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The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair

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Bone Research 2024年第2期12卷 289-301页

作者： Heeseog Kang Amy L.Strong Yuxiao Sun Lei Guo Conan Juan Alec C.Bancroft Ji Hae Choi Chase A.Pagani Aysel A.Fernandes Michael Woodard Juhoon Lee Sowmya Ramesh Aaron W.James David Hudson Kevin N.Dalby Lin Xu robert J.Tower Benjamin Levi Center for Organogenesis Regeneration and TraumaDepartment of SurgeryUniversity of Texas SouthwesternDallasTX 75390USA Section of Plastic Surgery Department of SurgeryUniversity of MichiganAnn ArborMI 48109USA Quantitative Biomedical Research Center Peter O’Donnell Jr.School of Public HealthUniversity of Texas SouthwesternDallasTX 75390USA Department of Orthopedics and Sports Medicine University of WashingtonSeattleWA 98195USA Division of Chemical Biology and Medicinal Chemistry College of PharmacyUniversity of Texas at AustinAustinTX 78712USA Department of Pathology Johns Hopkins UniversityBaltimoreMD 21218USA

While hypoxic signaling has been shown to play a role in many cellular processes,its role in metabolism-linked extracellular matrix(eCM)organization and downstream processes of cell fate after musculoskeletal injury remains to be ***(HO)is a debilitating condition where abnormal bone formation occurs within extra-skeletal *** andhypoxia-inducible factor 1α(HIF-1α)activation have been shown to promote ***,the underlying molecular mechanisms bywhich the HIF-1αpathway in mesenchymal progenitor cells(MPCs)contributes to pathologic bone formation remain to ***,we used a proven mouse injury-induced HO model to investigate the role of HIF-1αon aberrant cell ***-cell RNA sequencing(scRNA-seq)and spatial transcriptomics analyses of the HO site,we found that collagen eCM organizationis the most highly up-regulated biological process in *** mesenchymal cell-specific deletion of Hif1α(Hoxa11-CreeR^(T2);Hif1a^(fl/fl))significantly mitigated HO in ***-seq analysis of these Hoxa11-CreeR^(T2);Hif1a^(fl/fl)mice identified the PLOD2/LOXpathway for collagen cross-linking as downstream of the HIF-1αregulation of ***,our scRNA-seq data and mechanisticstudies further uncovered that glucose metabolism in MPCs is most highly impacted by HIF-1α*** a translational aspect,a pan-LOX inhibitor significantly decreased HO.A newly screened compound revealed that the inhibition of PLOD2 activity in MPCssignificantly decreased osteogenic differentiation and glycolytic *** suggests that the HIF-1α/PLOD2/LOX axis linked tometabolism regulates HO-forming MPC *** results suggest that the HIF-1α/PLOD2/LOX pathway represents a promisingstrategy to mitigate HO formation.

关键词： metabolism skeletal aberrant

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Putting it all together： intrinsic and extrinsic mechanisms governing proteasome biogenesis

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Frontiers in Biology 2017年第1期12卷 19-48页

作者： Lauren A. Howell robert J. Tomko jr. Andrew R. Kusmierczyk Department of Biomedical Sciences Florida State University College of Medicine Tallahassee FL 32306 USA Department of Biology Indiana University-Purdue Universi~ Indianapolis Indianapolis IN 46202 USA

BACKGROUND： The 26S proteasome is at the heart of the ubiquitin-proteasome system, which is the key cellular pathway for the regulated degradation of proteins and enforcement of protein quality control. The 26S proteasome is an unusually large and complicated protease comprising a 28-subunit core particle （CP） capped by one or two 19-subunit regulatory particles （RP）. Multiple activities within the RP process incoming ubiquitinated substrates for eventual degradation by the barrel-shaped Ce The large size and elaborate architecture of the proteasome have made it an exceptional model for understanding mechanistic themes in macromolecular assembly. OBJeCTIVe： In the present work, we highlight the most recent mechanistic insights into proteasome assembly, with particular emphasis on intrinsic and extrinsic factors regulating proteasome biogenesis. We also describe new and exciting questions arising about how proteasome assembly is regulated and deregulated in normal and diseased cells. MeTHODS： A comprehensive literature search using the PubMed search engine was performed, and key findings yielding mechanistic insight into proteasome assembly were included in this review. ReSULTS： Key recent studies have revealed that proteasome biogenesis is dependent upon intrinsic features of the subunits themselves as well as extrinsic factors, many of which function as dedicated chaperones. CONCLUSION： Cells rely on a diverse set of mechanistic strategies to ensure the rapid, efficient, and faithful assembly of proteasomes from their cognate subunits. Importantly, physiological as well as pathological changes to proteasome assembly are emerging as exciting paradigms to alter protein degradation in vivo.

