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Impact of a physician-supervised exercise-nutrition program with testosterone substitution in partial androgen-deficient middle-aged obese men

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Journal of Geriatric Cardiology 2011年第4期8卷 201-206页

作者： Ernst R Schwarz robert d.willix jr Cenegenics Education and Research Foundation Las Vegas and Heart Institute of Southern CaliforniaBeverly Hills348 S Oakhurst DrBeverly HillsCA 90212USA

Background Partial androgen deficiency syndrome in the aging male is associated with signs of aging such as a development of abdominal obesity,sexual dysfunction,increase body fat,weight gain and the development of cardiac *** We assessed the outcome of a commercially available physician supervised nutrition and exercise program with concomitant testosterone replacement therapy in middle age obese men with partial androgen deficiency in order to reduce cardiac risks *** Fifty-six self referred men without diabetes mellitus,hypertension,or cardiovascular disease(ages 52.3±7.8 years)were randomly selected from a large *** weight,body fat composition,fasting glucose,hemoglobin A1c and fasting lipid levels,as well as free and total testosterone levels were *** patients were assessed and followed 6–18 months after initiation of the *** program consisted of a low glycemic load balanced nutrition diet,a recommended structured daily exercise program of 30–60 minutes,as well as once to twice weekly intramuscular testosterone injections(113.0±27.8 mg).Results At follow up,weight was reduced from 233.9±30.0 pounds(lbs)to 221.3±25.1 lbs(Pduced from 33.2±3.3 kg/m2 to 31.3±2.8 kg/m^(2)(Pdy fat was 27.1%±5.2%vs.34.3%±5.7%at baseline(Pduced from 95.3±14.4 mg/dL to 87.5±12.6 mg/dL(Pduced from 195.4±33.0 mg/dL to 172.7±35.0 mg/dL(Pdverse events were *** Testosterone replacement therapy in middle aged obese men with partial androgen deficiency appeared safe and might have promoted the effects of a weight reduction diet and daily exercise program as long as an adequate physician supervision and follow up was *** combination therapy significantly reduced coronary risk factors such as glucose intolerance and hyperlipidemia.

关键词： aging heart disease androgen deficiency testosterone

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Andropause and the development of cardiovascular disease presentationmore than an epi-phenomenon

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Journal of Geriatric Cardiology 2011年第1期8卷 35-43页

作者： Emst R. Schwarz Anita Phan robert d. willix jr Cedars Sinai Heart Institute Cedars Sinai Medical Center 8700 Beverly Boulevard Suite 6215 Los Angeles CA 90048 USA Cenegenics Medical Institute 851 Rampart Blvd. Las Vegas NV 89145 USA

Andropause refers to a generalized decline of male hormones, including testosterone and dehydroepiandrosterone in middle-aged and aging men. This decline in hormones has been associated with changes such as depression, loss of libido, sexual dysfunction, and changes in body composition. Aging has been associated with an abundance of concomitant diseases, in particular cardiovascular diseases, and although andropause is correlated to aging, a causal relationship between reduction of androgens and the development of chronic diseases such as atherosclerosis and heart failure has not been convincingly established yet. On the other hand, increasing data has emerged that revealed the effects of low levels of androgens on cardiovascular disease progression. As an example, low levels of testosterone have been linked to a higher incidence of coronary artery disease. Whether hormone replacement therapy that is used for andropausal men to alleviate symptoms of ＂male menopause＂ can halt progression of cardiovascular disease, remains controversially discussed, primarily due to the lack of well-designed, randomized controlled trials. At least for symptom improvement, the use of androgen replacement therapy in andropausal men may be clinically indicated, and with the appropriate supervision and follow up may prove to be beneficial with regard to preservation of the integrity of cardiovascular health at higher ages.

关键词： andropause age androgen testosterone heart disease heart failure hormone therapy

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In Vivo Therapeutic Silencing of Hypoxia-Inducible Factor 1 Alpha(HIF-1)Using Single-Walled Carbon Nanotubes Noncovalently Coated with siRNA

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Nano Research 2009年第4期2卷 279-291页

作者： Geoffrey Bartholomeusz Paul Cherukuri John Kingston Laurent Cognet robert Lemos jr Tonya KLeeuw Laura Gumbiner-Russo RBruce Weisman Garth Powis department of Experimental Therapeutics University of Texas M.D.Anderson Cancer Center1515 Holcombe Blvd.HoustonTX 77030USA department of Chemistry Center for Biological and Environmental Nanotechnologyand Institute of Biosciences and BioengineeringRice University6100 Main StreetHoustonTX 77005USA Centre de Physique Moléculaire Optique et Hertzienne UniversitéBordeaux 1 and CNRS351 cours de la Libération33405 Talence CedexFrance

