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Journal of Energy Chemistry 2019年第8期28卷 220-227,I0008页

作者： Thomas Abo Atia giuseppe Elia robert hahn Pietro Altimari Francesca Pagnanelli Department of Chemistry Sapienza University of RomeRome 00185 Italy Waste Recycling Technologies Flemish Institute for Technological ResearchMol 2400 Belgium Technische Universitat Berlin Research Center of Microperipheric TechnologiesBerlin D-13355 Germany Fraunhofer-Institut für Zuverlassigkeit und Mikrointegration Berlin D-13355 Germany

This work presents an enhanced hydrometallurgical process for recycling lithium ion batteries. First, endof-life batteries were processed in a physical pre-treatment plant to obtain a representative electrode material. The resulting leachate was purified forth by iron-precipitation, liquid–liquid extractions, and an innovative Li–Na separation, in order to obtain valuable products. These products include high-grade graphite, cobalt oxide(Co3O4, purity 83%), cobalt oxalate(CoC2O4, purity 96%), nickel oxide(Ni O, purity89%), and lithium carbonate(Li2CO3, purity 99.8%). The recovery rate was quantitative for graphite, between 80% and 85% for cobalt depending on the nature of the recovery method, 90% for nickel, and 72%for lithium. Secondary streams were also valorized to obtain sodium sulfate(Na2SO4, purity 96%), and MnCoFe2O4 magnetic nano-sorbents according to the zero-waste concept. In order to close the loop, recycled Co3O4 and NiO were used as conversion-type anode materials for advanced lithium ion batteries showing promising performances.

关键词： LIB recycling graphite Cobalt Nickel Lithium Advanced LIB

Effects of tap water, electrolyte solution, and spontaneous and furosemide-stimulated urinary excretion on thirst

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World Journal of Experimental Medicine 2012年第1期2卷 1-6页

作者： Yu-Hong Li Nana Waldréus Joachim Zdolsek robert g.hahn Department of Anesthesia College of Medicine Zhejiang University Department of Anesthesia Faculty of Health Sciences Linkoping University Section for Research Department of Patient Safety and Quality S?dert?lje Hospital SE-152 86 S?dert?lje Sweden

AIM: To contrast the effects of various modifications of body fluid volumes on thirst as reported by healthy volunteers. METHODS: Ten male volunteers aged between 19 and 37 years(mean 22 years) underwent four experiments each, which comprised infusion of 400-800 m L of acetated Ringer's solution and intake of 600 m L of tap water. Half of the experiments were preceded by volume depletion(median 1.7 L) with furosemide. A visual analogue scale(0-100 mm) was used to assess perceived thirst during each experiment. RESULTS: Volume depletion(P ger's acetate did not significantly change the thirst rating(multiple regressions). More detailed analyses showed that the volume depletion increased the median(25th-75th percentiles) thirst rating from 28 mm(21-43) to 59 mm(46-72, P ge occurred in those who were only slightly thirsty(gan. Ringer's solution alleviated thirst in those who were very thirsty, but tended to increase thirst in the volunteers who were not thirsty before the infusion. Similarly, hydration with tap water decreased thirst(by 24 mm, P 60 mm) while the others reported no change.

关键词： Thirst perception Body fluid Homeostasis Volume depletion

Biophotonic sensors with integrated Si_(3)N_(4)-organic hybrid (SiNOH) lasers for point-of-care diagnostics

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Light(Science & Applications) 2021年第4期10卷 648-659页

作者： Daria Kohler gregor Schindler Lothar hahn Johannes Milvich Andreas Hofmann Kerstin Lange Wolfgang Freude Christian Koos Institute of Photonics and Quantum Elearo nics(IPQ) Karlsruhe Institute of Technology(KIT)Engesserstrasse 576131 KarlsruheGermany lnstitute of Microstructure Technology(IMT) Karlsruhe Institute of Technology(KIT)Hermann-von-Helmholtz-Platz 176344 Eggenstein-LeopoldshafenGermany robert Bosch gmbH Robert-Bosch-Campus 171272 RenningenGermany lnstitute for Autom ation and Applied Informatics(IAI) Karlsruhe Institute of Technology(KIT)Hermann-von-Helmholtz-Platz 176344 Eggenstein-LeopoldshafenGermany