关键词： proteasome assembly assembly chaperones ubiquitin-proteasome system proteolysis macromolecular complex

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A long-term in situ calibration system for chemistry analysis of seawater

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Journal of Zhejiang University-Science A(Applied Physics & engineering) 2010年第9期11卷 701-708页

作者： Chun-yang TAN Bo JIN Kang DING William e. SeYFRIeD jr. Ying CHeN State Key Lab of Fluid Power Transmission and Control Zhejiang University Hangzhou 310027 China Department of Geology and Geophysics University of Minnesota Minneapolis 55455 USA

An in situ calibration system is a versatile exploration instrument for electrochemical sensors investigating the biochemical properties of the marine environment. The purpose of this paper is to describe the design of an auto-calibrating system for electrochemical (pH) sensors, which permits two-point in situ calibration, suitable for long-term measurement in deep sea aqueous environments. Holding multiple sensors, the instrument is designed to perform long-term measurements and in situ calibrations at abyssal depth (up to 4000 m). The instrument is composed of a compact fluid control system which is pressure-equilibrated and designed for deep-sea operation. In situ calibration capability plays a key role in the quality and reproducibility of the data. This paper focuses on methods for extending the lifetime of the instrument, considering the fluidics design, mechanical design, and low-power consumption of the electronics controller. The instrument can last 46 d under normal operating conditions, fulfilling the need for long-term operation. Data concerning pH measured during the KNOX18RR cruise (Mid-Atlantic Ridge, July-August, 2008) illustrate the desirable properties of the instrument. Combined with different electrodes (pH, H2, H2S, etc.), it should be of great utility for the study of deep ocean environments, including water column and diffuse-flow hydrothermal fluids.

关键词： pH Long-term In situ calibration Flow control Low power

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High-performance warm white LeD based on thermally stable all inorganic perovskite quantum dots

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Opto-electronic Advances 2023年第3期6卷 84-87页

作者： jr-Hau He Department of Materials Science and engineering City University of Hong KongHong Kong 999077China

All inorganic CsPbBr_(3) quantum dots(QDs)are regarded as excellent candidates for next-generation emitters due to their high photoluminescence quantum yield(PLQY)and defect ***,the poor stability and degraded luminescent performance may impede their further commercialization because of the separation of conventional ligands from the QDs ***,Zang replaced the regular oleic acid with 2-hexyl-decanoic acid(DA),which possesses higher binding energy on the QDs surfaces,to act as ligands of QDs,exhibiting PLQY of 96%and excellent stabilities against ethanol and *** with DA-modified CsPbBr_(3) QDs achieved improved thermal stability,a color rendering index of 93,a power efficiency of 64.8 lm/W and a properly correlated color temperature value of 3018 K,implying their prominent applications in solid-state lighting and displays.

关键词： inorganic quantum performance

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Dynamic Fault Model for On-Line evaluation of Yarn end Breakage during Ring Spinning

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Journal of Donghua University(english edition) 2012年第5期29卷 423-427页

作者：黄迪山 BROUGHTON Roy M jr eLMOGAHZY Yelia e School of Mechatronic engineering and Automation Shanghai University Department of Polymer and Fiber engineering Auburn University

In this paper, a dynamic fault model is proposed to predict yarn end breakage in the spinning procedure through investigation of fault characteristics. In view of the principle that uniformity bad in raw material causes iustable yarn formation, the investigation focuses on the fault characteristic existing in the dynamic tension. Analyzing the dynamic spinning system, the phenomenon of over random shock in a spinning triangle is discovered to be the main physical event prior to yarn end breakage. The fault characteristic is further confirmed by dynamic tests and signal processing, and can be used to make an approach to predicting yarn end breakage. A relative energy feature is defined for evaluating the tendency of yarn end breakage, and its effectiveness is verified by *** monitoring tests in the laboratory. The research results show that the proposed dynamic fault model has not only an advantage in indicating the presence of fault characteristics, but also great potentials in quantitating fault in online spinning monitoring.

