Elevated urine formaldehyde in elderly patients with primary open angle glaucoma

作     者：Ying Cui Tao Su Shao-Dan Zhang Ping Huang Ying-Ge He Ying Liu Chun Zhang Robert Ritch Rong-Qiao He 

作者机构：Departrncnt of Ophthalmology Peking University Third Hospital Beijing 100191 China Key Laboratory of Vision Loss and Restoration Ministry of Education Beijing 100191 China State Key Laboratory of Brain and Cognitive ScienceInstitute of Biophysics Chinese Academy of SciencesBeijing 100101 China Einhorn Clinical Research Center New York Eye and Ear Infirmary of Mount Sinai New York NY 10003 USA 

出 版 物：《International Journal of Ophthalmology(English edition)》 (国际眼科杂志（英文版）)

年 卷 期：2016年第9卷第3期

页      面：411-416页

核心收录：

学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学] 

基　　金：Supported by National Basic Research Program of China(973 Program,No.2012CB911004) the National Natural Science Foundation of China(No. 81041008 No.30772376) 

主　　题：primary open angle glaucoma urineformaldehyde Alzheimer's disease 

摘      要：AIM：To investigate the risk factor of primary open angle glaucoma（POAG）,which is the leading cause of irreversible blindness *** abnormally high level of endogenous formaldehyde（FA） has recently been found correlated with cell death and neurodegenerative disease,raising the possibility of a putative correlation of abnormal endogenous FA with POAG.· METHODS：Thirty-four elderly patients with POAG and sixteen healthy controls were *** visual defects were present at both the functional（visual field） and structural[retinal nerve fiber layer（RNFL）thickness]*** urine samples were obtained and were analyzed by high-performance liquid chromatography（HPLC） to detect the endogenous FA level in a double blind manner.· RESULTS：Patients with POAG（P 〈0.05） had significantly higher urine FA *** urine FA level of patients with severe visual field defects[mean deviation（MD）≥12 dB]was significantly（P〈0.001） greater than that of patients with mild to moderate defects（MD〈12 dB）.By optical coherence tomography（OCT）,the superior and inferior RNFL thickness of POAG group was significantly（P〈0.001） thinner than in ***,the superior and inferior thinning of the RNFL was correlated with the elevation of urine FA ***：Endogenous FA level is positively correlated with the neuronal defects of POAG.