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Subpopulations of regulatory T cells are associated with subclinical atherosclerotic plaques,levels of LDL,and cardiorespiratory fitness in the elderly

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journal of Sport and Health Science 2024年第3期13卷 288-296,I0002页

作者： Tim Böttrich Pascal Bauer Vincent Gröβer Magdalena Huber Hartmann Raifer Torsten Frech Svenja Nolte Theresa Dombrowski Franz Cemic Natascha Sommer robert Ringseis Klaus Eder Karsten Krüger Christopher Weyh Department of Exercise Physiology and Sports Therapy Institute of Sports ScienceJustus-Liebig-UniversityGiessen 35394Germany Department of Cardiology and Angiology Justus-Liebig-University GiessenGiessen 35392Germany Institute for Systems Immunology Center for Tumor und ImmunologyMarburg 35032Germany TH Mittelhessen Department of Computer ScienceUniversity of Applied Sciences GiessenGiessen 35390Germany Department of Internal Medicine Universities of Giessen and Marburg Lung Center(UGMLC)Member of the German Center for Lung Research(DZL)Giessen 35394Germany Excellence Cluster Cardio-Pulmonary Institute(CPI) Justus-Liebig UniversityGiessen 35394Germany Institute of Animal Nutrition and Nutrition Physiology Justus-Liebig-University GiessenGiessen 35390Germany

Background:Atherosclerosis forms the pathological basis for the development of cardiovascular *** pathological processes initially develop without clinically relevant symptoms,the identification of early markers in the subclinical stage plays an important role for initiating early *** is evidence that regulatory T cells(Tregs)are involved in the development of ***,the present study aimed to identify and investigate associations with Tregs and their subsets in a cohort of healthy elderly individuals with and without subclinical atherosclerotic plaques(SAP).In addition,various lifestyle and risk factors,such as cardiorespiratory fitness,were investigated as associated ***:A cross-sectional study was performed in 79 participants(male:n=50;age=63.6±3.7 years;body mass index=24.9±3.1 kg/m2;mean±SD)who had no previous diagnosis of chronic disease and were not taking *** of the carotids to identify SAP,cardiovascular function measurement for vascular assessment and a cardiorespiratory fitness test to determine peak oxygen uptake were ***,tests were conducted to assess blood lipids and determine glucose *** of Tregs and their subtypes(resting(rTregs)and effector/memory(mTregs))was performed by 8-chanel flow *** were categorized according to atherosclerotic plaque *** and logistic regression models were used to analyze associations between ***:SAP was detected in a total of 29 *** participants with plaque were older(64.8±3.6 years vs.62.9±3.5 years)and had higher peripheral systolic blood pressure(133.8±14.7 mmHg vs.125.8±10.9 mmHg).The participants with SAP were characterized by a lower percentage of rTregs(28.8%±10.7%vs.34.6%±10.7%)and a higher percentage of mTregs(40.3%±14.7%vs.30.0%±11.9%).Multiple logistic regression identified age(odds ratio(OR)=1.20(95%confidence interval(95%CI):1.011.42))and

关键词： Cardiorespiratory fitness Elderly Regulatory T cells Subclinical atherosclerosis

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The transcriptional landscape of the developmental switch from regular pollen maturation towards microspore-derived plant regeneration in barley

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The Crop journal 2024年第4期12卷 1064-1080页

作者： Anna Nowicka Martin Kovacik Anna Maksylewicz Przemysław Kopec Ewa Dubas Monika Krzewska Agnieszka Springer robert E.Hoffie Diaaeldin S.Daghma Zbynek Milec Ales Pecinka jochen Kumlehn Iwona Zur The Franciszek Górski Institute of Plant Physiology Polish Academy of Sciences Niezapominajek 2130-239 KrakówPoland Institute of Experimental Botany of the Czech Academy of Sciences Centre of Plant Structural and Functional GenomicsŠlechtitelu3177900 OlomoucCzech Republic Department of Cell Biology and Genetics Faculty of SciencePalacky UniversityŠlechtitelu°2777900 OlomoucCzech Republic Malopolska Centre of Biotechnology Jagiellonian University30-387 KrakówPoland Leibniz Institute of Plant Genetics and Crop Plant Research(IPK)Gatersleben Corrensstraße 306466 Stadt SeelandGermany Institute for Breeding Research on Horticultural Crops Julius Kühn Institute(JKI)-Federal Research Centre for Cultivated PlantsErwin-Baur Straße 2706484 QuedlinburgGermany Global Change Research Institute Czech Academy of Sciences Beˇlidla 986/4a60300 BrnoCzech Republic