A new approach is described for delivering small interfering RNA(siRNA)into cancer cells by noncovalently complexing unmodifi ed siRNA with pristine single-walled carbon nanotubes(SWCNTs).The complexes were prepared by simple sonication of pristine SWCNTs in a solution of siRNA,which then served both as the cargo and as the suspending agent for the *** complexes containing siRNA targeted to hypoxia-inducible factor 1 alpha(HIF-1)were added to cells growing in serum containing culture media,there was strong specific inhibition of cellular HIF-1 *** ability to obtain a biological response to SWCNT/siRNA complexes was seen in a wide variety of cancer cell ***,intratumoral administration of SWCNT-HIF-1 siRNA complexes in mice bearing MiaPaCa-2/HRE tumors signifi cantly inhibited the activity of tumor *** elevated levels of HIF-1 are found in many human cancers and are associated with resistance to therapy and decreased patient survival,these results imply that SWCNT/siRNA complexes may have value as therapeutic agents.

关键词： siRNA single-walled carbon nanotubes anti-cancer therapy in vivo delivery agent

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新教改革的经济学分析

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开放时代 2009年第11期 94-115页

作者： robert B.Ekelund jr. robert F.Hébert robert d.Tollison 舒萍美国奥本大学商学院美国路易斯安那大学拉法叶校区工商管理学院美国密西西比大学工商管理学院

本文旨在从经济层面解释新教教会最初的成败。本文认为,通过操纵教义、排除异己以及各种形式的价格歧视,中世纪的罗马天主教会最终将其寻求Z商品"精神服务"的信徒置于叛教的边缘。这种垄断的做法鼓励了竞争对手的进入,其中有些对手与国... 详细信息

本文旨在从经济层面解释新教教会最初的成败。本文认为,通过操纵教义、排除异己以及各种形式的价格歧视,中世纪的罗马天主教会最终将其寻求Z商品"精神服务"的信徒置于叛教的边缘。这种垄断的做法鼓励了竞争对手的进入,其中有些对手与国内政府是同盟。本文假定,以封建制衰落、财富分配相对不稳定为特征的新兴企业家社会鼓励新教的进入,而主要是挥霍而不是创造财富的更具同质性的寻租社会则阻碍新教的进入。在这些社会中,罗马教会更有可能延续其价格歧视的做法。通过将长子继承制和城市增长作为财富稳定性的替代指标,可以对这一命题进行非正式的检验。

关键词：经济学分析新教罗马天主教会改革财富分配价格歧视竞争对手经济层面

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Comparison of approaches to quantify SARS-CoV-2 in wastewater using RT-qPCR: Results and implications from a collaborative inter-laboratory study in Canada

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Journal of Environmental Sciences 2021年第9期33卷 218-229页

作者： Alex H.S.Chik Melissa B.Glier Mark Servos Chand S.Mangat Xiao-Li Pang Yuanyuan Qiu Patrick M.d’Aoust Jean-Baptiste Burnet robert delatolla Sarah dorner Qiudi Geng John P.Giesy jr robert Mike McKay Michael R.Mulvey Natalie Prystajecky Nivetha Srikanthan Yuwei Xie Bernadette Conant Steve E.Hrudey Canadian SARS-CoV-Inter-Laboratory Consortium Consultant to Canadian Water Network Inc. KitchenerCanada Presently at Ontario Clean Water Agency MississaugaCanada Environmental Microbiology BC Centre for Disease ControlVancouverCanada department of Biology University of WaterlooWaterlooCanada National Microbiology Laboratory Public Health Agency of CanadaWinnipegCanada Public Health Laboratory Alberta Precision LaboratoryEdmontonCanada department of Laboratory Medicine&Pathology Faculty of Medicine and DentistryUniversity of AlbertaEdmontonAB T6G 2G3Canada Faculty of Engineering University of OttawaOttawaCanada département des génies civil géologique et des minesPolytechnique MontréalMontréalCanada Veterinary Biomedical Sciences University of SaskatchewanSaskatoonCanada Toxicology Centre University of SaskatchewanSaskatoonCanada Great Lakes Institute for Environmental Research University of WindsorWindsorCanada department of Medical Microbiology University of ManitobaWinnipegCanada department of Pathology and Laboratory Medicine University of British ColumbiaVancouverCanada Canadian Water Network Inc. WaterlooCanada Group author details below