关键词： yarn end breakage fault characteristic on-line monitoring spinning procedure fault model

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Impact on Soil Organic C and Total Soil N from Cool- and Warm-Season Legumes Used in a Green Manure-Forage Cropping System

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Agricultural Sciences 2024年第3期15卷 333-357页

作者： Clark B. Neely Francis M. Rouquette jr. Cristine L.S. Morgan Frank M. Hons William L. Rooney Gerald R. Smith Department of Soil and Crop Science Washington State University Pullman WA USA Texas A&M AgriLife Research Overton TX USA Chief Scientific Officer Soil Health Institute Morrisville NC USA Department of Soil and Crop Science Texas A&M University College Station TX USA

Annual forage legumes are important components of livestock production systems in east Texas and the southeastern US. Forage legumes contribute nitrogen (N) to cropping systems through biological N fixation, and their seasonal biomass production can be managed to complement forage grasses. Our research objectives were to evaluate both warm- and cool-season annual forage legumes as green manure for biomass, N content, ability to enhance soil organic carbon (SOC) and soil N, and impact on post season forage grass crops. Nine warm-season forage legumes (WSL) were spring planted and incorporated as green manure in the fall. Forage rye (Secale cereale L.) was planted following the incorporation of WSL treatments. eight cool-season forage legumes (CSL) were fall planted in previously fallow plots and incorporated as green manure in late spring. Sorghum-sudangrass (Sorghum bicolor x Sorghum bicolor var. sudanense) was planted over all treatments in early summer after forage rye harvest and incorporation of CSL treatments. Sorghum-sudangrass was harvested in June, August and September, and treatments were evaluated for dry matter and N concentration. Soil cores were taken from each plot, split into depths of 0 to 15, 15 to 30 and 30 to 60 cm, and soil C and N were measured using combustion analysis. Nylon mesh bags containing plant samples were buried at 15 cm and used to evaluate decomposition rate of above ground legume biomass, including change in C and N concentrations. Mungbean (Vigna radiata L. [Wilczek]) had the highest shoot biomass yield (6.24 t DM ha-1) and contributed the most total N (167 kg∙ha-1) and total C (3043 kg∙ha-1) of the WSL tested. Decomposition rate of WSL biomass was rapid in the first 10 weeks and very slow afterward. Winter pea (Pisum sativum L. spp. sativum), arrow leaf clover (Trifolium vesiculosum Savi.), and crimson clover (Trifolium incarnatum L.) were the most productive CSL in this trial. Austrian winter pea

关键词： Annual Legumes Soil N Soil Organic C Green Manure Deer Browse Forage Cropping Systems

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Systematic review with meta-analysis on transplantation for alcohol-related liver disease:Very low evidence of improved outcomes

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World Journal of Gastroenterology 2019年第13期25卷 1628-1639页

作者： Nicole T Shen Cristina Londono Stephanie Gold Ashley Wu Keith C Mages robert S jr Brown Department of Medicine Division of Gastroenterology and Hepatology Weill Cornell Medicine New York Department of Medicine Weill Cornell Medical College New York Department of Medicine Division of Internal Medicine Weill Cornell Medicine New York Department of Medicine Weill Cornell Medical College Samuel J. Wood Library and C.V. Starr Biomedical Information Center New York

BACKGROUND Alcohol-related liver disease(ALD) is a leading cause of liver failure and indication for liver transplantation that arises in the setting of alcohol use disorder(AUD). Previous reviews of transplantation for ALD are limited in scope of outcomes and type of ALD studied. A comprehensive systematic review could improve use of transplantation in ALD and improve future research. We hypothesize that while transplanting ALD may improve mortality and relapse,findings will be limited by pre-specified causes of heterogeneity-assessment and treatment of AUD, definition of ALD, spectrum of ALD studied, assessment and rates of relapse, and study quality and *** To optimize liver transplantation for ALD, understanding existing research to guide future research, we conducted a systematic review with *** We conducted a systematic review, comparing liver transplant to no-transplant in patients with ALD, with a primary outcome of both short-and long-term mortality and relapse. We performed a comprehensive search of MeDLINe,eMBASe, Web of Science, and The Cochrane Library databases for peer-reviewed journal articles comparing use of liver transplant in ALD to no-transplant. Two reviewers independently conducted screening, full text review, and data extraction according to the PRISMA guidelines. We report the quality of the evidence according to the GRADe *** We analyzed data from 10 studies. Of 1332 participants, 34.2%(456/1332) had undergone liver transplantation, while 65.8%(876/1332) had not. While random effects meta-analysis suggested transplant in comparison to no-transplant had an association of reduced mortality that did not reach statistical significance, relative risk(RR) = 0.51(0.25-1.05), but not relapse risk, RR = 0.52(0.18-1.53), significant heterogeneity limited these findings. When restricted to prospective data,transplant compared to no-transplant significantly reduced mortality, RR = 0.25(0.13-0.46, P elap

关键词： Alcohol-related hepatitis Alcohol-related cirrhosis Alcohol use disorder Liver transplantation Standardization

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菜单成本和菲利普斯曲线

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经济资料译丛 2008年第1期 58-75页

作者： Golosov Mikhail jr robert e lucas 张艳丽（译）任洲鸿（译）不详中国人民大学经济学院 100872 曲阜师范大学（日照校区）经济学院 273165