Early and efficient disease diagnosis with low-cost point-of-care devices is gaining importance for personalized medicine and public health *** this context,waveguide-(Wg)-based optical biosensors on the siliconnitride(Si_(3)N_(4))platform represent a particularly promising option,offering highly sensitive detection of indicative biomarkers in multiplexed sensor arrays operated by light in the visible-wavelength ***,while passive Si_(3)N_(4)-based photonic circuits lend themselves to highly scalable mass production,the integration of low-cost light sources remains a *** this paper,we demonstrate optical biosensors that combine Si_(3)N_(4)sensor circuits with hybrid on-chip organic *** Si_(3)N_(4)-organic hybrid(SiNOH)lasers rely on a dye-doped cladding material that are deposited on top of a passive Wg and that are optically pumped by an external light *** of the devices is simple:The underlying Si_(3)N_(4)Wgs are structured in a single lithography step,and the organic gain medium is subsequently applied by dispensing,spin-coating,or ink-jet printing processes.A highly parallel read-out of the optical sensor signals is accomplished with a simple *** our proof-of-concept experiment,we demonstrate the viability of the approach by detecting different concentrations of fibrinogen in phosphate-buffered saline solutions with a sensor-length(L-)-related sensitivity of S/L=0.16 rad nM^(-1)mm^(-1).To our knowledge,this is the first demonstration of an integrated optical circuit driven by a co-integrated low-cost organic light *** expect that the versatility of the device concept,the simple operation principle,and the compatibility with cost-efficient mass production will make the concept a highly attractive option for applications in biophotonics and point-of-care diagnostics.

关键词： passive waveguide pumped

grapefruit-seed extract attenuates ethanol-and stress-induced gastric lesions via activation of prostaglandin, nitric oxide and sensory nerve pathways

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World Journal of gastroenterology 2005年第41期11卷 6450-6458页

作者： Tomasz Brzozowski Peter C Konturek Danuta Drozdowicz Stanislaw J Konturek Oxana Zayachivska robert Pajdo Slawomir Kwiecien Wieslaw W Pawlik Eckhart g.hahn Department of Physiology Jagiellonian University Medical College CracowPoland Department of Medicine Ⅰ University of Erlangen-Nuremberg ErlangenGermany Oxana Zayachivska National Medical University LvivUkraine

AIM: grapefruit-seed extract (gSE) containing flavonoids, possesses antibacterial and antioxidative properties but whether it influences the gastric defense mechanism and gastroprotection against ethanol- and stress-induced gastric lesions remains unknown. METHODS: We compared the effects of gSE on gastric mucosal lesions induced in rats by topical application of 100% ethanol or 3.5 h of water immersion and restraint stress (WRS) with or without (A) inhibition of cyclooxygenase (COX)-1 activity by indomethacin and rofecoxib, the selective COX-2 inhibitor, (B) suppression of NO-synthase with L-NNA (20 mg/kg ip), and (C) inactivation by capsaicin (125 mg/kg sc) of sensory nerves with or without intragastric (ig) pretreatment with gSE applied 30 min prior to ethanol or WRS. One hour after ethanol and 3.5 h after the end of WRS, the number and area of gastric lesions were measured by planimetry, the gastric blood flow (gBF) was assessed by H2-gas clearance technique and plasma gastrin levels and the gastric mucosal generation of PgE2, superoxide dismutase (SOD) activity and malonyldialdehyde (MDA) concentration, as an index of lipid peroxidation were determined. RESULTS: Ethanol and WRS caused gastric lesions accompanied by the significant fall in the gBF and SOD activity and the rise in the mucosal MDA content. Pretreatment with gSE (8-64 mg/kg i g) dose-dependently attenuated gastric lesions induced by 100% ethanol and WRS; the dose reducing these lesions by 50% (ID50) was 25 and 36 mg/kg, respectively, and this protective effect was similar to that obtained with methyl PgE2 analog (5 μg/kg i g). gSE significantly raised the gBF, mucosal generation of PgE2, SOD activity and plasma gastrin levels while attenuating MDA content. Inhibition of PgE2 generation with indomethacin or rofecoxib and suppression of NO synthase by L-NNA or capsaicin denervation reversed the gSE-induced protection and the accompanying hyperemia. Co-treatment of exogenous calcitonine gene-related p

