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Photoacoustic detection of circulating melanoma cells in late stage patients

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Journal of Innovative Optical Health Sciences 2020年第6期3卷 47-54页

作者： John A.Viator Marc Hazur Andrea Sajewski Ahmad Tarhini Martin e.sanders robert H.edgar Department of engineering Duquesne University 600 Forbes Avenue PittsburghPennsylvania 15282USA Department of Bioengineering University of Pittsburgh 3700 O'Hara Street PittsburghPA 15260USA Moffitt Comprehensive Cancer Center and Research Institute 10920 McKinley Drive TampaFlorida 33612USA Acousys Biodevices Inc 1777 Highland Drive Ann ArborMichigan 48108USA

Melanoma is the deadliest skin cancer and is responsible for over 7000 deaths in the US *** spread of cancer,or metastasis,is responsible for these deaths,as secondary tumors interrupt normal organ *** tumor cells,or those cells that spread throughout the body from the primary tumor,are thought to be responsible for *** developed an optical method,photoacoustic flow cytometry,in order to detect and enumerate circulating melanoma cells(CMCs)from blood samples of *** tested the blood of StageⅣmelanoma patients to show the ability of the photoacoustic flow cytometer to detect these rare cells in *** then tested the system on archived blood samples from StageⅢmelanoma patients with known outcomes to determine if detection of CMCs can predict future *** detected between 0 and 66 CMCs in StageⅣ*** the StageⅢstudy,we found that of those samples with CMCs,two remained disease free and five developed *** those without CMCs,six remained disease free and one developed *** believe that photoacoustic detection of CMCs provides valuable information for the prediction of metastasis and we postulate a system for more accurate prognosis.

关键词： Diagnosis metastasis optoacoustics

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DB2数据库管理考试指南英文版影印版

丛书名：专业认证考试丛书

2003年

作者：（美）Roger e.sanders

本书共分三个部分，主要介绍了与DB2数据库管理认证相关的基本概念及最新的考试信息。

ISBN: (纸本)7505382780

本书共分三个部分，主要介绍了与DB2数据库管理认证相关的基本概念及最新的考试信息。

关键词：数据库管理系统关系型数据库考核

来源：畅想之星图书光盘版（南... 评论

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DB2通用数据库API开发人员指南 4

Hydrologic Time Scale:A Fundamental Stream Characteristic

丛书名： IBM/Lotus技术丛书

2001年

作者：（美）Roger e.sanders 杨正洪等译

本书详细介绍了DB2通用数据库API的基础知识与应用技巧。主要内容包括关系数据库的重要基本概念、DB2通用数据库应用程序开发基础技术、API函数的详细参考信息等。

ISBN: (纸本)7111090713

关键词：数据库管理系统关系型数据库

来源：畅想之星图书光盘版（南... 畅想之星图书光盘版（南... 评论

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Journal of earth Science 2022年第5期33卷 1291-1297页

作者： robert e.Criss Department of earth and Planetary Sciences Washington University in St.LouisSt.LouisMO63130USA

A new,fundamental catchment attribute called the hydrologic time scaleτgoverns the rate of delivery of runoff to a particular site,and is equal to∫Qdt/∫|dQ|,where Q is discharge and t is *** value ofτfor any gauged site is readily calculated from tabulated discharge data by replacing the integrals with *** quantity,coupled with the square root of catchment area,√A,form a coordinate pair that embodies the characteristic time and length scales for any catchment,which govern its flow *** fitting constants used in several unit hydrograph models are simple multiples ofτ,so knowledge ofτallows rapid calibration of these models for the particular site,facilitating flow prediction from rainfall *** ofτreflect many different landscape attributes,but for multiple sub-basins in watersheds with homogeneous land use and lithologic conditions,they correlate linearly with √*** ratio √A/τprovides a characteristic velocity that is high for channelized,floodprone rivers,for flashy urban streams with high impervious cover,and for sites downstream of hydropower *** with low velocities are resistant to flooding,as their landscapes have a greater ability to delay the delivery of runoff by retention,detention,and infiltration into the groundwater system.

关键词： unit hydrograph time constant flash floods impervious cover urban streams flashiness hydrogeology

Statistics of evolving Populations and Their Relevance to Flood Risk

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Journal of earth Science 2016年第1期27卷 2-8页

作者： robert e.Criss Department of earth and Planetary Sciences Washington University in St.Louis

Statistical methods are commonly used to evaluate natural populations and environmental variables, yet these must recognize temporal trends in population character to be appropriate in an evolving world. New equations presented here define the statistical measures of aggregate historical populations affected by linear changes in population means and standard deviations. These can be used to extract the statistical character of present-day populations, needed to define modern variability and risk, from tables of historical data that are dominated by measurements made when conditions were different. As an example, many factors such as climate change and in-channel structures are causing flood levels to rise, so realistic estimation of future flood levels must take such secular changes into account. The new equations provide estimates of water levels for ＂100-year＂ floods in the USA Midwest that are 0.5 to 2 m higher than official calculations that routinely assume population stationarity. These equations also show that flood levels will continue to rise by several centimeters per year. This rate is nearly ten times faster than the rise of sea level, and thus represents one of the fastest and most damaging rates of change that is documented by robust data.

关键词： flood risk statistical theory Mississippi River.