Plant formation from in vitro-cultivated microspores involves a complex network of internal and environmental ***/doubled haploids(DHs)derived from in vitro-cultured microspores are widely used in plant breeding and genetic ***,the mechanism underlying the developmental switch from regular pollen maturation towards microspore-derived plant regeneration remains poorly ***,RNA-sequencing was employed to elucidate the transcriptional landscapes of four early stages of microspore embryogenesis(ME)in barley cultivars Golden Promise and Igri,which exhibit contrasting responsiveness to microspore-derived plant *** experiments revealed fundamental regulatory networks,specific groups of genes,and transcription factor(TF)families potentially regulating the developmental *** identified a set of candidate genes crucial for genotype-dependent responsiveness/recalcitrance to *** high-resolution temporal transcriptome atlas provides an important resource for future functional studies on the genetic control of microspore developmental transition.

关键词： Hordeum vulgare Marker gene Microspore embryogenesis Stress response Transcriptome analysis

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Alzheimer's disease and low-dose radiation therapy:A new hope

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Radiation Medicine and Protection 2024年第1期5卷 1-6页

作者： Neal E.Dunlap robert P.Friedland Lu Cai Department of Radiation Oncology University of Louisville School of MedicineLouisvilleKY40202USA Department of Neurology The University of Louisville School of MedicineLouisvilleKY40202USA Pediatric Research Institute Departments of PediatricsPharmacology and ToxicologyUniversity of Louisville School of MedicineLouisvilleKY40202USA

The concept of low-dose radiation(LDR)-induced hormetic responses was initially observed approximately 70 years ago and systematically reviewed along with the discovery of LDR-induced adaptive responses in a cytogenetic in vitro study in *** the end of the 1990s,discussions regarding the potential applications of LDRinduced hormesis and adaptive responses for preventing or treating chronic diseases,such as Alzheimer’s disease(AD)had taken *** 2016,reports on radiotherapy for the subjects with AD and for genetic AD model mice were ***,several preclinical studies with animal models of AD and clinical studies in AD subjects were conducted.A significant milestone was achieved with the online availability of a new Systematic Review based on qualified publications from these preclinical and clinical *** mini-review provides a concise historical introduction to LDR-induced hormesis and adaptive responses with discussion of AD radiotherapy with either LDR or relatively high dose *** of this Systematic Review cover promising outcomes,challenges,and new questions,followed by discussion of potential mechanisms.

关键词： Alzheimer’s disease Low-dose radiation Radiation adaptive response Radiation hormesis

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透空结构与半潜式风机集成系统耦合运动响应特性分析

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哈尔滨工程大学学报（英文版） 2024年第2期23卷 491-505页

作者：姚一晟 robert Mayon 周宇朱祎宁德志 State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China Dalian Key Laboratory of Offshore Renewable Energy Dalian University of TechnologyDalian 116024China Powerchina Zhongnan Engineering Corporation Limited Changsha 410000China

A novel semi-submersible platform is proposed for 5 MW wind *** concept focuses on an integrated system formed by combining porous shells with a semi-submersible platform.A coupled aerodynamic–hydrodynamic–mooring analysis of the new system is *** motion responses of the novel platform system and the traditional platform are *** differences in hydrodynamic performance between the two platforms are also *** influence of the geometric parameters(porosity,diameter,and wall thickness)of porous shells on the motion response behavior of the new system is ***,the new semi-submersible platform exhibits superior stability in terms of pitch and heave degrees of freedom,demonstrating minimal effects on the motion response in the surge degree of freedom.

关键词： Semi-submersible platform Porous shells OC4-DeepCwind Motion response Hydrodynamic parameters Porous shells’geometric parameters

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National Social Investment Programmes in Nigeria:A Descriptive Analysis of the Socio-Economic Contributions of N-Power Programme in Benue State

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Management Studies 2024年第1期12卷 9-20页

作者： robert Idoko Ogwola Dennis Anyebe Olofu Charles Amobi Aneke Federal University GashuaNigeria National Council for Arts and Culture Garki-AbujaNigeria

This study analysed the socio-economic contributions of N-Power programme amongst the beneficiaries of the scheme in Benue *** to the introduction of N-Power programme,successive administrations in Nigeria have made concerted efforts towards improving the standard of living of the citizenry through the execution of various welfare or social intervention programmes,but not much successes were *** from the mistakes of the past regimes,and by way of deliberate state policy,the Buhari’s government initiated a multi-pronged social investment policy,one of which is the N-power programme that came onboard in 2016,which also doubles as the subject of this *** achieve the goal of this study,a combination of desktop research and survey design was *** were administered to 390 respondents through a combination of stratified and random sampling *** results of the survey were matched with that of the secondary data obtained through online websites and other related *** result indicated that N-Power made positive contributions to the socio-economic life of the beneficiaries in Benue State:specifically,the scheme contributed in poverty eradication,employment generation,skills acquisitions and capacity ***,some aspect of our findings revealed that the programme has a number of challenges such as:inadequate cash support,delay in monthly cash transfer to beneficiaries,distance participants had to move to their work stations,absence of posting in N-Teach scheme,and lack of adequate working tools amongst *** salvage this problem the paper recommended the following solutions:expansion of the scheme to cover N-Teach and other aspects,increment in the monthly cash transfer to cushion the high rate of inflation,support for the participants/beneficiaries in transportation and logistics,enrolment of more youth into the various schemes,proper monitoring and evaluation of the implementation of the schemes among