detection of SARS-CoV-2 RNA in wastewater is a promising tool for informing public health decisions during the COVId-19 ***,approaches for its analysis by use of reverse transcription quantitative polymerase chain reaction(RT-q PCR)are still far from standardized *** characterize inter-and intra-laboratory variability among results when using various methods deployed across Canada,aliquots from a real wastewater sample were spiked with surrogates of SARS-CoV-2(gamma-radiation inactivated SARS-CoV-2 and human coronavirus strain 229E[HCoV-229E])at low and high levels then provided"blind"to eight *** estimates reported by individual laboratories were consistently within a 1.0-log_(10) range for aliquots of the same spiked *** laboratories distinguished between low-and high-spikes for both *** expected,greater variability was observed in the results amongst laboratories than within individual laboratories,but SARS-CoV-2 RNA concentration estimates for each spiked condition remained mostly within 1.0-log_(10) *** no-spike wastewater aliquots provided yielded non-detects or trace levels(d to methods that included or focused on the solids fraction of the wastewater matrix and might represent in-situ SARS-CoV-2 to the wastewater ***-229E RNA was not detected in the no-spike ***,all methods yielded comparable results at the conditions *** behavior of SARS-CoV-2 and spiked surrogates in wastewater should be considered to evaluate method effectiveness.A consistent method and laboratory to explore wastewater SARS-CoV-2 temporal trends for a given system,with appropriate quality control protocols and documented in adequate detail should succeed.

关键词： COVId-19 Wastewater surveillance Public health Quality assurance Quality control

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Vitamin d and Number of Falls in a Long-Term Care Facility

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Pharmacology & Pharmacy 2012年第4期3卷 453-457页

作者： robert B. Raffa Frank Breve robert Taylor jr. Joseph V. Pergolizzi jr. Mid Atlantic PharmaTech Consultants LLC Ventnor City NJ USA Temple University School of Pharmacy Philadelphia PA USA NEMA Research Inc. Naples FL USA Temple University School of Medicine Temple University Philadelphia PA USA The Johns Hopkins University School of Medicine Baltimore MD and Georgetown University School of Medicine Washington DC USA

Falls represent a significant contribution to the morbidity and mortality of the elderly population. Because vitamin d is important in bone physiology, the use of vitamin d to restore deficient bone and ameliorate the effects of bone fractures due to falls has become a common practice in recent years. Following introduction of widespread use, reports began to emerge that vitamin d not only aided in repair of fall-induced bone fractures, but that it also reduced the occurrence of falls. Vitamin d now has become a routine intervention as a fall-prevention measure. Early analyses found evidence of prevention efficacy (reduced falls), but recent analyses are more equivocal. We retrospectively examined the records of 350 patients in a long-term care facility in which vitamin d administration and the number of falls were recorded as part of a comprehensive database of care. We found a dramatic rise in vitamin d use over the period covered (2006 – 2011) and a corresponding dramatic decrease in the number of falls. However, the number of falls continued to decline after 2008, despite a plateau in number of patients on vitamin d, particularly females. It appears that other factors contribute to the overall decline.

关键词： Falls Bone Fracture Vitamin d Long-Term Care Facility

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Entecavir for treatment of chronic hepatitis B: A clinical update for the treatment of patients with decompensated cirrhosis

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Open Journal of Internal Medicine 2012年第2期2卷 53-61页

作者： P. Patrick Basu robert S. Brown jr. department of Medicine College of Physicians and Surgeons Columbia University New York USA department of Medicine College of Physicians and Surgeons Columbia University New York USA

The introduction of nucleos(t)ide analogues for the treatment of chronic hepatitis B virus (HBV) infection was transformative in reducing morbidity and mortality. Entecavir, a potent selective nucleoside analogue first approved in 2005 for treatment of chronic HBV, is associated with significant antiviral, biochemical, serologic, and histologic responses. Rapid reductions in HBV dNA levels, low risk of resistance development, and a favorable adverse event profile have contributed to its clinical usefulness. Re-cent developments in the use of entecavir have increased its utility in the management of difficult-to-treat patients with chronic HBV, including those patients with decompensated liver disease. Recent studies in this population have demonstrated that entecavir 1.0 mg/d given for up to 48 weeks had superior antiviral activity when compared with adefovir and was generally safe and well tolerated. Long-term outcomes of entecavir in difficult-to-treat populations are eagerly anticipated.