Use of Geochemical and Geophysical Techniques to Characterize and Prospect for Geothermal Resources and Hydrothermal Ore Deposits

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Journal of earth Science 2015年第1期26卷 73-77页

作者： robert e.Criss Department of earth and Planetary Sciences Washington UniversitySt.Louis 63130USA

Fluid-rock interactions alter the geochemical, isotopic, petrographic and physical character of host rocks, producing a permanent record of hydrothermal activity. Maps of altered rock properties show regular variations that disclose master geologic controls and delineate likely sites for geothermal and mineral resources. In many cases, geochemical and stable isotope data re- veal the origins of thermal fluids, and they can also provide estimates of reservoir temperatures and identify zones of fluid recharge.

关键词： geothermal system hydrothermal system geophysical prospecting geochemicalprospecting Mt. Lassen oxygen isotope.

Global blue carbon accumulation in tidal wetlands increases with climate change

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National Science Review 2021年第9期8卷 145-155页

作者： Faming Wang Christian J.sanders Isaac R.Santos Jianwu Tang Mark Schuerch Matthew L.Kirwan robert e.Kopp Kai Zhu Xiuzhen Li Jiacan Yuan Wenzhi Liu Zhian Li Xiaoliang Research Station for Tropical Coastal ecosystems Key Laboratory of Vegetation Restoration and Management of Degraded Ecosystems and the CAS Engineering Laboratory for Ecological Restoration of Island and Coastal Ecosystems South China Botanical Garden Chinese Academy of Sciences Center of Plant ecology Core Botanical Gardens Chinese Academy of Sciences Southern Marine Science and engineering Guangdong Laboratory(Guangzhou) State Key Laboratory of estuarine and Coastal Research and Institute of eco-Chongming East China Normal University National Marine Science Centre School of Environment Science and Engineering Southern Cross University Department of Marine Sciences University of Gothenburg Lincoln Centre for Water and Planetary Health School of Geography University of Lincoln Virginia Institute of Marine Science College of William and Mary Department of earth and Planetary Sciences and Rutgers Institute of earth Ocean and Atmospheric Sciences Rutgers University Department of environmental Studies University of California Department of Atmospheric and Oceanic Sciences Fudan University CAS Key Laboratory of Aquatic Botany and Watershed ecology Wuhan Botanical GardenChinese Academy of Sciences

Coastal tidal wetlands produce and accumulate significant amounts of organic carbon(C) that help to mitigate climate change. However, previous data limitations have prevented a robust evaluation of the global rates and mechanisms driving C accumulation. Here, we go beyond recent soil C stock estimates to reveal global tidal wetland C accumulation and predict changes under relative sea level rise, temperature and precipitation. We use data from literature study sites and our new observations spanning wide latitudinal gradients and 20 countries. Globally, tidal wetlands accumulate 53.65(95%CI: 48.52–59.01)Tg C yr-1, which is ～30% of the organic C buried on the ocean floor. Modeling based on current climatic drivers and under projected emissions scenarios revealed a net increase in the global C accumulation by2100. This rapid increase is driven by sea level rise in tidal marshes, and higher temperature and precipitation in mangroves. Countries with large areas of coastal wetlands, like Indonesia and Mexico, are more susceptible to tidal wetland C losses under climate change, while regions such as Australia, Brazil, the USA and China will experience a significant C accumulation increase under all projected scenarios.

关键词： coastal wetlands blue C C burial rate global change

Dependence of Mean and Peak Streamflow on Basin Area in the Conterminous United States

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Journal of earth Science 2016年第1期27卷 83-88页

作者： William e.Winston robert e.Criss Department of earth and Planetary Sciences Washington University in St.Louis

Basin area is the primary control on both mean and peak streamflows, but relationships vary with regional meteorological conditions. Rich historical data sets permit deduction of these relationships for most areas of the United States, revealing both expected and unexpected correlations. On log-log plots, mean flows for most basins with 〉75 cm/y rainfall have unit slopes, with the y-intercept approximating the mean annual runoff. Lower slopes characterize regions where runoff is greatest at high topographic elevations, or where significant withdrawals for irrigation occur at lower elevations. Peak flows also correlate strongly with basin area, but the regressions for most regions have slopes ranging from 0.4 to 0.9, and y-intercepts that increase with increasing flood recurrence interval. The slopes on these log-log plots for peak flows are highest in cool regions with low sunshine and low evapotranspiration, and lowest where sunshine is abundant, evapotranspiration is high, and small convective storm cells are common. effects of relief are small and inconsistent. Peak flows of small watersheds are huge compared to their mean flows, commonly being several thousand times greater, particularly in the USA midcontinent where the slopes for peak flows are low.

关键词： floods GIS runoff rivers.

Machine Learning Models of Plastic Flow Based on Representation Theory

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Computer Modeling in engineering & Sciences 2018年第12期117卷 309-342页

作者： R.e.Jones J.A.Templeton C.M.sanders J.T.Ostien Sandia National Laboratories P.O.Box 969LivermoreCA 94551USA.

We use machine learning(ML)to infer stress and plastic flow rules using data from representative polycrystalline *** particular,we use so-called deep(multilayer)neural networks(NN)to represent the two response *** ML process does not choose appropriate inputs or outputs,rather it is trained on selected inputs and ***,its discrimination of features is crucially connected to the chosen inputoutput ***,we draw upon classical constitutive modeling to select inputs and enforce well-accepted symmetries and other *** the context of the results of numerous simulations,we discuss the design,stability and accuracy of constitutive NNs trained on typical experimental *** these developments,we enable rapid model building in real-time with experiments,and guide data collection and feature discovery.

关键词： Machine learning constitutive modeling plasticity invariance.