这篇文章提出了一个货币经济模型，在该模型中，个别厂商受制于特别生产率冲击和全面通货膨胀的影响。卖方在承担实际“菜单成本”的情况下才可能改变价格，利用Klenow和Kryvtsov所提供的美国最新的单个价格的数据集，我们校正这一成本... 详细信息

这篇文章提出了一个货币经济模型，在该模型中，个别厂商受制于特别生产率冲击和全面通货膨胀的影响。卖方在承担实际“菜单成本”的情况下才可能改变价格，利用Klenow和Kryvtsov所提供的美国最新的单个价格的数据集，我们校正这一成本和特殊冲击的方差以及自相关，该校正了的模型关于高通胀对价格变化频率影响的预测，与来自不同研究数据非常一致，

关键词：菜单成本菲利普斯曲线货币经济模型价格变化通货膨胀生产率数据集自相关

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Accuracy and safety of partial thickness femtosecond laser radial and arcuate keratotomy incisions in porcine eyes

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eye and Vision 2021年第1期8卷 412-421页

作者： e.Valas Teuma Frank A.Bucci jr Raman Bedi Gary Gray Mark Packer LeNSAR Inc.OrlandoFLUSA Bucci Laser Vision Institute Wilkes-BarreWilkes‑BarrePAUSA IrisARC ChandigarhIndia Packer Research Associates Inc.1400 Bluebell Ave.BoulderCO 80302USA

Background:To evaluate the accuracy and safety of micro radial and arcuate keratotomy incisions constructed by a femtosecond laser system with a curved contact patient interface in porcine ***:Partial thickness micro radial and arcuate keratotomy incisions were constructed in porcine eyes with a femtosecond laser system and evaluated for precision of depth,quality,and *** coherence tomography was used to determine the accuracy and precision of incision *** endothelial safety was assessed by a fluorescent live/dead cell viability assay to demonstrate laser-induced endothelial cell *** was evaluated by ease of opening and examination of ***:In two micro radial incision groups,intended incision depths of 50%and 80%resulted in mean achieved depths of 50.01%and 77.69%,*** three arcuate incision groups,intended incision depths of 80%,600μm or 100μm residual uncut bed thickness resulted in mean achieved depths of 80.16%,603.03μm and residual bed of 115μm,*** loss of endothelial cell density occurred when the residual corneal bed was maintained at a minimum of 85-116μ*** incisions were easy to open,and interfaces were ***:A femtosecond laser system with curved contact interface created precise and reproducible micro radial and arcuate keratotomy *** and precision of the incision depth and preservation of endothelial cell density demonstrated the effectiveness and safety of the system.

关键词： Partial thickness micro radial and arcuate keratotomy incisions Curved contact patient interface Micro radial keratotomy Arcuate keratotomy Femtosecond laser system with curved contact interface LeNSAR femtosecond laser system

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The Professional Characteristics of Secondary Science Teachers to Students’ Academic effects:a Case of Bukidnonin the Philippines

The Professional Characteristics of Secondary Science Teache...

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作者： Reynaldo e.Manuel.jr. 华东师范大学

学位级别：硕士

本论文是一项旨在考察菲律宾Bukidnon地区中学科学教师的专业特征与该地区学生学业结果的调查研究。论文详细考察了受访者的个人和专业的履历,这些都在他们3到5年的职业生涯中对学生在学业表现方面产生了影响。为了提供一个有说服力的... 详细信息

本论文是一项旨在考察菲律宾Bukidnon地区中学科学教师的专业特征与该地区学生学业结果的调查研究。论文详细考察了受访者的个人和专业的履历,这些都在他们3到5年的职业生涯中对学生在学业表现方面产生了影响。为了提供一个有说服力的、客观的框架结构来考察和呈现论题,本研究采用了定量和定性相结合的方法进行数据收集。研究结果揭示了菲律宾Bukidnon地区中学科学教师在教师专业发展背景下缺乏学科知识、教育学、信息通讯技术应用于其他领域等方面的足够训练。对受访者的调查还发现,他们的教学负担过重,以至于没有时间进行学生辅导、家庭作业检查和阅读书籍。过去三年的全国成就测试(National Achievement Test)的结果,还呈现出一种令人担忧的下滑趋势,这也使得我们要反思受访者的专业特征情况。此外,研究还发现超过一半的受访者在过去的五年中未赢得过任何学术竞赛。因而,这正是论文努力要呈现的在督导视角下的学科现状。从这个角度,本论文期望能够有一个参照框架建立起政策与实践之间的桥梁,并引起教育部门政策制定者的足够重视。

关键词：专业特征学业结果学生成就科学教师中学全国成就测试(NAT) 菲律宾

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