关键词： national social investment programme N-Power contributions socio-economic development

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Coverage and determinants of infant postnatal care in Nigeria:A population-based cross-sectional study

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Pediatric Investigation 2024年第1期8卷 27-36页

作者： Bolaji Emmanuel Egbewale Olusola Oyedeji jesse Bump Christopher robert Sudfeld Department of Global Health and Population Takemi Program in International HealthHarvard T.H.Chan School of Public HealthBostonMassachusettsUSA Department of Community Medicine College of Health SciencesLadoke Akintola University of TechnologyOgbomosoNigeria Department of Pediatrics and Child Health College of Health SciencesLadoke Akintola University of TechnologyOgbomosoNigeria

Importance:In 2019,Nigeria had the largest number of under-5 child deaths globally and many of these deaths occurred within the first week of *** World Health Organization recommends infant postnatal care(PNC)attendance to support newborn survival;however,utilization of PNC is known to be low in many ***:This study examined coverage and individual-level determinants of infant PNC attendance in ***:Nigeria Demographic Health Survey(NDHS)2018 data were used to evaluate infant PNC coverage and *** PNC was defined as receipt of care within 2 days of *** delivered up to 2 years before the 2018 NDHS were *** examined predictors of infant PNC with modified Poisson regression models to estimate relative risks(RRs).Results:The national coverage of infant PNC was 37.3%(95%confidence interval[CI]:35.8%–38.7%).Significant heterogeneity in PNC attendance existed at state and regional *** delivery was strongly associated with the uptake of PNC(RR:6.07;95%CI:5.60–6.58).Greater maternal education,maternal employment,urban residence,female head of household,and greater wealth were also associated with an increased likelihood of PNC ***:The uptake of infant PNC is low and interventions are urgently needed to promote equity in access and increase demand for PNC in Nigeria.

关键词： Infant postnatal care Epidemiology Coverage Determinants Nigeria

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A rare inter-haplotypic recombination at the S-locus contributed to the loss of self-incompatibility in trifoliate orange

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Plant Communications 2024年第9期5卷 16-20页

作者： jianbing Hu Furong Guo Zezhen Du Peng Chen Chunmei Shi jinzhi Zhang junli Ye Xiuxin Deng robert M.Larkin Wenbiao jiao Zongcheng Lin Maurice Bosch Lijun Chai National Key Laboratory for Germplasm Innovation and Utilization of Horticultural Crops College of Horticulture and Forestry SciencesHuazhong Agricultural UniversityWuhan 430070P.R.China Hubei Hongshan Laboratory Wuhan 430070P.R.China Horticultural Institute Hunan Academy of Agricultural SciencesChangsha 410125P.R.China Institute of Biological Environmental and Rural Sciences(IBERS)Aberystwyth UniversityAberystwyth SY233FLUK

Dear Editor,In trans-specific S-haplotypes,crossover recombination at the S-locus,which controls self-incompatibility,has been thought to be highly ***,we discovered a previously unreported super S haplotype,derived from a rare inter-haplotypic recombination event,that contained two complete suites of functional S-RNase and SLF genes and could break the SI response in trifoliate orange through“self-recognition”within the same pollen.

关键词： orange crossover trifolia

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Comparative Study of Exhaust Emissions from Diesel and Syngas Powered 3.5 kW Compression Ignition Engine with and without Load

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journal of Power and Energy Engineering 2024年第8期12卷 30-46页

作者： Benson Kariuki Paul Njogu joseph Kamau robert Kinyua Sameer Bachani Institute of Energy and Environmental Technology Jomo Kenyatta University of Agriculture & Technology Nairobi Kenya Department of Mechanical and Automotive Engineering Technical University of Mombasa Mombasa Kenya

