalmology(English edition) 2016年第3期9卷 411-416页

作者： Ying Cui Tao Su Shao-Dan Zhang Ping Huang Ying-Ge He Ying Liu Chun Zhang robert ritch Rong-Qiao He Departrncnt of Ophthalmology Peking University Third Hospital Beijing 100191 China Key Laboratory of Vision Loss and Restoration Ministry of Education Beijing 100191 China State Key Laboratory of Brain and Cognitive Science Institute of Biophysics Chinese Academy of SciencesBeijing 100101 China Einhorn Clinical Research Center New York Eye and Ear Infirmary of Mount Sinai New York NY 10003 USA

AIM：To investigate the risk factor of primary open angle glaucoma（POAG）,which is the leading cause of irreversible blindness *** abnormally high level of endogenous formaldehyde（FA） has recently been found correlated with cell death and neurodegenerative disease,raising the possibility of a putative correlation of abnormal endogenous FA with POAG.· METHODS：Thirty-four elderly patients with POAG and sixteen healthy controls were *** visual defects were present at both the functional（visual field） and structural[retinal nerve fiber layer（RNFL）thickness]*** urine samples were obtained and were analyzed by high-performance liquid chromatography（HPLC） to detect the endogenous FA level in a double blind manner.· RESULTS：Patients with POAG（P 〈0.05） had significantly higher urine FA *** urine FA level of patients with severe visual field defects[mean deviation（MD）≥12 dB]was significantly（P〈0.001） greater than that of patients with mild to moderate defects（MD〈12 dB）.By optical coherence tomography（OCT）,the superior and inferior RNFL thickness of POAG group was significantly（P〈0.001） thinner than in ***,the superior and inferior thinning of the RNFL was correlated with the elevation of urine FA ***：Endogenous FA level is positively correlated with the neuronal defects of POAG.

关键词： primary open angle glaucoma urineformaldehyde Alzheimer's disease

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氩激光治疗药物不能控制的急性闭角性青光眼发作

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眼科新进展 1983年第3期 214-215页

作者： robert ritch ,郭子英三二四医院

急性闭角性青光眼最严重的问题之一是用药物不能在发作时控制眼压。这些病例又常在眼压显著升高和炎症情况下施行周边虹膜切除术。在此等情况下进行手术是很危险的。手术中和手术后的并发症都较常见。三种氩激光光凝术可控制急性发作:... 详细信息

急性闭角性青光眼最严重的问题之一是用药物不能在发作时控制眼压。这些病例又常在眼压显著升高和炎症情况下施行周边虹膜切除术。在此等情况下进行手术是很危险的。手术中和手术后的并发症都较常见。三种氩激光光凝术可控制急性发作:周边虹膜成形术,瞳孔成形术和激光虹膜切除术。采用一种或联合手术即可成功地治疗几乎所有药物不能控制的急性闭角性青光眼发作。作者治疗了7例药物不能控制的病人,用氩激光很容易控制发作。病例报告(从略)

关键词：急性闭角性青光眼晶状体虹膜切除术前房角镜激光斑瞳孔括约肌匹罗卡品

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正常眼压性青光眼与高眼压性青光眼视神经图像分析的对比研究

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中华眼底病杂志 2002年第2期18卷 109-112页

作者：窦宏亮 Pons Mauricio Mistlberger Andrea Ishikawa Hiroshi Liebmann Jeffrey ritch robert 第二炮兵总医院眼科北京100088 The New York Eye and Ear Infirmary

目的　探讨正常眼压性青光眼 (normal- tension glaucoma,NTG)与高眼压性青光眼 (high-tension glaucoma,HTG)视盘和视神经纤维层 (retinal nerve fiber layer,RNFL )损害的差异。　方法　选择具有青光眼性视神经损害或 RNFL 缺损、相... 详细信息

目的　探讨正常眼压性青光眼 (normal- tension glaucoma,NTG)与高眼压性青光眼 (high-tension glaucoma,HTG)视盘和视神经纤维层 (retinal nerve fiber layer,RNFL )损害的差异。　方法　选择具有青光眼性视神经损害或 RNFL 缺损、相应的视野缺损的青光眼患者 ,NTG至少 2次 2 4 h眼压曲线和多次眼压测量均≤ 2 1mm Hg(1mm Hg=0 .133k Pa) ,HTG的眼压至少 2次测量≥ 2 5 mm Hg。患者进行详细的眼科检查 ,同时用扫描激光偏振仪 (scanning laser polarimetry,SL P)、光学相干断层扫描 (opticalcoherence tomography,OCT)和海德堡视网膜成像仪 (Heidelberg retinal tomography,HRT)定量测定视盘形态和 RNFL厚度。比较两组视盘总体和相同象限测量参数。　结果　 30例 NTG和 19例 HTG (共 4 9只眼 )患者的平均年龄分别为 (5 9.6± 8.6 )岁 (39～ 71岁 )和 (5 9.2± 12 .3)岁 (36～ 75岁 )。两组间视野缺损的平均偏差 (mean deviation,MD)差异不显著 (P>0 .0 5 )。HRT测量的视盘 C/ D面积比 ,除鼻侧象限外 ,NTG者视盘总体和上、下、颞侧 3个象限均显著大于 HTG者 (P<0 .0 5 ) ,而盘缘面积小于 HTG者 (P<0 .0 5 ) ;两组间其他视盘参数差异不显著。 3种激光扫描技术所测定的总体和象限 RNFL厚度。

关键词：正常眼压性青光眼高眼压性青光眼视神经图像视神经损伤病理生理学视盘损害对比分析 NTG HTG

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