关键词：葡萄柚乙醇胃损伤活化作用氧化氮感觉神经

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液体治疗可能比想象中困难得多

麻醉与镇痛 2008年第4期4卷 41-42页

作者： robert g. hahn 唐李隽(译) 李士通(校) Clinical Research Centre the Soedertaelje Hospital Soedertaelje Sweden 不详

长久以来，我们一直教育年轻麻醉医生静脉液体治疗的主要目标是替代体液损失量。毫无疑问，手术中液体缺乏是因为手术前禁食、手术失血、蒸发和排尿。各类麻醉引起的血管扩张使血管床可以容纳更多血浆，而这部分额外的容量需求一般须通... 详细信息

长久以来，我们一直教育年轻麻醉医生静脉液体治疗的主要目标是替代体液损失量。毫无疑问，手术中液体缺乏是因为手术前禁食、手术失血、蒸发和排尿。各类麻醉引起的血管扩张使血管床可以容纳更多血浆，而这部分额外的容量需求一般须通过静脉输液补充。很多同仁主张输注更多液体以补充转移至“第三间隙”的容量。也有观点认为，还需补充由炎症介质引起的毛细血管间白蛋白渗漏增加所导致的液体外渗量。上述因素可能使患者在一台常规手术中输液达到数升。

关键词：液体治疗手术中输液麻醉医生静脉输液手术前禁食手术失血血管扩张液体外渗

Multi-Modality Imaging in a Hybrid Setting Facilitates Transcatheter Closure of a Traumatic Ventricular Septal Defect

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World Journal of Cardiovascular Surgery 2013年第6期3卷 186-189页

作者： Tamim Nazif Rebecca T. hahn robert Sommer Susheel K. Kodali Mathew R. Williams Isaac george Divisions of Interventional Cardiology and Cardiothoracic Surgery Columbia University College of Physicians and Surgeons New York USA

We present a case of transcatheter closure of a traumatic ventricular septal defect (VSD), in which simultaneous 3-dimensional (3D) transesophageal echocardiography (TEE) and angiography played a critical role in defe... 详细信息

关键词： Ventricular Septal Defect Transcatheter Percutaneous

重症监护病房中患者的血液、血浆和红细胞容量

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麻醉与镇痛 2009年第4期5卷 59-60页

作者： robert hahn 崔灿(译) 王庆(校) 赵国栋(校) Clinical Research Center Sodertalje County 152 86 Sodertalje Sweden 不详

大多数临床医生不愿意测量重症监护病房（ICU）中患者的血容量，因为这个过程需要大量的时间、多个血液样本、操作复杂的设备和（或）接触放射性物质。因此，循环血容量经常用例如心排血量等中心血流动力学数据推测得出。自20世纪90年... 详细信息

大多数临床医生不愿意测量重症监护病房（ICU）中患者的血容量，因为这个过程需要大量的时间、多个血液样本、操作复杂的设备和（或）接触放射性物质。因此，循环血容量经常用例如心排血量等中心血流动力学数据推测得出。自20世纪90年代晚期吲哚青绿脉搏光谱测定法出现以来，研究人员一直尝试使直接测量法更简易。最近，一家名为Daxor的纽约公司已经在销售一种相当简单的仪器BVA-100，该仪器以一种更经典的方法来测定血浆和血容量。

关键词：重症监护病房血液样本红细胞容量血浆循环血容量光谱测定法直接测量法心血流动力学

Assessment of metastatic liver disease in patients with primary extrahepatic tumors by contrast-enhanced sonography versus CT and MRI