Despite diesel engines being highly efficient, with low fuel consumption and reduced carbon dioxide emissions, they emit relatively high levels of particulate matter and oxides of nitrogen (NOx) due to high exhaust gas temperatures. Engine emissions show the quality and completeness of combustion. This paper aims to present the results of a study comparing exhaust emissions from a diesel and syngas powered engine. Syngas was produced from co-firing coal and biomass in a gasifier then cleaned, cooled and applied as an alternative fuel in an engine operated from 0 - 100% load. Exhaust-emissions were monitored at this load conditions. The exhaust-temperature was measured using thermocouples and the emission gases were analyzed using Testo 350. The emissions were lower and decreased as the engine load increased, except for sulphur dioxide and NOx. The study shows that levels of carbon monoxide, were higher in a range of 46.5 - 80.2%, while carbon dioxide was 3.3 - 18% higher compared to those from diesel. Hydrocarbon emissions were 480 and 1250 ppm for diesel and syngas respectively. The study reveals that the engine operates optimally at higher loads since hydrocarbons and oxides of carbon are low due to complete combustion at higher temperatures. Exhaust gas temperature was higher in the syngas fuel and increased as the engine load increased in the range of 455.83 - 480.03˚C which influenced the formation of NOx. NOx from diesel was found to be higher, ranging from 32.5 - 40.5%, compared to those from syngas with an engine load of 75%. The study observed that relative to diesel, the emissions of sulfur dioxide at 50% engine load were lower in a range of 23.7 - 57.1%. Emissions of hydrocarbons depended on the degree of substitution of diesel and engine load. The study therefore shows that, relative to diesel, emissions decreased when syngas was used with upgraded syngas from Prosporis juliflora presenting as the best alternative followed by Hyphanae compressa, and last

关键词： Emissions Engine Load Temperature Neat-Diesel Syngas

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The Sigma-1 Receptor as a Pharmacologic Chaperone: Energetics

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journal of Biosciences and Medicines 2024年第8期12卷 347-356页

作者： robert B. Raffa joseph V. Pergolizzi jr. School of Pharmacy (Emeritus) Temple University Philadelphia PA USA College of Pharmacy (Adjunct) University of Arizona Tucson AZ USA NEMA Research Naples FL USA

Initially thought to be an opioid receptor subtype, Sigma-1 receptors (S1R) are now known to be unique proteins that have chaperone-like properties. As such, they play critical roles in cellular signaling, homeostasis, and cell survival. These roles offer significant insight for understanding homeostasis of normal physiologic processes, and the pathophysiologic consequences of disruption of normal function. Because of the broad nature of chaperone action, S1R agonists and antagonists represent potential drug discovery goals for the pharmacotherapeutic treatment of a variety of disorders that result from dysfunctional proteins. The present study summarizes the S1R as a pharmacologic chaperone crucial for protein folding and cellular homeostasis. Through literature review and thermodynamic analysis, it explores how S1R stabilizes target proteins, influencing neuroprotection and potential drug therapies. The binding of chaperones to target proteins is thermodynamically favorable, offering insights into treating diseases linked to protein misfolding.

关键词： Chaperone Sigma-1 Receptor Energetics Thermodynamics Isothermal Titration Microcalorimetry

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具有半子模式欧拉拓扑绝缘体的声学观测

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Science Bulletin 2024年第11期69卷 1653-1659页

作者：姜斌 Adrien Bouhon 吴世巧孔泽霖林志康 robert-jan Slager 蒋建华 Suzhou Institute for Advanced Research University of Science and Technology of ChinaSuzhou 215123China School of Physical Science and Technology&Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow UniversitySuzhou 215006China TCM Group Cavendish LaboratoryUniversity of CambridgeCambridge CB30HEUK NORDITA Stockholm University and KTH Royal Institute of TechnologyStockholm SE-10691Sweden

Topological band theory has conventionally been concerned with the topology of bands around a single gap. Only recently non-Abelian topologies that thrive on involving multiple gaps were studied, unveiling a new horizon in topological physics beyond the conventional paradigm. Here, we report on the first experimental realization of a topological Euler insulator phase with unique meronic characterization in an acoustic metamaterial. We demonstrate that this topological phase has several nontrivial features:First, the system cannot be described by conventional topological band theory, but has a nontrivial Euler class that captures the unconventional geometry of the Bloch bands in the Brillouin ***, we uncover in theory and probe in experiments a meronic configuration of the bulk Bloch states for the first time. Third, using a detailed symmetry analysis, we show that the topological Euler insulator evolves from a non-Abelian topological semimetal phase via. the annihilation of Dirac points in pairs in one of the band gaps. With these nontrivial properties, we establish concretely an unconventional bulk-edge correspondence which is confirmed by directly measuring the edge states via. pump-probe techniques. Our work thus unveils a nontrivial topological Euler insulator phase with a unique meronic pattern and paves the way as a platform for non-Abelian topological phenomena.

关键词： Euler insulators Meronic waves Acoustic metamaterials Topological phases of matter

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