关键词： Aminotransferase Coinfection decompensated Liver disease Entecavir HAART Hepatitis B Virus Hepatocellular Carcinoma Nucleoside Analogue Resistance

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Embryonic Hypertension Following Exposure to Teratogenic doses of 5-Fluoro-2'-deoxyuridine

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Biomedical and Environmental Sciences 1996年第4期9卷 408-417页

作者： VINU d. PATEL robert S. NOLAN NORMAN HU EdWARd B. CLARKA dAVId R. HOOTNICK E. MARK LEVINSOHN ANd dAVId S. PACKARd, jr.(departments of Obstetrics and Gynecology, Anatomy and Cell Biotogy, and Pediatrics, Stale University of New York Health Science C department of Obstetrics and Gynecology State University of New York Health Science Center Syracuse New York 13210 USA.

The teratogenicity of 5-fluoro-2'-deoxyuridine (FdU) is well established. Previously, we have demonstrated that teratogenic doses of FdU produce hematomas and suggested that those hematomas produced skeletal malformations in chicken embryos. In this study, the cardiovascular effects of teratogenic doses of FdU in chicken embryos were studied. A dose of either 0.026 μg FdU or 0.030 μg FdU was injected into the yolk sacs of fertile chicken eggs containing embryos at Hamburger and Hamilton stages 17-19 of development. The embryos were then returned to the incubator. Aortic systolic and diastolic blood pressure,blood velocity and heart rate were measured at stages 21, 24 or 27 using a servonull system and doppler ultrasound. In addition, mean arterial blood pressure, blood flow, and stroke volume were calculated from these data. Similar data were also recorded from uninjected and saline injected control embryos. Systolic and mean arterial blood pressures were significantly increased in FdU-treated embryos at stage 27. The other parameters measured or calculated were not significantly different from control embryos. Our study suggests that elevated systolic blood pressure in chicken embryos treated with FdU may lead to hematoma formation and subsequent birth defects

关键词： deoxyuridine Embryonic Hypertension Following Exposure to Teratogenic doses of 5-Fluoro-2

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古生态学概念与应用 1

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1989年

作者：（美）J.robert dodd ANd robert J.STANTON jr. 徐珊红钱文龙王雪等译

来源：汇雅图书（南通市图书馆... 评论

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Modified Green Tea Polyphenols, EGCG-S and LTP, Inhibit Endospore in Three <i>Bacillus</i>spp.

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Advances in Microbiology 2017年第3期7卷 175-187页

作者： Bushra Ali Lee H. Lee Nozrin Laskar Nadia Shaikh Hassan Tahir Stephen d. Hsu robert Newby jr. Jonathan Valsechi-diaz Tinchun Chu department of Biology Montclair State University Montclair NJ USA department of Oral Biology Augusta University Augusta GA USA department of Biological Sciences Seton Hall University South Orange NJ USA

Endospores have the ability to withstand extreme temperature, desiccation, ultraviolet radiation and chemicals which make them a threat to the food and healthcare industry. Green tea polyphenols (GTP), contain anti-microbial and anti-spore properties but not stable. In this study, two modified lipophilic green tea polyphenols, epigallocatechin-3-gallate-sterate (EGCG-S) and crude lipophilic green tea polyphenols (LTP), were used to compare their anti-spore effect with EGCG and crude GTP. Purified endospores from Bacillus cereus (B. cereus), B. megaterium and B. subtilis were treated with 1% or 5% of four tea polyphenols. Log reduction showed colony forming units (CFU) reduced significantly in all treated samples, ranging from 1.27 to 4.31 with no survivals (CFU = 0) in four samples (P d from 91.68% to 100%. The EGCG-S and LTP have equal or better anti-spore activities compared with EGCG and GTP. EGCG-S and LTP were further used to carry out time course study on B. cereus. The results indicated that 15 min of treatment of 1% and 5% LTP and EGCG-S are able to inhibit 98.7% to 100% of germination. Transmission and scanning electron microscopy studies showed that EGCG-S caused surface disruption and damaged spores structural integrity. EGCG-S and LTP are stable anti-spore agents may aid in preventing food and beverage spoilage caused by spore-forming bacteria as well as preventing contamination in the medical industry.

关键词： Bacterial Spores Antimicrobials Bacillus Germination Biocontrol

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