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World Journal of gastroenterology 2006年第11期12卷 1699-1705页

作者： Christoph F Dietrich Wolfgang Kratzer Deike Strobel Etienne Danse robert Fessl Alfred Bunk Udo Vossas Karlheinz Hauenstein Wilhelm Koch Wolfgang Blank Matthijs Oudkerk Dietbert hahn Christian greis Department of Internal Medicine Ⅱ Johann Wolfgang goethe University Hospital 60590 FrankfurtGermany Department of Internal Medicine Ⅰ University Hospital Ulm 89070Germany Medical Clinic Ⅰ University Hospital Erlangen 91054Germany Department of Radiology University Hospital St.Luc Brussels 1200Belgium Department of Radiology Central Hospital Augsburg 86156Germany Department for Visceral Thoracic and Vascular Surgery University HospitalDresden 01307Germany Department of Radiology Marien Hospital DUsseldorf 40479Germany Department of Radiology University Hospital Rostock 18055Germany Medical Clinic Ⅱ Leopoldina Hospital Schweinfurt 97422Germany Department of Internal Medicine Hospital am Steinenberg Reutlingen 72764Germany Department of Radiology University Hospital Groningen 9700Netherlands Department of Radiology University Hospital Würzburg 97080Germany Clinical Research Bracco Altana Pharma Konstanz 78467Germany

瞄准：与已知的额外的肝的原发性瘤对包括 CT， MRI 和临床 / 组织学的数据的联合标准答案在病人在肝转移的察觉用 SonoVue 评估提高对比的 ultrasonography (CEUS ) 。方法：它是一国际多集中学习，并且有 12 个中心和 125 个病人(64 ... 详细信息

瞄准：与已知的额外的肝的原发性瘤对包括 CT， MRI 和临床 / 组织学的数据的联合标准答案在病人在肝转移的察觉用 SonoVue 评估提高对比的 ultrasonography (CEUS ) 。方法：它是一国际多集中学习，并且有 12 个中心和 125 个病人(64 男性， 61 女性，变老 59+/-11 年) 包含，与 102 个病人一起每协议。原发性瘤是在 35% 表面的颜色，在 27% 的胸，在 17% 胰腺并且其它在 21% 。用 SonoVue 的 CEUS 用西门子 Elegra， Philips HDI 5000 和 Acuson 红杉与一种 low-mechanical-index 技术和对比特定的软件被采用；为至少五分钟的连续扫描。结果：有 SonoVue 的 CEUS 显著地增加了检测的焦点的肝损害对 unenhanced sonography 的数字。在 31.4% 病人，更多的损害在对比改进以后被发现。检测的损害的全部的数字与 CEUS (55 ) 是可比较的，三倍阶段的螺线 CT (61 ) 和有一个肝特定的对比代理人(53 ) 的 MRI。变形疾病的察觉的精确性(即至少一变形损害) 比为 unenhanced sonography (81.4%) 为 CEUS (91.2%) 是显著地更高的并且类似于三倍阶段的螺线 CT (89.2%) 的。在其 CEUS 检查否定的 53 个病人，后续考试 3-6 瞬间以后在 50 个病人(94.4%) 证实了变形损害的缺席。结论：CEUS 被证明在在有已知的额外的肝的原发性瘤的病人的肝转移的察觉可靠并且怀疑肝损害。

关键词：肝疾病原发性肝外肿瘤超声检查 CT检查

Observation of a single protein by ultrafast X-ray diffraction

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Light(Science & Applications) 2024年第1期13卷 80-90页

作者： Tomas Ekeberg Dameli Assalauova Johan Bielecki Rebecca Boll Benedikt J.Daurer Lutz A.Eichacker Linda E.Franken Davide E.galli Luca gelisio Lars gumprecht Laura H.gunn Janos Hajdu robert Hartmann Dirk Hasse Alexandr Ignatenko Jayanath Koliyadu Olena Kulyk Ruslan Kurta Markus Kuster Wolfgang Lugmayr Jannik Lübke Adrian P.Mancuso Tommaso Mazza Carl Nettelblad Yevheniy Ovcharenko Daniel E.Rivas Max Rose Amit K.Samanta Philipp Schmidt Egor Sobolev Nicusor Timneanu Sergey Usenko Daniel Westphal Tamme Wollweber Lena Worbs Paul Lourdu Xavier Hazem Yousef Kartik Ayyer Henry N.Chapman Jonas A.Sellberg Carolin Seuring Ivan A.Vartanyants Jochen Küpper Michael Meyer Filipe R.N.C.Maia Laboratory of Molecular Biophysics Department of Cell and Molecular BiologyUppsala UniversityHusargatan 3(Box 596)SE-75124 UppsalaSweden Deutsches Electronen-Synchrotron DESY Notkestrasse 8522607 HamburgGermany European XFEL Holzkoppel 422869 SchenefeldGermany Diamond Light Source Harwell Science&Innovation CampusDidcot OX110DEUK University of Stavanger Centre Organelle ResearchRichard-Johnsensgate 44021 StavangerNorway Leibniz Institute for Experimental Virology(HPI) Centre for Structural Systems BiologyNotkestraße 8522607 HamburgGermany Dipartimento di Fisica“Aldo Pontremoli” Universitàdegli Studi di Milanovia Celoria 1620133 MilanoItaly Center for Free-Electron Laser Science DESY22607 HamburgGermany Plant Biology Section School of Integrative Plant ScienceCornell UniversityIthacaNY 14853USA PNSensor gmbH Otto-Hahn-Ring 6D-81739 MünchenGermany Biomedical and X-Ray Physics Department of Applied PhysicsAlbaNova University CenterKTH Royal Institute of TechnologySE-10691 StockholmSweden ELI Beamlines/IoP Institute of Physics AS CR v.v.i.Na Slovance 218221 Prague 8Czech Republic Multi-User CryoEM Facility Centre for Structural Systems BiologyNotkestr.8522607 HamburgGermany University Medical Center Hamburg-Eppendorf(UKE) Martinistrasse 5220246 HamburgGermany The Hamburg Center for Ultrafast Imaging Universität HamburgLuruper Chaussee 14922761 HamburgGermany Department of Physics Universität HamburgLuruper Chaussee 14922761 HamburgGermany Department of Chemistry and Physics La Trobe Institute for Molecular ScienceLa Trobe UniversityMelbourneVIC 3086Australia Division of Scientific Computing Science for Life LaboratoryDepartment of Information TechnologyUppsala UniversityBox 337SE-75105 UppsalaSweden European Molecular Biology Laboratory c/o DESYNotkestrasse 8522607 HamburgGermany Department of Physics and Astronomy Uppsala UniversityBox 516SE-75120 UppsalaSweden Max Planck Institute for the Structure and Dynamics of Matter Luruper Chaussee 14922761 HamburgGe

The idea of using ultrashort X-ray pulses to obtain images of single proteins frozen in time has fascinated and inspired *** was one of the arguments for building X-ray free-electron *** to theory,the extremely intense pulses provide sufficient signal to dispense with using crystals as an amplifier,and the ultrashort pulse duration permits capturing the diffraction data before the sample inevitably *** was first demonstrated on biological samples a decade ago on the giant *** then,a large collaboration has been pushing the limit of the smallest sample that can be *** ability to capture snapshots on the timescale of atomic vibrations,while keeping the sample at room temperature,may allow probing the entire conformational phase space of *** we show the first observation of an X-ray diffraction pattern from a single protein,that of Escherichia coli groEL which at 14 nm in diameter is the smallest biological sample ever imaged by X-rays,and demonstrate that the concept of diffraction before destruction extends to single *** the pattern,it is possible to determine the approximate orientation of the *** experiment demonstrates the feasibility of ultrafast imaging of single proteins,opening the way to single-molecule time-resolved studies on the femtosecond timescale.

关键词： smallest intense ultrafast